Python tests

MRG: add skipmers; switch to reading frame approach for translation, skipmers #7608

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Run time

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Job	Run time
test (ubuntu-22.04, 3.12)	10m 35s
test (ubuntu-22.04, 3.11)	9m 26s
test (ubuntu-22.04, 3.10)	11m 0s
test (macos-latest, 3.12)	6m 24s
test (macos-latest, 3.11)	6m 40s
test (macos-latest, 3.10)	7m 23s
	51m 28s