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study-designs.owl
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study-designs.owl
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<?xml version="1.0"?>
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xml:base="http://purl.obolibrary.org/obo/obi/dev/modules/study-designs.owl"
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<obo:IAO_0000111>intervention design</obo:IAO_0000111>
<obo:IAO_0000112>PMID: 18208636.Br J Nutr. 2008 Jan 22;:1-11.Effect of vitamin D supplementation on bone and vitamin D status among Pakistani immigrants in Denmark: a randomised double-blinded placebo-controlled intervention study.</obo:IAO_0000112>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
<obo:IAO_0000115 xml:lang="en">An intervention design is a study design in which a controlled process applied to the subjects (the intervention) serves as the independent variable manipulated by the experimentalist. The treatment (perturbation or intervention) defined can be defined as a combination of values taken by independent variable manipulated by the experimentalists are applied to the recruited subjects assigned (possibly by applying specific methods) to treatment groups. The specificity of intervention design is the fact that independent variables are being manipulated and a response of the biological system is evaluated via response variables as monitored by possibly a series of assays.</obo:IAO_0000115>
<obo:IAO_0000117>Philppe Rocca-Serra</obo:IAO_0000117>
<obo:IAO_0000119>OBI branch derived</obo:IAO_0000119>
<rdfs:label>intervention design</rdfs:label>
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<!-- http://purl.obolibrary.org/obo/OBI_0000873 -->
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<obo:IAO_0000111>compound treatment design</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">an intervention design in which the treatment is the administration of a compound</obo:IAO_0000115>
<obo:IAO_0000116>This is meant to include all kinds of material administrations, including vaccinations, chemical compounds etc.</obo:IAO_0000116>
<obo:IAO_0000117>PERSON: Bjoern Peters</obo:IAO_0000117>
<obo:IAO_0000119>MO_555 compound_treatment_design</obo:IAO_0000119>
<rdfs:label>compound treatment design</rdfs:label>
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<obo:IAO_0000111>growth condition intervention design</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">A study design in which the independent variable is the environmental condition in which the specimen is growing</obo:IAO_0000115>
<obo:IAO_0000117>PERSON: Bjoern Peters</obo:IAO_0000117>
<obo:IAO_0000119>MO_588 growth_condition_design</obo:IAO_0000119>
<rdfs:label>growth condition intervention design</rdfs:label>
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<obo:IAO_0000111>validation by reverse transcription PCR design</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">a study design in which checks the accuracy or the quality of the result of an assay by comparing with reverse transcription PCR results</obo:IAO_0000115>
<obo:IAO_0000117>PERSON: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119>MO_986 reverse_transcription_PCR_quality_control</obo:IAO_0000119>
<rdfs:label>validation by reverse transcription PCR design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001166 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001166">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
<obo:IAO_0000111>validation by real time PCR design</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">a study design in which the accuracy or the quality of the result of an assay is checked by comparing with real time PCR results</obo:IAO_0000115>
<obo:IAO_0000117>PERSON: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119>MO_434 real_time_PCR_quality_control</obo:IAO_0000119>
<rdfs:label>validation by real time PCR design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001185 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001185"/>
<!-- http://purl.obolibrary.org/obo/OBI_0001195 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001195">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
<rdfs:subClassOf>
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<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000750"/>
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<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_9606"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000116"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000111>operator variation design</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">A study design that assesses the operator performance and relation to data consistency and quality.</obo:IAO_0000115>
<obo:IAO_0000117>Person: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119>MO_519 operator_variation_design</obo:IAO_0000119>
<rdfs:label>operator variation design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001197 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001197">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000131"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000111>comparative genome hybridization by array design</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">A study design that detects genomic copy number variations using microarray technology.</obo:IAO_0000115>
<obo:IAO_0000117>Person: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119>MO_856 comparative_genome_hybridization_design</obo:IAO_0000119>
<rdfs:label>comparative genome hybridization by array design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001199 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001199">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">A study design that is conducted entirely in a living organism, e.g. a compound treatment in a mouse model.</obo:IAO_0000115>
<obo:IAO_0000117>Person: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119>MO_454 in_vivo_design</obo:IAO_0000119>
<rdfs:label>in vivo design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001200 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001200">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0001444"/>
<obo:IAO_0000111>genotyping by high throughput sequencing design</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">A study design that classifies an individual or group of individuals on the basis of alleles, haplotypes, SNPs using high througput sequencing techniques.</obo:IAO_0000115>
<obo:IAO_0000117>Person: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119>MO_560 genotyping_design</obo:IAO_0000119>
<rdfs:label>genotyping by high throughput sequencing design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001202 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001202">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000268"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000111>innate behavior design</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">A study design in which the innate behavior of the organism is examined, e.g. path finding in bees.</obo:IAO_0000115>
<obo:IAO_0000117>Person: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119>MO_355 innate_behavior_design</obo:IAO_0000119>
<rdfs:label>innate behavior design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001205 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001205">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000219"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000750"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0005575"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000111>cell component comparison design</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">A study design that compares samples from different cell components.</obo:IAO_0000115>
<obo:IAO_0000117>Person: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119>MO_1019 cell_component_comparison_design</obo:IAO_0000119>
<rdfs:label>cell component comparison design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001211 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001211">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
<obo:IAO_0000111>ex vivo design</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">A study design where all or part of an organism is removed and studied in vitro, e.g. part of a mouse is removed and cultured in vitro. A cell culture with an established cell line is an in vitro experiment.</obo:IAO_0000115>
<obo:IAO_0000117>Person: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119>MO_808 ex_vivo_design</obo:IAO_0000119>
<rdfs:label>ex vivo design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001214 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001214">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000242"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000750"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0200169"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000111>normalization testing design</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">A study design that tests different normalization procedures.</obo:IAO_0000115>
<obo:IAO_0000117>Person: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119>MO_729 normalization_testing_design</obo:IAO_0000119>
<rdfs:label>normalization testing design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001226 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001226">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000015"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000111>environmental history design</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">A study design in which some aspect of the organism's environmental history is studied, such as exposure to teratogen, radiation, climate etc.</obo:IAO_0000115>
<obo:IAO_0000117>Person: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119>MO_698 environmental_history_design</obo:IAO_0000119>
<rdfs:label>environmental history design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001234 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001234"/>
<!-- http://purl.obolibrary.org/obo/OBI_0001239 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001239">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001331"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">A study design in which sequencing technology (e.g. Solexa/454) is used to generate RNA sequence, analyse the transcibed regions of the genome, and/or to quantitate transcript abundance</obo:IAO_0000115>
<obo:IAO_0000117>Person: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119>Group: ArrayExpress production team</obo:IAO_0000119>
<rdfs:label>transcription profiling by high throughput sequencing design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001252 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001252">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000208"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000750"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000052"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000111>array platform variation design</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">A study design in which the array platform is compared, e.g. Agilent versus Affymetrix.</obo:IAO_0000115>
<obo:IAO_0000117>Person: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119>MO_899 array_platform_variation_design</obo:IAO_0000119>
<rdfs:label>array platform variation design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001258 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001258">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001234"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001398"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000111>ChIP-seq design</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">A study design which aims to identify protein and DNA interactions using a combination of chromatin immunoprecipitation and high throughput sequencing. Massively parallel sequence analyses are used in conjunction with whole-genome sequence databases to analyze the interaction pattern of any protein with DNA, or the pattern of any epigenetic chromatin modifications.</obo:IAO_0000115>
<obo:IAO_0000117>Person: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119>http://en.wikipedia.org/wiki/Chip-Sequencing</obo:IAO_0000119>
<rdfs:label>ChIP-seq design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001259 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001259">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000015"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000111>translational bias design</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">A study design that characterizes the association of transcripts and translation machinery.</obo:IAO_0000115>
<obo:IAO_0000117>Person: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119>MO_939 translational_bias_design</obo:IAO_0000119>
<rdfs:label>translational bias design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001278 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001278">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001234"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000111>DNA methylation profiling by array design</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">A study design in which the methylation state of DNA is determined and is compared between samples using array technology.</obo:IAO_0000115>
<obo:IAO_0000117>Person: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119>GROUP: ArrayExpress production team</obo:IAO_0000119>
<rdfs:label>DNA methylation profiling by array design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001285 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001285">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
<obo:IAO_0000111>in vitro design</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">A study design that is done in a test tube or a culture dish, e.g. A bacterial invasion assay in an established cell culture.</obo:IAO_0000115>
<obo:IAO_0000117>Person: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119>MO_347 in_vitro_design</obo:IAO_0000119>
<rdfs:label>in vitro design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001286 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001286">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000131"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000111>RNAi profiling by array design</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">A study design in which experiment double stranded RNA is synthesized with a sequence complementary to a gene(s) of interest and introduced into a cell or organism, where it is recognized as exogenous genetic material and activates the RNAi pathway resulting in knockdown of the transcripts and providing a means to study downstream changes in gene expression.</obo:IAO_0000115>
<obo:IAO_0000117>Person: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119>Group: ArrayExpress production team</obo:IAO_0000119>
<rdfs:label>RNAi profiling by array design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001290 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001290">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001331"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000111>transcription profiling by array design</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">A study design that identifies forms and abundance of transcripts in the genome using microarray technology.</obo:IAO_0000115>
<obo:IAO_0000117>Person: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119>MO_533 transcript_identification_design</obo:IAO_0000119>
<rdfs:label>transcription profiling by array design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001293 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001293">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000268"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
<owl:someValuesFrom>
<owl:Class>
<owl:intersectionOf rdf:parseType="Collection">
<rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000750"/>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000031"/>
</owl:Restriction>
</owl:intersectionOf>
</owl:Class>
</owl:someValuesFrom>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000111>disease state design</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">A study design in which the pathological condition of a part, organ, or system of an organism is studied. The etiology may be from infection, genetic defect, or environmental stress.</obo:IAO_0000115>
<obo:IAO_0000117>Person: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119>MO_902 disease_state_design</obo:IAO_0000119>
<rdfs:label>disease state design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001306 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001306">
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<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33697"/>
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<obo:IAO_0000111>RNA stability design</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">A study design that examines the stability and/or decay of RNA transcripts.</obo:IAO_0000115>
<obo:IAO_0000117>Person: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119>MO_553 RNA_stability_design</obo:IAO_0000119>
<rdfs:label>RNA stability design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001310 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001310">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
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<rdfs:subClassOf>
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<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0100026"/>
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</owl:intersectionOf>
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</owl:someValuesFrom>
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<obo:IAO_0000111>species comparison design</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">A study design that assays differences between distinct species.</obo:IAO_0000115>
<obo:IAO_0000117>Person: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119>MO_675 species_design</obo:IAO_0000119>
<rdfs:label>species comparison design</rdfs:label>
</owl:Class>
<!-- http://purl.obolibrary.org/obo/OBI_0001313 -->
<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001313">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
<rdfs:subClassOf>
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<obo:IAO_0000111>transcription profiling by RT-PCR design</obo:IAO_0000111>
<obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
<obo:IAO_0000115 xml:lang="en">A study design which aims to examine the transcriptome of a biological sample by reverse transcription PCR (RT-PCR).</obo:IAO_0000115>
<obo:IAO_0000117>Person: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
<obo:IAO_0000119>Group: ArrayExpress production team</obo:IAO_0000119>
<rdfs:label>transcription profiling by RT-PCR design</rdfs:label>
</owl:Class>