diff --git a/Cargo.lock b/Cargo.lock
index 3ecd1da..55ae400 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -1374,9 +1374,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3"
-version = "0.22.0"
+version = "0.22.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "1962a33ed2a201c637fc14a4e0fd4e06e6edfdeee6a5fede0dab55507ad74cf7"
+checksum = "4e99090d12f6182924499253aaa1e73bf15c69cea8d2774c3c781e35badc3548"
 dependencies = [
  "anyhow",
  "cfg-if",
@@ -1393,9 +1393,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-build-config"
-version = "0.22.0"
+version = "0.22.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "ab7164b2202753bd33afc7f90a10355a719aa973d1f94502c50d06f3488bc420"
+checksum = "7879eb018ac754bba32cb0eec7526391c02c14a093121857ed09fbf1d1057d41"
 dependencies = [
  "once_cell",
  "target-lexicon",
@@ -1403,9 +1403,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-ffi"
-version = "0.22.0"
+version = "0.22.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "c6424906ca49013c0829c5c1ed405e20e2da2dc78b82d198564880a704e6a7b7"
+checksum = "ce2baa5559a411fc1cf519295f24c34b53d5d725818bc96b5abf94762da09041"
 dependencies = [
  "libc",
  "pyo3-build-config",
@@ -1413,9 +1413,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-macros"
-version = "0.22.0"
+version = "0.22.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "82b2f19e153122d64afd8ce7aaa72f06a00f52e34e1d1e74b6d71baea396460a"
+checksum = "049621c20a23f2def20f4fe67978d1da8d8a883d64b9c21362f3b776e254edc7"
 dependencies = [
  "proc-macro2",
  "pyo3-macros-backend",
@@ -1425,9 +1425,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-macros-backend"
-version = "0.22.0"
+version = "0.22.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "dd698c04cac17cf0fe63d47790ab311b8b25542f5cb976b65c374035c50f1eef"
+checksum = "0e969ee2e025435f1819d31a275ba4bb9cbbdf3ac535227fdbd85b9322ffe144"
 dependencies = [
  "heck 0.5.0",
  "proc-macro2",
diff --git a/Cargo.toml b/Cargo.toml
index 1fdec2f..7fc5cd3 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -9,7 +9,7 @@ name = "sourmash_plugin_directsketch"
 crate-type = ["cdylib"]
 
 [dependencies]
-pyo3 = { version = "0.22.0", features = ["extension-module", "anyhow"] }
+pyo3 = { version = "0.22.1", features = ["extension-module", "anyhow"] }
 rayon = "1.10.0"
 serde = { version = "1.0.204", features = ["derive"] }
 sourmash = { version = "0.14.1"}