diff --git a/CHANGES.rst b/CHANGES.rst
index b52821c454..629cd6e780 100644
--- a/CHANGES.rst
+++ b/CHANGES.rst
@@ -7,6 +7,12 @@ since the branch point at Zope 4.1.2.
 The change log for the previous version, Zope 4, is at
 https://github.com/zopefoundation/Zope/blob/4.x/CHANGES.rst
 
+5.10.1 (unreleased)
+-------------------
+
+- Update to newest compatible versions of dependencies.
+
+
 5.10 (2024-05-18)
 -----------------
 
diff --git a/constraints.txt b/constraints.txt
index 7fff92cc16..ec4a10b70d 100644
--- a/constraints.txt
+++ b/constraints.txt
@@ -1,13 +1,15 @@
 AccessControl==6.3
-Acquisition==5.1
+Acquisition==5.2
 AuthEncoding==5.0
-BTrees==5.1
-Chameleon==4.2.0
-DateTime==5.3
+BTrees==5.2
+Chameleon==4.2.0; python_version == '3.7'
+Chameleon==4.4.4; python_version == '3.8'
+Chameleon==4.4.4; python_version > '3.8'
+DateTime==5.5
 DocumentTemplate==4.6
 ExtensionClass==5.1
 MultiMapping==5.0
-Paste==3.7.1
+Paste==3.10.1
 PasteDeploy==2.1.1; python_version == '3.7'
 PasteDeploy==3.1.0; python_version > '3.7'
 Persistence==4.1
@@ -15,28 +17,30 @@ RestrictedPython==7.1
 WSGIProxy2==0.5.1
 WebOb==1.8.7
 WebTest==3.0.0
-ZConfig==4.0
-ZODB==5.8.1
+ZConfig==4.1
+ZODB==6.0
 Zope2==4.0
-beautifulsoup4==4.12.2
+beautifulsoup4==4.12.3
 cffi==1.15.1; python_version == '3.7'
 cffi==1.16.0; python_version > '3.7'
 multipart==0.2.4
-persistent==5.1
-pycparser==2.21
+persistent==5.2
+pycparser==2.21; python_version == '3.7'
+pycparser==2.22; python_version > '3.7'
 python-gettext==5.0
-pytz==2023.3.post1
-roman==4.1
+pytz==2024.1
+roman==4.2
 six==1.16.0
 soupsieve==2.4.1; python_version == '3.7'
 soupsieve==2.5; python_version > '3.7'
 transaction==4.0
-waitress==2.1.2
-z3c.pt==4.0
+waitress==2.1.2; python_version == '3.7'
+waitress==3.0.0; python_version > '3.7'
+z3c.pt==4.3
 zExceptions==5.0
 zc.lockfile==3.0.post1
 zc.recipe.egg==2.0.7
-zodbpickle==3.1
+zodbpickle==3.3
 zope.annotation==5.0
 zope.browser==3.0
 zope.browsermenu==5.0
@@ -44,7 +48,7 @@ zope.browserpage==5.0
 zope.browserresource==5.1
 zope.cachedescriptors==5.0
 zope.component==6.0
-zope.configuration==5.0
+zope.configuration==5.0.1
 zope.container==5.2
 zope.contentprovider==5.0
 zope.contenttype==5.1
@@ -59,12 +63,12 @@ zope.globalrequest==2.0
 zope.hookable==6.0
 zope.i18n==5.1
 zope.i18nmessageid==6.1.0
-zope.interface==6.3
+zope.interface==6.4
 zope.lifecycleevent==5.0
 zope.location==5.0
-zope.pagetemplate==5.0
+zope.pagetemplate==5.1
 zope.processlifetime==3.0
-zope.proxy==5.1
+zope.proxy==5.2
 zope.ptresource==5.0
 zope.publisher==7.0
 zope.schema==7.0.1
diff --git a/requirements-full.txt b/requirements-full.txt
index 1ed2fd3b6d..dac553088a 100644
--- a/requirements-full.txt
+++ b/requirements-full.txt
@@ -1,14 +1,16 @@
-Zope==5.10
+-e git+https://github.com/zopefoundation/Zope.git@master#egg=Zope
 AccessControl==6.3
-Acquisition==5.1
+Acquisition==5.2
 AuthEncoding==5.0
-BTrees==5.1
-Chameleon==4.2.0
-DateTime==5.3
+BTrees==5.2
+Chameleon==4.2.0; python_version == '3.7'
+Chameleon==4.4.4; python_version == '3.8'
+Chameleon==4.4.4; python_version > '3.8'
+DateTime==5.5
 DocumentTemplate==4.6
 ExtensionClass==5.1
 MultiMapping==5.0
-Paste==3.7.1
+Paste==3.10.1
 PasteDeploy==2.1.1; python_version == '3.7'
 PasteDeploy==3.1.0; python_version > '3.7'
 Persistence==4.1
@@ -16,28 +18,30 @@ RestrictedPython==7.1
 WSGIProxy2==0.5.1
 WebOb==1.8.7
 WebTest==3.0.0
-ZConfig==4.0
-ZODB==5.8.1
+ZConfig==4.1
+ZODB==6.0
 Zope2==4.0
-beautifulsoup4==4.12.2
+beautifulsoup4==4.12.3
 cffi==1.15.1; python_version == '3.7'
 cffi==1.16.0; python_version > '3.7'
 multipart==0.2.4
-persistent==5.1
-pycparser==2.21
+persistent==5.2
+pycparser==2.21; python_version == '3.7'
+pycparser==2.22; python_version > '3.7'
 python-gettext==5.0
-pytz==2023.3.post1
-roman==4.1
+pytz==2024.1
+roman==4.2
 six==1.16.0
 soupsieve==2.4.1; python_version == '3.7'
 soupsieve==2.5; python_version > '3.7'
 transaction==4.0
-waitress==2.1.2
-z3c.pt==4.0
+waitress==2.1.2; python_version == '3.7'
+waitress==3.0.0; python_version > '3.7'
+z3c.pt==4.3
 zExceptions==5.0
 zc.lockfile==3.0.post1
 zc.recipe.egg==2.0.7
-zodbpickle==3.1
+zodbpickle==3.3
 zope.annotation==5.0
 zope.browser==3.0
 zope.browsermenu==5.0
@@ -45,7 +49,7 @@ zope.browserpage==5.0
 zope.browserresource==5.1
 zope.cachedescriptors==5.0
 zope.component==6.0
-zope.configuration==5.0
+zope.configuration==5.0.1
 zope.container==5.2
 zope.contentprovider==5.0
 zope.contenttype==5.1
@@ -60,12 +64,12 @@ zope.globalrequest==2.0
 zope.hookable==6.0
 zope.i18n==5.1
 zope.i18nmessageid==6.1.0
-zope.interface==6.3
+zope.interface==6.4
 zope.lifecycleevent==5.0
 zope.location==5.0
-zope.pagetemplate==5.0
+zope.pagetemplate==5.1
 zope.processlifetime==3.0
-zope.proxy==5.1
+zope.proxy==5.2
 zope.ptresource==5.0
 zope.publisher==7.0
 zope.schema==7.0.1
diff --git a/setup.py b/setup.py
index 0d3d461710..3c2f4a24d7 100644
--- a/setup.py
+++ b/setup.py
@@ -29,7 +29,7 @@ def _read_file(filename):
 README = _read_file('README.rst')
 CHANGES = _read_file('CHANGES.rst')
 
-version = '5.10'
+version = '5.10.1.dev0'
 
 setup(
     name='Zope',
diff --git a/versions-prod.cfg b/versions-prod.cfg
index 9a0f34d178..ab07d3d23a 100644
--- a/versions-prod.cfg
+++ b/versions-prod.cfg
@@ -2,43 +2,43 @@
 # Version pins for required and commonly used dependencies.
 
 [versions]
-Zope = 5.10
+Zope =
 Zope2 = 4.0
 AccessControl = 6.3
-Acquisition = 5.1
+Acquisition = 5.2
 AuthEncoding = 5.0
-BTrees = 5.1
-Chameleon = 4.2.0
-DateTime = 5.3
+BTrees = 5.2
+Chameleon = 4.4.4
+DateTime = 5.5
 DocumentTemplate = 4.6
 ExtensionClass = 5.1
 MultiMapping = 5.0
-Paste = 3.7.1
+Paste = 3.10.1
 PasteDeploy = 3.1.0
 Persistence = 4.1
 RestrictedPython = 7.1
 WebTest = 3.0.0
 WSGIProxy2 = 0.5.1
 WebOb = 1.8.7
-ZConfig = 4.0
-ZODB = 5.8.1
-beautifulsoup4 = 4.12.2
+ZConfig = 4.1
+ZODB = 6.0
+beautifulsoup4 = 4.12.3
 cffi = 1.16.0
 multipart = 0.2.4
-persistent = 5.1
-pycparser = 2.21
+persistent = 5.2
+pycparser = 2.22
 python-gettext = 5.0
-pytz = 2023.3.post1
+pytz = 2024.1
 six = 1.16.0
-roman = 4.1
+roman = 4.2
 soupsieve = 2.5
 transaction = 4.0
-waitress = 2.1.2
-z3c.pt = 4.0
+waitress = 3.0.0
+z3c.pt = 4.3
 zExceptions = 5.0
 zc.lockfile = 3.0.post1
 zc.recipe.egg = 2.0.7
-zodbpickle = 3.1
+zodbpickle = 3.3
 zope.annotation = 5.0
 zope.browser = 3.0
 zope.browsermenu = 5.0
@@ -46,7 +46,7 @@ zope.browserpage = 5.0
 zope.browserresource = 5.1
 zope.cachedescriptors = 5.0
 zope.component = 6.0
-zope.configuration = 5.0
+zope.configuration = 5.0.1
 zope.container = 5.2
 zope.contentprovider = 5.0
 zope.contenttype = 5.1
@@ -61,12 +61,12 @@ zope.globalrequest = 2.0
 zope.hookable = 6.0
 zope.i18n = 5.1
 zope.i18nmessageid = 6.1.0
-zope.interface = 6.3
+zope.interface = 6.4
 zope.lifecycleevent = 5.0
 zope.location = 5.0
-zope.pagetemplate = 5.0
+zope.pagetemplate = 5.1
 zope.processlifetime = 3.0
-zope.proxy = 5.1
+zope.proxy = 5.2
 zope.ptresource = 5.0
 zope.publisher = 7.0
 zope.schema = 7.0.1
@@ -82,10 +82,20 @@ zope.testing = 5.0.1
 zope.traversing = 5.0
 zope.viewlet = 5.0
 
+[versions:python38]
+# Chameleon >= 4.5 requires Python 3.9
+Chameleon = 4.4.4
+
 [versions:python37]
+# Chameleon >= 4.3 requires Python 3.8
+Chameleon = 4.2.0
 # PasteDeploy 3.x works on Python 3.7 but pulls tons of dependencies
 PasteDeploy = 2.1.1
+# pycparser >= 2.22 requires Python 3.8
+pycparser = 2.21
 # SoupSieve 2.5 and up requires Python 3.8
 soupsieve = 2.4.1
 # cffi 1.16.0 requires Python 3.8
 cffi = 1.15.1
+# waitress >= 3.0 requires Python 3.8
+waitress = 2.1.2
diff --git a/versions.cfg b/versions.cfg
index a9a25a6878..cffbf62b5d 100644
--- a/versions.cfg
+++ b/versions.cfg
@@ -5,47 +5,52 @@ versions = versions
 
 [versions]
 # Version pins for development and optional dependencies.
-Babel = 2.13.1
-Jinja2 = 3.1.2
+Babel = 2.15.0
+Jinja2 = 3.1.4
 Missing = 5.0
-MarkupSafe = 2.1.3
+MarkupSafe = 2.1.5
 Products.BTreeFolder2 = 5.1
-Products.ZCatalog = 7.0
-Pygments = 2.17.2
-Record = 4.0
-Sphinx = 7.2.6
-alabaster = 0.7.13
+Products.ZCatalog = 7.1
+Pygments = 2.18.0
+Record = 4.1
+Sphinx = 7.3.7
+alabaster = 0.7.16
 certifi = 2024.2.2
 charset-normalizer = 3.3.2
 collective.recipe.template = 2.2
 colorama = 0.4.6
-# sphinx-rtd-theme 1.3.0 requires docutils<19
-docutils = 0.18.1
+# sphinx-rtd-theme 2.0.0 requires docutils <21
+docutils = 0.20.1
 five.localsitemanager = 4.0
-idna = 3.4
+idna = 3.7
 imagesize = 1.4.1
-importlib-metadata = 6.8.0
+importlib-metadata = 7.1.0
 mr.developer = 2.0.2
-packaging = 23.2
+packaging = 24.0
 plone.recipe.command = 1.1
 requests = 2.31.0
 snowballstemmer = 2.2.0
-sphinx-rtd-theme = 1.3.0
-sphinxcontrib-applehelp = 1.0.7
-sphinxcontrib-devhelp = 1.0.5
-sphinxcontrib-htmlhelp = 2.0.4
+sphinx-rtd-theme = 2.0.0
+sphinxcontrib-applehelp = 1.0.8
+sphinxcontrib-devhelp = 1.0.6
+sphinxcontrib-htmlhelp = 2.0.5
 sphinxcontrib-jquery = 4.1
 sphinxcontrib-jsmath = 1.0.1
-sphinxcontrib-qthelp = 1.0.6
-sphinxcontrib-serializinghtml = 1.1.9
+sphinxcontrib-qthelp = 1.0.7
+sphinxcontrib-serializinghtml = 1.1.10
 tempstorage = 6.0
-urllib3 = 2.1.0
+tomli = 2.0.1
+urllib3 = 2.2.1
 z3c.checkversions = 2.1
 zc.recipe.testrunner = 3.0
-zipp = 3.17.0
+zipp = 3.18.2
 zope.testrunner = 6.4
 
 [versions:python38]
+# alabaster >= 0.7.14 requires Python 3.9
+alabaster = 0.7.13
+# Required dependency on Python 3.8 only
+importlib-resources = 6.4.0
 # Sphinx >= 7.2 requires Python 3.9+
 Sphinx = 7.1.2
 # sphinxcontrib-serializinghtml >= 1.1.6 requires Python 3.9+
@@ -60,8 +65,16 @@ sphinxcontrib-devhelp = 1.0.2
 sphinxcontrib-applehelp = 1.0.4
 
 [versions:python37]
+# alabaster >= 0.7.14 requires Python 3.9
+alabaster = 0.7.13
+# Babel >= 2.15 requires Python 3.8+
+Babel = 2.14.0
+# Sphinx 5.3.0 requires docutils <0.20
+docutils = 0.19
 # importlib-metadata 6.8.0 requires Python 3.8+
 importlib-metadata = 6.7.0
+# Pygments >= 2.18 requires Python 3.8+
+Pygments = 2.17.2
 # Sphinx >= 6.0 requires Python 3.8+
 Sphinx = 5.3.0
 # Sphinx 5.3 requires typing-extensions for Python 3.7