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Support resistance mutation in oncokb-annotator #180

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zhx828 opened this issue Jun 15, 2022 · 0 comments
Open
2 tasks

Support resistance mutation in oncokb-annotator #180

zhx828 opened this issue Jun 15, 2022 · 0 comments

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@zhx828
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zhx828 commented Jun 15, 2022

This is an effort to support resistance mutation based on the upcoming structure. We currently do assign resistance to mutation, but we are about to separate the resistance from oncogenicity. A mutation can be oncogenic and resistance at the same time.
To do list:

  • Add column RESISTANCE_MUTATION, True, False in MAF/SV/CNA/Fusion annotations
  • Update the logics in the clinical annotator to use resistance field returned through API to calculate the RESISTANCE_MUTATIONS and #RESISTANCE_MUTATIONS
@zhx828 zhx828 transferred this issue from oncokb/oncokb Jun 15, 2022
@zhx828 zhx828 self-assigned this Jun 15, 2022
@zhx828 zhx828 removed their assignment Dec 12, 2024
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