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Raw data and synthetic network source files from Purcell et al. 2013
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classdef NoGene1 < edu.stanford.covert.cell.sim.runners.SimulationRunner | ||
methods | ||
function this = NoGene1(varargin) | ||
this = [email protected](varargin{:}); | ||
end | ||
end | ||
|
||
methods (Access = protected) | ||
function modifyNetworkStructure(this, kb) | ||
import edu.stanford.covert.cell.kb.Gene; | ||
import edu.stanford.covert.cell.kb.ProteinMonomer; | ||
import edu.stanford.covert.cell.kb.ProteinComplex; | ||
import edu.stanford.covert.cell.kb.Stimuli; | ||
import edu.stanford.covert.cell.kb.TranscriptionUnit; | ||
meanHL = mean([kb.mRNAGenes.halfLife]); | ||
expression = zeros(1, 3); | ||
genome = kb.genome; | ||
promoter = 'TATCTACAGAGGCCCGCTTTAAGCATCCACGACCCTACTCACTTCAAAGTGGAACCACCCGTCGACGTGTGTCTTAACCCCTGCCGCTGCAAGGTGTGAG'; | ||
lacI = 'ATGAAACCAGTAACGTTATACGATGTCGCAGAGTATGCCGGTGTCTCTTATCAGACCGTTTCCCGCGTGGTGAACCAGGCCAGCCACGTTTCTGCGAAAACGCGGGAAAAAGTGGAAGCGGCGATGGCGGAGCTGAATTACATTCCCAACCGCGTGGCACAACAACTGGCGGGCAAACAGTCGTTGCTGATTGGCGTTGCCACCTCCAGTCTGGCCCTGCACGCGCCGTCGCAAATTGTCGCGGCGATTAAATCTCGCGCCGATCAACTGGGTGCCAGCGTGGTGGTGTCGATGGTAGAACGAAGCGGCGTCGAAGCCTGTAAAGCGGCGGTGCACAATCTTCTCGCGCAACGCGTCAGTGGGCTGATCATTAACTATCCGCTGGATGACCAGGATGCCATTGCTGTGGAAGCTGCCTGCACTAATGTTCCGGCGTTATTTCTTGATGTCTCTGACCAGACACCCATCAACAGTATTATTTTCTCCCATGAAGACGGTACGCGACTGGGCGTGGAGCATCTGGTCGCATTGGGTCACCAGCAAATCGCGCTGTTAGCGGGCCCATTAAGTTCTGTCTCGGCGCGTCTGCGTCTGGCTGGCTGGCATAAATATCTCACTCGCAATCAAATTCAGCCGATAGCGGAACGGGAAGGCGACTGGAGTGCCATGTCCGGTTTTCAACAAACCATGCAAATGCTGAATGAGGGCATCGTTCCCACTGCGATGCTGGTTGCCAACGATCAGATGGCGCTGGGCGCAATGCGCGCCATTACCGAGTCCGGGCTGCGCGTTGGTGCGGATATCTCGGTAGTGGGATACGACGATACCGAAGACAGCTCATGTTATATCCCGCCGTCAACCACCATCAAACAGGATTTTCGCCTGCTGGGGCAAACCAGCGTGGACCGCTTGCTGCAACTCTCTCAGGGCCAGGCGGTGAAGGGCAATCAGCTGTTGCCCGTCTCACTGGTGAAAAGAAAAACCACCCTGGCGCCCAATACGCAAACCGCCTCTCCCCGCGCGTTGGCCGATTCATTAATGCAGCTGGCACGACAGGTTTCCCGACTGGAAAGCGGGCAGTAA'; | ||
genome.sequence = [genome.sequence repmat([promoter lacI], [1, 1])]; | ||
genome.sequenceLength = length(genome.sequence); | ||
cytosol = kb.compartments(kb.cytosolCompartmentIndexs); | ||
extracellularSpace = kb.compartments(kb.extracellularCompartmentIndexs); | ||
this.modifyNetworkStructure@edu.stanford.covert.cell.sim.runners.SimulationRunner(kb); | ||
end | ||
function modifyNetworkParameters(~, sim) | ||
g = sim.gene; | ||
time = sim.state('Time'); | ||
rna = sim.state('Rna'); | ||
trn = sim.process('Transcription'); | ||
end | ||
end | ||
end |
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classdef NoGene10 < edu.stanford.covert.cell.sim.runners.SimulationRunner | ||
methods | ||
function this = NoGene10(varargin) | ||
this = [email protected](varargin{:}); | ||
end | ||
end | ||
|
||
methods (Access = protected) | ||
function modifyNetworkStructure(this, kb) | ||
import edu.stanford.covert.cell.kb.Gene; | ||
import edu.stanford.covert.cell.kb.ProteinMonomer; | ||
import edu.stanford.covert.cell.kb.ProteinComplex; | ||
import edu.stanford.covert.cell.kb.Stimuli; | ||
import edu.stanford.covert.cell.kb.TranscriptionUnit; | ||
meanHL = mean([kb.mRNAGenes.halfLife]); | ||
expression = zeros(1, 3); | ||
genome = kb.genome; | ||
promoter = 'TATCTACAGAGGCCCGCTTTAAGCATCCACGACCCTACTCACTTCAAAGTGGAACCACCCGTCGACGTGTGTCTTAACCCCTGCCGCTGCAAGGTGTGAG'; | ||
lacI = 'ATGAAACCAGTAACGTTATACGATGTCGCAGAGTATGCCGGTGTCTCTTATCAGACCGTTTCCCGCGTGGTGAACCAGGCCAGCCACGTTTCTGCGAAAACGCGGGAAAAAGTGGAAGCGGCGATGGCGGAGCTGAATTACATTCCCAACCGCGTGGCACAACAACTGGCGGGCAAACAGTCGTTGCTGATTGGCGTTGCCACCTCCAGTCTGGCCCTGCACGCGCCGTCGCAAATTGTCGCGGCGATTAAATCTCGCGCCGATCAACTGGGTGCCAGCGTGGTGGTGTCGATGGTAGAACGAAGCGGCGTCGAAGCCTGTAAAGCGGCGGTGCACAATCTTCTCGCGCAACGCGTCAGTGGGCTGATCATTAACTATCCGCTGGATGACCAGGATGCCATTGCTGTGGAAGCTGCCTGCACTAATGTTCCGGCGTTATTTCTTGATGTCTCTGACCAGACACCCATCAACAGTATTATTTTCTCCCATGAAGACGGTACGCGACTGGGCGTGGAGCATCTGGTCGCATTGGGTCACCAGCAAATCGCGCTGTTAGCGGGCCCATTAAGTTCTGTCTCGGCGCGTCTGCGTCTGGCTGGCTGGCATAAATATCTCACTCGCAATCAAATTCAGCCGATAGCGGAACGGGAAGGCGACTGGAGTGCCATGTCCGGTTTTCAACAAACCATGCAAATGCTGAATGAGGGCATCGTTCCCACTGCGATGCTGGTTGCCAACGATCAGATGGCGCTGGGCGCAATGCGCGCCATTACCGAGTCCGGGCTGCGCGTTGGTGCGGATATCTCGGTAGTGGGATACGACGATACCGAAGACAGCTCATGTTATATCCCGCCGTCAACCACCATCAAACAGGATTTTCGCCTGCTGGGGCAAACCAGCGTGGACCGCTTGCTGCAACTCTCTCAGGGCCAGGCGGTGAAGGGCAATCAGCTGTTGCCCGTCTCACTGGTGAAAAGAAAAACCACCCTGGCGCCCAATACGCAAACCGCCTCTCCCCGCGCGTTGGCCGATTCATTAATGCAGCTGGCACGACAGGTTTCCCGACTGGAAAGCGGGCAGTAA'; | ||
genome.sequence = [genome.sequence repmat([promoter lacI], [1, 10])]; | ||
genome.sequenceLength = length(genome.sequence); | ||
cytosol = kb.compartments(kb.cytosolCompartmentIndexs); | ||
extracellularSpace = kb.compartments(kb.extracellularCompartmentIndexs); | ||
this.modifyNetworkStructure@edu.stanford.covert.cell.sim.runners.SimulationRunner(kb); | ||
end | ||
function modifyNetworkParameters(~, sim) | ||
g = sim.gene; | ||
time = sim.state('Time'); | ||
rna = sim.state('Rna'); | ||
trn = sim.process('Transcription'); | ||
end | ||
end | ||
end |
33 changes: 33 additions & 0 deletions
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src/+edu/+stanford/+covert/+cell/+sim/+runners/NoGene100.m
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classdef NoGene100 < edu.stanford.covert.cell.sim.runners.SimulationRunner | ||
methods | ||
function this = NoGene100(varargin) | ||
this = [email protected](varargin{:}); | ||
end | ||
end | ||
|
||
methods (Access = protected) | ||
function modifyNetworkStructure(this, kb) | ||
import edu.stanford.covert.cell.kb.Gene; | ||
import edu.stanford.covert.cell.kb.ProteinMonomer; | ||
import edu.stanford.covert.cell.kb.ProteinComplex; | ||
import edu.stanford.covert.cell.kb.Stimuli; | ||
import edu.stanford.covert.cell.kb.TranscriptionUnit; | ||
meanHL = mean([kb.mRNAGenes.halfLife]); | ||
expression = zeros(1, 3); | ||
genome = kb.genome; | ||
promoter = 'TATCTACAGAGGCCCGCTTTAAGCATCCACGACCCTACTCACTTCAAAGTGGAACCACCCGTCGACGTGTGTCTTAACCCCTGCCGCTGCAAGGTGTGAG'; | ||
lacI = 'ATGAAACCAGTAACGTTATACGATGTCGCAGAGTATGCCGGTGTCTCTTATCAGACCGTTTCCCGCGTGGTGAACCAGGCCAGCCACGTTTCTGCGAAAACGCGGGAAAAAGTGGAAGCGGCGATGGCGGAGCTGAATTACATTCCCAACCGCGTGGCACAACAACTGGCGGGCAAACAGTCGTTGCTGATTGGCGTTGCCACCTCCAGTCTGGCCCTGCACGCGCCGTCGCAAATTGTCGCGGCGATTAAATCTCGCGCCGATCAACTGGGTGCCAGCGTGGTGGTGTCGATGGTAGAACGAAGCGGCGTCGAAGCCTGTAAAGCGGCGGTGCACAATCTTCTCGCGCAACGCGTCAGTGGGCTGATCATTAACTATCCGCTGGATGACCAGGATGCCATTGCTGTGGAAGCTGCCTGCACTAATGTTCCGGCGTTATTTCTTGATGTCTCTGACCAGACACCCATCAACAGTATTATTTTCTCCCATGAAGACGGTACGCGACTGGGCGTGGAGCATCTGGTCGCATTGGGTCACCAGCAAATCGCGCTGTTAGCGGGCCCATTAAGTTCTGTCTCGGCGCGTCTGCGTCTGGCTGGCTGGCATAAATATCTCACTCGCAATCAAATTCAGCCGATAGCGGAACGGGAAGGCGACTGGAGTGCCATGTCCGGTTTTCAACAAACCATGCAAATGCTGAATGAGGGCATCGTTCCCACTGCGATGCTGGTTGCCAACGATCAGATGGCGCTGGGCGCAATGCGCGCCATTACCGAGTCCGGGCTGCGCGTTGGTGCGGATATCTCGGTAGTGGGATACGACGATACCGAAGACAGCTCATGTTATATCCCGCCGTCAACCACCATCAAACAGGATTTTCGCCTGCTGGGGCAAACCAGCGTGGACCGCTTGCTGCAACTCTCTCAGGGCCAGGCGGTGAAGGGCAATCAGCTGTTGCCCGTCTCACTGGTGAAAAGAAAAACCACCCTGGCGCCCAATACGCAAACCGCCTCTCCCCGCGCGTTGGCCGATTCATTAATGCAGCTGGCACGACAGGTTTCCCGACTGGAAAGCGGGCAGTAA'; | ||
genome.sequence = [genome.sequence repmat([promoter lacI], [1, 100])]; | ||
genome.sequenceLength = length(genome.sequence); | ||
cytosol = kb.compartments(kb.cytosolCompartmentIndexs); | ||
extracellularSpace = kb.compartments(kb.extracellularCompartmentIndexs); | ||
this.modifyNetworkStructure@edu.stanford.covert.cell.sim.runners.SimulationRunner(kb); | ||
end | ||
function modifyNetworkParameters(~, sim) | ||
g = sim.gene; | ||
time = sim.state('Time'); | ||
rna = sim.state('Rna'); | ||
trn = sim.process('Transcription'); | ||
end | ||
end | ||
end |
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classdef NoGene20 < edu.stanford.covert.cell.sim.runners.SimulationRunner | ||
methods | ||
function this = NoGene20(varargin) | ||
this = [email protected](varargin{:}); | ||
end | ||
end | ||
|
||
methods (Access = protected) | ||
function modifyNetworkStructure(this, kb) | ||
import edu.stanford.covert.cell.kb.Gene; | ||
import edu.stanford.covert.cell.kb.ProteinMonomer; | ||
import edu.stanford.covert.cell.kb.ProteinComplex; | ||
import edu.stanford.covert.cell.kb.Stimuli; | ||
import edu.stanford.covert.cell.kb.TranscriptionUnit; | ||
meanHL = mean([kb.mRNAGenes.halfLife]); | ||
expression = zeros(1, 3); | ||
genome = kb.genome; | ||
promoter = 'TATCTACAGAGGCCCGCTTTAAGCATCCACGACCCTACTCACTTCAAAGTGGAACCACCCGTCGACGTGTGTCTTAACCCCTGCCGCTGCAAGGTGTGAG'; | ||
lacI = 'ATGAAACCAGTAACGTTATACGATGTCGCAGAGTATGCCGGTGTCTCTTATCAGACCGTTTCCCGCGTGGTGAACCAGGCCAGCCACGTTTCTGCGAAAACGCGGGAAAAAGTGGAAGCGGCGATGGCGGAGCTGAATTACATTCCCAACCGCGTGGCACAACAACTGGCGGGCAAACAGTCGTTGCTGATTGGCGTTGCCACCTCCAGTCTGGCCCTGCACGCGCCGTCGCAAATTGTCGCGGCGATTAAATCTCGCGCCGATCAACTGGGTGCCAGCGTGGTGGTGTCGATGGTAGAACGAAGCGGCGTCGAAGCCTGTAAAGCGGCGGTGCACAATCTTCTCGCGCAACGCGTCAGTGGGCTGATCATTAACTATCCGCTGGATGACCAGGATGCCATTGCTGTGGAAGCTGCCTGCACTAATGTTCCGGCGTTATTTCTTGATGTCTCTGACCAGACACCCATCAACAGTATTATTTTCTCCCATGAAGACGGTACGCGACTGGGCGTGGAGCATCTGGTCGCATTGGGTCACCAGCAAATCGCGCTGTTAGCGGGCCCATTAAGTTCTGTCTCGGCGCGTCTGCGTCTGGCTGGCTGGCATAAATATCTCACTCGCAATCAAATTCAGCCGATAGCGGAACGGGAAGGCGACTGGAGTGCCATGTCCGGTTTTCAACAAACCATGCAAATGCTGAATGAGGGCATCGTTCCCACTGCGATGCTGGTTGCCAACGATCAGATGGCGCTGGGCGCAATGCGCGCCATTACCGAGTCCGGGCTGCGCGTTGGTGCGGATATCTCGGTAGTGGGATACGACGATACCGAAGACAGCTCATGTTATATCCCGCCGTCAACCACCATCAAACAGGATTTTCGCCTGCTGGGGCAAACCAGCGTGGACCGCTTGCTGCAACTCTCTCAGGGCCAGGCGGTGAAGGGCAATCAGCTGTTGCCCGTCTCACTGGTGAAAAGAAAAACCACCCTGGCGCCCAATACGCAAACCGCCTCTCCCCGCGCGTTGGCCGATTCATTAATGCAGCTGGCACGACAGGTTTCCCGACTGGAAAGCGGGCAGTAA'; | ||
genome.sequence = [genome.sequence repmat([promoter lacI], [1, 20])]; | ||
genome.sequenceLength = length(genome.sequence); | ||
cytosol = kb.compartments(kb.cytosolCompartmentIndexs); | ||
extracellularSpace = kb.compartments(kb.extracellularCompartmentIndexs); | ||
this.modifyNetworkStructure@edu.stanford.covert.cell.sim.runners.SimulationRunner(kb); | ||
end | ||
function modifyNetworkParameters(~, sim) | ||
g = sim.gene; | ||
time = sim.state('Time'); | ||
rna = sim.state('Rna'); | ||
trn = sim.process('Transcription'); | ||
end | ||
end | ||
end |
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@@ -0,0 +1,33 @@ | ||
classdef NoGene5 < edu.stanford.covert.cell.sim.runners.SimulationRunner | ||
methods | ||
function this = NoGene5(varargin) | ||
this = [email protected](varargin{:}); | ||
end | ||
end | ||
|
||
methods (Access = protected) | ||
function modifyNetworkStructure(this, kb) | ||
import edu.stanford.covert.cell.kb.Gene; | ||
import edu.stanford.covert.cell.kb.ProteinMonomer; | ||
import edu.stanford.covert.cell.kb.ProteinComplex; | ||
import edu.stanford.covert.cell.kb.Stimuli; | ||
import edu.stanford.covert.cell.kb.TranscriptionUnit; | ||
meanHL = mean([kb.mRNAGenes.halfLife]); | ||
expression = zeros(1, 3); | ||
genome = kb.genome; | ||
promoter = 'TATCTACAGAGGCCCGCTTTAAGCATCCACGACCCTACTCACTTCAAAGTGGAACCACCCGTCGACGTGTGTCTTAACCCCTGCCGCTGCAAGGTGTGAG'; | ||
lacI = 'ATGAAACCAGTAACGTTATACGATGTCGCAGAGTATGCCGGTGTCTCTTATCAGACCGTTTCCCGCGTGGTGAACCAGGCCAGCCACGTTTCTGCGAAAACGCGGGAAAAAGTGGAAGCGGCGATGGCGGAGCTGAATTACATTCCCAACCGCGTGGCACAACAACTGGCGGGCAAACAGTCGTTGCTGATTGGCGTTGCCACCTCCAGTCTGGCCCTGCACGCGCCGTCGCAAATTGTCGCGGCGATTAAATCTCGCGCCGATCAACTGGGTGCCAGCGTGGTGGTGTCGATGGTAGAACGAAGCGGCGTCGAAGCCTGTAAAGCGGCGGTGCACAATCTTCTCGCGCAACGCGTCAGTGGGCTGATCATTAACTATCCGCTGGATGACCAGGATGCCATTGCTGTGGAAGCTGCCTGCACTAATGTTCCGGCGTTATTTCTTGATGTCTCTGACCAGACACCCATCAACAGTATTATTTTCTCCCATGAAGACGGTACGCGACTGGGCGTGGAGCATCTGGTCGCATTGGGTCACCAGCAAATCGCGCTGTTAGCGGGCCCATTAAGTTCTGTCTCGGCGCGTCTGCGTCTGGCTGGCTGGCATAAATATCTCACTCGCAATCAAATTCAGCCGATAGCGGAACGGGAAGGCGACTGGAGTGCCATGTCCGGTTTTCAACAAACCATGCAAATGCTGAATGAGGGCATCGTTCCCACTGCGATGCTGGTTGCCAACGATCAGATGGCGCTGGGCGCAATGCGCGCCATTACCGAGTCCGGGCTGCGCGTTGGTGCGGATATCTCGGTAGTGGGATACGACGATACCGAAGACAGCTCATGTTATATCCCGCCGTCAACCACCATCAAACAGGATTTTCGCCTGCTGGGGCAAACCAGCGTGGACCGCTTGCTGCAACTCTCTCAGGGCCAGGCGGTGAAGGGCAATCAGCTGTTGCCCGTCTCACTGGTGAAAAGAAAAACCACCCTGGCGCCCAATACGCAAACCGCCTCTCCCCGCGCGTTGGCCGATTCATTAATGCAGCTGGCACGACAGGTTTCCCGACTGGAAAGCGGGCAGTAA'; | ||
genome.sequence = [genome.sequence repmat([promoter lacI], [1, 5])]; | ||
genome.sequenceLength = length(genome.sequence); | ||
cytosol = kb.compartments(kb.cytosolCompartmentIndexs); | ||
extracellularSpace = kb.compartments(kb.extracellularCompartmentIndexs); | ||
this.modifyNetworkStructure@edu.stanford.covert.cell.sim.runners.SimulationRunner(kb); | ||
end | ||
function modifyNetworkParameters(~, sim) | ||
g = sim.gene; | ||
time = sim.state('Time'); | ||
rna = sim.state('Rna'); | ||
trn = sim.process('Transcription'); | ||
end | ||
end | ||
end |
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@@ -0,0 +1,34 @@ | ||
classdef NoGene50 < edu.stanford.covert.cell.sim.runners.SimulationRunner | ||
methods | ||
function this = NoGene50(varargin) | ||
this = [email protected](varargin{:}); | ||
end | ||
end | ||
|
||
methods (Access = protected) | ||
function modifyNetworkStructure(this, kb) | ||
import edu.stanford.covert.cell.kb.Gene; | ||
import edu.stanford.covert.cell.kb.ProteinMonomer; | ||
import edu.stanford.covert.cell.kb.ProteinComplex; | ||
import edu.stanford.covert.cell.kb.Stimuli; | ||
import edu.stanford.covert.cell.kb.TranscriptionUnit; | ||
meanHL = mean([kb.mRNAGenes.halfLife]); | ||
expression = zeros(1, 3); | ||
genome = kb.genome; | ||
promoter = 'TATCTACAGAGGCCCGCTTTAAGCATCCACGACCCTACTCACTTCAAAGTGGAACCACCCGTCGACGTGTGTCTTAACCCCTGCCGCTGCAAGGTGTGAG'; | ||
lacI = 'ATGAAACCAGTAACGTTATACGATGTCGCAGAGTATGCCGGTGTCTCTTATCAGACCGTTTCCCGCGTGGTGAACCAGGCCAGCCACGTTTCTGCGAAAACGCGGGAAAAAGTGGAAGCGGCGATGGCGGAGCTGAATTACATTCCCAACCGCGTGGCACAACAACTGGCGGGCAAACAGTCGTTGCTGATTGGCGTTGCCACCTCCAGTCTGGCCCTGCACGCGCCGTCGCAAATTGTCGCGGCGATTAAATCTCGCGCCGATCAACTGGGTGCCAGCGTGGTGGTGTCGATGGTAGAACGAAGCGGCGTCGAAGCCTGTAAAGCGGCGGTGCACAATCTTCTCGCGCAACGCGTCAGTGGGCTGATCATTAACTATCCGCTGGATGACCAGGATGCCATTGCTGTGGAAGCTGCCTGCACTAATGTTCCGGCGTTATTTCTTGATGTCTCTGACCAGACACCCATCAACAGTATTATTTTCTCCCATGAAGACGGTACGCGACTGGGCGTGGAGCATCTGGTCGCATTGGGTCACCAGCAAATCGCGCTGTTAGCGGGCCCATTAAGTTCTGTCTCGGCGCGTCTGCGTCTGGCTGGCTGGCATAAATATCTCACTCGCAATCAAATTCAGCCGATAGCGGAACGGGAAGGCGACTGGAGTGCCATGTCCGGTTTTCAACAAACCATGCAAATGCTGAATGAGGGCATCGTTCCCACTGCGATGCTGGTTGCCAACGATCAGATGGCGCTGGGCGCAATGCGCGCCATTACCGAGTCCGGGCTGCGCGTTGGTGCGGATATCTCGGTAGTGGGATACGACGATACCGAAGACAGCTCATGTTATATCCCGCCGTCAACCACCATCAAACAGGATTTTCGCCTGCTGGGGCAAACCAGCGTGGACCGCTTGCTGCAACTCTCTCAGGGCCAGGCGGTGAAGGGCAATCAGCTGTTGCCCGTCTCACTGGTGAAAAGAAAAACCACCCTGGCGCCCAATACGCAAACCGCCTCTCCCCGCGCGTTGGCCGATTCATTAATGCAGCTGGCACGACAGGTTTCCCGACTGGAAAGCGGGCAGTAA'; | ||
genome.sequence = [genome.sequence repmat([promoter lacI], [1, 50])]; | ||
genome.sequenceLength = length(genome.sequence); | ||
cytosol = kb.compartments(kb.cytosolCompartmentIndexs); | ||
extracellularSpace = kb.compartments(kb.extracellularCompartmentIndexs); | ||
this.modifyNetworkStructure@edu.stanford.covert.cell.sim.runners.SimulationRunner(kb); | ||
|
||
end | ||
function modifyNetworkParameters(~, sim) | ||
g = sim.gene; | ||
time = sim.state('Time'); | ||
rna = sim.state('Rna'); | ||
trn = sim.process('Transcription'); | ||
end | ||
end | ||
end |
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