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update to readthedocs
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Gibbsdavidl committed Feb 10, 2024
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6 changes: 2 additions & 4 deletions README.md
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Expand Up @@ -4,18 +4,16 @@ Gene Set Scoring on the Nearest Neighbor Graph (gssnng) for Single Cell RNA-seq

This package works with Scanpy AnnData objects stored as h5ad files.

* **[Read the Docs!](https://gssnng.readthedocs.io/en/latest/)**

* **Notebook using gmt files ===>>>** [![Open In Colab](https://colab.research.google.com/assets/colab-badge.svg)](https://colab.research.google.com/github/IlyaLab/gssnng/blob/main/notebooks/gssnng_quick_start.ipynb)

* **Notebook using Decoupler/Omnipath style API ===>>>** [![Open In Colab](https://colab.research.google.com/assets/colab-badge.svg)](https://colab.research.google.com/github/IlyaLab/gssnng/blob/main/notebooks/Scoring_PBMC_data_with_the_GSSNNG_decoupleR_API.ipynb)

* **Notebook for smoothing counts, breaks AnnData into groups.
* **Notebook for smoothing counts. COMING SOON! For now, see the example script in test.

* **See the paper ===>>>** [gssnng](https://academic.oup.com/bioinformaticsadvances/article/3/1/vbad150/7321111?login=false)

* and finally, [Read the Docs!](https://gssnng.readthedocs.io/en/latest/)


The GSSNNG method is based on using the nearest neighbor graph of cells for data smoothing. This essentially creates
mini-pseudobulk expression profiles for each cell, which can be scored by using single sample gene set scoring
methods often associated with bulk RNA-seq.
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9 changes: 1 addition & 8 deletions docs/decoupler_api_doc.rst
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Expand Up @@ -13,14 +13,7 @@ Gene Set Scoring on the Nearest Neighbor Graph (gssnng) for Single Cell RNA-seq
:caption: Table of Contents
:maxdepth: 2
Installation
Example script
Usage
Scoring Functions
Parameters
Groupby
Gene sets
References
___Usage


`**Notebook using gmt files** <https://colab.research.google.com/github/IlyaLab/gssnng/blob/main/notebooks/gssnng_quick_start.ipynb>`_
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11 changes: 3 additions & 8 deletions docs/gmt_files_doc.rst
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Expand Up @@ -13,14 +13,9 @@ Gene Set Scoring on the Nearest Neighbor Graph (gssnng) for Single Cell RNA-seq
:caption: Table of Contents
:maxdepth: 2
Installation
Example script
Usage
Scoring Functions
Parameters
Groupby
Gene sets
References
___Usage
___Scoring Functions
___Parameters


`**Notebook using gmt files** <https://colab.research.google.com/github/IlyaLab/gssnng/blob/main/notebooks/gssnng_quick_start.ipynb>`_
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4 changes: 2 additions & 2 deletions docs/index.rst
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Expand Up @@ -14,8 +14,8 @@ Contents

.. toctree::
gssnng with gene set gmt files <gmt_files_doc>
gssnng with a decoupler/omnipath style <decoupler_api>
gssnng to smooth count matrices <smoothing_adatas>
gssnng with a decoupler/omnipath style <decoupler_api_doc>
gssnng to smooth count matrices <smoothing_adatas_doc>

The problem: The sparsity of scRNA-seq data creates a poor overlap with many gene sets, which in turn makes gene set scoring difficult.
The GSSNNG method is based on using the nearest neighbor graph of cells for data smoothing. This essentially creates mini-pseudobulk expression profiles for each cell, which can be scored by using single sample gene set scoring methods often associated with bulk RNA-seq.
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9 changes: 2 additions & 7 deletions docs/smoothing_adatas.rst → docs/smoothing_adatas_doc.rst
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Expand Up @@ -13,13 +13,8 @@ Gene Set Scoring on the Nearest Neighbor Graph (gssnng) for Single Cell RNA-seq
:caption: Table of Contents
:maxdepth: 2
Installation
Example script
Usage
Parameters
Groupby
Gene sets
References
__Usage



`**Notebook using gmt files** <https://colab.research.google.com/github/IlyaLab/gssnng/blob/main/notebooks/gssnng_quick_start.ipynb>`_
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