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Multimodal immunogenomic biomarker analysis of tumours from pediatric patients enrolled to a phase 1-2 study of single-agent atezolizumab

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pughlab/iMATRIX-Atezo_Biomarker

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Biomarker analysis of tumours from pediatric patients treated with atezolizumab

This repo contains custom R codes used for figures in the manuscript "Multimodal immunogenomic biomarker analysis of tumours from pediatric patients enrolled to a phase 1-2 study of single-agent atezolizumab".

Dependencies

survminer, survival, forestplot, ggplot2, ggbeeswarm, ggsignif, ComplexHeatmap, circlize, Hmisc, fgsea, ggrepel

How to run

Clone the repo to your home directory (~/). Upon data request approval (see below), download supplementary tables in data/. Run scripts in main/. Output will be in folder out/.

Data availability

Individual patient-level data, including de-identified clinical metadata, raw RNAseq data, raw TCRseq data, and processed F1 sequencing data will be made available to qualified researchers at the European Genome-Phenome Archive under accession number EGAS00001006004. For further information, please contact lead authors.

Contact

Arash Nabbi: [email protected]

Katherine E. Hutchinson: [email protected]

Trevor J. Pugh: [email protected]

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Multimodal immunogenomic biomarker analysis of tumours from pediatric patients enrolled to a phase 1-2 study of single-agent atezolizumab

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