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Synopsis

Tools to analyze the supplemental data from The Allen Institute's publication of their mouse connectome atlas in 2014: Nature (508)207--217. The suppl data reveal large scale connectivity between brain regions, allowing you to ask questions of the data without having to use the much more detailed (but larger/more difficult) raw data available from the Allen's website.

Code Example

See saved data.docx for some analyese I ran to look at HPC connectivity. A fast example is below:

[Presm Postsm]=whosConnected('ENTm',Wipsi,Areas,AreasLookup,Pipsi,0.2); Presm

Presm =

'Entorhinal area, lateral part'        [0.3317]    [2.9865e-66]
'Medial septal nucleus'                [0.4397]    [7.6496e-24]
'Parasubiculum'                        [0.7726]    [5.8431e-21]
'Nucleus of reunions'                  [0.2745]    [1.0476e-14]
'Diagonal band nucleus'                [0.2626]    [6.0253e-09]
'Parataenial nucleus'                  [1.2141]    [1.4927e-05]
'Subiculum, ventral part'              [0.1288]    [3.8951e-04]
                        [1x41 char]    [0.1397]    [4.1244e-04]
'Postsubiculum'                        [0.4902]    [    0.0014]
'Subiculum, dorsal part'               [0.1480]    [    0.0021]
'Lateral visual area'                  [0.1680]    [    0.0049]
'Posterior amygdalar nucleus'          [0.8548]    [    0.0294]
'Posterolateral visual area'           [0.1525]    [    0.0350]
'Claustrum'                            [0.4798]    [    0.0377]
'Field CA1'                            [0.0727]    [    0.0389]
                        [1x34 char]    [0.8072]    [    0.0473]
'Dentate gyrus'                        [0.0462]    [    0.0714]
'Field CA3'                            [0.0465]    [    0.0764]
'Basolateral amygdalar nucleus'        [0.1215]    [    0.0781]
'Endopiriform nucleus, dorsal part'    [0.2363]    [    0.1155]
'Piriform-amygdalar area'              [0.2833]    [    0.1556]
'Medial mammillary nucleus'            [0.2955]    [    0.1618]

This list shows brain regions that send inputs to the medial entorhinal cortex. The first column is the "weight" of the connection, the second column is a p-value indicating the probability of of a null hypothesis of accidentally observing this connectivity given there was not actually any anatomical basis for it.

Installation

Put this in a directory and cd to it in Matlab. You're done.

Contributors

Jason G. Fleischer

License

You are free to use and distribute this code as you see fit. Please credit the original author.

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Analysis tools for supplemntal data of Oh et al., Nature (508)207--217, 2014

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