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Merge pull request #8 from simularium/feature/update-data-and-title
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Update title and add data release link
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blairlyons authored Sep 11, 2024
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<h1>Simulating Actin Compression</h1>
<h2>
Comparing simulations of actin filament bending and twisting reveals tradeoff between
computational cost and capturing detailed behaviors
Comparing simulations of actin filament compression reveals tradeoff between computational cost and capturing supertwist
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<h4>
Blair Lyons<sup>1, *</sup>,
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to produce force. The actin cytoskeleton plays a central role in force production in these processes.
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<p>
Actin filaments bend and twist in response to mechanical forces, storing elastic energy. Bent actin filaments
are found in diverse cellular structures, where this elastic energy can be used to do mechanical work.
Actin filaments bend and twist in response to mechanical forces, storing elastic energy. Bent actin filaments
are found in diverse cellular structures, where this elastic energy can be used to do mechanical work.
</p>
<p>
The helical structure of actin filaments results in the coupling of filament twisting and bending,
which impacts the geometry of the actin network in 3D space. This influences how actin networks respond to
which impacts the geometry of the actin network in 3D space. This influences how actin networks respond to
and participate in subcellular force production.
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<img src="img/bibeau2023twist_fig2A.png" />
<p>
Fluorescence micrograph of an actin filament (magenta) attached to a paramagnetic bead (cyan).
Fluorescence micrograph of an actin filament (magenta) attached to a paramagnetic bead (cyan).
<br /><br />
JP Bibeau, NG Pandit, S Gray, N Shatery Nejad, CV Sindelar, W Cao, EM De La Cruz. <strong>Twist response of actin filaments</strong> (Figure 2A). <em>Proceedings of the National Academy of Sciences</em>, 120(4):e2208536120, 2023. DOI: <a target="_blank" href="https://doi.org/10.1073/pnas.2208536120">10.1073/pnas.2208536120</a>
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<p>
Our simulation, analysis, and visualization pipeline code is available
<a href="https://github.com/simularium/subcell-pipeline" target="_blank">here</a> and simulation data is available
<a href="" target="_blank">here</a>.
</p>
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[TODO: add link to simulation data]
<a href="https://open.quiltdata.com/b/allencell/tree/aics/subcellular_model_simulations/subcellular_model_simulations_actin_comparison/" target="_blank">here</a>.
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