Python tests

MRG: add skipmers; switch to reading frame approach for translation, skipmers #7607

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Run time

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Job	Run time
test (ubuntu-22.04, 3.12)	11m 21s
test (ubuntu-22.04, 3.11)	9m 25s
test (ubuntu-22.04, 3.10)	10m 56s
test (macos-latest, 3.12)	6m 48s
test (macos-latest, 3.11)	7m 7s
test (macos-latest, 3.10)	7m 2s
	52m 39s