diff --git a/Rakefile b/Rakefile
index 7ee7099acb135..24bb5ace8e78b 100644
--- a/Rakefile
+++ b/Rakefile
@@ -585,8 +585,7 @@ namespace :py do
     nightly = ".#{Time.now.strftime('%Y%m%d%H%M')}"
     new_version = updated_version(old_version, arguments[:version], nightly)
 
-    ['py/setup.py',
-     'py/pyproject.toml',
+    ['py/pyproject.toml',
      'py/BUILD.bazel',
      'py/selenium/__init__.py',
      'py/selenium/webdriver/__init__.py',
@@ -1048,7 +1047,6 @@ namespace :all do
                                            'py/selenium/webdriver/__init__.py',
                                            'py/selenium/__init__.py',
                                            'py/BUILD.bazel',
-                                           'py/setup.py',
                                            'rb/lib/selenium/webdriver/version.rb',
                                            'rb/Gemfile.lock'])
 
@@ -1110,7 +1108,6 @@ namespace :all do
              'py/selenium/webdriver/__init__.py',
              'py/BUILD.bazel',
              'py/CHANGES',
-             'py/setup.py',
              'rb/lib/selenium/webdriver/version.rb',
              'rb/CHANGES',
              'rb/Gemfile.lock',
diff --git a/py/BUILD.bazel b/py/BUILD.bazel
index 47158c4ab59ed..49fae4aecd61d 100644
--- a/py/BUILD.bazel
+++ b/py/BUILD.bazel
@@ -231,7 +231,6 @@ pkg_files(
         "CHANGES",
         "README.rst",
         "pyproject.toml",
-        "setup.py",
         ":license",
         ":selenium-pkg",
         ":selenium-pkginfo",
diff --git a/py/pyproject.toml b/py/pyproject.toml
index e99a03cd5d7a2..a30b604e49be0 100644
--- a/py/pyproject.toml
+++ b/py/pyproject.toml
@@ -44,6 +44,9 @@ exclude = ["test*"]
 namespaces = false
 # include-package-data is `true` by default in pyproject.toml
 
+[[tool.setuptools-rust.bins]]
+target = "selenium.webdriver.common.selenium-manager"
+
 [project.urls]
 Repository = "https://github.com/SeleniumHQ/selenium/"
 BugTracker = "https://github.com/SeleniumHQ/selenium/issues"
diff --git a/py/setup.py b/py/setup.py
deleted file mode 100755
index 0f93e33f0ecae..0000000000000
--- a/py/setup.py
+++ /dev/null
@@ -1,38 +0,0 @@
-# Licensed to the Software Freedom Conservancy (SFC) under one
-# or more contributor license agreements.  See the NOTICE file
-# distributed with this work for additional information
-# regarding copyright ownership.  The SFC licenses this file
-# to you under the Apache License, Version 2.0 (the
-# "License"); you may not use this file except in compliance
-# with the License.  You may obtain a copy of the License at
-#
-#   http://www.apache.org/licenses/LICENSE-2.0
-#
-# Unless required by applicable law or agreed to in writing,
-# software distributed under the License is distributed on an
-# "AS IS" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY
-# KIND, either express or implied.  See the License for the
-# specific language governing permissions and limitations
-# under the License.
-
-from distutils.command.install import INSTALL_SCHEMES
-from os.path import dirname, join, abspath
-from setuptools import setup
-from setuptools.command.install import install
-from setuptools_rust import Binding, RustExtension
-
-
-for scheme in INSTALL_SCHEMES.values():
-    scheme['data'] = scheme['purelib']
-
-setup_args = {
-    'cmdclass': {'install': install},
-    'rust_extensions': [
-        RustExtension(
-            {"selenium-manager": "selenium.webdriver.common.selenium-manager"},
-            binding=Binding.Exec
-        )
-    ],
-}
-
-setup(**setup_args)