SARS-CoV-2_Alignments

Sequence alignments of SARS-CoV-2 proteins and previously studied proteins

GitHub Pages: https://alexanderpico.github.io/SARS-CoV-2_Alignments/

Purpose

While curating pathway models for the various functions of SARS-CoV-2 proteins, I often stumbled upon previously published pathway figures and solved protein structures relating to the prior rounds of coronavirus research. The obvious question in these cases is "how similar are the sequences; are the critical residues conserved?"

In the spirit of open science, I'm sharing these protein sequence alignments along with my observations on particularly interesting similarities and, by extension, structural and functional predictions.

Content

• index.html provides a consolidated web view of all alignments in this repo
• .fa files are separate multiple sequence alignment files in fasta format
• .jvp file is a Jalview project file containing all alignments