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8__transcript.txt
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[Music]
welcome to the huberman lab guest Series
where I and an expert guest discuss
science and science-based tools for
everyday life
I'm Andrew huberman and I'm a professor
of neurobiology and Ophthalmology at
Stanford School of Medicine today's
episode is the fifth in a six episode
series on fitness exercise and
performance and today's episode is all
about recovery that is how to maximize
your recovery to achieve your fitness
and exercise and performance goals and
how to avoid over training Dr Andy
Galpin
great to be back
today we're discussing recovery and I'm
very excited to have this discussion
because as we know despite the fact that
different types of exercise can be used
to trigger different types of adaptation
such as increased long distance
endurance
anaerobic capacity strength hypertrophy
Etc
the workouts themselves are not actually
when the progress occurs when the
adaptation occurs and this to me is
extremely interesting because it
parallels what we see with so-called
neuroplasticity which is the nervous
system's ability to change in response
to experience we sit down to learn
something
we experience something
and that is the trigger for rewiring of
the nervous system but the actual
rewiring occurs away from the experience
or the learning
so too in Fitness and in exercise
recovery is where the Real Results
actually emerge where we get better
so I'd love for you to explain what
recovery really is
and the different types of recovery
certainly different ways to enhance
recovery and I'd also love for you to
explain whether or not there are ways
that people can become better at
recovering because if indeed recovery is
when progress emerges when we get better
well then anything that supports our
recovery and gets us better at
recovering
ought to increase our rate and our
degree of progress absolutely you nailed
it in the description what people really
want is some sort of change whether you
are talking athletes or general
population this change is uh some sort
of improvement in muscle function
reduction in body fat
higher functioning metabolism whatever
the case is and the only way that
happens is
we talk about the equation of stress
causes adaptation but as you alluded to
the piece in the middle is only if you
can recover from it and so the game
we're playing here is we all agree we
want more adaptation that means we need
to bring more stress into the system but
we then have to ensure that our recovery
outpaces
the stress input or else no adaptation
will occur in fact what happens is you
will actually be in a negative spot and
start going backwards and so what I
would love to do is is talk about how
we've handled this and I've had a decent
amount of experience here I was
fortunate enough to do my master's
degree in the laboratory of a gentleman
named Andy Frye who's an nsca Lifetime
Achievement Award winner and he studied
in large part recovery over training
overuse overload in a lot of areas in
addition I've been fortunate enough to
work with individuals from high
functioning CEOs and Executives who have
little time for Recovery High job stress
to in to athletes uh and they think of
the example of pitchers in Major League
Baseball who have to recover in a matter
of four days that they can pitch again
at maximum velocity so I would love to
outline some of the tools and tactics
strategies that we use for all these
individuals give you some foundational
stuff and I would love to maybe actually
cover some things that most people have
never heard of some stuff you may not
have access to some technologies that we
use some biomarkers and then even a
whole bunch of things that are keeping
with the theme of your show here cost
free or extremely low cost so all those
strategies what I'd also like to do is
cover nutrition and supplementation and
fueling and hydration and things but
that's probably going to have to be
saved for an additional conversation
that we'll do in the next episode yes so
we will absolutely hold a conversation
about nutrition and supplementation
where you can educate us about all the
top Contour stuff all the way down to
the the fine details
I do have a question about recovery and
it's one that I think most people are
familiar with themselves
which is soreness
we think of it as a muscle soreness but
I was trained early on in my scientific
career to always question the
seemingly obvious so a couple of
questions about soreness first of all
what does soreness really reflect
is it really muscle soreness
it feels like it's in the muscles but
what other organ systems and tissues and
cell types does it involve and then I'm
particularly interested in this concept
or this experience that many of us
including myself
had which is delayed onset muscle
soreness why would it be that when we
are less in shape or when we perform a
movement that is extremely novel to us
the soreness seems to arrive after
a reasonable delay of maybe even a day
you know we're fine the next day but
then 48 hours later we are exceedingly
sore
and as we get more fit or more familiar
with the movement the soreness seems to
arrive earlier so I realized I just
asked you about three questions or more
first of all what is muscle soreness
at a seller level which sells which
organ systems and so forth what is it
mean if we are sore is something I know
we'll get into a little bit later and
then why the delayed onset muscle
soreness it's actually one question so
it's totally fine you answered all you
asked all three because I'm going to
actually answer number three which will
answer number two which will actually
answer number one
I'd love to tell you that I set it up
that way intentionally but uh I'm just
happy to hear that where I was unable to
be concise you are able to be concise
thank you
we are still learning a lot about this
area it's actually really difficult to
perform these studies anytime you ask a
question about something like pain
or soreness you're immediately talking
about perception
and there is obviously a physical
component to that and there's also
perception and so teasing those things
out is extraordinarily challenging that
said there has been a lot of work in
this area in fact probably um you may
have a show already out on pain or maybe
one's coming down the road we did an
episode on pain uh a while ago but it's
definitely time to revisit that
literature I also have some amazing
colleagues at Stanford who work on pain
both from the uh cellular molecular side
but also from the psychological side
about how our understanding of pain and
what we believe about pain shapes the
experience of pain and Pain Relief
amazing that's that stuff is incredibly
important and I'm glad we flagged that
and maybe we'll just call that good for
now they could come back later for
another one of your shows so that being
said
why does it happen uh 28 to 48 hours
after you exercise well that actually
should give you some Clues into what's
happening so the traditional dogma of
delayed onset muscle soreness is what
this is called is that it is a result of
quote unquote micro tears and the muscle
and so you can sort of think I challenge
the muscle there was some small tears in
there and I'm feeling the results of
that well in fact that certainly does
happen and it can happen that is not
what's explaining your muscle soreness
and in fact you can be quite sore
from exercise and have no measurable
amount of muscle damage
and so much like anything else when
we're in this idea of pain it's not a
one-to-one
explanation there are multiple factors
that are probably causing your
perception of pain muscle damage
can be one of them it is not the only
one and it is probably in my opinion
though this has yet to be shown
definitively
probably not even the leading cause of
it and so what's actually happening well
the reason is taking you 24 to 48 hours
is you can actually find various papers
literature reviews dating back in a
number of years now over a decade that
show these wonderful curves of an
inflammatory and immune response and we
don't need to necessarily go through the
entire physiology right now but
effectively what's happening is those
things have a little bit of a time delay
and so some of those steps happen
immediately like right when the exercise
is there and then some of them are
delayed six to 24 to 48 hours if you
know a little bit about this physiology
it's you have a combination of
neutrophils and macrophages and a bunch
of things happening and this has a Time
sequence so what happens is by the time
we get to this 28 to 48 hour window
now the muscle soreness kicks in
which wait a minute if I if this was a
result of my muscles being torn
and that happened immediately
wouldn't that pain start immediately
well the answer is it would and so that
that is your first clue that that's not
responsible for it when we look at that
immune response and we see that that is
actually Peak 24 to 48 hours later
and then that's the same time the pain
kicked in that's cooling you with the
problem so we have this immune response
happening in inflammation then all of a
sudden we start getting fluid
accumulation and now there are what are
called nociceptors and you're probably
very obviously you're very familiar with
these and these are pain receptors
what's actually interesting is we don't
necessarily know
a lot of information about how many pain
receptors are in muscle
they're not really in the belly in fact
this is why I can perform my muscle
biopsies and they don't really hurt you
mean in the belly of the muscle correct
yeah we do have pressure sensors though
and so if you change the volume of the
tissue you will respond to that very
very quickly so by enhancing swelling in
the actual muscle that is immediately
putting pressure
on those pressure receptors if you will
that's the signal so what's probably
happening here and I just I just hate to
give you another bone but a lot of
delayed on some muscle soreness is
probably just a neural feedback loop
rather than it is actual muscle damage
yeah it makes a lot of sense there's a
lot of interactions between the types of
neurons that control
touch sensation and pain sensation and
itch sensation in fact a lot of people
um kind of collapse itch and pain
together Bingo yeah you know that's
something it's painful and it itches is
a familiar thing for people mosquito
bites and such
um and of course there's the classic
gait theory of pain yeah which uh people
will be familiar with and then I'll
explain why I'm explaining this
um which is if you you something hurts
you know you Bonk your knee or you stub
your toe we tend to grab that body part
and try and rub it totally and that
rubbing is not a coincidental thing it
activates a set of uh touch sensors that
are that respond to kind of broad dull
touch
um and that actively inhibits through
the release of an inhibitory
neurotransmitter the fibers that control
the pain signal so anytime we rub a you
know like a charlie horse our leg or we
or we stub our toe and we you know we
wince and then we grab the tone we got
like squeezing it a little bit that's
actually deactivating or partially
inactivating the the pain mechanism so
the idea that uh a swelling response
would then trigger a neural response
that then would recruit the pain
receptor response here I'm using broad
broad brush
um Strokes here to explain this
um makes very good sense to me
um now and only now that you've
explained how this process works I can
actually even add more to that so
if you remember how muscles work so we
have to have some sort of signal from
the nervous system that has to actually
go in and tell the muscle to contract
well remember there are a few episodes
ago we covered the physiology here of
what's called a motor unit
okay well what I didn't explain to you
are called muscle spindles
and we have talked about proprioception
in an episode of before as well but we
never tied this picture together so let
me walk you through that really quickly
and it's going to tie this Loop into a
nice bow so what happens is
um this motor unit is is coming in from
what's called an alpha motor unit and
that's going to be innervating your
muscle fibers and that's going to tell
the muscle fibers to contract those are
typically spread out throughout the uh
all sides of the muscle in interior
exterior all over on the outside though
there is another type of muscle called a
muscle spindle now these are
non-contractiles so they don't have that
actin and myosin and they don't produce
Force they are responsive they are
proprioceptive so what that means is
they sense stretch and this is why for
example if you were to stretch a
hamstring and stretch any muscle group
it doesn't really matter or muscle
its innate response is to fire back to
close that distance and this is what
keeps you from say if you're leaning to
the right
you can imagine that the example we give
is if you're if you're standing on one
foot
and you start swaying to the right
all right let's say you're standing on
your right foot and this makes this
easier for folks and you start swaying
to the right like you're going to fall
on your right ear will hit the ground
the inside of your right calf muscle
will start being stretched the outside
will start being compressed right so the
stretch on the inside of the right calf
muscle will sense that stretch and it
will respond by Contracting that pulls
you back to the middle and stops you
from falling that's proprioception and
muscle spindles sense stretch and tell
you to contract the way that they work
is is through gamma motor neurons and so
these are sensory things so what's
happening is unlike when you tell your
muscle to contract it goes Alpha
to the muscle contract these muscle
spindles work such that it is oh I've
been stretched sends signal back to some
Central Point typically in the spinal
cord and we don't actually want to go
all the way up the brain we've got a
time delay this is why these are
subconscious autonomic right versus
somatic so the gamma is going to go back
to the central location and then come
back through the Alpha motor neurons
until it to contract so you have this
wonderful mechanism of sensing stretch
going back well one Theory that's been
put forward regarding muscle damage is
that the pressure is actually being
applied to those nerve endings of the
muscle spindles
and that's actually responsible for the
pain signal that's going back
and coming up to your brain and you're
registering that as pain rather than it
is actually in the the contractile units
so the muscle fibers that's a very
intriguing idea uh because
it would suggest that stretching muscles
in order to alleviate soreness might be
the exact incorrect thing to do yeah now
I'm not saying that's for sure for
certain I'm just building off the
mechanistic logic that we've laid out
here yeah really that you've laid out
here there's the more effective
principle based on exactly that which is
this is generally why low level movement
is effective at reducing acute soreness
because that's low-level contraction
with the muscles and you're going to
anti-stretch and get tissue out and get
fluid out
wow you're literally pumping it out of
the the cell yes and in our previous
episode where we were talking about
programming we're using the Wii but
let's be fair here where you were
educating us including me
um in the audience about different
structures for programming exercise
for specific adaptations Etc of the
month
week year scales Etc
we had a brief um discussion about the
fact that if one trains legs very hard
with resistance training you know some
heavy squatting or dead lifting it yeah
or and there's some soreness that
oftentimes doing some quote-unquote
lighter cardio or
um some uh low impact work the next day
or or any number of different things
that involve
um not high intensity
contractions of the muscles but that do
require contractions of the muscles that
it can alleviate soreness more quickly
than if one were to Simply lie around
and you know watch Netflix or something
yeah that's exactly right the um
to go back just a little bit as well the
if that's really the case
um the question is like where is this
inflammatory signal coming from and
while there's much to be learned there
there is a little bit of
information right now that suggests it's
potentially coming from free radicals
released from the mitochondria again
that may or may not hold up as more
research comes I'm not sure but if you
remember back to our uh conversation on
endurance so we talked about the
electron transport chain and aerobic
metabolism and regardless of whether or
not you're getting energy from
glycolysis
or carbohydrates remember they have to
be finished
through aerobic metabolism so even if
you're lifting weights
and you're using carbs for your fuel you
have got to finish that metabolism by
running it into the mitochondria and
Performing oxidative metabolism as a
result of that that electron transport
chain runs so theoretically if free
radicals which is which are
hyper-reactive oxygen species basically
they're oxygen molecules that are
missing in electrons so that they react
to a lot of things they're the opposite
of antioxidants by the way this is
the oxygen molecules with extra protons
so they can balance the charge if those
leak out that in and of itself is going
to be a massive inflammatory signal and
that's probably what signals the cause
of these neutrophils and macrophages and
kicks off this entire Cascade again I
believe we need more research there I
need to look into it maybe it's more
definitive than I that I know but that's
probably what's happening potentially
what's happening rather
causes that Cascade in Signal also
what you have is this combination of
well if that's the case why am I not
getting tremendous amount of muscle
damage when I do more aerobic based
exercise
well because you don't have the
mechanical tension pulling on the fibers
that's actually causing damage to the
cell wall that allows these free
radicals to escape the mitochondria and
the cell wall so that's the best we can
postulate at this moment as to why those
things are happening and then why again
low level exercise tends to enhance even
things like percussion so using either
instruments that put a low level of
vibration into your leg or like
pneumatic boots so you can massage all
these things are generally probably
helping because they're moving that
stuff out
a demon most specifically so pressure
comes off of those nerve endings and the
muscle spindles
and allows you to stop receiving that
signal of pain despite the fact that you
didn't actually regenerate tissue at all
yet
fascinating and I think
that beautifully frames where we're
headed next which is to talk about all
the different modes of recovery and how
to accelerate them and perhaps even how
to combine different forms of recovery
in order to become better at recovering
and in doing so make faster progress
with Fitness before we begin I'd like to
emphasize that this podcast is separate
from my teaching and research roles at
Stanford it is also separate from Dr
Andy galpin's teaching and research
roles at Cal State Fullerton it is
however part of our desire and effort to
bring zero cost to Consumer information
about science and science related tools
to the general public in keeping with
that theme we'd like to thank the
sponsors of today's podcast our first
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discussion about recovery
and with the understanding that recovery
is when the specific adaptations to
exercise actually occur
I'd love for you to share with us what
happens or needs to happen during
recovery in order for us to get better
at anything endurance strength Etc
but also how specific types of exercise
stimuli and specific types of
adaptations that we trigger so running a
bit further lifting a bit more weight
slowing the Cadence of a given movement
Etc how those specific types of triggers
for adaptation relate to the specific or
maybe similar types of recovery that are
required for us to make progress in one
of our previous episodes we were talking
about how the Harvard fatigue lab really
identified this idea of homeostasis or
at least sort of championed it for it
and that's important because
and all levels physiology wants to
return to homeostasis so what happens in
terms of adaptation is you've challenged
it to a level that it realizes if it
does not make a change it will not be
able to get back to the same level of
homeostasis that's fundamentally what's
happening that is recovery that process
of taking an insult being temporarily
reduced in functionality
causing a change so that now we come
back and get what we often call in
support performance super compensation
all that really is doing though is
bringing you to a new level of
homeostasis effectively
it is understanding if that same insult
comes again
I need to be able to make sure that that
doesn't cause the same level of
disruption and so we raise the bar
whether this is enhancing our ability to
take the same level of mechanical
tension on the muscle and not result in
micro damage whether this is being able
to take the same reduction in energy and
not have that compromise of sleep or
anything it's really fundamentally
changing so we can have a new level of
homeostasis because it's presuming it's
predicting that that same insult is
going to come again down the road
I wanted to clarify for people that when
Dr Galvin says insult
while he may actually insult me
um insult is the nerd speak terminology
for some sort of damage inflicted to a
tissue or system so
um he's speaking about the insult to the
muscle or insult to the neuromuscular
connection created by adding more weight
to the bar running a further distance
um
running a bit fast or or pedaling faster
that creates a micro insult or an insult
and now because everyone is familiar
with um psychological and verbal insults
you'll never forget that biological
concept it's important we tag another
thing here which is called hormesis it's
one of my favorite phenomenon and it
effectively means this that there is a
dosage or toxicity
responds to almost everything and if you
think about this in the context of say
drugs what this means is if I gave you
10 milligrams of something
that it would be okay but if I give you
20 it'd be a problem and eventually if I
go up and give you enough this thing
turns toxic this is the case of
everything from cyanide where it can
actually be in small dosages in nature
in fact it's in many of the fruits that
you eat but it's not a dosage that it
doesn't matter if that dosage gets
higher though that actually can cause
problems and if it is high enough it can
actually kill you instantaneously
the back end of that though is because
you introduce this micro insult as you
framed it for me perfectly your body
will then adapt to it and that's really
what's happening with exercise
adaptation is it is a hormetic stressor
and why that's important is
if you look at the immediate responses
to exercise you see an extremely large
increase in inflammation you see
oxidative stress you see a whole Cascade
of autophagy like all these problems
quote unquote happening it's what's
actually quite funny here is as a part
of my PhD the academic portion I had to
go through the medical side of the
school and so I was my physiology class
was in med school so I'm the only
non-medical doctor in that class right
I'm a PhD so I leave my lab I walk
across campus and I take physiology
class with these folks and I died the
whole time internally because every time
we would cover a new area
it was basically the the exact same
value or number
in a medical setting is like oh my gosh
they're going to die
and in performance setting is like this
person's in fantastic shape
is I I I've never it still amuses me to
this day obviously because it's just
simple things like total blood volume
right and you cover like okay if you
have a patient come in and their blood
volume is six liters you know I can
immediately get them on a diuretic of
some sort because they're going to have
a heart attack as blood pressure gets up
right now I'm immediately thinking damn
six leaders that that person is super
fit because that is actually a positive
adaptation to training it's one of the
most important if not the most important
adaptation to endurance training is
enhance total blood volume so you'll
store more blood in your body when
you're more fit than you are less fit so
I mean I could go on all these things
sodium concentrations potassium
concentrations are like you look at
these things on paper and you don't know
if that person is about to die because
they're 65 years old and out of shape or
if that person is going to break a world
record the marathon this brings up a
very important tangent which is uh for
instance if you go and take a blood test
and you are somebody who exercises very
intensely uh with resistance training
you're blood creatinine levels can be
way out of range and if your physician
doesn't know that you're doing certain
forms of exercise might say wow there's
a lot of muscle tissue damage occurring
in your body yeah as you mentioned
before your total blood volume is is
dangerously High when in fact you are
far healthier and and need much fitter
than the person who as numbers would be
in range that said obviously there are
um limits to these to these statements
whereby you would want to be cautious
and take action to ameliorate a very
elevated blood creatinine level or
something of that sort but the point
you're you're bringing up is is also one
about the field of medicine which is
that
many not all but many Physicians don't
take into consideration uh the outside
activities that people are doing and so
it becomes a kind of a plug-and-play
type um type way of looking at blood
charts yeah we've done many thousand
athletes blood chemistry and uh we we
don't use
first of all we never look at disease
stuff that's not what we do we take
people that are healthy and try to
optimize performance and blood chemistry
is one of the best tools if you really
understand what you're doing there you
can get some incredibly powerful
information out of blood chemistry that
actually relates to what we're going to
talk to today in terms of measuring
everything from acute to Chronic
dehydration to sleep deprivation can be
identified in in blood chemistry to
optimization improvements in nutrition
supplementation there's a lot you can
get there if people are interested in
that field I would Point them to a
gentleman named Dan Garner it was just
an absolute Juggernaut and wizard in
blood chemistry for high performance but
well you can get a ton of information
from that if you understand the
difference between exactly what you
talked about looking for signals of
increased risk of cardiovascular events
25 years down the road versus is this
the optimal value for high performance
in an athlete which is what our our
database and all of our software and
stuff does is only looking for those
things so I'm going to talk about some
of the biomarkers to look for a little
bit later salivary so some blood stuff
but we'll maybe save that part of the
conversation for down the road tell me
about different time scales of recovery
sure this is actually where I was trying
to answer your question for and then I
got myself way off track but the reason
I brought up the Hermetic thing is if
you understand that some things in the
acute say 24 to 40 hour period
look terrible
it's actually fine right so this is the
stimuli that's causing adaptation so the
reason I brought up the medical
exchange there is because you if you
looked at inflammatory markers and then
you mentioned some of them you would see
that they are highest acute within
seconds to minutes to hours after
exercise however that's exactly the
stimuli needed to bring them down
chronically
okay and so chronically meaning maybe in
that moment they are elevated and then
maybe they're coming down 24 hours later
in 48 hours however if you were to
compare your resting level say that
Monday before you worked out
to your resting level that Monday the
week following the week following that
what you would probably see is your
Baseline inflammation goes down
and so we got to be really careful are
we talking immediately post-exercise man
these markers look terrible maybe my
recovery score is awful
Etc that's not necessarily a bad thing
because what we're like looking to do is
to not only change what's happening
today but we're trying to cause
adaptation that may take us weeks or
months to actually
access
I love that you're highlighting this
principle because one of the more
obvious ones to me now that you've said
this is heart rate absolutely my heart
rate goes very very high during exercise
and I do that fairly consistently or
even semi-consistently my resting heart
rate will actually be quite a bit lower
that's a fantastic example really what
you're getting at here is this concept
where I think it's important to
differentiate between adaptation and
optimization
now we hear that word and I use it and
most scientists hate it but it's a good
communication tool optimization
if you're optimizing for the current
moment
you're almost surely compromising the
late adaptation
right if if I were to say do the thing
right now that makes you feel the
absolute best in the world and you're
like great you took a nap and you had a
donut like awesome you feel amazing but
you know it's causing long-term issues
the same can be said on the back end if
you're never choosing things that make
you better right now
you're never actually going to see an
adaptation so what we're really doing
with this recovery conversation is
playing this game of balancing immediate
gratification with the leg gratification
and how do we identify how much to do
now versus not how do I use a value or a
marker whether this is how tired I feel
today how sore I am today versus a score
on an app or a tracking metric but this
is a blood marker anything and
understand if that's what I need to
cause the adaptation I want a week a
month three months from now in the case
of
some of our other athletes it's even up
to four years right we're trying to
cause adaptations that will get us where
we want to get in the Olympics or World
Championships or World Cup or wherever
we're going to be so that's the
framework we have to think about
recovery we we maybe falsely think about
it as I need to maximize my recovery
today
and you could do something like
taken anti-inflammatory whether this is
a supplementation or a drug or maybe
this is ice
oh cool that's great that will enhance
your recovery in this moment that'll
make you feel better today probably
tomorrow but what we know is that blocks
the signal for adaptation so you're not
going to get the same results you know
four six eight weeks from now so when we
talk about recovery we have to
understand what tool am I using and why
and in order to do that we have to
understand what am I training for
and what am I trying to maximize if I am
in the middle of a season with an
athlete and we are competing tomorrow I
am going to head towards acute recovery
right because I have to actuate that
performance right now if I am starting
the off season
I'm not hedging towards recovery I'm
actually hedging towards adaptation so
we're not going to deploy any of these
especially things like
there's evidence that a combination of
vitamin C and vitamin E
will blunt hypertrophic adaptations
because they're anti-inflammatory with
antioxidants right other other Studies
have shown maybe they don't have
uh an inhibitory fact they may or may
not
point is conceptually
you want to be careful of what you're
trying to optimize for and you have to
have that forethought and that alone is
going to dictate your decision making
with whether or not again you get in the