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Update entropy types #1915
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Update entropy types #1915
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Original file line number | Diff line number | Diff line change |
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@@ -2,66 +2,96 @@ | |
import { defaultEntropyState } from "../reducers/entropy"; | ||
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type JsonAnnotations = Record<string, JsonAnnotation> | ||
// enum Strand {'+', '-'} // other GFF-valid options are '.' and '?' | ||
type Strand = string; | ||
type JsonSegmentRange = {start: number, end: number}; // Start is 1-based, End is 1-based closed (GFF) | ||
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// '.' and '?' are GFF-valid options | ||
type Strand = '+' | '-' | '.' | '?' | ||
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interface JsonSegmentRange { | ||
/** 1-based */ | ||
start: number | ||
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/** 1-based closed (GFF) */ | ||
end: number | ||
} | ||
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interface JsonAnnotation { | ||
/* Other properties are commonly set in the JSON structure, but the following are | ||
the only ones read by Auspice */ | ||
end?: number; | ||
start?: number; | ||
segments?: JsonSegmentRange[]; | ||
strand: Strand; | ||
gene?: string; | ||
color?: string; | ||
display_name?: string; | ||
description?: string; | ||
end?: number | ||
start?: number | ||
segments?: JsonSegmentRange[] | ||
strand?: Strand | ||
There was a problem hiding this comment. Choose a reason for hiding this commentThe reason will be displayed to describe this comment to others. Learn more. A broader comment / question about TS as it relates to the JSON dataset. Beyond being semantically valid JSON anything could be present in the JSON (we don't do formal schema validation within Auspice). So should any types relating to the dataset contents therefore allow any and every field to be optional, and also all values to be This relates to a7578d2, which proposes - if (typeof annotation.display_name === 'string') {
+ if (annotation.display_name !== undefined) { ( |
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gene?: string | ||
color?: string | ||
display_name?: string | ||
description?: string | ||
} | ||
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/* Specifies the range of the each segment's corresponding position in the genome, | ||
or defines the range of the genome (chromosome) itself. | ||
Start is always less than or equal to end. | ||
Start is 1-based, End is 1-based closed. I.e. GFF. */ | ||
type RangeGenome = [number, number]; | ||
/* Same as RangeGenome but now relative to the nucleotides which make up the CDS | ||
(i.e. after slippage, splicing etc). The first CDS segment's RangeLocal will always | ||
start at 1, and the end value (of the last segment) corresponds to the number of nt in the CDS: | ||
range_segLast[1] - range_seg1[0] + 1 = 3 * number_of_amino_acids_in_translated_CDS */ | ||
type RangeLocal = [number, number]; | ||
type ChromosomeMetadata = { | ||
strandsObserved: Set<Strand>, | ||
posStrandStackHeight: number, | ||
negStrandStackHeight: number, | ||
/** | ||
* Specifies the range of the each segment's corresponding position in the genome, | ||
* or defines the range of the genome (chromosome) itself. | ||
* Start is always less than or equal to end. | ||
* Start is 1-based, End is 1-based closed. I.e. GFF. | ||
*/ | ||
type RangeGenome = [number, number] | ||
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/** | ||
* Same as RangeGenome but now relative to the nucleotides which make up the CDS | ||
* (i.e. after slippage, splicing etc). The first CDS segment's RangeLocal will always | ||
* start at 1, and the end value (of the last segment) corresponds to the number of nt in the CDS: | ||
* range_segLast[1] - range_seg1[0] + 1 = 3 * number_of_amino_acids_in_translated_CDS | ||
*/ | ||
type RangeLocal = [number, number] | ||
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interface ChromosomeMetadata { | ||
strandsObserved: Set<Strand> | ||
posStrandStackHeight: number | ||
negStrandStackHeight: number | ||
} | ||
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type GenomeAnnotation = Chromosome[]; | ||
type GenomeAnnotation = Chromosome[] | ||
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interface Chromosome { | ||
name: string; | ||
range: RangeGenome; | ||
genes: Gene[]; | ||
name: string | ||
range: RangeGenome | ||
genes: Gene[] | ||
metadata: ChromosomeMetadata | ||
} | ||
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interface Gene { | ||
name: string; | ||
cds: CDS[]; | ||
name: string | ||
cds: CDS[] | ||
} | ||
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interface CDS { | ||
length: number; /* length of the CDS in nucleotides. Will be a multiple of 3 */ | ||
segments: CdsSegment[]; | ||
strand: Strand; | ||
color: string; | ||
name: string; | ||
isWrapping: boolean; | ||
displayName?: string; | ||
description?: string; | ||
stackPosition?: number; | ||
/** length of the CDS in nucleotides. Will be a multiple of 3 */ | ||
length: number | ||
segments: CdsSegment[] | ||
strand: Strand | ||
color: string | ||
name: string | ||
isWrapping: boolean | ||
displayName?: string | ||
description?: string | ||
stackPosition?: number | ||
} | ||
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type Phase = 0 | 1 | 2 | ||
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type Frame = 0 | 1 | 2 | ||
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interface CdsSegment { | ||
rangeLocal: RangeLocal; | ||
rangeGenome: RangeGenome; | ||
segmentNumber: number; /* 1-based */ | ||
phase: number; /* 0, 1 or 2. Indicates where the next codon begins relative to the 5' end of this segment */ | ||
frame: number; /* 0, 1 or 2. The frame the codons are in, relative to the 5' end of the genome. It thus takes into account the phase */ | ||
rangeLocal: RangeLocal | ||
rangeGenome: RangeGenome | ||
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/** 1-based */ | ||
segmentNumber: number | ||
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/** Indicates where the next codon begins relative to the 5' end of this segment */ | ||
phase: Phase | ||
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/** The frame the codons are in, relative to the 5' end of the genome. It thus takes into account the phase */ | ||
frame: Frame | ||
} | ||
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/** | ||
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@@ -159,7 +189,7 @@ | |
}; | ||
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function validColor(color:(string|undefined)) { | ||
function validColor(color: string | undefined) { | ||
if (!color) return false; | ||
return color; // TODO XXX | ||
} | ||
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@@ -175,7 +205,12 @@ | |
/** | ||
* Returns a CDS object parsed from the provided JsonAnnotation block | ||
*/ | ||
function cdsFromAnnotation(cdsName: string, annotation: JsonAnnotation, rangeGenome: RangeGenome, defaultColor: (string|void)): CDS { | ||
function cdsFromAnnotation( | ||
cdsName: string, | ||
annotation: JsonAnnotation, | ||
rangeGenome: RangeGenome, | ||
defaultColor: string | void, | ||
): CDS { | ||
const invalidCds: CDS = { | ||
name: '__INVALID__', | ||
length: 0, | ||
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@@ -190,7 +225,7 @@ | |
* which are represented by augur as '?' and null, respectively. (null comes from `None` in python.) | ||
* In both cases it's not a good idea to make an assumption of strandedness, or to assume it's even a CDS. */ | ||
console.error(`[Genome annotation] ${cdsName} has strand ` + | ||
(Object.prototype.hasOwnProperty.call(annotation, "strand") ? String(annotation.strand) : '(missing)') + | ||
(annotation.strand !== undefined ? annotation.strand : '(missing)') + | ||
". This CDS will be ignored."); | ||
return invalidCds; | ||
} | ||
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@@ -234,7 +269,7 @@ | |
For -ve strand that's 3' to 5'. The rangeGenome within each segment is always 5' to 3'. */ | ||
const segmentLength = segment.end - segment.start + 1; // in nucleotides | ||
/* phase is the number of nucs we need to add to the so-far-observed length to make it mod 3 */ | ||
const phase = length%3===0 ? 0 : (length%3===1 ? 2 : 1); | ||
const phase: Phase = length%3===0 ? 0 : (length%3===1 ? 2 : 1); | ||
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const s: CdsSegment = { | ||
segmentNumber: segmentNumber++, | ||
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@@ -267,10 +302,10 @@ | |
isWrapping: _isCdsWrapping(strand, segments), | ||
color: validColor(annotation.color) || defaultColor || '#000', | ||
} | ||
if (typeof annotation.display_name === 'string') { | ||
if (annotation.display_name !== undefined) { | ||
cds.displayName = annotation.display_name; | ||
} | ||
if (typeof annotation.description === 'string') { | ||
if (annotation.description !== undefined) { | ||
cds.description = annotation.description; | ||
} | ||
return cds | ||
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@@ -280,17 +315,26 @@ | |
* Calculates the (open reading) frame the provided segment is in. | ||
* For +ve strand this is calculated 5'->3', for -ve strand it's 3'->5'. | ||
* The frame is calculated once the CDS is back in phase. | ||
* start: 1 based, rangeGenome[0] of the segment | ||
* end: 1 based, rangeGenome[1] of the segment | ||
* start < end always | ||
* genomeLength: 1 based | ||
* positiveStrand: boolean | ||
* Returns a number in the set {0, 1, 2} | ||
*/ | ||
function _frame(start:number, end:number, phase: number, genomeLength:number, positiveStrand:boolean) { | ||
return positiveStrand ? | ||
function _frame( | ||
/** 1 based, rangeGenome[0] of the segment */ | ||
start: number, | ||
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/** | ||
* 1 based, rangeGenome[1] of the segment. | ||
* start < end always | ||
*/ | ||
end: number, | ||
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phase: Phase, | ||
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/** 1 based */ | ||
genomeLength: number, | ||
positiveStrand: boolean, | ||
): Frame { | ||
return (positiveStrand ? | ||
Check failure on line 335 in src/util/entropyCreateStateFromJsons.ts GitHub Actions / lint (16)
Check failure on line 335 in src/util/entropyCreateStateFromJsons.ts GitHub Actions / lint (18)
Check failure on line 335 in src/util/entropyCreateStateFromJsons.ts GitHub Actions / lint (20)
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(start+phase-1)%3 : | ||
Math.abs((end-phase-genomeLength)%3); | ||
Math.abs((end-phase-genomeLength)%3)) as Frame; | ||
} | ||
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/** | ||
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@@ -300,7 +344,10 @@ | |
* refers to this being a stacking problem.) The stack position starts at 1. | ||
* Returns the maximum position observed. | ||
*/ | ||
function calculateStackPosition(genes: Gene[], strand: (Strand|null) = null):number { | ||
function calculateStackPosition( | ||
genes: Gene[], | ||
strand: Strand | null = null, | ||
There was a problem hiding this comment. Choose a reason for hiding this commentThe reason will be displayed to describe this comment to others. Learn more. Related to a previous comment,
and, potentially,
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): number { | ||
/* List of CDSs, sorted by their earliest occurrence in the genome (for any segment) */ | ||
let cdss = genes.reduce((acc: CDS[], gene) => [...acc, ...gene.cds], []); | ||
if (strand) { | ||
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@@ -350,7 +397,7 @@ | |
* Given an array of sorted integers, if there are any spaces (starting with 1) | ||
* then return the value which can fill that space. Returns 0 if no spaces. | ||
*/ | ||
function _emptySlots(values: number[]):number { | ||
function _emptySlots(values: number[]): number { | ||
if ((values[0] || 0) > 1) return 1; | ||
for (let i=1; i<values.length; i++) { | ||
/* intermediate variables because of https://github.com/microsoft/TypeScript/issues/46253 */ | ||
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@@ -365,7 +412,10 @@ | |
* between-segment space of an existing segment, then return the stackPosition | ||
* of that existing CDS. Otherwise return 0; | ||
*/ | ||
function _fitCdssTogether(existing: CDS[], newCds: CDS):number { | ||
function _fitCdssTogether( | ||
existing: CDS[], | ||
newCds: CDS, | ||
): number { | ||
const a = Math.min(...newCds.segments.map((s) => s.rangeGenome[0])); | ||
const b = Math.max(...newCds.segments.map((s) => s.rangeGenome[1])); | ||
for (const cds of existing) { | ||
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@@ -400,10 +450,13 @@ | |
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/* Does a CDS wrap the origin? */ | ||
function _isCdsWrapping(strand: Strand, segments: CdsSegment[]): boolean { | ||
function _isCdsWrapping( | ||
strand: Strand, | ||
segments: CdsSegment[], | ||
): boolean { | ||
const positive = strand==='+'; | ||
// segments ordered to guarantee rangeLocal will always be greater (than the previous segment) | ||
let prevSegment; | ||
let prevSegment: CdsSegment; | ||
for (const segment of segments) { | ||
if (prevSegment) { | ||
if (positive && prevSegment.rangeGenome[0] > segment.rangeGenome[0]) { | ||
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making sure this needed to become optional to match some usage somewhere?
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In 2d3a331 the matched usage was
Object.prototype.hasOwnProperty.call(annotation, "strand")
which to me indicates that it is optional. It's hard to tell from other usage because the entireJsonAnnotation
object is represented byjson.meta.genome_annotations
here:auspice/src/actions/recomputeReduxState.js
Line 819 in a7578d2
auspice/src/actions/recomputeReduxState.js
Line 870 in a7578d2
@jameshadfield might have a better idea.
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It's optional for the
nuc
annotation. You could argue it should be required, but we relaxed this and just assert that it's not negative:auspice/src/util/entropyCreateStateFromJsons.ts
Lines 93 to 94 in c0ca42f
For CDSs to be considered valid it must be "+" or "-":
auspice/src/util/entropyCreateStateFromJsons.ts
Lines 187 to 188 in c0ca42f