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dbouget authored May 3, 2022
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[![Build Actions Status](https://github.com/dbouget/neuro_rads_prototype/workflows/Build/badge.svg)](https://github.com/dbouget/neuro_rads_prototype/actions)

## 1. Description
Software to automatically segment tumors and their from pre-operative CTs and MRIs, and report them in a standardized manner.
Software to automatically segment brain tumors from pre-operative MRI scans, compute their characteristics (e.g., volume, location), and generate a standardized report.

The software was introduced in the article "Brain tumor preoperative surgery imaging: models and software solutions for
segmentation and standardized reporting", which has been submitted to [Frontiers in Neurology](https://www.frontiersin.org/journals/neurology).

## 2. Softwares and usage
An installer is provided for the three main Operating Systems: Windows (~v10, 64-bit), macOS (>= Catalina), and Ubuntu Linux (>= 18.04).
The software can be downloaded from [here](https://github.com/SINTEFMedtek/GSI-RADS/releases) (see **Assets**).
The software can be downloaded from [here](https://github.com/dbouget/Raidionics/releases) (see **Assets**).

### 2.1 Download and installation
These steps are only needed to do once:
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3) Search for the software "Raidionics" and double click to run.

### 2.2 Usage
1) Click 'Input MRI...' to select from your file explorer the MRI scan to process (unique file).
Two modes are proposed: (i) Single-use for processing one MRI scan at a time with the possibility to view and interact with the results, and (ii) Batch-mode for processing multiple MRI scans in a row, without any vizualisation.

For the single use case:
1) Click 'Input MRI...' to select from your file explorer the MRI scan to process (unique file), preferably as nifti (*.nii, *.nii.gz).
1*) Alternatively, Click 'File > Import DICOM...' if you wish to process an MRI scan as a DICOM sequence.
2) Click 'Output destination' to choose a directory where to save the results.
3) (OPTIONAL) Click 'Input segmentation' to choose a tumor segmentation mask file, if nothing is provided the internal model with generate the segmentation automatically.
4) Click 'Run diagnosis' to perform the analysis. The human-readable version of the results will be displayed directly in the interface.

NOTE: The output folder is populated automatically with the following:
* The diagnosis results in human-readable text (report.txt) and Excel-ready format (report.csv).
* The automatic segmentation masks of the brain and the tumor in the original patient space (input_brain_mask.nii.gz and input_tumor_mask.nii.gz).
* The cortical structures mask in original patient space for the different atlases used.
* The input volume and tumor segmentation mask in MNI space in the sub-directory named \'registration\'.
4) Select the tumor type from the drop-down menu, supported types are: (i) High-Grade Glioma (glioblastoma), (ii) Low-Grade Glioma, (iii) Meningioma, and (iv) Metastasis.
5) Click 'Run segmentation' to generate the brain tumor mask, or 'Run standard reporting' to perform the full analysis. The human-readable version of the results will be displayed directly in the interface.

### 2.3 Computed features
The following features are automatically computed and reported to the user:
- **Multifocality**: whether the tumor is multifocal or not, the total number of foci, and the largest minimum distance between two foci.
- **Volume**: total tumor volume in original patient space and MNI space (in ml).
- **Laterality**: tumor percentage in each hemisphere, and assessment of midline crossing.
- **Resectability**: expected residual volumes (in ml) and resection index.
- **Resectability**: expected residual volumes (in ml) and resection index (for high-grade gliomas only).
- **Cortical structures**: percentage of the tumor volume overlapping each structure from the MNI atlas, the Harvard-Oxford atlas, and Schaefer atlas (version 7 and 17).
- **Subcortical structures**: percentage of the tumor volume overlapping each structure from the BCB atlas. If no overlap, the minimum distance to the structure is provided (in mm).

### 2.4 Generated results
The output folder is populated automatically with the following:
* The diagnosis results in human-readable text (report.txt) and Excel-ready format (report.csv).
* The automatic segmentation masks of the brain and the tumor in the original patient space (input_brain_mask.nii.gz and input_tumor_mask.nii.gz).
* The cortical structures mask in original patient space for the different atlases used.
* The input volume and tumor segmentation mask in MNI space in the sub-directory named \'registration\'.

## 3. Source code usage

### 3.1 Installation
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> pip install -r ../requirements.txt
> deactivate
Then, to download the trained models locally, run the following:
> source venv/bin/activate
> python setup.py
> deactivate
### 3.2 Usage
The command line input parameters are:
* -g [--use_gui]: Must be set to 0 to disable the gui, otherwise 1.
* -i [--input_filename]: Complete path to the MRI volume to process.
* (optional) -s [--input_tumor_segmentation_filename]: Complete path to the corresponding tumor mask, to avoid re-segmentation.
* -o [--output_folder]: Main destination directory. A unique timestamped folder will be created inside for each run.
* -d [--gpu_id]: Number of the GPU to use for the segmentation task. Set the value to -1 to run on CPU.
* -t [--task]: Process to perform, either segmentation or diagnosis (for generating the standardized report).
* -m [--model_segmentation]: Name of the trained model to use (from the list of automatically downloadable models).

To run directly from command line, without the use of the GUI, run the following:
To run segmentation directly from command line, without the use of the GUI, run the following:
> source venv/bin/activate
> python main.py -g 0 -i /path/to/volume/T1.nii.gz -o /path/to/output/ -d 0
> python main.py -g 0 -i /path/to/volume/T1.nii.gz -o /path/to/output/ -d 0 -t segmentation -m MRI_Meningioma
> deactivate
### How to cite
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