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feat: added resistance mutations
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feat: added resistance mutations
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gordonkoehn authored Dec 16, 2024
2 parents 53a8b7f + 10106bb commit 6df66ad
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33 changes: 20 additions & 13 deletions .devcontainer/devcontainer.json
Original file line number Diff line number Diff line change
@@ -1,22 +1,29 @@
// For format details, see https://aka.ms/devcontainer.json. For config options, see the
// README at: https://github.com/devcontainers/templates/tree/main/src/python
{
"name": "vpipe-frontend",
// Or use a Dockerfile or Docker Compose file. More info: https://containers.dev/guide/dockerfile
"image": "mcr.microsoft.com/devcontainers/python:1-3.12-bullseye"
"name": "vpipe-frontend",
// Or use a Dockerfile or Docker Compose file. More info: https://containers.dev/guide/dockerfile
"image": "mcr.microsoft.com/devcontainers/python:1-3.12-bullseye",

// Features to add to the dev container. More info: https://containers.dev/features.
// "features": {},
// Features to add to the dev container. More info: https://containers.dev/features.
// "features": {},

// Use 'forwardPorts' to make a list of ports inside the container available locally.
// "forwardPorts": [],
// Use 'forwardPorts' to make a list of ports inside the container available locally.
"forwardPorts": [8000],

// Use 'postCreateCommand' to run commands after the container is created.
// "postCreateCommand": "pip3 install --user -r requirements.txt",
// Use 'postCreateCommand' to run commands after the container is created.
"postCreateCommand": "pip3 install --user -r requirements.txt",
"customizations": {
"vscode": {
"settings": {
"editor.rulers": [80]
}
}
}

// Configure tool-specific properties.
// "customizations": {},
// Configure tool-specific properties.
// "customizations": {},

// Uncomment to connect as root instead. More info: https://aka.ms/dev-containers-non-root.
// "remoteUser": "root"
// Uncomment to connect as root instead. More info: https://aka.ms/dev-containers-non-root.
// "remoteUser": "root"
}
4 changes: 4 additions & 0 deletions app.py
Original file line number Diff line number Diff line change
Expand Up @@ -2,11 +2,15 @@
import index
import mutation_freq
import variant_deconv
import resistance_mut
import resistance_mut_silo

PAGES = {
"Home": {"module": index},
"Mutation Frequency": {"module": mutation_freq},
"Variant Deconvolution": {"module": variant_deconv},
"Resistance Mutations (clinical)": {"module": resistance_mut},
"Resistance Mutations (ww)": {"module": resistance_mut_silo}
}

def sidebar():
Expand Down
3 changes: 2 additions & 1 deletion config.yaml
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@@ -1,2 +1,3 @@
server:
ip_address: "http://68.221.168.92:8000"
ip_address: "http://68.221.168.92:8000"
lapis_address: "http://localhost:8080"
72 changes: 72 additions & 0 deletions data/3CLpro_inhibitors_datasheet.csv
Original file line number Diff line number Diff line change
@@ -0,0 +1,72 @@
Mutation,NTV: fold,NTV: pocket,ENS: fold,fitness,in patient,in vitro,Prevalence
T21I,1.5,,1.6,1.6,,12,0.1%
T25A,12.6,,87.7,,,,0.002%
T25N,0.8,,22.9,,,,0.00006%
T45I,1.6,1,4.8,,,,0.02%
D48Y,2,1,5.9,,,,0.0005%
M49I,1.1,1,10.1,1.8,,,0.02%
M49L,1.4,1,40.9,1.2,,2,0.0002%
M49T,0.8,1,3.6,1.4,,,0.0005%
M49del,2.8,1,,0.5,,,
L50F,1.5,1,1.1,2.3,1,9,0.04%
G138S,3.5,,,,,1,0.00008%
F140L,5.9,,,,,2,0.0001%
F140S,260,,,,,,0.00004%
N142D,1.5,1,3.2,1.1,,,0.0008%
N142L,2.5,1,,1.4,,,0.0001%
N142S,1.2,1,4.9,1.2,,,0.001%
G143S,147.7,1,15.6,0,,,0.00001%
S144A,7.3,1,17.2,0.6,,2,0.00009%
S144E,81.5,1,,0,,,0.00001%
S144L,1154.1,1,,0,,,0.00006%
S144P,2851.7,1,,0,,,0.00001%
C160F,1,,,0.7,,4,0.01%
M165R,384.2,1,,0,,,0.00001%
M165T,15.8,1,,0.1,,,0.00003%
E166A,10,1,6.3,0.1,1,5,0.00004%
E166G,6.2,1,,0.1,,,0.00004%
E166K,76.6,1,,0,,,0.00003%
E166Q,2.7,1,,1,,,0.00005%
E166V,287.5,1,50.3,0.1,5,3,0.0001%
L167F,7,1,12.8,0.3,,6,0.0002%
P168del,7,1,6.1,,,,
T169I,1.1,1,1.3,,,2,0.003%
H172L,898.8,1,,0,,,0.00001%
H172N,464.1,1,,0,,,0.00001%
H172Q,5.8,1,,0.3,,1,0.00004%
H172Y,24.2,1,,0.2,,2,0.00009%
A173T,2.5,,1.2,,,1,0.002%
A173V,6.4,,1.3,,,3,0.002%
V186A,,1,,,,2,0.0004%
R188G,38,1,,,,2,0.00009%
R188S,2.9,1,5.8,0.9,,,0.0007%
Q189I,4.2,1,,,,,0.00003%
Q189K,8.6,1,1.9,0.3,,,0.0003%
T190I,1.2,1,2.9,1.3,,,0.02%
A191T,1.2,1,4.6,1.7,,3,0.006%
A191V,1.6,1,3.6,1.9,,7,0.08%
Q192A,18.2,1,,0.2,,,0.0007%
Q192C,16.3,1,,0.1,,,0.00006%
Q192D,10.4,1,,0,,,0.00006%
Q192E,34.2,1,,0.1,,,0.00003%
Q192F,24.6,1,,0.3,,,0.00001%
Q192G,34.4,1,,0.1,,,0.00009%
Q192H,24.7,1,,0.1,,,0.00009%
Q192I,13.7,1,,0.2,,,0.00008%
Q192K,27.9,1,,0,,,0.0003%
Q192L,29,1,,0.2,,,0.0002%
Q192N,2.8,1,,0.1,,,0.00001%
Q192P,7.8,1,,0.1,,,0.0002%
Q192R,19.2,1,3.2,0.1,,1,0.0002%
Q192S,24.3,1,,0.1,,,0.0003%
Q192T,16.8,1,,0.1,,,0.0002%
Q192V,10.1,1,,0.1,,,0.0002%
Q192W,12.9,1,,0.1,,,0.00001%
Q192Y,384.2,1,,0,,,0.0001%
A193P,,,,,,2,0.0004%
A194S,3.3,,,,,1,0.002%
P252L,5.8,,1.3,,,5,0.004%
V297A,3,,,,,,0.00001%
S301P,,,,,,2,0.0002%
T304I,2.5,,1,,,8,0.007%
F305L,,,,,,2,0.001%
20 changes: 20 additions & 0 deletions data/RdRP_inhibitors_datasheet.csv
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@@ -0,0 +1,20 @@
Mutation,RDV: fold,in patient,in vitro,Prevalence
V166A,,,1,0.0008%
V166L,1.5,2,1,0.004%
N198S,,,1,0.01%
R285C,,2,,0.006%
A376V,12.6,,,0.00002%
A449V,,2,,0.07%
F480L,2,,1,0.0002%
D484Y,3.1,1,,0.0008%
A526V,,,1,0.04%
V557L,2,,1,0.0003%
G671S,1,2,,47%
S759A,2.6,,1,0%
V792I,2.6,3,1,0.002%
E796G,2.8,,1,0.0007%
C799F,3.4,,2,0.0009%
C799R,2.8,,1,0.00006%
E802A,3,,,0.0002%
E802D,6,1,1,0.002%
M924R,,2,,0.003%
165 changes: 165 additions & 0 deletions data/spike_mAbs_datasheet.csv
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@@ -0,0 +1,165 @@
Mutation,BAM: fold,BAM: dms,ETE: fold,ETE: dms,CAS: fold,CAS: dms,IMD: fold,IMD: dms,CIL: fold,CIL: dms,TIX: fold,TIX: dms,SOT: fold,SOT: dms,BEB: fold,BEB: dms,REG: fold,AMU: fold,ROM: fold,ADI: fold,C135: fold,C135: dms,C144: fold,C144: dms,in patient,in vitro,Prevalence
P337H,,,,,,,,,,,,,6.3,1,,,,,,,,,,,6,,0.0008%
P337L,,,,,,,5,,,,,,186,0.997,,,,,,,,,,,10,1,0.003%
P337R,,,,,,,,,,,,,234,0.999,,,,,,,,,,,4,,0.0004%
P337S,,,,,,,,,,,,,1.8,0.999,,,,,,,,,,,22,,0.003%
P337T,,,,,,,,,,,,,8,0.992,,,,,,,,,,,,,0.001%
E340A,,,,,,,,,,,,,100,0.997,,,,,,,,,,,13,3,0.002%
E340D,,,,,,,,,,,,,14.8,0.988,,,,,,,,,,,23,,0.003%
E340G,,,,,,,,,,,,,22.6,0.986,,,,,,,,,,,1,,0.0008%
E340K,,,0.4,,,,,,,,,,5148,0.997,,,,,,,,,,,25,1,0.004%
E340Q,,,,,,,,,,,,,50,0.966,,,,,,,,,,,4,,0.0005%
E340V,,,,,,,,,,,,,200,,,,,,,,,,,,7,,0.001%
T345P,,,,,,,,,,,,,,0.991,,,,,,,,,,,,1,0.0001%
R346G,,,,,,,,,,0.606,,,0.9,,,,,,,,,0.697,,,,4,0.005%
R346I,,,,,,,,,200,0.728,,,1.7,,,,,,,,,0.734,,,2,3,0.01%
R346K,1.3,,2.4,,1.1,,2.9,,2.6,,2.2,,1.4,,0.7,,0.3,0.8,21,0.8,2296.4,0.82,0.8,,2,2,8.9%
R346S,,,1.8,,,,,,,0.763,,,1.8,,0.4,,,,,,2700,0.813,0.9,,2,1,0.03%
R346T,,,,,,,,,,0.9,,,1.3,,,,,,,,,0.804,,,3,,0.006%
K356Q,,,,,,,,,,,,,0.9,0.106,,,,,,,,,,,,,0.001%
K356T,,,,,,,,,,,,,5.9,0.9,,,,,,,,,,,3,,0.0008%
S371F,0.9,,143,,13.5,,87,,1.3,,26,,13.3,,2.4,,20.8,124.5,22,51.6,,,,,6,,6.0%
S371L,1.6,,17.1,,3.9,,18.4,,1,,4,,9.7,,2.2,,1.1,17.1,17,15,,,,,2,,17%
D405E,,,,0.186,,,,,,,,,,,,,,,,,,,,,,,0.0006%
D405N,1.8,,20.9,0.275,10.9,,1.9,,1,,2.1,,0.7,,0.5,,1,2,1.6,2.1,,,,,1,1,6.0%
E406D,,,,,51,,,,,,,,,,,,,,,,,,,,,,0.001%
K417E,,,,0.99,165.4,0.564,0.9,,0.4,,,,0.9,,1.3,,,,,,,,,,,9,0.0004%
K417H,,,,0.987,,0.34,,,,,,,,,,,,,,,,,,,,,0.0002%
K417I,,,,0.999,,,,,,,,,,,,,,,,,,,,,1,,0.0002%
K417M,,,,0.966,,,,,,,,,,,,,,,,,,,,,,,0.0003%
K417N,0.6,,381.7,0.997,12.5,,0.7,,0.7,,0.4,,0.7,,0.7,,0.6,1.7,0.5,0.9,0.3,,0.8,,3,6,23%
K417R,,,,0.115,61,,,,,,,,,,,,,,,,,,,,,2,0.004%
K417S,,,,0.98,,,,,,,,,,,,,,,,,,,,,,,0.0002%
K417T,,,49,0.987,7.1,,1.1,,,,,,0.7,,0.7,,0.7,0.9,0.6,,,,,,3,1,1.4%
D420A,,,,0.987,,,,,,,,,,,,,,,,,,,,,,,0.0002%
D420N,2.6,,60.6,0.993,,,,,,,,,,,0.7,,,,,,,,,,,1,0.0008%
N439K,2.4,,0.4,,0.8,,28.8,,1.2,,,,1,,0.5,,,1,0.9,,238.6,,0.8,,,2,0.6%
N440D,,,,,,,,0.473,,,,,1.3,,1.9,,,,,,,,,,1,2,0.0004%
N440E,,,,,,,,0.632,,,,,0.8,,,,,,,,,,,,,,0.0001%
N440I,,,,,,,,0.918,,,,,1.2,,,,,,,,,0.424,,,,,0.0006%
N440K,1.2,,1.1,,1,,92,0.565,1.3,,1,,1.5,,0.8,,0.3,2.1,1.6,1.8,647.1,0.815,1.1,,3,2,23%
N440R,,,,,,,,,,,,,,,,,,,,,,0.23,,,,,0.0002%
N440T,,,,,,,,0.496,,,,,0.8,,,,,,,,,,,,,,0.001%
N440Y,,,,,,,,0.504,,,,,0.7,,,,,,,,,,,,,,0.004%
S443Y,,,,,,,,0.821,,0.194,,,,,,,,,,,,0.585,,,,,0.0001%
K444E,,,,,,,,0.962,291.2,0.946,,,,,,0.81,,,,,,0.627,,,,8,0.0002%
K444F,,,,,,,,0.958,,0.883,,,,,,0.678,,,,,,0.672,,,,,0.0001%
K444I,,,,,,,,0.994,,0.982,,,,,,0.678,,,,,,0.641,,,,,0.0002%
K444L,,,,,,,153,0.971,,0.988,,,,,,0.69,,,,,,0.624,,,,,0.0001%
K444M,,,,,,,1577,0.969,,0.979,,,,,,,,,,,,0.208,,,,1,0.002%
K444N,,,,,,,755,0.943,,0.933,,,,,1901,0.718,,,,,33.7,,1.1,,,7,0.01%
K444R,,,,,,,,,200,0.964,,,,,,,,,,,1.1,,1.2,,,5,0.01%
K444T,,,,,2,,1026.6,0.982,,0.956,,,,,1814,0.635,,,,,44.3,,2,,5,4,0.002%
V445A,,,,,1.8,,548,0.98,35.5,,,,3.4,,83.3,,,,,,,,,,2,5,0.005%
V445D,,,,,,,,0.957,,0.564,,,,,,0.764,,,,,,,,,,1,0.0001%
V445F,,,,,,,,0.885,,,,,,,369,0.654,,,,,,,,,1,1,0.003%
V445I,,,,,,,,,,,,,,,,,,,,,5.6,,1.5,,,,0.003%
V445L,,,,,,,,0.806,,,,,,,,,,,,,7.2,,1.1,,,,0.0002%
G446A,,,,,,,,0.745,,,,,,,,,,,,,,,,,,,0.001%
G446D,,,,,,,,0.978,,,,,,,69,,,,,,,,,,8,4,0.001%
G446I,,,,,,,,0.953,,,,,,,,,,,,,,0.164,,,,1,0.0001%
G446N,,,,,,,,0.924,,,,,,,,,,,,,,,,,,,0.0008%
G446R,,,,,,,,0.953,,,,,,,7,,,,,,,,,,,1,0.002%
G446S,1.2,,0.9,,1.3,,574,0.824,3.7,,1.2,,1.6,,2,,1.1,0.9,1.3,3.4,3.5,,1.1,,1,,17%
G446T,,,,,,,,0.986,,,,,,,,,,,,,,,,,,,0.0002%
G446V,,,0.8,,0.7,,348.5,0.959,3.6,,,,1.5,,4.3,,,0.9,,,858,0.16,1.3,,4,4,0.1%
G447C,,,,,,,,0.591,,,,,,,,,,,,,,,,,,,0.0002%
G447D,,,,,,,,0.986,,0.935,,,,,,,,,,,,,,,,,0.0002%
G447F,,,,,,,,0.908,,0.863,,,,,,,,,,,,,,,,,0.0001%
G447S,,,,,,,,0.652,,0.171,,,,,,,,,,,,,,,,2,0.0007%
G447V,,,,,,,,0.841,,0.882,,,,,,,,,,,,,,,,,0.001%
N448D,,,,,,,,0.613,,0.859,,,,,,,,,,,,,,,,1,0.0005%
N448K,,,,,,,,0.691,,0.97,,,,,,,,,,,,0.47,,,,1,0.0006%
N448T,,,,,,,,0.126,,0.854,,,,,,,,,,,,,,,,,0.0006%
N448Y,,,,,,,,,,0.841,,,,,,,,,,,,0.672,,,,,0.0001%
Y449D,,,,,,,,,,0.674,,,,,,,,,,,,,,,,,0.0007%
N450D,,,,,1.4,,20.9,,382.3,0.7,,,,,,,,,,,,,,,1,5,0.002%
N450K,,,0.4,,,,,,9.1,,,,0.8,,0.7,,,,,,,,,,,2,0.03%
L452M,1,,0.9,,0.4,,1,,1,,0.5,,2.1,,0.6,,,0.9,8.1,1.3,,,,,,,0.03%
L452Q,3,,1.8,,3.1,,4.2,,2.2,,0.5,,2.7,,0.8,,,1.3,21.3,1.3,,,,,,,0.1%
L452R,1254.5,0.934,1,,1.1,,1.7,,5.7,,0.5,,1.1,,0.6,,35,1.3,116,1.1,,,,,4,6,38%
L452W,,0.179,,,,,,,,,,,,,,,,,,,,,,,,,0.002%
Y453F,1.4,,1.4,,456,0.574,1.3,,0.8,,,,1.1,,0.7,,,1.1,1.3,,,,1.1,,2,3,0.03%
Y453H,,,,,,0.427,,,,,,,,,,,,,,,,,,,,,0.0003%
L455F,,,,,80,0.364,1.1,,0.6,,3.6,,0.6,,,,,,,,1.7,,68.3,0.802,3,2,0.03%
L455M,,,,,,,,,,,,,,0.108,,,,,,,,,,,,,0.0002%
L455S,,,,,,0.545,,,,,,,,,,,,,,,,,,0.941,1,,0.002%
L455W,,,,0.966,,0.578,,,,,,,,,,,,,,,,,,0.973,2,,0.0001%
F456C,,,,0.987,,,,,,,,,,,,,,,,,,,,0.994,,,0.0002%
F456L,,,,,,,,,,,,,,,,,,,,,,,,0.946,2,1,0.005%
F456V,,,,0.969,,,,,,,,,,,,,,,,,0.2,,159.9,0.952,,3,0.0004%
S459P,,,,0.685,,,,,,,,,,,,,,,,,,,,,,,0.0004%
N460D,,,,0.105,,,,,,,,,,,,,,,,,,,,,,,0.0008%
N460H,,,,0.975,,,,,,,,,,,,,,,,,,,,,,1,0.0001%
N460I,,,,0.995,,,,,,,,,,,,,,,,,,,,,,,0.001%
N460K,1.5,,76.3,0.996,1.3,,1.3,,0.8,,1,,1.2,,1.2,,,8.9,2.4,,,,,,2,1,0.002%
N460S,0.5,,155.3,0.957,,,,,,,,,,,0.7,,,,,,,,,,,1,0.01%
N460T,2.3,,75,0.992,,,,,,,,,0.6,,,,,,,,,,,,,1,0.0003%
N460Y,1.7,,100,0.886,,,,,,,,,,,,,,,,,,,,,1,1,0.001%
A475D,,,,0.964,,0.381,,,,,,0.929,,,,,,,,,0.5,,1.2,,,1,0.0001%
A475V,,,16.7,0.611,,,,,0.6,,,,2.3,,,,,70.8,,,1.3,,1.2,,2,,0.03%
G476D,,,,,,0.895,,,,,,0.987,,,,,,,,,,,,,1,7,0.0007%
G476R,,,,0.733,,0.469,,,,,,0.973,,,,,,,,,,,,,,,0.0001%
G476T,,,,0.967,,,,,,,,0.929,,,,,,,,,,,,,,,0.0001%
V483A,39.6,,1,,0.4,,0.6,,,,,,,,0.3,,,1.5,,,1,,1,,8,,0.005%
E484A,678.6,0.911,3.4,,9,,1.5,,1.3,,8.1,,0.9,,1.4,,1.1,7.7,1.9,3.6,1.8,,1743.2,0.973,6,5,23%
E484D,100,0.889,,,,,,,,,7.1,,,,1,,,,,,1,,181.7,0.817,1,5,0.003%
E484G,,,,,,,,,,,,,,,,,,,,,,,137.3,0.937,2,3,0.003%
E484K,1333.3,0.97,2.9,,18.4,,1,,1,,8.1,,0.4,,0.7,,8.7,1.4,2.5,,0.4,,1388,0.966,30,33,2.9%
E484P,,0.993,,,,,,,,,,,,,,,,,,,,,,0.992,,,0.0008%
E484Q,100,0.987,1.3,,19,,1,,,,3,,0.4,,0.7,,,1.5,2.6,,1.4,,1743.2,0.991,11,1,0.2%
E484R,,0.991,,,,,,,,,,,,,,,,,,,,,,0.953,,,0.0005%
E484S,,0.702,,,,,,,,,,,,,,,,,,,,,,0.97,,,0.0008%
E484T,,0.954,,,,,,,,,,,,,,,,,,,,,,0.997,,,0.0007%
E484V,,0.977,,,,0.555,,,,,,,,,,,,,,,,,,0.983,2,2,0.01%
G485D,,0.75,,,4.4,,0.6,,,,,0.673,,,,,,,,,,,,,,3,0.001%
G485R,,0.885,,,,,,,,,,,,,,,,,,,,,0.7,,2,,0.001%
F486D,,,,,,0.983,,,,,,0.996,,,,,,,,,,,,,,,0.0002%
F486I,,0.803,,,,0.825,,,,,,0.149,,,1.7,,,,,,,,,,2,1,0.001%
F486L,,0.86,7.6,,61,0.267,0.8,,,,,,1.4,,,,,3.1,2.1,,,,1.1,,,2,0.002%
F486N,,,,0.163,,0.968,,,,,,0.985,,,,,,,,,,,,,,,0.0001%
F486P,,0.878,,0.316,,0.965,,,,,,0.985,,,,,,,,,,,,0.283,,1,0.0002%
F486S,,,,0.249,509.9,0.97,0.4,,,,600,0.997,,,,,,,,,,,,0.39,3,6,0.003%
F486T,,0.804,,0.157,,0.963,,,,,,0.987,,,,,,,,,,,,,,,0.0002%
F486V,490.3,0.73,11.3,0.142,814.9,0.945,0.9,,0.7,,135.5,0.285,1.1,,1.5,,,12.8,1.6,1.3,,,,,1,9,0.0007%
N487D,,,,0.952,,0.819,,,,,,0.939,,,,,,,,,,,,0.448,,3,0.0002%
N487H,,,,0.949,,,,,,,,0.41,,,,,,,,,,,,,,,0.0002%
N487S,,,,0.994,,,,,,,,0.471,,,,,,,,,,,,,,1,0.0002%
Y489H,,,,0.991,,0.943,,,,,,0.42,1.5,,2,,,,,,,,20.2,0.813,1,,0.001%
Y489W,,,,0.913,,0.738,,,,,,0.955,,,,,,,,,,,,,,,0.0002%
F490G,,0.908,,,,,,,,,,,,,,,,,,,,,,0.968,,,0.0001%
F490I,,,,,,,,,,,,,,,,,,,,,,,,0.981,,,0.0007%
F490L,844.3,,2.1,,2.9,,0.8,,,,,,,,1,,,0.7,,,2.1,,233.4,0.967,4,4,0.02%
F490R,,0.985,,,,,,,,,,,,,,,,,,,,,,0.993,,,0.002%
F490S,333.3,0.858,1.1,,0.8,,1.2,,1.1,,,,0.8,,1.7,,,1.3,134.9,,1.2,,4.1,,7,5,0.2%
F490V,,,,,,,,,,,,,,,,,,,,,,,,0.882,,2,0.003%
F490Y,,0.15,,,,,,,,,,,,,,,,,,,,,,,1,,0.002%
Q493D,,,,,,0.795,,,,,,,,,,,,,,,,,,0.866,,,0.0002%
Q493E,,,,,446,0.72,,,,,,,,,,,,,,,,,,,1,,0.009%
Q493H,13.9,,1,,,0.195,,,,,,,,,,,,,,,,,,,,,0.001%
Q493K,2451.3,0.983,54.2,0.378,301,0.633,1.4,,1.6,,1.9,,1.6,,1,,,,,,1.4,,3349,0.996,8,8,0.002%
Q493L,9.9,,3.8,,,0.179,,,,,,,1.1,,,,,,,,2,,20.5,0.72,1,,0.003%
Q493R,1185,0.965,46.4,0.582,42,0.112,1.5,,1.1,,6.5,,1.2,,1,,949,11.6,2,1.4,1,,917.3,0.981,17,6,23%
Q493V,,0.137,,0.131,,,,,,,,,,,,,,,,,,,,0.861,,,0.0002%
S494P,100,0.881,0.6,,2.1,,1.5,,1.2,,,,2,,0.7,,,0.7,1.6,,0.8,,99.1,0.905,12,3,0.2%
S494R,844.3,0.981,3.1,,1.1,,3,,,0.881,,,,,1.5,,,,,,,,,,,,0.0001%
G496S,1.1,,1.3,,1,,5.5,,1.8,,0.9,,1.1,,1.7,,0.6,2.5,1.2,2.2,,,,,,,17%
Q498H,,,,,,,17,,,,,,,,,,,,,,,,,,,,0.0004%
P499H,,,,,,,,0.334,,,,,,,1606,0.644,,,,,,,,,,2,0.001%
P499R,,,,,,,,0.892,,,,,,,976.7,0.668,,,,,,,,,,2,0.008%
P499S,,,,,,,206,0.813,,,,,,,37.5,,,,,,,,,,,,0.003%
P499T,,,,,,,,0.606,,,,,,,,,,,,,,,,,,,0.0007%
N501T,1.1,,10,,,,,,,,,,,,,,,,,,,,,,9,1,0.08%
N501Y,1.1,,5.3,,1,,1,,1.3,,1.5,,1.6,,0.7,,3.8,1,2.3,3.1,1.4,,1.5,,8,3,45%
G504C,,,,0.791,,,,,,,,,,,,,,,,,,,,,,,0.0001%
G504D,,,,0.237,,,,,,,,,,,,,,,,,,,1.8,,1,6,0.002%
G504I,,,,0.908,,,,,,,,,,,,,,,,,,,,,,,0.0002%
G504L,,,,0.684,,,,,,,,,,,,,,,,,,,,,,,0.0002%
G504N,,,,0.295,,,,,,,,,,,,,,,,,,,,,,,0.0006%
G504R,,,,0.281,,,,,,,,,,,,,,,,,,,,,,,0.0001%
G504V,,,,0.705,,,,,,,,,,,,,,,,,,,,,,,0.0006%
P507A,,,,,,,,0.361,,,,,,,,,,,,,,,,,,,0.0005%
N856K,1.4,,9.2,,2.1,,1.4,,1.3,,2.9,,1.7,,1.3,,1.3,1.6,2.3,1.7,,,,,,,18%
N969K,1.5,,5.7,,1.4,,1.6,,1.4,,2.4,,1.5,,3.9,,0.9,3.1,1.4,1.9,,,,,,,24%
E990A,,,,,,,,,,,6.1,,,,,,,,,,,,,,,,0.0004%
T1009I,,,,,,,,,,,8.2,,,,,,,,,,,,,,,,0.01%
3 changes: 2 additions & 1 deletion requirements.txt
Original file line number Diff line number Diff line change
Expand Up @@ -8,4 +8,5 @@ s3fs
st-files-connection
seaborn
matplotlib
pillow
pillow
aiohttp
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