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lite file description
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dgulhan-bio authored Jun 18, 2019
2 parents 7a5612c + 773d54b commit 045ea54
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Expand Up @@ -92,6 +92,17 @@ lite <- lite_df(df)
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or by setting `lite_format = T` in the settings of `run()`.

In the lite file:
* `total_snvs` indicates the number of SNVs in that sample
* columns ending with `_ml` indicate the total likelihood of clusters which are high in that signature, e.g. `Signature_3_ml` is the total likelihood of clusters with Signature 3
* `Signature_3_c` is the cosine similarity to Signature 3
* `exp_sig3` is the exposure of Signature 3 calculated with NNLS
* `Signature_3_l_rat` is the likelihood ratio of the NNLS decomposition with Signature 3 considering the possibility of an alternative decompositions without Signature 3. A value of 0.5 indicate that an NNLS decomposition without Signature 3 is as likely.
* `Signature_3_mva` is the SigMA score indicating the presence of Signature 3 estimated by the gradient boosting classifier implemented in SigMA
* `pass_mva` and `pass_mva_strict` are booleans indicating the presence of Signature 3 with the looser and strict selection thresholds that corresponds to 10% FPR and 1-5% FPR respectively
* `sigs_all` and `exps_all` are the names of signatures included in NNLS calculation and the exposures.
* `categ` is the general category the sample falls into according to the dominant signatures. The `Signature_3_hc` indicates that the sample passes the strict threshold and hc stands for high confidence, and `Signature_3_lc` indicates that the sample passes the looser threshold but not the strict threshold.

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### 7. Tumor type tags
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