diff --git a/zhaquirks/__init__.py b/zhaquirks/__init__.py
index 3aca7f8f58..fd419f7893 100644
--- a/zhaquirks/__init__.py
+++ b/zhaquirks/__init__.py
@@ -13,7 +13,7 @@
 
 import zigpy.device
 import zigpy.endpoint
-from zigpy.quirks import CustomCluster, CustomDevice
+from zigpy.quirks import DEVICE_REGISTRY, CustomCluster, CustomDevice
 import zigpy.types as t
 from zigpy.util import ListenableMixin
 from zigpy.zcl import foundation
@@ -432,6 +432,9 @@ async def command(self, command, *args, expect_reply=None, **kwargs):
 def setup(custom_quirks_path: str | None = None) -> None:
     """Register all quirks with zigpy, including optional custom quirks."""
 
+    if custom_quirks_path is not None:
+        DEVICE_REGISTRY.purge_custom_quirks(custom_quirks_path)
+
     # Import all quirks in the `zhaquirks` package first
     for _importer, modname, _ispkg in pkgutil.walk_packages(
         path=__path__,