Makefile_SupportingInfo

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# (C) 2016 Tyler W. H. Backman
# Purpose: Supporting Information for Target Selectivity Manuscript
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# Note this is a project workflow (in comments) mixed in with actual analysis steps
#	(in Makefile syntax)

# generate file with Target selectivity, cluster selectivity,
# domain selectivity, and Promiscuity probabilities or all highly screened active compounds
working/supportingInfo_promiscuity.tab: src/supportingInfo_promiscuity.R working/selectivityCountsIndividual.txt working/selectivityCountskClust.txt working/selectivityCountsdomains.txt working/promiscuityProbability.tab working/highlyScreenedCids.txt working/activeCids.txt
    $^ $@
    
# generate Fully screened compound vs target cluster binary matrix
working/supportingInfo_fullyScreened.tab: src/supportingInfo_fullyScreened.R working/fullyScreened.RData working/clusterAnnotations.csv
    $^ $@
    
# Purpose: produce list of Pfam domains including median target, cluster, and domain selectivities for FDA approved and non-FDA compounds
working/supportingInfo_domains.tab: src/supportingInfo_domains.R working/targetSelectivityByDomain.tab
    $^ $@

# Purpose: produce bicluster lists for supplement
working/supportingInfo_biclusterCids.xls: src/supportingInfo_biclusters.R working/biClusters.RData working/clusterAnnotations.csv 
	$^ $@ working/supportingInfo_biclusterTargets.xls

# Purpose: produce list of novel drug-target pairs
working/supportingInfo_novelTargets.xls: src/supportingInfo_novelTargets.R working/drugComparisonMatrix.RData working/clusterAnnotations.csv
    $^ $@