diff --git a/pyproject.toml b/pyproject.toml
index b50664156ef4..381258c8d880 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -236,6 +236,7 @@ keep-runtime-typing = true
 
 [tool.uv]
 default-groups = []
+environments = ["python_full_version == '3.8'", "python_full_version >= '3.9'"]  # https://github.com/astral-sh/uv/issues/6127
 extra-index-url = ["https://wheels.galaxyproject.org/simple"]
 index-strategy = "unsafe-best-match"
 package = false