diff --git a/Cargo.lock b/Cargo.lock
index b648343..ab6eac1 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -1379,9 +1379,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3"
-version = "0.22.2"
+version = "0.22.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "831e8e819a138c36e212f3af3fd9eeffed6bf1510a805af35b0edee5ffa59433"
+checksum = "15ee168e30649f7f234c3d49ef5a7a6cbf5134289bc46c29ff3155fa3221c225"
 dependencies = [
  "anyhow",
  "cfg-if",
@@ -1398,9 +1398,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-build-config"
-version = "0.22.2"
+version = "0.22.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "1e8730e591b14492a8945cdff32f089250b05f5accecf74aeddf9e8272ce1fa8"
+checksum = "e61cef80755fe9e46bb8a0b8f20752ca7676dcc07a5277d8b7768c6172e529b3"
 dependencies = [
  "once_cell",
  "target-lexicon",
@@ -1408,9 +1408,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-ffi"
-version = "0.22.2"
+version = "0.22.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "5e97e919d2df92eb88ca80a037969f44e5e70356559654962cbb3316d00300c6"
+checksum = "67ce096073ec5405f5ee2b8b31f03a68e02aa10d5d4f565eca04acc41931fa1c"
 dependencies = [
  "libc",
  "pyo3-build-config",
@@ -1418,9 +1418,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-macros"
-version = "0.22.2"
+version = "0.22.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "eb57983022ad41f9e683a599f2fd13c3664d7063a3ac5714cae4b7bee7d3f206"
+checksum = "2440c6d12bc8f3ae39f1e775266fa5122fd0c8891ce7520fa6048e683ad3de28"
 dependencies = [
  "proc-macro2",
  "pyo3-macros-backend",
@@ -1430,9 +1430,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-macros-backend"
-version = "0.22.2"
+version = "0.22.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "ec480c0c51ddec81019531705acac51bcdbeae563557c982aa8263bb96880372"
+checksum = "1be962f0e06da8f8465729ea2cb71a416d2257dff56cbe40a70d3e62a93ae5d1"
 dependencies = [
  "heck 0.5.0",
  "proc-macro2",
diff --git a/Cargo.toml b/Cargo.toml
index 5faea78..01a3abd 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -9,7 +9,7 @@ name = "sourmash_plugin_directsketch"
 crate-type = ["cdylib"]
 
 [dependencies]
-pyo3 = { version = "0.22.2", features = ["extension-module", "anyhow"] }
+pyo3 = { version = "0.22.3", features = ["extension-module", "anyhow"] }
 rayon = "1.10.0"
 serde = { version = "1.0.204", features = ["derive"] }
 sourmash = { version = "0.15.2"}