Keyboard mapping feature (for example, map Cmd-down to PC Insert key)?

[emendelson]

Does Wine or Wineskin offer a way to change the macOS keyboard mapping? The Mac does not have an Insert key, for example. Under DOSBox I can use a mapper file to map the Mac's Cmd-Down key combination to the Ins key on a PC. I've never found a way to do this. Is there any chance of adding it to Wine somehow?

There's a discussion here about remapping the modifier keys (Alt, etc.) but it involves making a custom build of Wine, and doesn't apply to the Insert key:

https://palant.info/2014/02/14/crazy-hacks-changing-wine-key-mappings-on-mac-os-x/

EDIT: Some forums report that Fn-return should emulate the Ins key, but it doesn't work in my experiments.

Any thoughts on how this might be possible will be welcome.