diff --git a/src/ontology/imports/hgnc_terms.txt b/src/ontology/imports/hgnc_terms.txt
index 01ce75ddf5..50add59286 100644
--- a/src/ontology/imports/hgnc_terms.txt
+++ b/src/ontology/imports/hgnc_terms.txt
@@ -895,6 +895,7 @@ http://identifiers.org/hgnc/15974
 http://identifiers.org/hgnc/15977
 http://identifiers.org/hgnc/15979
 http://identifiers.org/hgnc/15984
+http://identifiers.org/hgnc/15992
 http://identifiers.org/hgnc/15993
 http://identifiers.org/hgnc/15999
 http://identifiers.org/hgnc/160
@@ -1606,6 +1607,7 @@ http://identifiers.org/hgnc/2227
 http://identifiers.org/hgnc/2228
 http://identifiers.org/hgnc/2230
 http://identifiers.org/hgnc/2235
+http://identifiers.org/hgnc/2236
 http://identifiers.org/hgnc/2244
 http://identifiers.org/hgnc/22448
 http://identifiers.org/hgnc/225
@@ -3237,6 +3239,7 @@ http://identifiers.org/hgnc/6909
 http://identifiers.org/hgnc/691
 http://identifiers.org/hgnc/6912
 http://identifiers.org/hgnc/6913
+http://identifiers.org/hgnc/6919
 http://identifiers.org/hgnc/6922
 http://identifiers.org/hgnc/6929
 http://identifiers.org/hgnc/6930
diff --git a/src/ontology/imports/manual_seed.txt b/src/ontology/imports/manual_seed.txt
index 618866f214..d7fbedfcb8 100644
--- a/src/ontology/imports/manual_seed.txt
+++ b/src/ontology/imports/manual_seed.txt
@@ -201,3 +201,10 @@ http://identifiers.org/ncbigene/100127354
 http://identifiers.org/hgnc/2088
 http://identifiers.org/ncbigene/101150212
 http://identifiers.org/ncbigene/488381
+http://identifiers.org/ncbigene/100127354
+http://identifiers.org/hgnc/2088
+http://identifiers.org/ncbigene/101150212
+http://identifiers.org/ncbigene/2236
+http://identifiers.org/hgnc/2236
+http://identifiers.org/hgnc/6919
+http://identifiers.org/hgnc/15992
\ No newline at end of file
diff --git a/src/ontology/imports/merged_import.owl b/src/ontology/imports/merged_import.owl
index 442900259c..c869ce4432 100644
--- a/src/ontology/imports/merged_import.owl
+++ b/src/ontology/imports/merged_import.owl
@@ -7,7 +7,7 @@ Prefix(rdfs:=<http://www.w3.org/2000/01/rdf-schema#>)
 
 
 Ontology(<http://purl.obolibrary.org/obo/mondo/imports/merged_import.owl>
-<http://purl.obolibrary.org/obo/mondo/releases/2024-10-23/imports/merged_import.owl>
+<http://purl.obolibrary.org/obo/mondo/releases/2024-11-25/imports/merged_import.owl>
 Annotation(<http://purl.org/dc/elements/1.1/source> <http://dbpedia.org>)
 Annotation(<http://purl.org/dc/elements/1.1/source> <http://palaeos.com>)
 Annotation(<http://purl.org/dc/elements/1.1/source> <http://www.brain-map.org>)
@@ -67,7 +67,7 @@ Annotation(<http://purl.org/dc/elements/1.1/source> "PMID:16417468 Forgotten and
 Annotation(<http://purl.org/dc/elements/1.1/source> "aggregates AAO from 13:04:2012")
 Annotation(<http://purl.org/dc/elements/1.1/source> "aggregates TAO from 09:08:2012")
 Annotation(<http://purl.org/dc/elements/1.1/source> "aggregates VSAO from 16:07:2012")
-Annotation(owl:versionInfo "2024-10-23")
+Annotation(owl:versionInfo "2024-11-25")
 
 Declaration(Class(<http://identifiers.org/hgnc/10001>))
 Declaration(Class(<http://identifiers.org/hgnc/10004>))
@@ -964,6 +964,7 @@ Declaration(Class(<http://identifiers.org/hgnc/15974>))
 Declaration(Class(<http://identifiers.org/hgnc/15977>))
 Declaration(Class(<http://identifiers.org/hgnc/15979>))
 Declaration(Class(<http://identifiers.org/hgnc/15984>))
+Declaration(Class(<http://identifiers.org/hgnc/15992>))
 Declaration(Class(<http://identifiers.org/hgnc/15993>))
 Declaration(Class(<http://identifiers.org/hgnc/15999>))
 Declaration(Class(<http://identifiers.org/hgnc/160>))
@@ -1674,6 +1675,7 @@ Declaration(Class(<http://identifiers.org/hgnc/2227>))
 Declaration(Class(<http://identifiers.org/hgnc/2228>))
 Declaration(Class(<http://identifiers.org/hgnc/2230>))
 Declaration(Class(<http://identifiers.org/hgnc/2235>))
+Declaration(Class(<http://identifiers.org/hgnc/2236>))
 Declaration(Class(<http://identifiers.org/hgnc/2244>))
 Declaration(Class(<http://identifiers.org/hgnc/22448>))
 Declaration(Class(<http://identifiers.org/hgnc/225>))
@@ -3304,6 +3306,7 @@ Declaration(Class(<http://identifiers.org/hgnc/6909>))
 Declaration(Class(<http://identifiers.org/hgnc/691>))
 Declaration(Class(<http://identifiers.org/hgnc/6912>))
 Declaration(Class(<http://identifiers.org/hgnc/6913>))
+Declaration(Class(<http://identifiers.org/hgnc/6919>))
 Declaration(Class(<http://identifiers.org/hgnc/6922>))
 Declaration(Class(<http://identifiers.org/hgnc/6929>))
 Declaration(Class(<http://identifiers.org/hgnc/6930>))
@@ -3949,15 +3952,26 @@ Declaration(Class(<http://identifiers.org/ncbigene/100174922>))
 Declaration(Class(<http://identifiers.org/ncbigene/100216331>))
 Declaration(Class(<http://identifiers.org/ncbigene/100233164>))
 Declaration(Class(<http://identifiers.org/ncbigene/100240724>))
+Declaration(Class(<http://identifiers.org/ncbigene/100298265>))
 Declaration(Class(<http://identifiers.org/ncbigene/100302391>))
 Declaration(Class(<http://identifiers.org/ncbigene/100345183>))
+Declaration(Class(<http://identifiers.org/ncbigene/100345295>))
 Declaration(Class(<http://identifiers.org/ncbigene/100350127>))
+Declaration(Class(<http://identifiers.org/ncbigene/100393557>))
+Declaration(Class(<http://identifiers.org/ncbigene/100401034>))
+Declaration(Class(<http://identifiers.org/ncbigene/100407052>))
+Declaration(Class(<http://identifiers.org/ncbigene/100423163>))
+Declaration(Class(<http://identifiers.org/ncbigene/100427716>))
+Declaration(Class(<http://identifiers.org/ncbigene/100472661>))
+Declaration(Class(<http://identifiers.org/ncbigene/100520674>))
 Declaration(Class(<http://identifiers.org/ncbigene/100526136>))
 Declaration(Class(<http://identifiers.org/ncbigene/100623036>))
 Declaration(Class(<http://identifiers.org/ncbigene/100623352>))
 Declaration(Class(<http://identifiers.org/ncbigene/100625536>))
+Declaration(Class(<http://identifiers.org/ncbigene/100626812>))
 Declaration(Class(<http://identifiers.org/ncbigene/100682877>))
 Declaration(Class(<http://identifiers.org/ncbigene/100688240>))
+Declaration(Class(<http://identifiers.org/ncbigene/100739753>))
 Declaration(Class(<http://identifiers.org/ncbigene/100750221>))
 Declaration(Class(<http://identifiers.org/ncbigene/100750233>))
 Declaration(Class(<http://identifiers.org/ncbigene/100855679>))
@@ -3981,24 +3995,39 @@ Declaration(Class(<http://identifiers.org/ncbigene/101120574>))
 Declaration(Class(<http://identifiers.org/ncbigene/101121049>))
 Declaration(Class(<http://identifiers.org/ncbigene/101123558>))
 Declaration(Class(<http://identifiers.org/ncbigene/101824015>))
+Declaration(Class(<http://identifiers.org/ncbigene/101833915>))
 Declaration(Class(<http://identifiers.org/ncbigene/101837953>))
+Declaration(Class(<http://identifiers.org/ncbigene/101926433>))
+Declaration(Class(<http://identifiers.org/ncbigene/101926677>))
+Declaration(Class(<http://identifiers.org/ncbigene/102135998>))
+Declaration(Class(<http://identifiers.org/ncbigene/102138674>))
 Declaration(Class(<http://identifiers.org/ncbigene/103023169>))
+Declaration(Class(<http://identifiers.org/ncbigene/103347222>))
 Declaration(Class(<http://identifiers.org/ncbigene/107305840>))
+Declaration(Class(<http://identifiers.org/ncbigene/119881609>))
 Declaration(Class(<http://identifiers.org/ncbigene/280798>))
 Declaration(Class(<http://identifiers.org/ncbigene/280916>))
 Declaration(Class(<http://identifiers.org/ncbigene/281187>))
 Declaration(Class(<http://identifiers.org/ncbigene/281769>))
 Declaration(Class(<http://identifiers.org/ncbigene/281877>))
+Declaration(Class(<http://identifiers.org/ncbigene/281917>))
 Declaration(Class(<http://identifiers.org/ncbigene/282149>))
+Declaration(Class(<http://identifiers.org/ncbigene/282179>))
 Declaration(Class(<http://identifiers.org/ncbigene/282401>))
 Declaration(Class(<http://identifiers.org/ncbigene/286772>))
 Declaration(Class(<http://identifiers.org/ncbigene/327664>))
+Declaration(Class(<http://identifiers.org/ncbigene/397036>))
 Declaration(Class(<http://identifiers.org/ncbigene/397055>))
 Declaration(Class(<http://identifiers.org/ncbigene/397060>))
 Declaration(Class(<http://identifiers.org/ncbigene/397156>))
+Declaration(Class(<http://identifiers.org/ncbigene/397276>))
+Declaration(Class(<http://identifiers.org/ncbigene/397323>))
 Declaration(Class(<http://identifiers.org/ncbigene/397359>))
 Declaration(Class(<http://identifiers.org/ncbigene/397506>))
+Declaration(Class(<http://identifiers.org/ncbigene/397663>))
 Declaration(Class(<http://identifiers.org/ncbigene/399653>))
+Declaration(Class(<http://identifiers.org/ncbigene/403159>))
+Declaration(Class(<http://identifiers.org/ncbigene/403407>))
 Declaration(Class(<http://identifiers.org/ncbigene/403492>))
 Declaration(Class(<http://identifiers.org/ncbigene/403554>))
 Declaration(Class(<http://identifiers.org/ncbigene/403590>))
@@ -4011,6 +4040,7 @@ Declaration(Class(<http://identifiers.org/ncbigene/403841>))
 Declaration(Class(<http://identifiers.org/ncbigene/403849>))
 Declaration(Class(<http://identifiers.org/ncbigene/403851>))
 Declaration(Class(<http://identifiers.org/ncbigene/403873>))
+Declaration(Class(<http://identifiers.org/ncbigene/407142>))
 Declaration(Class(<http://identifiers.org/ncbigene/414755>))
 Declaration(Class(<http://identifiers.org/ncbigene/420212>))
 Declaration(Class(<http://identifiers.org/ncbigene/431665>))
@@ -4019,16 +4049,28 @@ Declaration(Class(<http://identifiers.org/ncbigene/442998>))
 Declaration(Class(<http://identifiers.org/ncbigene/443060>))
 Declaration(Class(<http://identifiers.org/ncbigene/444852>))
 Declaration(Class(<http://identifiers.org/ncbigene/474479>))
+Declaration(Class(<http://identifiers.org/ncbigene/474985>))
+Declaration(Class(<http://identifiers.org/ncbigene/475010>))
 Declaration(Class(<http://identifiers.org/ncbigene/475316>))
 Declaration(Class(<http://identifiers.org/ncbigene/475579>))
 Declaration(Class(<http://identifiers.org/ncbigene/476086>))
 Declaration(Class(<http://identifiers.org/ncbigene/476149>))
+Declaration(Class(<http://identifiers.org/ncbigene/476336>))
+Declaration(Class(<http://identifiers.org/ncbigene/476548>))
+Declaration(Class(<http://identifiers.org/ncbigene/476649>))
+Declaration(Class(<http://identifiers.org/ncbigene/477604>))
 Declaration(Class(<http://identifiers.org/ncbigene/478100>))
 Declaration(Class(<http://identifiers.org/ncbigene/478121>))
+Declaration(Class(<http://identifiers.org/ncbigene/478239>))
 Declaration(Class(<http://identifiers.org/ncbigene/478582>))
+Declaration(Class(<http://identifiers.org/ncbigene/478798>))
 Declaration(Class(<http://identifiers.org/ncbigene/478836>))
+Declaration(Class(<http://identifiers.org/ncbigene/479129>))
+Declaration(Class(<http://identifiers.org/ncbigene/479277>))
+Declaration(Class(<http://identifiers.org/ncbigene/479346>))
 Declaration(Class(<http://identifiers.org/ncbigene/479382>))
 Declaration(Class(<http://identifiers.org/ncbigene/479931>))
+Declaration(Class(<http://identifiers.org/ncbigene/480409>))
 Declaration(Class(<http://identifiers.org/ncbigene/480413>))
 Declaration(Class(<http://identifiers.org/ncbigene/480684>))
 Declaration(Class(<http://identifiers.org/ncbigene/481133>))
@@ -4038,10 +4080,13 @@ Declaration(Class(<http://identifiers.org/ncbigene/482186>))
 Declaration(Class(<http://identifiers.org/ncbigene/483352>))
 Declaration(Class(<http://identifiers.org/ncbigene/483420>))
 Declaration(Class(<http://identifiers.org/ncbigene/483662>))
+Declaration(Class(<http://identifiers.org/ncbigene/483706>))
 Declaration(Class(<http://identifiers.org/ncbigene/483745>))
 Declaration(Class(<http://identifiers.org/ncbigene/483766>))
+Declaration(Class(<http://identifiers.org/ncbigene/483870>))
 Declaration(Class(<http://identifiers.org/ncbigene/484357>))
 Declaration(Class(<http://identifiers.org/ncbigene/484830>))
+Declaration(Class(<http://identifiers.org/ncbigene/484949>))
 Declaration(Class(<http://identifiers.org/ncbigene/485187>))
 Declaration(Class(<http://identifiers.org/ncbigene/485337>))
 Declaration(Class(<http://identifiers.org/ncbigene/485498>))
@@ -4049,9 +4094,12 @@ Declaration(Class(<http://identifiers.org/ncbigene/486775>))
 Declaration(Class(<http://identifiers.org/ncbigene/487634>))
 Declaration(Class(<http://identifiers.org/ncbigene/488089>))
 Declaration(Class(<http://identifiers.org/ncbigene/488558>))
+Declaration(Class(<http://identifiers.org/ncbigene/488635>))
 Declaration(Class(<http://identifiers.org/ncbigene/488683>))
+Declaration(Class(<http://identifiers.org/ncbigene/488853>))
 Declaration(Class(<http://identifiers.org/ncbigene/489157>))
 Declaration(Class(<http://identifiers.org/ncbigene/489236>))
+Declaration(Class(<http://identifiers.org/ncbigene/489479>))
 Declaration(Class(<http://identifiers.org/ncbigene/489766>))
 Declaration(Class(<http://identifiers.org/ncbigene/490978>))
 Declaration(Class(<http://identifiers.org/ncbigene/491317>))
@@ -4061,16 +4109,21 @@ Declaration(Class(<http://identifiers.org/ncbigene/493879>))
 Declaration(Class(<http://identifiers.org/ncbigene/493927>))
 Declaration(Class(<http://identifiers.org/ncbigene/493928>))
 Declaration(Class(<http://identifiers.org/ncbigene/497068>))
+Declaration(Class(<http://identifiers.org/ncbigene/507654>))
+Declaration(Class(<http://identifiers.org/ncbigene/509837>))
 Declaration(Class(<http://identifiers.org/ncbigene/510763>))
 Declaration(Class(<http://identifiers.org/ncbigene/512056>))
 Declaration(Class(<http://identifiers.org/ncbigene/518117>))
 Declaration(Class(<http://identifiers.org/ncbigene/519225>))
 Declaration(Class(<http://identifiers.org/ncbigene/525040>))
+Declaration(Class(<http://identifiers.org/ncbigene/525795>))
 Declaration(Class(<http://identifiers.org/ncbigene/529186>))
 Declaration(Class(<http://identifiers.org/ncbigene/533175>))
+Declaration(Class(<http://identifiers.org/ncbigene/534319>))
 Declaration(Class(<http://identifiers.org/ncbigene/538590>))
 Declaration(Class(<http://identifiers.org/ncbigene/538746>))
 Declaration(Class(<http://identifiers.org/ncbigene/554324>))
+Declaration(Class(<http://identifiers.org/ncbigene/574011>))
 Declaration(Class(<http://identifiers.org/ncbigene/607077>))
 Declaration(Class(<http://identifiers.org/ncbigene/608697>))
 Declaration(Class(<http://identifiers.org/ncbigene/609630>))
@@ -4085,6 +4138,8 @@ Declaration(Class(<http://identifiers.org/ncbigene/678673>))
 Declaration(Class(<http://identifiers.org/ncbigene/698782>))
 Declaration(Class(<http://identifiers.org/ncbigene/700261>))
 Declaration(Class(<http://identifiers.org/ncbigene/707478>))
+Declaration(Class(<http://identifiers.org/ncbigene/780411>))
+Declaration(Class(<http://identifiers.org/ncbigene/782170>))
 Declaration(Class(<http://purl.obolibrary.org/obo/BFO_0000001>))
 Declaration(Class(<http://purl.obolibrary.org/obo/BFO_0000002>))
 Declaration(Class(<http://purl.obolibrary.org/obo/BFO_0000003>))
@@ -18487,7 +18542,6 @@ Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_6072>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_6073>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_607660>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_61172>))
-Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_61379>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_6157>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_6178>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_6179>))
@@ -18922,6 +18976,8 @@ Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_9627>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_9632>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_9639>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_9643>))
+Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_9645>))
+Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_9646>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_9647>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_9648>))
 Declaration(Class(<http://purl.obolibrary.org/obo/NCBITaxon_9649>))
@@ -28643,9 +28699,9 @@ SubClassOf(<http://identifiers.org/hgnc/11510> <http://purl.obolibrary.org/obo/S
 AnnotationAssertion(rdfs:label <http://identifiers.org/hgnc/11515> "TBXT")
 SubClassOf(<http://identifiers.org/hgnc/11515> <http://purl.obolibrary.org/obo/SO_0000704>)
 
-# Class: <http://identifiers.org/hgnc/1152> (BVES)
+# Class: <http://identifiers.org/hgnc/1152> (POPDC1)
 
-AnnotationAssertion(rdfs:label <http://identifiers.org/hgnc/1152> "BVES")
+AnnotationAssertion(rdfs:label <http://identifiers.org/hgnc/1152> "POPDC1")
 SubClassOf(<http://identifiers.org/hgnc/1152> <http://purl.obolibrary.org/obo/SO_0000704>)
 
 # Class: <http://identifiers.org/hgnc/11521> (TAC3)
@@ -31513,6 +31569,11 @@ SubClassOf(<http://identifiers.org/hgnc/15979> <http://purl.obolibrary.org/obo/S
 AnnotationAssertion(rdfs:label <http://identifiers.org/hgnc/15984> "APTX")
 SubClassOf(<http://identifiers.org/hgnc/15984> <http://purl.obolibrary.org/obo/SO_0000704>)
 
+# Class: <http://identifiers.org/hgnc/15992> (ZNF341)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/hgnc/15992> "ZNF341")
+SubClassOf(<http://identifiers.org/hgnc/15992> <http://purl.obolibrary.org/obo/SO_0000704>)
+
 # Class: <http://identifiers.org/hgnc/15993> (CHST8)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/hgnc/15993> "CHST8")
@@ -35063,6 +35124,11 @@ SubClassOf(<http://identifiers.org/hgnc/2230> <http://purl.obolibrary.org/obo/SO
 AnnotationAssertion(rdfs:label <http://identifiers.org/hgnc/2235> "KLF6")
 SubClassOf(<http://identifiers.org/hgnc/2235> <http://purl.obolibrary.org/obo/SO_0000704>)
 
+# Class: <http://identifiers.org/hgnc/2236> (COPG1)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/hgnc/2236> "COPG1")
+SubClassOf(<http://identifiers.org/hgnc/2236> <http://purl.obolibrary.org/obo/SO_0000704>)
+
 # Class: <http://identifiers.org/hgnc/2244> (COQ7)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/hgnc/2244> "COQ7")
@@ -43213,6 +43279,11 @@ SubClassOf(<http://identifiers.org/hgnc/6912> <http://purl.obolibrary.org/obo/SO
 AnnotationAssertion(rdfs:label <http://identifiers.org/hgnc/6913> "MAX")
 SubClassOf(<http://identifiers.org/hgnc/6913> <http://purl.obolibrary.org/obo/SO_0000704>)
 
+# Class: <http://identifiers.org/hgnc/6919> (MBD4)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/hgnc/6919> "MBD4")
+SubClassOf(<http://identifiers.org/hgnc/6919> <http://purl.obolibrary.org/obo/SO_0000704>)
+
 # Class: <http://identifiers.org/hgnc/6922> (MBL2)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/hgnc/6922> "MBL2")
@@ -46449,6 +46520,12 @@ AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/100240724> "SGCD
 SubClassOf(<http://identifiers.org/ncbigene/100240724> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/100240724> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9823>))
 
+# Class: <http://identifiers.org/ncbigene/100298265> (CPAMD8)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/100298265> "CPAMD8")
+SubClassOf(<http://identifiers.org/ncbigene/100298265> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/100298265> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9913>))
+
 # Class: <http://identifiers.org/ncbigene/100302391> (GRHPR)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/100302391> "GRHPR")
@@ -46461,12 +46538,60 @@ AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/100345183> "DMP1
 SubClassOf(<http://identifiers.org/ncbigene/100345183> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/100345183> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9986>))
 
+# Class: <http://identifiers.org/ncbigene/100345295> (RORB)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/100345295> "RORB")
+SubClassOf(<http://identifiers.org/ncbigene/100345295> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/100345295> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9986>))
+
 # Class: <http://identifiers.org/ncbigene/100350127> (FAH)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/100350127> "FAH")
 SubClassOf(<http://identifiers.org/ncbigene/100350127> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/100350127> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9986>))
 
+# Class: <http://identifiers.org/ncbigene/100393557> (ATXN3)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/100393557> "ATXN3")
+SubClassOf(<http://identifiers.org/ncbigene/100393557> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/100393557> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9483>))
+
+# Class: <http://identifiers.org/ncbigene/100401034> (PSEN1)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/100401034> "PSEN1")
+SubClassOf(<http://identifiers.org/ncbigene/100401034> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/100401034> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9483>))
+
+# Class: <http://identifiers.org/ncbigene/100407052> (APP)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/100407052> "APP")
+SubClassOf(<http://identifiers.org/ncbigene/100407052> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/100407052> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9483>))
+
+# Class: <http://identifiers.org/ncbigene/100423163> (TARDBP)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/100423163> "TARDBP")
+SubClassOf(<http://identifiers.org/ncbigene/100423163> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/100423163> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9544>))
+
+# Class: <http://identifiers.org/ncbigene/100427716> (APP)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/100427716> "APP")
+SubClassOf(<http://identifiers.org/ncbigene/100427716> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/100427716> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9544>))
+
+# Class: <http://identifiers.org/ncbigene/100472661> (MIP)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/100472661> "MIP")
+SubClassOf(<http://identifiers.org/ncbigene/100472661> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/100472661> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9646>))
+
+# Class: <http://identifiers.org/ncbigene/100520674> (KIF21A)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/100520674> "KIF21A")
+SubClassOf(<http://identifiers.org/ncbigene/100520674> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/100520674> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9823>))
+
 # Class: <http://identifiers.org/ncbigene/100526136> (NF1)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/100526136> "NF1")
@@ -46491,6 +46616,12 @@ AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/100625536> "GUCY
 SubClassOf(<http://identifiers.org/ncbigene/100625536> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/100625536> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9823>))
 
+# Class: <http://identifiers.org/ncbigene/100626812> (SORL1)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/100626812> "SORL1")
+SubClassOf(<http://identifiers.org/ncbigene/100626812> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/100626812> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9823>))
+
 # Class: <http://identifiers.org/ncbigene/100682877> (TNXB)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/100682877> "TNXB")
@@ -46503,6 +46634,12 @@ AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/100688240> "PCAR
 SubClassOf(<http://identifiers.org/ncbigene/100688240> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/100688240> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
 
+# Class: <http://identifiers.org/ncbigene/100739753> (TARDBP)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/100739753> "TARDBP")
+SubClassOf(<http://identifiers.org/ncbigene/100739753> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/100739753> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9823>))
+
 # Class: <http://identifiers.org/ncbigene/100750221> (CYP27B1)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/100750221> "CYP27B1")
@@ -46641,24 +46778,66 @@ AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/101824015> "Il2r
 SubClassOf(<http://identifiers.org/ncbigene/101824015> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/101824015> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_10036>))
 
+# Class: <http://identifiers.org/ncbigene/101833915> (Tp53)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/101833915> "Tp53")
+SubClassOf(<http://identifiers.org/ncbigene/101833915> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/101833915> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_10036>))
+
 # Class: <http://identifiers.org/ncbigene/101837953> (Sgcd)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/101837953> "Sgcd")
 SubClassOf(<http://identifiers.org/ncbigene/101837953> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/101837953> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_10036>))
 
+# Class: <http://identifiers.org/ncbigene/101926433> (APP)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/101926433> "APP")
+SubClassOf(<http://identifiers.org/ncbigene/101926433> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/101926433> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9541>))
+
+# Class: <http://identifiers.org/ncbigene/101926677> (TARDBP)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/101926677> "TARDBP")
+SubClassOf(<http://identifiers.org/ncbigene/101926677> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/101926677> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9541>))
+
+# Class: <http://identifiers.org/ncbigene/102135998> (TP53)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/102135998> "TP53")
+SubClassOf(<http://identifiers.org/ncbigene/102135998> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/102135998> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9541>))
+
+# Class: <http://identifiers.org/ncbigene/102138674> (PSEN1)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/102138674> "PSEN1")
+SubClassOf(<http://identifiers.org/ncbigene/102138674> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/102138674> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9541>))
+
 # Class: <http://identifiers.org/ncbigene/103023169> (oca2)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/103023169> "oca2")
 SubClassOf(<http://identifiers.org/ncbigene/103023169> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/103023169> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_7994>))
 
+# Class: <http://identifiers.org/ncbigene/103347222> (FAM83H)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/103347222> "FAM83H")
+SubClassOf(<http://identifiers.org/ncbigene/103347222> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/103347222> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9986>))
+
 # Class: <http://identifiers.org/ncbigene/107305840> (SLC45A2)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/107305840> "SLC45A2")
 SubClassOf(<http://identifiers.org/ncbigene/107305840> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/107305840> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_93934>))
 
+# Class: <http://identifiers.org/ncbigene/119881609> (VMP1)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/119881609> "VMP1")
+SubClassOf(<http://identifiers.org/ncbigene/119881609> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/119881609> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
+
 # Class: <http://identifiers.org/ncbigene/280798> (GAA)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/280798> "GAA")
@@ -46689,12 +46868,24 @@ AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/281877> "ITGB2")
 SubClassOf(<http://identifiers.org/ncbigene/281877> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/281877> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9913>))
 
+# Class: <http://identifiers.org/ncbigene/281917> (MOCS1)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/281917> "MOCS1")
+SubClassOf(<http://identifiers.org/ncbigene/281917> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/281917> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9913>))
+
 # Class: <http://identifiers.org/ncbigene/282149> (BCKDHA)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/282149> "BCKDHA")
 SubClassOf(<http://identifiers.org/ncbigene/282149> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/282149> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9913>))
 
+# Class: <http://identifiers.org/ncbigene/282179> (CHRNB1)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/282179> "CHRNB1")
+SubClassOf(<http://identifiers.org/ncbigene/282179> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/282179> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9913>))
+
 # Class: <http://identifiers.org/ncbigene/282401> (ADAMTS2)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/282401> "ADAMTS2")
@@ -46713,6 +46904,12 @@ AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/327664> "PYGM")
 SubClassOf(<http://identifiers.org/ncbigene/327664> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/327664> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9913>))
 
+# Class: <http://identifiers.org/ncbigene/397036> (SOD1)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/397036> "SOD1")
+SubClassOf(<http://identifiers.org/ncbigene/397036> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/397036> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9823>))
+
 # Class: <http://identifiers.org/ncbigene/397055> (CYP27B1)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/397055> "CYP27B1")
@@ -46731,6 +46928,18 @@ AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/397156> "IL2RG")
 SubClassOf(<http://identifiers.org/ncbigene/397156> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/397156> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9823>))
 
+# Class: <http://identifiers.org/ncbigene/397276> (TP53)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/397276> "TP53")
+SubClassOf(<http://identifiers.org/ncbigene/397276> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/397276> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9823>))
+
+# Class: <http://identifiers.org/ncbigene/397323> (COL2A1)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/397323> "COL2A1")
+SubClassOf(<http://identifiers.org/ncbigene/397323> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/397323> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9823>))
+
 # Class: <http://identifiers.org/ncbigene/397359> (MC4R)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/397359> "MC4R")
@@ -46743,12 +46952,30 @@ AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/397506> "RAG1")
 SubClassOf(<http://identifiers.org/ncbigene/397506> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/397506> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9823>))
 
+# Class: <http://identifiers.org/ncbigene/397663> (APP)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/397663> "APP")
+SubClassOf(<http://identifiers.org/ncbigene/397663> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/397663> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9823>))
+
 # Class: <http://identifiers.org/ncbigene/399653> (PDE6B)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/399653> "PDE6B")
 SubClassOf(<http://identifiers.org/ncbigene/399653> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/399653> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
 
+# Class: <http://identifiers.org/ncbigene/403159> (RUNX3)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/403159> "RUNX3")
+SubClassOf(<http://identifiers.org/ncbigene/403159> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/403159> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9823>))
+
+# Class: <http://identifiers.org/ncbigene/403407> (APP)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/403407> "APP")
+SubClassOf(<http://identifiers.org/ncbigene/403407> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/403407> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
+
 # Class: <http://identifiers.org/ncbigene/403492> (G6PC1)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/403492> "G6PC1")
@@ -46821,6 +47048,12 @@ AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/403873> "GLB1")
 SubClassOf(<http://identifiers.org/ncbigene/403873> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/403873> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
 
+# Class: <http://identifiers.org/ncbigene/407142> (COL2A1)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/407142> "COL2A1")
+SubClassOf(<http://identifiers.org/ncbigene/407142> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/407142> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9913>))
+
 # Class: <http://identifiers.org/ncbigene/414755> (PLN)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/414755> "PLN")
@@ -46869,6 +47102,18 @@ AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/474479> "CYB5R3"
 SubClassOf(<http://identifiers.org/ncbigene/474479> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/474479> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
 
+# Class: <http://identifiers.org/ncbigene/474985> (SNX14)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/474985> "SNX14")
+SubClassOf(<http://identifiers.org/ncbigene/474985> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/474985> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
+
+# Class: <http://identifiers.org/ncbigene/475010> (HACE1)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/475010> "HACE1")
+SubClassOf(<http://identifiers.org/ncbigene/475010> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/475010> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
+
 # Class: <http://identifiers.org/ncbigene/475316> (PPT1)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/475316> "PPT1")
@@ -46893,6 +47138,30 @@ AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/476149> "LOC4761
 SubClassOf(<http://identifiers.org/ncbigene/476149> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/476149> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
 
+# Class: <http://identifiers.org/ncbigene/476336> (VLDLR)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/476336> "VLDLR")
+SubClassOf(<http://identifiers.org/ncbigene/476336> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/476336> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
+
+# Class: <http://identifiers.org/ncbigene/476548> (ITPR1)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/476548> "ITPR1")
+SubClassOf(<http://identifiers.org/ncbigene/476548> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/476548> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
+
+# Class: <http://identifiers.org/ncbigene/476649> (FYCO1)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/476649> "FYCO1")
+SubClassOf(<http://identifiers.org/ncbigene/476649> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/476649> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
+
+# Class: <http://identifiers.org/ncbigene/477604> (SCN8A)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/477604> "SCN8A")
+SubClassOf(<http://identifiers.org/ncbigene/477604> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/477604> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
+
 # Class: <http://identifiers.org/ncbigene/478100> (HEXB)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/478100> "HEXB")
@@ -46905,18 +47174,48 @@ AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/478121> "BBS2")
 SubClassOf(<http://identifiers.org/ncbigene/478121> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/478121> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
 
+# Class: <http://identifiers.org/ncbigene/478239> (SLC12A6)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/478239> "SLC12A6")
+SubClassOf(<http://identifiers.org/ncbigene/478239> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/478239> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
+
 # Class: <http://identifiers.org/ncbigene/478582> (IQCB1)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/478582> "IQCB1")
 SubClassOf(<http://identifiers.org/ncbigene/478582> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/478582> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
 
+# Class: <http://identifiers.org/ncbigene/478798> (SLC25A12)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/478798> "SLC25A12")
+SubClassOf(<http://identifiers.org/ncbigene/478798> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/478798> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
+
 # Class: <http://identifiers.org/ncbigene/478836> (COL5A2)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/478836> "COL5A2")
 SubClassOf(<http://identifiers.org/ncbigene/478836> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/478836> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
 
+# Class: <http://identifiers.org/ncbigene/479129> (KCNIP4)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/479129> "KCNIP4")
+SubClassOf(<http://identifiers.org/ncbigene/479129> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/479129> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
+
+# Class: <http://identifiers.org/ncbigene/479277> (RAB24)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/479277> "RAB24")
+SubClassOf(<http://identifiers.org/ncbigene/479277> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/479277> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
+
+# Class: <http://identifiers.org/ncbigene/479346> (SELENOP)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/479346> "SELENOP")
+SubClassOf(<http://identifiers.org/ncbigene/479346> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/479346> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
+
 # Class: <http://identifiers.org/ncbigene/479382> (RETREG1)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/479382> "RETREG1")
@@ -46929,6 +47228,12 @@ AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/479931> "AGL")
 SubClassOf(<http://identifiers.org/ncbigene/479931> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/479931> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
 
+# Class: <http://identifiers.org/ncbigene/480409> (SEL1L)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/480409> "SEL1L")
+SubClassOf(<http://identifiers.org/ncbigene/480409> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/480409> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
+
 # Class: <http://identifiers.org/ncbigene/480413> (TTC8)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/480413> "TTC8")
@@ -46983,6 +47288,12 @@ AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/483662> "CTSD")
 SubClassOf(<http://identifiers.org/ncbigene/483662> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/483662> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
 
+# Class: <http://identifiers.org/ncbigene/483706> (SPTBN2)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/483706> "SPTBN2")
+SubClassOf(<http://identifiers.org/ncbigene/483706> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/483706> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
+
 # Class: <http://identifiers.org/ncbigene/483745> (CAPN1)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/483745> "CAPN1")
@@ -46995,6 +47306,12 @@ AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/483766> "FERMT3"
 SubClassOf(<http://identifiers.org/ncbigene/483766> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/483766> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
 
+# Class: <http://identifiers.org/ncbigene/483870> (BIN1)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/483870> "BIN1")
+SubClassOf(<http://identifiers.org/ncbigene/483870> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/483870> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
+
 # Class: <http://identifiers.org/ncbigene/484357> (ACP4)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/484357> "ACP4")
@@ -47007,6 +47324,12 @@ AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/484830> "SLC5A5"
 SubClassOf(<http://identifiers.org/ncbigene/484830> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/484830> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
 
+# Class: <http://identifiers.org/ncbigene/484949> (DNM2)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/484949> "DNM2")
+SubClassOf(<http://identifiers.org/ncbigene/484949> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/484949> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
+
 # Class: <http://identifiers.org/ncbigene/485187> (SERPINH1)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/485187> "SERPINH1")
@@ -47049,12 +47372,24 @@ AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/488558> "CLN8")
 SubClassOf(<http://identifiers.org/ncbigene/488558> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/488558> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
 
+# Class: <http://identifiers.org/ncbigene/488635> (KCNJ10)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/488635> "KCNJ10")
+SubClassOf(<http://identifiers.org/ncbigene/488635> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/488635> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
+
 # Class: <http://identifiers.org/ncbigene/488683> (OCA2)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/488683> "OCA2")
 SubClassOf(<http://identifiers.org/ncbigene/488683> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/488683> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
 
+# Class: <http://identifiers.org/ncbigene/488853> (LGI2)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/488853> "LGI2")
+SubClassOf(<http://identifiers.org/ncbigene/488853> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/488853> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
+
 # Class: <http://identifiers.org/ncbigene/489157> (NIPAL4)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/489157> "NIPAL4")
@@ -47067,6 +47402,12 @@ AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/489236> "SLC45A2
 SubClassOf(<http://identifiers.org/ncbigene/489236> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/489236> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
 
+# Class: <http://identifiers.org/ncbigene/489479> (ATP1B2)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/489479> "ATP1B2")
+SubClassOf(<http://identifiers.org/ncbigene/489479> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/489479> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
+
 # Class: <http://identifiers.org/ncbigene/489766> (HSF4)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/489766> "HSF4")
@@ -47121,6 +47462,18 @@ AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/497068> "CLN6")
 SubClassOf(<http://identifiers.org/ncbigene/497068> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/497068> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
 
+# Class: <http://identifiers.org/ncbigene/507654> (ADAMTSL4)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/507654> "ADAMTSL4")
+SubClassOf(<http://identifiers.org/ncbigene/507654> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/507654> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9913>))
+
+# Class: <http://identifiers.org/ncbigene/509837> (SUOX)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/509837> "SUOX")
+SubClassOf(<http://identifiers.org/ncbigene/509837> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/509837> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9913>))
+
 # Class: <http://identifiers.org/ncbigene/510763> (MYBPC1)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/510763> "MYBPC1")
@@ -47151,6 +47504,12 @@ AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/525040> "IL17RA"
 SubClassOf(<http://identifiers.org/ncbigene/525040> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/525040> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9913>))
 
+# Class: <http://identifiers.org/ncbigene/525795> (AGRN)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/525795> "AGRN")
+SubClassOf(<http://identifiers.org/ncbigene/525795> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/525795> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9913>))
+
 # Class: <http://identifiers.org/ncbigene/529186> (CLN5)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/529186> "CLN5")
@@ -47163,6 +47522,12 @@ AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/533175> "CHD7")
 SubClassOf(<http://identifiers.org/ncbigene/533175> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/533175> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9913>))
 
+# Class: <http://identifiers.org/ncbigene/534319> (NID1)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/534319> "NID1")
+SubClassOf(<http://identifiers.org/ncbigene/534319> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/534319> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9913>))
+
 # Class: <http://identifiers.org/ncbigene/538590> (COL5A2)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/538590> "COL5A2")
@@ -47181,6 +47546,12 @@ AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/554324> "FGFR3")
 SubClassOf(<http://identifiers.org/ncbigene/554324> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/554324> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9940>))
 
+# Class: <http://identifiers.org/ncbigene/574011> (HACD1)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/574011> "HACD1")
+SubClassOf(<http://identifiers.org/ncbigene/574011> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/574011> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9615>))
+
 # Class: <http://identifiers.org/ncbigene/607077> (MLPH)
 
 AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/607077> "MLPH")
@@ -47265,6 +47636,18 @@ AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/707478> "BBS7")
 SubClassOf(<http://identifiers.org/ncbigene/707478> <http://purl.obolibrary.org/obo/SO_0000704>)
 SubClassOf(<http://identifiers.org/ncbigene/707478> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9544>))
 
+# Class: <http://identifiers.org/ncbigene/780411> (PSEN1)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/780411> "PSEN1")
+SubClassOf(<http://identifiers.org/ncbigene/780411> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/780411> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9823>))
+
+# Class: <http://identifiers.org/ncbigene/782170> (TWIST1)
+
+AnnotationAssertion(rdfs:label <http://identifiers.org/ncbigene/782170> "TWIST1")
+SubClassOf(<http://identifiers.org/ncbigene/782170> <http://purl.obolibrary.org/obo/SO_0000704>)
+SubClassOf(<http://identifiers.org/ncbigene/782170> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002162> <http://purl.obolibrary.org/obo/NCBITaxon_9913>))
+
 # Class: <http://purl.obolibrary.org/obo/BFO_0000001> (entity)
 
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000116> <http://purl.obolibrary.org/obo/BFO_0000001> "BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81"@en)
@@ -47544,10 +47927,10 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_13941> ObjectSomeValuesFrom(<ht
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_139588> (alpha-hydroxy ketone)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_139588> "An alpha-oxyketone that has a hydroxy group as the alpha-oxy moiety.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_139588> "A ketone containing a hydroxy group on the alpha-carbon relative to the C=O group.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_139588> "alpha-hydroxy ketone")
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_139588> <http://purl.obolibrary.org/obo/CHEBI_30879>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_139588> <http://purl.obolibrary.org/obo/CHEBI_52396>)
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_139588> <http://purl.obolibrary.org/obo/CHEBI_17087>)
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_139588> <http://purl.obolibrary.org/obo/CHEBI_33822>)
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_139589> (retinoid anion)
 
@@ -48100,7 +48483,7 @@ AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_16705> "6-a
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16705> <http://purl.obolibrary.org/obo/CHEBI_25865>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16705> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_50904>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16705> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#has_functional_parent> <http://purl.obolibrary.org/obo/CHEBI_37806>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16705> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_30938>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16705> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_30938>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_16705> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_tautomer_of> <http://purl.obolibrary.org/obo/CHEBI_57869>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_16709> (pyridoxine)
@@ -48857,7 +49240,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_22744> ObjectSomeValuesFrom(<ht
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_228364> (NMR chemical shift reference compound)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_228364> "Any compound that produces a peak used to reference an NMR spectrum during data pre-processing.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_228364> "Any compound that produces a peak used as reference frequency in the delta chemical shift scale.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_228364> "NMR chemical shift reference compound")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_228364> <http://purl.obolibrary.org/obo/CHEBI_33232>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_228364> <http://purl.obolibrary.org/obo/CHEBI_51086>)
@@ -50174,8 +50557,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_27902> ObjectSomeValuesFrom(<ht
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_27902> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_36047>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_27902> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_48001>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_27902> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_76971>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_27902> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_71392>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_27902> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_77932>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_27902> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_tautomer_of> <http://purl.obolibrary.org/obo/CHEBI_77932>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_27933> (beta-lactam antibiotic)
 
@@ -50670,7 +51052,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_30879> <http://purl.obolibrary.
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_30938> "6-aminopenicillanate")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_30938> <http://purl.obolibrary.org/obo/CHEBI_51356>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_30938> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_16705>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_30938> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_16705>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_30938> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_57869>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_30985> (4,4'-bipyridine)
@@ -51959,10 +52341,10 @@ AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.ob
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_35230> "fossil fuel")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35230> <http://purl.obolibrary.org/obo/CHEBI_33292>)
 
-# Class: <http://purl.obolibrary.org/obo/CHEBI_35238> (amino acid zwitterion)
+# Class: <http://purl.obolibrary.org/obo/CHEBI_35238> (amino-acid zwitterion)
 
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_35238> "The zwitterionic form of an amino acid having a negatively charged carboxyl group and a positively charged amino group.")
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_35238> "amino acid zwitterion")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_35238> "amino-acid zwitterion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_35238> <http://purl.obolibrary.org/obo/CHEBI_27369>)
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_35267> (quaternary ammonium ion)
@@ -54112,7 +54494,7 @@ AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_50906> "rol
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_50908> (hepatotoxic agent)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_50908> "A role played by a chemical compound exihibiting itself through the ability to induce damage to the liver in animals.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_50908> "A role played by a chemical compound exhibiting itself through the ability to induce damage to the liver in animals.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_50908> "hepatotoxic agent")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_50908> <http://purl.obolibrary.org/obo/CHEBI_52209>)
 
@@ -55154,10 +55536,9 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_71300> <http://purl.obolibrary.
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_71392> (tetracycline(1-))
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_71392> "An organic anion that is the conjugate base of tetracycline obtained by deprotonation of the two enolic hydroxy groups and protonation of the tertiary amino group.")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_71392> "An organic anion that is the conjugate base of tetracycline zwitterion obtained by deprotonation of the two enolic hydroxy groups and protonation of the tertiary amino group.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_71392> "tetracycline(1-)")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_71392> <http://purl.obolibrary.org/obo/CHEBI_25696>)
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_71392> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_27902>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_71392> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_77932>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_72695> (organic molecule)
@@ -55570,7 +55951,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_77932> ObjectSomeValuesFrom(<ht
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_77932> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_36047>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_77932> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_48001>))
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_77932> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_71392>))
-SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_77932> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_27902>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_77932> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_tautomer_of> <http://purl.obolibrary.org/obo/CHEBI_27902>))
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_77938> (barbiturate(1-))
 
@@ -55647,10 +56028,10 @@ AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.ob
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_78505> "venom")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_78505> <http://purl.obolibrary.org/obo/CHEBI_27026>)
 
-# Class: <http://purl.obolibrary.org/obo/CHEBI_78608> (alpha-amino acid zwitterion)
+# Class: <http://purl.obolibrary.org/obo/CHEBI_78608> (alpha-amino-acid zwitterion)
 
-AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_78608> "An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of any alpha-amino acid; major species at pH 7.3.")
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_78608> "alpha-amino acid zwitterion")
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_78608> "An amino acid-zwitterion obtained by transfer of a proton from the carboxy to the amino group of any alpha-amino acid; major species at pH 7.3.")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_78608> "alpha-amino-acid zwitterion")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_78608> <http://purl.obolibrary.org/obo/CHEBI_35238>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_78608> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_tautomer_of> <http://purl.obolibrary.org/obo/CHEBI_33704>))
 
@@ -55776,10 +56157,10 @@ AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.ob
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_83820> "non-proteinogenic amino acid")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_83820> <http://purl.obolibrary.org/obo/CHEBI_33709>)
 
-# Class: <http://purl.obolibrary.org/obo/CHEBI_83821> (amino acid derivative)
+# Class: <http://purl.obolibrary.org/obo/CHEBI_83821> (amino-acid derivative)
 
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_83821> "Any derivative of an amino acid resulting from reaction at an amino group, carboxy group, side-chain functional group, or from the replacement of any hydrogen by a heteroatom. The definition normally excludes peptides containing amino acid residues.")
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_83821> "amino acid derivative")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_83821> "amino-acid derivative")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_83821> <http://purl.obolibrary.org/obo/CHEBI_35352>)
 
 # Class: <http://purl.obolibrary.org/obo/CHEBI_83822> (non-proteinogenic L-alpha-amino acid)
@@ -73908,6 +74289,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0000819> <http://purl.obolibrary.o
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0000820> "regulation of glutamine family amino acid metabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0000820> <http://purl.obolibrary.org/obo/GO_0006521>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0000820> <http://purl.obolibrary.org/obo/GO_0062012>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0000820> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0009064>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0000902> (cell morphogenesis)
@@ -74112,6 +74494,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0001667> <http://purl.obolibrary.o
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0001671> "ATPase activator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0001671> <http://purl.obolibrary.org/obo/GO_0060590>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0001671> <http://purl.obolibrary.org/obo/GO_0140677>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0001671> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0140657>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0001675> (acrosome assembly)
 
@@ -74386,7 +74769,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0001870> ObjectSomeValuesFrom(<htt
 # Class: <http://purl.obolibrary.org/obo/GO_0001887> (selenium compound metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0001887> "selenium compound metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0001887> <http://purl.obolibrary.org/obo/GO_0044237>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0001887> <http://purl.obolibrary.org/obo/GO_0008152>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0001894> (tissue homeostasis)
 
@@ -76436,23 +76819,27 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0004807> <http://purl.obolibrary.o
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0004857> "enzyme inhibitor activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0004857> <http://purl.obolibrary.org/obo/GO_0030234>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0004857> <http://purl.obolibrary.org/obo/GO_0140678>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0004857> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0003824>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0004860> (protein kinase inhibitor activity)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0004860> "protein kinase inhibitor activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0004860> <http://purl.obolibrary.org/obo/GO_0019210>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0004860> <http://purl.obolibrary.org/obo/GO_0019887>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0004860> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0004672>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0004866> (endopeptidase inhibitor activity)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0004866> "endopeptidase inhibitor activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0004866> <http://purl.obolibrary.org/obo/GO_0030414>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0004866> <http://purl.obolibrary.org/obo/GO_0061135>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0004866> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0004175>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0004867> (serine-type endopeptidase inhibitor activity)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0004867> "serine-type endopeptidase inhibitor activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0004867> <http://purl.obolibrary.org/obo/GO_0004866>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0004867> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0004252>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0004871> (obsolete signal transducer activity)
 
@@ -76576,6 +76963,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0005244> <http://purl.obolibrary.o
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0005246> "calcium channel regulator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0005246> <http://purl.obolibrary.org/obo/GO_0099106>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0005246> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0005262>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0005261> (monoatomic cation channel activity)
 
@@ -77105,7 +77493,6 @@ AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0006073> "
 # Class: <http://purl.obolibrary.org/obo/GO_0006082> (organic acid metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0006082> "organic acid metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0006082> <http://purl.obolibrary.org/obo/GO_0044237>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0006082> <http://purl.obolibrary.org/obo/GO_0044281>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0006090> (pyruvate metabolic process)
@@ -77116,7 +77503,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0006090> <http://purl.obolibrary.o
 # Class: <http://purl.obolibrary.org/obo/GO_0006091> (generation of precursor metabolites and energy)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0006091> "generation of precursor metabolites and energy")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0006091> <http://purl.obolibrary.org/obo/GO_0044237>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0006091> <http://purl.obolibrary.org/obo/GO_0008152>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0006094> (gluconeogenesis)
 
@@ -77137,6 +77524,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0006096> <http://purl.obolibrary.o
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0006096> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_0004618>))
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0006096> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_0004619>))
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0006096> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_0004634>))
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0006096> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_0004743>))
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0006096> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_0043891>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0006099> (tricarboxylic acid cycle)
@@ -77330,13 +77718,16 @@ AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0006412> "tran
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0006412> <http://purl.obolibrary.org/obo/GO_0009059>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0006412> <http://purl.obolibrary.org/obo/GO_0019538>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0006412> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/GO_0010467>))
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0006412> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_0006413>))
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0006412> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_0006414>))
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0006412> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_0006415>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0006413> (translational initiation)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0006413> "translational initiation")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0006413> <http://purl.obolibrary.org/obo/GO_0044237>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0006413> <http://purl.obolibrary.org/obo/GO_0008152>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0006413> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/GO_0006412>))
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0006413> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_0001677>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0006414> (translational elongation)
 
@@ -77453,11 +77844,9 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0006518> <http://purl.obolibrary.o
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0006520> "amino acid metabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0006520> <http://purl.obolibrary.org/obo/GO_0044238>)
 
-# Class: <http://purl.obolibrary.org/obo/GO_0006521> (regulation of cellular amino acid metabolic process)
+# Class: <http://purl.obolibrary.org/obo/GO_0006521> (regulation of amino acid metabolic process)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0006521> "regulation of cellular amino acid metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0006521> <http://purl.obolibrary.org/obo/GO_0010565>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0006521> <http://purl.obolibrary.org/obo/GO_0033238>)
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0006521> "regulation of amino acid metabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0006521> <http://purl.obolibrary.org/obo/GO_0080090>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0006521> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0006520>))
 
@@ -77539,10 +77928,10 @@ AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0006573> "vali
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0006573> <http://purl.obolibrary.org/obo/GO_0009081>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0006573> <http://purl.obolibrary.org/obo/GO_1901605>)
 
-# Class: <http://purl.obolibrary.org/obo/GO_0006575> (cellular modified amino acid metabolic process)
+# Class: <http://purl.obolibrary.org/obo/GO_0006575> (modified amino acid metabolic process)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0006575> "cellular modified amino acid metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0006575> <http://purl.obolibrary.org/obo/GO_0044237>)
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0006575> "modified amino acid metabolic process")
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0006575> <http://purl.obolibrary.org/obo/GO_0008152>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0006576> (biogenic amine metabolic process)
 
@@ -77604,8 +77993,8 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0006629> <http://purl.obolibrary.o
 # Class: <http://purl.obolibrary.org/obo/GO_0006631> (fatty acid metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0006631> "fatty acid metabolic process")
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0006631> <http://purl.obolibrary.org/obo/GO_0006629>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0006631> <http://purl.obolibrary.org/obo/GO_0032787>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0006631> <http://purl.obolibrary.org/obo/GO_0044255>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0006633> (fatty acid biosynthetic process)
 
@@ -77617,14 +78006,15 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0006633> <http://purl.obolibrary.o
 # Class: <http://purl.obolibrary.org/obo/GO_0006643> (membrane lipid metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0006643> "membrane lipid metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0006643> <http://purl.obolibrary.org/obo/GO_0044255>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0006643> <http://purl.obolibrary.org/obo/GO_0006629>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0006643> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000066> <http://purl.obolibrary.org/obo/GO_0016020>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0006644> (phospholipid metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0006644> "phospholipid metabolic process")
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0006644> <http://purl.obolibrary.org/obo/GO_0006629>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0006644> <http://purl.obolibrary.org/obo/GO_0006796>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0006644> <http://purl.obolibrary.org/obo/GO_0019637>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0006644> <http://purl.obolibrary.org/obo/GO_0044255>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0006650> (glycerophospholipid metabolic process)
 
@@ -77704,7 +78094,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0006707> <http://purl.obolibrary.o
 # Class: <http://purl.obolibrary.org/obo/GO_0006720> (isoprenoid metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0006720> "isoprenoid metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0006720> <http://purl.obolibrary.org/obo/GO_0044255>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0006720> <http://purl.obolibrary.org/obo/GO_0006629>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0006721> (terpenoid metabolic process)
 
@@ -77816,12 +78206,12 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0006778> <http://purl.obolibrary.o
 # Class: <http://purl.obolibrary.org/obo/GO_0006790> (sulfur compound metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0006790> "sulfur compound metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0006790> <http://purl.obolibrary.org/obo/GO_0044237>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0006790> <http://purl.obolibrary.org/obo/GO_0008152>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0006793> (phosphorus metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0006793> "phosphorus metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0006793> <http://purl.obolibrary.org/obo/GO_0044237>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0006793> <http://purl.obolibrary.org/obo/GO_0008152>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0006796> (phosphate-containing compound metabolic process)
 
@@ -78036,6 +78426,8 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0006911> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0006915> "apoptotic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0006915> <http://purl.obolibrary.org/obo/GO_0012501>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0006915> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_0097190>))
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0006915> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_0097194>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0006921> (cellular component disassembly involved in execution phase of apoptosis)
 
@@ -78296,6 +78688,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0007166> <http://purl.obolibrary.o
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0007215> "glutamate receptor signaling pathway")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0007215> <http://purl.obolibrary.org/obo/GO_0007166>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0007215> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_0008066>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0007249> (canonical NF-kappaB signal transduction)
 
@@ -78696,6 +79089,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0008046> ObjectSomeValuesFrom(<htt
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0008047> "enzyme activator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0008047> <http://purl.obolibrary.org/obo/GO_0030234>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0008047> <http://purl.obolibrary.org/obo/GO_0140677>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0008047> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0003824>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0008066> (glutamate receptor activity)
 
@@ -78732,7 +79126,7 @@ AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0008150> "biol
 # Class: <http://purl.obolibrary.org/obo/GO_0008152> (metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0008152> "metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0008152> <http://purl.obolibrary.org/obo/GO_0008150>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0008152> <http://purl.obolibrary.org/obo/GO_0009987>)
 DisjointClasses(<http://purl.obolibrary.org/obo/GO_0008152> <http://purl.obolibrary.org/obo/GO_0044848>)
 DisjointClasses(<http://purl.obolibrary.org/obo/GO_0008152> <http://purl.obolibrary.org/obo/GO_0051179>)
 
@@ -78752,6 +79146,7 @@ AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0008200> "ion
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0008200> <http://purl.obolibrary.org/obo/GO_0016248>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0008200> <http://purl.obolibrary.org/obo/GO_0099106>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0008200> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_0044325>))
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0008200> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0005216>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0008202> (steroid metabolic process)
 
@@ -78780,7 +79175,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0008211> <http://purl.obolibrary.o
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0008212> "mineralocorticoid metabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0008212> <http://purl.obolibrary.org/obo/GO_0008202>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0008212> <http://purl.obolibrary.org/obo/GO_0009987>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0008212> <http://purl.obolibrary.org/obo/GO_0042445>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0008217> (regulation of blood pressure)
@@ -78973,6 +79367,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0008585> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0008607> "phosphorylase kinase regulator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0008607> <http://purl.obolibrary.org/obo/GO_0019887>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0008607> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0004689>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0008610> (lipid biosynthetic process)
 
@@ -78983,9 +79378,9 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0008610> <http://purl.obolibrary.o
 # Class: <http://purl.obolibrary.org/obo/GO_0008611> (ether lipid biosynthetic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0008611> "ether lipid biosynthetic process")
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0008611> <http://purl.obolibrary.org/obo/GO_0008610>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0008611> <http://purl.obolibrary.org/obo/GO_0046485>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0008611> <http://purl.obolibrary.org/obo/GO_0046504>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0008611> <http://purl.obolibrary.org/obo/GO_0097384>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0008614> (pyridoxine metabolic process)
 
@@ -79040,8 +79435,8 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0009058> <http://purl.obolibrary.o
 # Class: <http://purl.obolibrary.org/obo/GO_0009059> (macromolecule biosynthetic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0009059> "macromolecule biosynthetic process")
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0009059> <http://purl.obolibrary.org/obo/GO_0009058>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0009059> <http://purl.obolibrary.org/obo/GO_0043170>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0009059> <http://purl.obolibrary.org/obo/GO_0044249>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0009060> (aerobic respiration)
 
@@ -79152,7 +79547,6 @@ AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0009108> "
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0009110> "vitamin biosynthetic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0009110> <http://purl.obolibrary.org/obo/GO_0006766>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0009110> <http://purl.obolibrary.org/obo/GO_0044249>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0009110> <http://purl.obolibrary.org/obo/GO_0044283>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0009112> (nucleobase metabolic process)
@@ -79613,14 +80007,14 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0009891> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0009892> "negative regulation of metabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0009892> <http://purl.obolibrary.org/obo/GO_0019222>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0009892> <http://purl.obolibrary.org/obo/GO_0048519>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0009892> <http://purl.obolibrary.org/obo/GO_0048523>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0009892> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0008152>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0009893> (positive regulation of metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0009893> "positive regulation of metabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0009893> <http://purl.obolibrary.org/obo/GO_0019222>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0009893> <http://purl.obolibrary.org/obo/GO_0048518>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0009893> <http://purl.obolibrary.org/obo/GO_0048522>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0009893> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0008152>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0009894> (regulation of catabolic process)
@@ -79816,7 +80210,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0010470> ObjectSomeValuesFrom(<htt
 # Class: <http://purl.obolibrary.org/obo/GO_0010511> (regulation of phosphatidylinositol biosynthetic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0010511> "regulation of phosphatidylinositol biosynthetic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0010511> <http://purl.obolibrary.org/obo/GO_0031326>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010511> <http://purl.obolibrary.org/obo/GO_0071071>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010511> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0006661>))
 
@@ -79824,7 +80217,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0010511> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0010512> "negative regulation of phosphatidylinositol biosynthetic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010512> <http://purl.obolibrary.org/obo/GO_0010511>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0010512> <http://purl.obolibrary.org/obo/GO_0031327>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010512> <http://purl.obolibrary.org/obo/GO_0071072>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010512> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0006661>))
 
@@ -79832,31 +80224,30 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0010512> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0010513> "positive regulation of phosphatidylinositol biosynthetic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010513> <http://purl.obolibrary.org/obo/GO_0010511>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0010513> <http://purl.obolibrary.org/obo/GO_0031328>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010513> <http://purl.obolibrary.org/obo/GO_0071073>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010513> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0006661>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0010556> (regulation of macromolecule biosynthetic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0010556> "regulation of macromolecule biosynthetic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0010556> <http://purl.obolibrary.org/obo/GO_0031326>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0010556> <http://purl.obolibrary.org/obo/GO_0009889>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010556> <http://purl.obolibrary.org/obo/GO_0060255>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010556> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0009059>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0010557> (positive regulation of macromolecule biosynthetic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0010557> "positive regulation of macromolecule biosynthetic process")
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0010557> <http://purl.obolibrary.org/obo/GO_0009891>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010557> <http://purl.obolibrary.org/obo/GO_0010556>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010557> <http://purl.obolibrary.org/obo/GO_0010604>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0010557> <http://purl.obolibrary.org/obo/GO_0031328>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010557> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0009059>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0010558> (negative regulation of macromolecule biosynthetic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0010558> "negative regulation of macromolecule biosynthetic process")
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0010558> <http://purl.obolibrary.org/obo/GO_0009890>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010558> <http://purl.obolibrary.org/obo/GO_0010556>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010558> <http://purl.obolibrary.org/obo/GO_0010605>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0010558> <http://purl.obolibrary.org/obo/GO_0031327>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010558> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0009059>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0010559> (regulation of glycoprotein biosynthetic process)
@@ -79885,14 +80276,14 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0010561> ObjectSomeValuesFrom(<htt
 # Class: <http://purl.obolibrary.org/obo/GO_0010562> (positive regulation of phosphorus metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0010562> "positive regulation of phosphorus metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0010562> <http://purl.obolibrary.org/obo/GO_0031325>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0010562> <http://purl.obolibrary.org/obo/GO_0009893>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010562> <http://purl.obolibrary.org/obo/GO_0051174>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010562> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0006793>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0010563> (negative regulation of phosphorus metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0010563> "negative regulation of phosphorus metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0010563> <http://purl.obolibrary.org/obo/GO_0031324>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0010563> <http://purl.obolibrary.org/obo/GO_0009892>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010563> <http://purl.obolibrary.org/obo/GO_0051174>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010563> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0006793>))
 
@@ -79902,18 +80293,18 @@ AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0010564> "regu
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010564> <http://purl.obolibrary.org/obo/GO_0051726>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010564> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0022402>))
 
-# Class: <http://purl.obolibrary.org/obo/GO_0010565> (regulation of cellular ketone metabolic process)
+# Class: <http://purl.obolibrary.org/obo/GO_0010565> (regulation of ketone metabolic process)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0010565> "regulation of cellular ketone metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0010565> <http://purl.obolibrary.org/obo/GO_0031323>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0010565> <http://purl.obolibrary.org/obo/GO_0062012>)
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0010565> "regulation of ketone metabolic process")
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0010565> <http://purl.obolibrary.org/obo/GO_0019222>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010565> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0042180>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0010566> (regulation of ketone biosynthetic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0010566> "regulation of ketone biosynthetic process")
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0010566> <http://purl.obolibrary.org/obo/GO_0009889>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010566> <http://purl.obolibrary.org/obo/GO_0010565>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0010566> <http://purl.obolibrary.org/obo/GO_0031326>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0010566> <http://purl.obolibrary.org/obo/GO_0062012>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010566> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0042181>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0010604> (positive regulation of macromolecule metabolic process)
@@ -80318,7 +80709,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0010955> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0010957> "negative regulation of vitamin D biosynthetic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010957> <http://purl.obolibrary.org/obo/GO_0010894>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0010957> <http://purl.obolibrary.org/obo/GO_0031327>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010957> <http://purl.obolibrary.org/obo/GO_0046137>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010957> <http://purl.obolibrary.org/obo/GO_0060556>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0010957> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0042368>))
@@ -80392,6 +80782,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0010986> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0012501> "programmed cell death")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0012501> <http://purl.obolibrary.org/obo/GO_0008219>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0012501> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_0007165>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0012505> (endomembrane system)
 
@@ -81145,7 +81536,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0016052> <http://purl.obolibrary.o
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0016053> "organic acid biosynthetic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0016053> <http://purl.obolibrary.org/obo/GO_0006082>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0016053> <http://purl.obolibrary.org/obo/GO_0044249>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0016053> <http://purl.obolibrary.org/obo/GO_0044283>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0016054> (organic acid catabolic process)
@@ -81249,12 +81639,14 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0016234> <http://purl.obolibrary.o
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0016247> "channel regulator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0016247> <http://purl.obolibrary.org/obo/GO_0141108>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0016247> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0015267>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0016248> (channel inhibitor activity)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0016248> "channel inhibitor activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0016248> <http://purl.obolibrary.org/obo/GO_0016247>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0016248> <http://purl.obolibrary.org/obo/GO_0141110>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0016248> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0015267>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0016250> (N-sulfoglucosamine sulfohydrolase activity)
 
@@ -81384,6 +81776,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0016491> <http://purl.obolibrary.o
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0016504> "peptidase activator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0016504> <http://purl.obolibrary.org/obo/GO_0008047>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0016504> <http://purl.obolibrary.org/obo/GO_0061134>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0016504> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0008233>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0016505> (peptidase activator activity involved in apoptotic process)
 
@@ -81825,36 +82218,42 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0019203> <http://purl.obolibrary.o
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0019207> "kinase regulator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0019207> <http://purl.obolibrary.org/obo/GO_0030234>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0019207> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0016301>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0019208> (phosphatase regulator activity)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0019208> "phosphatase regulator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0019208> <http://purl.obolibrary.org/obo/GO_0030234>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0019208> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_0019902>))
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0019208> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0016791>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0019209> (kinase activator activity)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0019209> "kinase activator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0019209> <http://purl.obolibrary.org/obo/GO_0008047>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0019209> <http://purl.obolibrary.org/obo/GO_0019207>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0019209> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0016301>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0019210> (kinase inhibitor activity)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0019210> "kinase inhibitor activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0019210> <http://purl.obolibrary.org/obo/GO_0004857>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0019210> <http://purl.obolibrary.org/obo/GO_0019207>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0019210> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0016301>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0019211> (phosphatase activator activity)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0019211> "phosphatase activator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0019211> <http://purl.obolibrary.org/obo/GO_0008047>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0019211> <http://purl.obolibrary.org/obo/GO_0019208>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0019211> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0016791>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0019212> (phosphatase inhibitor activity)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0019212> "phosphatase inhibitor activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0019212> <http://purl.obolibrary.org/obo/GO_0004857>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0019212> <http://purl.obolibrary.org/obo/GO_0019208>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0019212> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0016791>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0019216> (regulation of lipid metabolic process)
 
@@ -81867,6 +82266,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0019216> ObjectSomeValuesFrom(<htt
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0019217> "regulation of fatty acid metabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0019217> <http://purl.obolibrary.org/obo/GO_0010565>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0019217> <http://purl.obolibrary.org/obo/GO_0019216>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0019217> <http://purl.obolibrary.org/obo/GO_0062012>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0019217> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0006631>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0019218> (regulation of steroid metabolic process)
@@ -81896,7 +82296,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0019221> ObjectSomeValuesFrom(<htt
 # Class: <http://purl.obolibrary.org/obo/GO_0019222> (regulation of metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0019222> "regulation of metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0019222> <http://purl.obolibrary.org/obo/GO_0050789>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0019222> <http://purl.obolibrary.org/obo/GO_0050794>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0019222> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0008152>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0019226> (transmission of nerve impulse)
@@ -82042,7 +82442,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0019730> <http://purl.obolibrary.o
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0019747> "regulation of isoprenoid metabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0019747> <http://purl.obolibrary.org/obo/GO_0019216>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0019747> <http://purl.obolibrary.org/obo/GO_0031323>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0019747> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0006720>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0019751> (polyol metabolic process)
@@ -82098,6 +82497,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0019853> <http://purl.obolibrary.o
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0019855> "calcium channel inhibitor activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0019855> <http://purl.obolibrary.org/obo/GO_0005246>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0019855> <http://purl.obolibrary.org/obo/GO_0008200>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0019855> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0005262>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0019866> (organelle inner membrane)
 
@@ -82115,6 +82515,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0019882> <http://purl.obolibrary.o
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0019887> "protein kinase regulator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0019887> <http://purl.obolibrary.org/obo/GO_0019207>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0019887> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_0019901>))
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0019887> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0004672>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0019889> (pteridine metabolic process)
 
@@ -82705,6 +83106,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0030225> <http://purl.obolibrary.o
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0030234> "enzyme regulator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0030234> <http://purl.obolibrary.org/obo/GO_0098772>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0030234> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0003824>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0030252> (growth hormone secretion)
 
@@ -82714,7 +83116,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0030252> <http://purl.obolibrary.o
 # Class: <http://purl.obolibrary.org/obo/GO_0030258> (lipid modification)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0030258> "lipid modification")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0030258> <http://purl.obolibrary.org/obo/GO_0044255>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0030258> <http://purl.obolibrary.org/obo/GO_0006629>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0030261> (chromosome condensation)
 
@@ -82761,12 +83163,14 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0030286> <http://purl.obolibrary.o
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0030291> "protein serine/threonine kinase inhibitor activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0030291> <http://purl.obolibrary.org/obo/GO_0004860>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0030291> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0004674>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0030295> (protein kinase activator activity)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0030295> "protein kinase activator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0030295> <http://purl.obolibrary.org/obo/GO_0019209>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0030295> <http://purl.obolibrary.org/obo/GO_0019887>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0030295> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0004672>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0030312> (external encapsulating structure)
 
@@ -82817,6 +83221,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0030343> ObjectSomeValuesFrom(<htt
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0030414> "peptidase inhibitor activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0030414> <http://purl.obolibrary.org/obo/GO_0004857>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0030414> <http://purl.obolibrary.org/obo/GO_0061134>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0030414> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0008233>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0030416> (methylamine metabolic process)
 
@@ -82901,18 +83306,21 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0030522> <http://purl.obolibrary.o
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0030545> "signaling receptor regulator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0030545> <http://purl.obolibrary.org/obo/GO_0098772>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0030545> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0038023>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0030546> (signaling receptor activator activity)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0030546> "signaling receptor activator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0030546> <http://purl.obolibrary.org/obo/GO_0030545>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0030546> <http://purl.obolibrary.org/obo/GO_0140677>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0030546> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0038023>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0030547> (signaling receptor inhibitor activity)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0030547> "signaling receptor inhibitor activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0030547> <http://purl.obolibrary.org/obo/GO_0030545>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0030547> <http://purl.obolibrary.org/obo/GO_0140678>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0030547> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0038023>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0030593> (neutrophil chemotaxis)
 
@@ -83201,74 +83609,59 @@ AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0100001> <http://purl.ob
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0031305> "obsolete integral component of mitochondrial inner membrane")
 AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0031305> "true"^^xsd:boolean)
 
-# Class: <http://purl.obolibrary.org/obo/GO_0031323> (regulation of cellular metabolic process)
+# Class: <http://purl.obolibrary.org/obo/GO_0031323> (obsolete regulation of cellular metabolic process)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0031323> "regulation of cellular metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031323> <http://purl.obolibrary.org/obo/GO_0019222>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031323> <http://purl.obolibrary.org/obo/GO_0050794>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031323> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0044237>))
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0100001> <http://purl.obolibrary.org/obo/GO_0031323> "GO:0019222")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0031323> "obsolete regulation of cellular metabolic process")
+AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0031323> "true"^^xsd:boolean)
 
-# Class: <http://purl.obolibrary.org/obo/GO_0031324> (negative regulation of cellular metabolic process)
+# Class: <http://purl.obolibrary.org/obo/GO_0031324> (obsolete negative regulation of cellular metabolic process)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0031324> "negative regulation of cellular metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031324> <http://purl.obolibrary.org/obo/GO_0009892>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031324> <http://purl.obolibrary.org/obo/GO_0031323>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031324> <http://purl.obolibrary.org/obo/GO_0048523>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031324> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0044237>))
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0100001> <http://purl.obolibrary.org/obo/GO_0031324> "GO:0009892")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0031324> "obsolete negative regulation of cellular metabolic process")
+AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0031324> "true"^^xsd:boolean)
 
-# Class: <http://purl.obolibrary.org/obo/GO_0031325> (positive regulation of cellular metabolic process)
+# Class: <http://purl.obolibrary.org/obo/GO_0031325> (obsolete positive regulation of cellular metabolic process)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0031325> "positive regulation of cellular metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031325> <http://purl.obolibrary.org/obo/GO_0009893>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031325> <http://purl.obolibrary.org/obo/GO_0031323>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031325> <http://purl.obolibrary.org/obo/GO_0048522>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031325> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0044237>))
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0100001> <http://purl.obolibrary.org/obo/GO_0031325> "GO:0009893")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0031325> "obsolete positive regulation of cellular metabolic process")
+AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0031325> "true"^^xsd:boolean)
 
-# Class: <http://purl.obolibrary.org/obo/GO_0031326> (regulation of cellular biosynthetic process)
+# Class: <http://purl.obolibrary.org/obo/GO_0031326> (obsolete regulation of cellular biosynthetic process)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0031326> "regulation of cellular biosynthetic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031326> <http://purl.obolibrary.org/obo/GO_0009889>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031326> <http://purl.obolibrary.org/obo/GO_0031323>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031326> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0044249>))
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0100001> <http://purl.obolibrary.org/obo/GO_0031326> "GO:0009889")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0031326> "obsolete regulation of cellular biosynthetic process")
+AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0031326> "true"^^xsd:boolean)
 
-# Class: <http://purl.obolibrary.org/obo/GO_0031327> (negative regulation of cellular biosynthetic process)
+# Class: <http://purl.obolibrary.org/obo/GO_0031327> (obsolete negative regulation of cellular biosynthetic process)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0031327> "negative regulation of cellular biosynthetic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031327> <http://purl.obolibrary.org/obo/GO_0009890>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031327> <http://purl.obolibrary.org/obo/GO_0031324>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031327> <http://purl.obolibrary.org/obo/GO_0031326>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031327> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0044249>))
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0100001> <http://purl.obolibrary.org/obo/GO_0031327> "GO:0009890")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0031327> "obsolete negative regulation of cellular biosynthetic process")
+AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0031327> "true"^^xsd:boolean)
 
-# Class: <http://purl.obolibrary.org/obo/GO_0031328> (positive regulation of cellular biosynthetic process)
+# Class: <http://purl.obolibrary.org/obo/GO_0031328> (obsolete positive regulation of cellular biosynthetic process)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0031328> "positive regulation of cellular biosynthetic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031328> <http://purl.obolibrary.org/obo/GO_0009891>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031328> <http://purl.obolibrary.org/obo/GO_0031325>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031328> <http://purl.obolibrary.org/obo/GO_0031326>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031328> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0044249>))
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0100001> <http://purl.obolibrary.org/obo/GO_0031328> "GO:0009891")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0031328> "obsolete positive regulation of cellular biosynthetic process")
+AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0031328> "true"^^xsd:boolean)
 
-# Class: <http://purl.obolibrary.org/obo/GO_0031329> (regulation of cellular catabolic process)
+# Class: <http://purl.obolibrary.org/obo/GO_0031329> (obsolete regulation of cellular catabolic process)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0031329> "regulation of cellular catabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031329> <http://purl.obolibrary.org/obo/GO_0009894>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031329> <http://purl.obolibrary.org/obo/GO_0031323>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031329> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0044248>))
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0100001> <http://purl.obolibrary.org/obo/GO_0031329> "GO:0009894")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0031329> "obsolete regulation of cellular catabolic process")
+AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0031329> "true"^^xsd:boolean)
 
-# Class: <http://purl.obolibrary.org/obo/GO_0031330> (negative regulation of cellular catabolic process)
+# Class: <http://purl.obolibrary.org/obo/GO_0031330> (obsolete negative regulation of cellular catabolic process)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0031330> "negative regulation of cellular catabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031330> <http://purl.obolibrary.org/obo/GO_0009895>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031330> <http://purl.obolibrary.org/obo/GO_0031324>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031330> <http://purl.obolibrary.org/obo/GO_0031329>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031330> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0044248>))
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0100001> <http://purl.obolibrary.org/obo/GO_0031330> "GO:0009895")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0031330> "obsolete negative regulation of cellular catabolic process")
+AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0031330> "true"^^xsd:boolean)
 
-# Class: <http://purl.obolibrary.org/obo/GO_0031331> (positive regulation of cellular catabolic process)
+# Class: <http://purl.obolibrary.org/obo/GO_0031331> (obsolete positive regulation of cellular catabolic process)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0031331> "positive regulation of cellular catabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031331> <http://purl.obolibrary.org/obo/GO_0009896>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031331> <http://purl.obolibrary.org/obo/GO_0031325>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031331> <http://purl.obolibrary.org/obo/GO_0031329>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031331> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0044248>))
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0100001> <http://purl.obolibrary.org/obo/GO_0031331> "GO:0009896")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0031331> "obsolete positive regulation of cellular catabolic process")
+AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0031331> "true"^^xsd:boolean)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0031333> (negative regulation of protein-containing complex assembly)
 
@@ -83519,14 +83912,12 @@ AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0031933> "
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0031943> "regulation of glucocorticoid metabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0031943> <http://purl.obolibrary.org/obo/GO_0019218>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031943> <http://purl.obolibrary.org/obo/GO_0031323>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0031943> <http://purl.obolibrary.org/obo/GO_0032350>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0031943> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0008211>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0031944> (negative regulation of glucocorticoid metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0031944> "negative regulation of glucocorticoid metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031944> <http://purl.obolibrary.org/obo/GO_0031324>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0031944> <http://purl.obolibrary.org/obo/GO_0031943>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0031944> <http://purl.obolibrary.org/obo/GO_0032351>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0031944> <http://purl.obolibrary.org/obo/GO_0045939>)
@@ -83535,7 +83926,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0031944> ObjectSomeValuesFrom(<htt
 # Class: <http://purl.obolibrary.org/obo/GO_0031945> (positive regulation of glucocorticoid metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0031945> "positive regulation of glucocorticoid metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0031945> <http://purl.obolibrary.org/obo/GO_0031325>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0031945> <http://purl.obolibrary.org/obo/GO_0031943>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0031945> <http://purl.obolibrary.org/obo/GO_0032352>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0031945> <http://purl.obolibrary.org/obo/GO_0045940>)
@@ -83880,7 +84270,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0032352> ObjectSomeValuesFrom(<htt
 # Class: <http://purl.obolibrary.org/obo/GO_0032353> (negative regulation of hormone biosynthetic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0032353> "negative regulation of hormone biosynthetic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0032353> <http://purl.obolibrary.org/obo/GO_0031327>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0032353> <http://purl.obolibrary.org/obo/GO_0009890>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0032353> <http://purl.obolibrary.org/obo/GO_0032351>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0032353> <http://purl.obolibrary.org/obo/GO_0046885>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0032353> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0042446>))
@@ -85039,6 +85429,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0035229> ObjectSomeValuesFrom(<htt
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0035235> "ionotropic glutamate receptor signaling pathway")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0035235> <http://purl.obolibrary.org/obo/GO_0007215>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0035235> <http://purl.obolibrary.org/obo/GO_1990806>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0035235> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_0004970>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0035239> (tube morphogenesis)
 
@@ -85392,6 +85783,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0040020> ObjectSomeValuesFrom(<htt
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0042030> "ATPase inhibitor activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0042030> <http://purl.obolibrary.org/obo/GO_0060590>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0042030> <http://purl.obolibrary.org/obo/GO_0140678>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0042030> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0140657>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0042044> (fluid transport)
 
@@ -85503,17 +85895,15 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0042158> <http://purl.obolibrary.o
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0042165> "obsolete neurotransmitter binding")
 AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0042165> "true"^^xsd:boolean)
 
-# Class: <http://purl.obolibrary.org/obo/GO_0042180> (cellular ketone metabolic process)
+# Class: <http://purl.obolibrary.org/obo/GO_0042180> (ketone metabolic process)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0042180> "cellular ketone metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0042180> <http://purl.obolibrary.org/obo/GO_0044237>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0042180> <http://purl.obolibrary.org/obo/GO_0044281>)
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0042180> "ketone metabolic process")
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0042180> <http://purl.obolibrary.org/obo/GO_0008152>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0042181> (ketone biosynthetic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0042181> "ketone biosynthetic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0042181> <http://purl.obolibrary.org/obo/GO_0042180>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0042181> <http://purl.obolibrary.org/obo/GO_0044249>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0042181> <http://purl.obolibrary.org/obo/GO_0044283>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0042221> (response to chemical)
@@ -85536,7 +85926,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0042303> <http://purl.obolibrary.o
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0042304> "regulation of fatty acid biosynthetic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0042304> <http://purl.obolibrary.org/obo/GO_0019217>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0042304> <http://purl.obolibrary.org/obo/GO_0031326>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0042304> <http://purl.obolibrary.org/obo/GO_0046890>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0042304> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0006633>))
 
@@ -85625,9 +86014,9 @@ AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0042391> "regu
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0042391> <http://purl.obolibrary.org/obo/GO_0065008>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0042391> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_0034220>))
 
-# Class: <http://purl.obolibrary.org/obo/GO_0042398> (cellular modified amino acid biosynthetic process)
+# Class: <http://purl.obolibrary.org/obo/GO_0042398> (modified amino acid biosynthetic process)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0042398> "cellular modified amino acid biosynthetic process")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0042398> "modified amino acid biosynthetic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0042398> <http://purl.obolibrary.org/obo/GO_0006575>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0042398> <http://purl.obolibrary.org/obo/GO_0009058>)
 
@@ -85962,7 +86351,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0042756> <http://purl.obolibrary.o
 # Class: <http://purl.obolibrary.org/obo/GO_0042762> (regulation of sulfur metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0042762> "regulation of sulfur metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0042762> <http://purl.obolibrary.org/obo/GO_0031323>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0042762> <http://purl.obolibrary.org/obo/GO_0019222>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0042762> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0006790>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0042776> (proton motive force-driven mitochondrial ATP synthesis)
@@ -86222,9 +86611,9 @@ AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0043227> "memb
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0043227> <http://purl.obolibrary.org/obo/GO_0043226>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0043227> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_0016020>))
 
-# Class: <http://purl.obolibrary.org/obo/GO_0043228> (non-membrane-bounded organelle)
+# Class: <http://purl.obolibrary.org/obo/GO_0043228> (membraneless organelle)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0043228> "non-membrane-bounded organelle")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0043228> "membraneless organelle")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0043228> <http://purl.obolibrary.org/obo/GO_0043226>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0043229> (intracellular organelle)
@@ -86245,9 +86634,9 @@ AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0043231> "intr
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0043231> <http://purl.obolibrary.org/obo/GO_0043227>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0043231> <http://purl.obolibrary.org/obo/GO_0043229>)
 
-# Class: <http://purl.obolibrary.org/obo/GO_0043232> (intracellular non-membrane-bounded organelle)
+# Class: <http://purl.obolibrary.org/obo/GO_0043232> (intracellular membraneless organelle)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0043232> "intracellular non-membrane-bounded organelle")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0043232> "intracellular membraneless organelle")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0043232> <http://purl.obolibrary.org/obo/GO_0043228>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0043232> <http://purl.obolibrary.org/obo/GO_0043229>)
 
@@ -86301,9 +86690,9 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0043255> <http://purl.obolibrary.o
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0043255> <http://purl.obolibrary.org/obo/GO_0009889>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0043255> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0016051>))
 
-# Class: <http://purl.obolibrary.org/obo/GO_0043264> (extracellular non-membrane-bounded organelle)
+# Class: <http://purl.obolibrary.org/obo/GO_0043264> (extracellular membraneless organelle)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0043264> "extracellular non-membrane-bounded organelle")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0043264> "extracellular membraneless organelle")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0043264> <http://purl.obolibrary.org/obo/GO_0043228>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0043264> <http://purl.obolibrary.org/obo/GO_0043230>)
 
@@ -86421,7 +86810,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0043462> ObjectSomeValuesFrom(<htt
 # Class: <http://purl.obolibrary.org/obo/GO_0043467> (regulation of generation of precursor metabolites and energy)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0043467> "regulation of generation of precursor metabolites and energy")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0043467> <http://purl.obolibrary.org/obo/GO_0031323>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0043467> <http://purl.obolibrary.org/obo/GO_0019222>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0043467> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0006091>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0043470> (regulation of carbohydrate catabolic process)
@@ -86459,6 +86848,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0043504> <http://purl.obolibrary.o
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0043539> "protein serine/threonine kinase activator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0043539> <http://purl.obolibrary.org/obo/GO_0030295>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0043539> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0004674>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0043549> (regulation of kinase activity)
 
@@ -86684,11 +87074,11 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0044149> ObjectSomeValuesFrom(<htt
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0100001> <http://purl.obolibrary.org/obo/GO_0044212> <http://purl.obolibrary.org/obo/GO_0000976>)
 AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0044212> "true"^^xsd:boolean)
 
-# Class: <http://purl.obolibrary.org/obo/GO_0044237> (cellular metabolic process)
+# Class: <http://purl.obolibrary.org/obo/GO_0044237> (obsolete cellular metabolic process)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0044237> "cellular metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0044237> <http://purl.obolibrary.org/obo/GO_0008152>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0044237> <http://purl.obolibrary.org/obo/GO_0009987>)
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0100001> <http://purl.obolibrary.org/obo/GO_0044237> "GO:0008152")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0044237> "obsolete cellular metabolic process")
+AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0044237> "true"^^xsd:boolean)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0044238> (primary metabolic process)
 
@@ -86705,19 +87095,18 @@ AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0044247> "
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0044248> "cellular catabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0044248> <http://purl.obolibrary.org/obo/GO_0009056>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0044248> <http://purl.obolibrary.org/obo/GO_0044237>)
 
-# Class: <http://purl.obolibrary.org/obo/GO_0044249> (cellular biosynthetic process)
+# Class: <http://purl.obolibrary.org/obo/GO_0044249> (obsolete cellular biosynthetic process)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0044249> "cellular biosynthetic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0044249> <http://purl.obolibrary.org/obo/GO_0009058>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0044249> <http://purl.obolibrary.org/obo/GO_0044237>)
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0100001> <http://purl.obolibrary.org/obo/GO_0044249> "GO:0009058")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0044249> "obsolete cellular biosynthetic process")
+AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0044249> "true"^^xsd:boolean)
 
-# Class: <http://purl.obolibrary.org/obo/GO_0044255> (cellular lipid metabolic process)
+# Class: <http://purl.obolibrary.org/obo/GO_0044255> (obsolete cellular lipid metabolic process)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0044255> "cellular lipid metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0044255> <http://purl.obolibrary.org/obo/GO_0006629>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0044255> <http://purl.obolibrary.org/obo/GO_0044237>)
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0100001> <http://purl.obolibrary.org/obo/GO_0044255> "GO:0006629")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0044255> "obsolete cellular lipid metabolic process")
+AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0044255> "true"^^xsd:boolean)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0044260> (obsolete cellular macromolecule metabolic process)
 
@@ -86758,7 +87147,7 @@ AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0044271> "
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0044272> "sulfur compound biosynthetic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0044272> <http://purl.obolibrary.org/obo/GO_0006790>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0044272> <http://purl.obolibrary.org/obo/GO_0044249>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0044272> <http://purl.obolibrary.org/obo/GO_0009058>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0044273> (sulfur compound catabolic process)
 
@@ -87011,7 +87400,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0044877> <http://purl.obolibrary.o
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0045017> "glycerolipid biosynthetic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045017> <http://purl.obolibrary.org/obo/GO_0008610>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0045017> <http://purl.obolibrary.org/obo/GO_0044249>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045017> <http://purl.obolibrary.org/obo/GO_0046486>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0045026> (plasma membrane fusion)
@@ -87688,7 +88076,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0045702> ObjectSomeValuesFrom(<htt
 # Class: <http://purl.obolibrary.org/obo/GO_0045717> (negative regulation of fatty acid biosynthetic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0045717> "negative regulation of fatty acid biosynthetic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0045717> <http://purl.obolibrary.org/obo/GO_0031327>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045717> <http://purl.obolibrary.org/obo/GO_0042304>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045717> <http://purl.obolibrary.org/obo/GO_0045922>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045717> <http://purl.obolibrary.org/obo/GO_0051055>)
@@ -87706,7 +88093,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0045719> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0045721> "negative regulation of gluconeogenesis")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045721> <http://purl.obolibrary.org/obo/GO_0006111>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0045721> <http://purl.obolibrary.org/obo/GO_0031327>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0045721> <http://purl.obolibrary.org/obo/GO_0009890>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045721> <http://purl.obolibrary.org/obo/GO_0045912>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045721> <http://purl.obolibrary.org/obo/GO_0062014>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045721> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0006094>))
@@ -87715,14 +88102,13 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0045721> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0045722> "positive regulation of gluconeogenesis")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045722> <http://purl.obolibrary.org/obo/GO_0006111>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0045722> <http://purl.obolibrary.org/obo/GO_0009891>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045722> <http://purl.obolibrary.org/obo/GO_0010907>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0045722> <http://purl.obolibrary.org/obo/GO_0031328>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045722> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0006094>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0045723> (positive regulation of fatty acid biosynthetic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0045723> "positive regulation of fatty acid biosynthetic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0045723> <http://purl.obolibrary.org/obo/GO_0031328>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045723> <http://purl.obolibrary.org/obo/GO_0042304>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045723> <http://purl.obolibrary.org/obo/GO_0045923>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045723> <http://purl.obolibrary.org/obo/GO_0046889>)
@@ -87756,7 +88142,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0045727> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0045738> "negative regulation of DNA repair")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045738> <http://purl.obolibrary.org/obo/GO_0006282>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0045738> <http://purl.obolibrary.org/obo/GO_0048523>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045738> <http://purl.obolibrary.org/obo/GO_0048585>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045738> <http://purl.obolibrary.org/obo/GO_0051053>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045738> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0006281>))
@@ -87765,7 +88150,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0045738> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0045739> "positive regulation of DNA repair")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045739> <http://purl.obolibrary.org/obo/GO_0006282>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0045739> <http://purl.obolibrary.org/obo/GO_0048522>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045739> <http://purl.obolibrary.org/obo/GO_0048584>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045739> <http://purl.obolibrary.org/obo/GO_0051054>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045739> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0006281>))
@@ -87784,18 +88168,18 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0045760> <http://purl.obolibrary.o
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045760> <http://purl.obolibrary.org/obo/GO_0098900>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045760> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0001508>))
 
-# Class: <http://purl.obolibrary.org/obo/GO_0045763> (negative regulation of cellular amino acid metabolic process)
+# Class: <http://purl.obolibrary.org/obo/GO_0045763> (negative regulation of amino acid metabolic process)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0045763> "negative regulation of cellular amino acid metabolic process")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0045763> "negative regulation of amino acid metabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045763> <http://purl.obolibrary.org/obo/GO_0006521>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0045763> <http://purl.obolibrary.org/obo/GO_0033239>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0045763> <http://purl.obolibrary.org/obo/GO_0009892>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045763> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0006520>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0045764> (positive regulation of amino acid metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0045764> "positive regulation of amino acid metabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045764> <http://purl.obolibrary.org/obo/GO_0006521>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0045764> <http://purl.obolibrary.org/obo/GO_0033240>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0045764> <http://purl.obolibrary.org/obo/GO_0009893>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045764> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0006520>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0045765> (regulation of angiogenesis)
@@ -87874,7 +88258,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0045807> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0045818> "negative regulation of glycogen catabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045818> <http://purl.obolibrary.org/obo/GO_0005981>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0045818> <http://purl.obolibrary.org/obo/GO_0031330>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0045818> <http://purl.obolibrary.org/obo/GO_0009895>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045818> <http://purl.obolibrary.org/obo/GO_0070874>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045818> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0005980>))
 
@@ -87882,7 +88266,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0045818> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0045819> "positive regulation of glycogen catabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045819> <http://purl.obolibrary.org/obo/GO_0005981>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0045819> <http://purl.obolibrary.org/obo/GO_0031331>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0045819> <http://purl.obolibrary.org/obo/GO_0009896>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045819> <http://purl.obolibrary.org/obo/GO_0070875>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045819> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0005980>))
 
@@ -87899,7 +88283,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0045820> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0045821> "positive regulation of glycolytic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045821> <http://purl.obolibrary.org/obo/GO_0006110>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0045821> <http://purl.obolibrary.org/obo/GO_0031331>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045821> <http://purl.obolibrary.org/obo/GO_0033123>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045821> <http://purl.obolibrary.org/obo/GO_0045913>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045821> <http://purl.obolibrary.org/obo/GO_1903580>)
@@ -87933,7 +88316,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0045824> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0045827> "negative regulation of isoprenoid metabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045827> <http://purl.obolibrary.org/obo/GO_0019747>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0045827> <http://purl.obolibrary.org/obo/GO_0031324>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045827> <http://purl.obolibrary.org/obo/GO_0045833>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045827> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0006720>))
 
@@ -87941,7 +88323,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0045827> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0045828> "positive regulation of isoprenoid metabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045828> <http://purl.obolibrary.org/obo/GO_0019747>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0045828> <http://purl.obolibrary.org/obo/GO_0031325>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045828> <http://purl.obolibrary.org/obo/GO_0045834>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045828> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0006720>))
 
@@ -88209,7 +88590,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0045921> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0045922> "negative regulation of fatty acid metabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045922> <http://purl.obolibrary.org/obo/GO_0019217>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0045922> <http://purl.obolibrary.org/obo/GO_0031324>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045922> <http://purl.obolibrary.org/obo/GO_0045833>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045922> <http://purl.obolibrary.org/obo/GO_0062014>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045922> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0006631>))
@@ -88218,7 +88598,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0045922> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0045923> "positive regulation of fatty acid metabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045923> <http://purl.obolibrary.org/obo/GO_0019217>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0045923> <http://purl.obolibrary.org/obo/GO_0031325>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045923> <http://purl.obolibrary.org/obo/GO_0045834>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045923> <http://purl.obolibrary.org/obo/GO_0062013>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0045923> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0006631>))
@@ -88587,7 +88966,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0046434> <http://purl.obolibrary.o
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0046467> "membrane lipid biosynthetic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0046467> <http://purl.obolibrary.org/obo/GO_0006643>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0046467> <http://purl.obolibrary.org/obo/GO_0008610>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0046467> <http://purl.obolibrary.org/obo/GO_0044249>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0046474> (glycerophospholipid biosynthetic process)
 
@@ -88605,13 +88983,13 @@ AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0046483> "
 # Class: <http://purl.obolibrary.org/obo/GO_0046485> (ether lipid metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0046485> "ether lipid metabolic process")
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0046485> <http://purl.obolibrary.org/obo/GO_0006629>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0046485> <http://purl.obolibrary.org/obo/GO_0006662>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0046485> <http://purl.obolibrary.org/obo/GO_0044255>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0046486> (glycerolipid metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0046486> "glycerolipid metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0046486> <http://purl.obolibrary.org/obo/GO_0044255>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0046486> <http://purl.obolibrary.org/obo/GO_0006629>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0046488> (phosphatidylinositol metabolic process)
 
@@ -88627,7 +89005,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0046496> <http://purl.obolibrary.o
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0046504> "glycerol ether biosynthetic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0046504> <http://purl.obolibrary.org/obo/GO_0006662>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0046504> <http://purl.obolibrary.org/obo/GO_0044249>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0046504> <http://purl.obolibrary.org/obo/GO_1901503>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0046541> (saliva secretion)
@@ -88801,14 +89178,14 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0046883> ObjectSomeValuesFrom(<htt
 # Class: <http://purl.obolibrary.org/obo/GO_0046885> (regulation of hormone biosynthetic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0046885> "regulation of hormone biosynthetic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0046885> <http://purl.obolibrary.org/obo/GO_0031326>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0046885> <http://purl.obolibrary.org/obo/GO_0009889>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0046885> <http://purl.obolibrary.org/obo/GO_0032350>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0046885> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0042446>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0046886> (positive regulation of hormone biosynthetic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0046886> "positive regulation of hormone biosynthetic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0046886> <http://purl.obolibrary.org/obo/GO_0031328>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0046886> <http://purl.obolibrary.org/obo/GO_0009891>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0046886> <http://purl.obolibrary.org/obo/GO_0032352>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0046886> <http://purl.obolibrary.org/obo/GO_0046885>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0046886> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0042446>))
@@ -88910,27 +89287,23 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0046943> <http://purl.obolibrary.o
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0046943> <http://purl.obolibrary.org/obo/GO_0008514>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0046943> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/GO_1905039>))
 
-# Class: <http://purl.obolibrary.org/obo/GO_0046950> (cellular ketone body metabolic process)
+# Class: <http://purl.obolibrary.org/obo/GO_0046950> (obsolete cellular ketone body metabolic process)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0046950> "cellular ketone body metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0046950> <http://purl.obolibrary.org/obo/GO_0044237>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0046950> <http://purl.obolibrary.org/obo/GO_0044281>)
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0100001> <http://purl.obolibrary.org/obo/GO_0046950> "GO:1902224")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0046950> "obsolete cellular ketone body metabolic process")
+AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0046950> "true"^^xsd:boolean)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0046951> (ketone body biosynthetic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0046951> "ketone body biosynthetic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0046951> <http://purl.obolibrary.org/obo/GO_0044249>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0046951> <http://purl.obolibrary.org/obo/GO_0044283>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0046951> <http://purl.obolibrary.org/obo/GO_0046950>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0046951> <http://purl.obolibrary.org/obo/GO_1901570>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0046951> <http://purl.obolibrary.org/obo/GO_1902224>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0046952> (ketone body catabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0046952> "ketone body catabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0046952> <http://purl.obolibrary.org/obo/GO_0044248>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0046952> <http://purl.obolibrary.org/obo/GO_0044282>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0046952> <http://purl.obolibrary.org/obo/GO_0046950>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0046952> <http://purl.obolibrary.org/obo/GO_1901569>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0046952> <http://purl.obolibrary.org/obo/GO_1902224>)
 
@@ -88975,7 +89348,6 @@ AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0048018> "rece
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0048018> <http://purl.obolibrary.org/obo/GO_0005102>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0048018> <http://purl.obolibrary.org/obo/GO_0030546>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0048018> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/GO_0007165>))
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0048018> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0038023>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0048103> (somatic stem cell division)
 
@@ -89656,14 +90028,13 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0050729> ObjectSomeValuesFrom(<htt
 # Class: <http://purl.obolibrary.org/obo/GO_0050746> (regulation of lipoprotein metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0050746> "regulation of lipoprotein metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0050746> <http://purl.obolibrary.org/obo/GO_0031323>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0050746> <http://purl.obolibrary.org/obo/GO_0051246>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0050746> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0042157>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0050747> (positive regulation of lipoprotein metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0050747> "positive regulation of lipoprotein metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0050747> <http://purl.obolibrary.org/obo/GO_0031328>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0050747> <http://purl.obolibrary.org/obo/GO_0009891>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0050747> <http://purl.obolibrary.org/obo/GO_0050746>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0050747> <http://purl.obolibrary.org/obo/GO_0051247>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0050747> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0042157>))
@@ -89671,7 +90042,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0050747> ObjectSomeValuesFrom(<htt
 # Class: <http://purl.obolibrary.org/obo/GO_0050748> (negative regulation of lipoprotein metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0050748> "negative regulation of lipoprotein metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0050748> <http://purl.obolibrary.org/obo/GO_0031324>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0050748> <http://purl.obolibrary.org/obo/GO_0050746>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0050748> <http://purl.obolibrary.org/obo/GO_0051248>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0050748> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0042157>))
@@ -90464,20 +90834,20 @@ AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0051173> "
 # Class: <http://purl.obolibrary.org/obo/GO_0051174> (regulation of phosphorus metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0051174> "regulation of phosphorus metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0051174> <http://purl.obolibrary.org/obo/GO_0031323>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0051174> <http://purl.obolibrary.org/obo/GO_0019222>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0051174> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0006793>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0051175> (negative regulation of sulfur metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0051175> "negative regulation of sulfur metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0051175> <http://purl.obolibrary.org/obo/GO_0031324>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0051175> <http://purl.obolibrary.org/obo/GO_0009892>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0051175> <http://purl.obolibrary.org/obo/GO_0042762>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0051175> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0006790>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0051176> (positive regulation of sulfur metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0051176> "positive regulation of sulfur metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0051176> <http://purl.obolibrary.org/obo/GO_0031325>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0051176> <http://purl.obolibrary.org/obo/GO_0009893>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0051176> <http://purl.obolibrary.org/obo/GO_0042762>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0051176> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0006790>))
 
@@ -91453,6 +91823,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0055092> <http://purl.obolibrary.o
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0055103> "ligase regulator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0055103> <http://purl.obolibrary.org/obo/GO_0030234>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0055103> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0016874>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0055114> (obsolete oxidation-reduction process)
 
@@ -91689,6 +92060,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0060271> <http://purl.obolibrary.o
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0060271> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_0035082>))
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0060271> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_0035735>))
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0060271> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_0061512>))
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0060271> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_0097711>))
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0060271> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_0097712>))
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0060271> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_1905349>))
 
@@ -91923,7 +92295,6 @@ AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0060548> "
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0060556> "regulation of vitamin D biosynthetic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0060556> <http://purl.obolibrary.org/obo/GO_0030656>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0060556> <http://purl.obolibrary.org/obo/GO_0031326>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0060556> <http://purl.obolibrary.org/obo/GO_0050810>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0060556> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0042368>))
 
@@ -91931,7 +92302,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0060556> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0060557> "positive regulation of vitamin D biosynthetic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0060557> <http://purl.obolibrary.org/obo/GO_0010893>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0060557> <http://purl.obolibrary.org/obo/GO_0031328>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0060557> <http://purl.obolibrary.org/obo/GO_0046136>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0060557> <http://purl.obolibrary.org/obo/GO_0060556>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0060557> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0042368>))
@@ -91958,11 +92328,13 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0060562> <http://purl.obolibrary.o
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0060589> "nucleoside-triphosphatase regulator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0060589> <http://purl.obolibrary.org/obo/GO_0030234>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0060589> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0017111>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0060590> (ATPase regulator activity)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0060590> "ATPase regulator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0060590> <http://purl.obolibrary.org/obo/GO_0098772>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0060590> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0140657>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0060591> (chondroblast differentiation)
 
@@ -92178,17 +92550,20 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0061064> ObjectSomeValuesFrom(<htt
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0061133> "endopeptidase activator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0061133> <http://purl.obolibrary.org/obo/GO_0016504>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0061133> <http://purl.obolibrary.org/obo/GO_0061135>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0061133> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0004175>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0061134> (peptidase regulator activity)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0061134> "peptidase regulator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0061134> <http://purl.obolibrary.org/obo/GO_0030234>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0061134> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/GO_0002020>))
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0061134> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0008233>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0061135> (endopeptidase regulator activity)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0061135> "endopeptidase regulator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0061135> <http://purl.obolibrary.org/obo/GO_0061134>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0061135> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0004175>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0061138> (morphogenesis of a branching epithelium)
 
@@ -92758,7 +93133,6 @@ AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0070838> "
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0070857> "regulation of bile acid biosynthetic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0070857> <http://purl.obolibrary.org/obo/GO_0010565>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0070857> <http://purl.obolibrary.org/obo/GO_0031326>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0070857> <http://purl.obolibrary.org/obo/GO_0050810>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0070857> <http://purl.obolibrary.org/obo/GO_1904251>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0070857> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0006699>))
@@ -92767,7 +93141,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0070857> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0070858> "negative regulation of bile acid biosynthetic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0070858> <http://purl.obolibrary.org/obo/GO_0010894>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0070858> <http://purl.obolibrary.org/obo/GO_0031327>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0070858> <http://purl.obolibrary.org/obo/GO_0070857>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0070858> <http://purl.obolibrary.org/obo/GO_1904252>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0070858> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0006699>))
@@ -92776,7 +93149,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0070858> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0070859> "positive regulation of bile acid biosynthetic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0070859> <http://purl.obolibrary.org/obo/GO_0010893>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0070859> <http://purl.obolibrary.org/obo/GO_0031328>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0070859> <http://purl.obolibrary.org/obo/GO_0070857>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0070859> <http://purl.obolibrary.org/obo/GO_1904253>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0070859> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0006699>))
@@ -92792,7 +93164,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0070873> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0070874> "negative regulation of glycogen metabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0070874> <http://purl.obolibrary.org/obo/GO_0010605>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0070874> <http://purl.obolibrary.org/obo/GO_0031324>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0070874> <http://purl.obolibrary.org/obo/GO_0045912>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0070874> <http://purl.obolibrary.org/obo/GO_0070873>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0070874> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0005977>))
@@ -92802,7 +93173,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0070874> ObjectSomeValuesFrom(<htt
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0070875> "positive regulation of glycogen metabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0070875> <http://purl.obolibrary.org/obo/GO_0010604>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0070875> <http://purl.obolibrary.org/obo/GO_0010907>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0070875> <http://purl.obolibrary.org/obo/GO_0031325>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0070875> <http://purl.obolibrary.org/obo/GO_0070873>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0070875> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0005977>))
 
@@ -93452,7 +93822,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0090153> ObjectSomeValuesFrom(<htt
 # Class: <http://purl.obolibrary.org/obo/GO_0090154> (positive regulation of sphingolipid biosynthetic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0090154> "positive regulation of sphingolipid biosynthetic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0090154> <http://purl.obolibrary.org/obo/GO_0031328>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0090154> <http://purl.obolibrary.org/obo/GO_0046889>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0090154> <http://purl.obolibrary.org/obo/GO_0090153>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0090154> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0030148>))
@@ -93460,7 +93829,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0090154> ObjectSomeValuesFrom(<htt
 # Class: <http://purl.obolibrary.org/obo/GO_0090155> (negative regulation of sphingolipid biosynthetic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0090155> "negative regulation of sphingolipid biosynthetic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0090155> <http://purl.obolibrary.org/obo/GO_0031327>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0090155> <http://purl.obolibrary.org/obo/GO_0051055>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0090155> <http://purl.obolibrary.org/obo/GO_0090153>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0090155> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0030148>))
@@ -93630,12 +93998,14 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0090327> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0090357> "regulation of tryptophan metabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0090357> <http://purl.obolibrary.org/obo/GO_0006521>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0090357> <http://purl.obolibrary.org/obo/GO_0033238>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0090357> <http://purl.obolibrary.org/obo/GO_0062012>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0090357> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0006568>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0090358> (positive regulation of tryptophan metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0090358> "positive regulation of tryptophan metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0090358> <http://purl.obolibrary.org/obo/GO_0031325>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0090358> <http://purl.obolibrary.org/obo/GO_0033240>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0090358> <http://purl.obolibrary.org/obo/GO_0045764>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0090358> <http://purl.obolibrary.org/obo/GO_0062013>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0090358> <http://purl.obolibrary.org/obo/GO_0090357>)
@@ -93645,6 +94015,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0090358> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0090368> "regulation of ornithine metabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0090368> <http://purl.obolibrary.org/obo/GO_0006521>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0090368> <http://purl.obolibrary.org/obo/GO_0062012>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0090368> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0006591>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0090394> (negative regulation of excitatory postsynaptic potential)
@@ -93767,11 +94138,11 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0097254> <http://purl.obolibrary.o
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0097325> "melanocyte proliferation")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0097325> <http://purl.obolibrary.org/obo/GO_0050673>)
 
-# Class: <http://purl.obolibrary.org/obo/GO_0097384> (cellular lipid biosynthetic process)
+# Class: <http://purl.obolibrary.org/obo/GO_0097384> (obsolete cellular lipid biosynthetic process)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0097384> "cellular lipid biosynthetic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0097384> <http://purl.obolibrary.org/obo/GO_0008610>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_0097384> <http://purl.obolibrary.org/obo/GO_0044255>)
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0100001> <http://purl.obolibrary.org/obo/GO_0097384> "GO:0008610")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0097384> "obsolete cellular lipid biosynthetic process")
+AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0097384> "true"^^xsd:boolean)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0097447> (dendritic tree)
 
@@ -93848,6 +94219,7 @@ AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0097689> "
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0097690> "iron ion transmembrane transporter inhibitor activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0097690> <http://purl.obolibrary.org/obo/GO_0141110>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0097690> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0005381>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0097708> (intracellular vesicle)
 
@@ -94270,11 +94642,13 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0099094> <http://purl.obolibrary.o
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0099103> "channel activator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0099103> <http://purl.obolibrary.org/obo/GO_0016247>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0099103> <http://purl.obolibrary.org/obo/GO_0141109>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0099103> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0015267>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0099106> (ion channel regulator activity)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0099106> "ion channel regulator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0099106> <http://purl.obolibrary.org/obo/GO_0016247>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0099106> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0005216>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0099111> (microtubule-based transport)
 
@@ -94471,6 +94845,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0099601> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0099602> "neurotransmitter receptor regulator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0099602> <http://purl.obolibrary.org/obo/GO_0030545>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0099602> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0030594>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0099643> (signal release from synapse)
 
@@ -94559,9 +94934,9 @@ AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0100036> "
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0100051> "obsolete positive regulation of meiotic nuclear division by transcription from RNA polymerase II promoter")
 AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0100051> "true"^^xsd:boolean)
 
-# Class: <http://purl.obolibrary.org/obo/GO_0100070> (obsolete obsolete regulation of fatty acid biosynthetic process by transcription from RNA polymerase II promoter)
+# Class: <http://purl.obolibrary.org/obo/GO_0100070> (obsolete regulation of fatty acid biosynthetic process by transcription from RNA polymerase II promoter)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0100070> "obsolete obsolete regulation of fatty acid biosynthetic process by transcription from RNA polymerase II promoter")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0100070> "obsolete regulation of fatty acid biosynthetic process by transcription from RNA polymerase II promoter")
 AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0100070> "true"^^xsd:boolean)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0102175> (3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity)
@@ -94656,9 +95031,9 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0110111> <http://purl.obolibrary.o
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0110111> <http://purl.obolibrary.org/obo/GO_2000027>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0110111> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0009887>))
 
-# Class: <http://purl.obolibrary.org/obo/GO_0110165> (cellular anatomical entity)
+# Class: <http://purl.obolibrary.org/obo/GO_0110165> (cellular anatomical structure)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0110165> "cellular anatomical entity")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0110165> "cellular anatomical structure")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0110165> <http://purl.obolibrary.org/obo/GO_0005575>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_0120025> (plasma membrane bounded cell projection)
@@ -94917,6 +95292,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0140375> <http://purl.obolibrary.o
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0140416> "transcription regulator inhibitor activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0140416> <http://purl.obolibrary.org/obo/GO_0140678>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0140416> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/GO_0010468>))
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0140416> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0140110>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0140513> (nuclear protein-containing complex)
 
@@ -94929,6 +95305,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0140513> ObjectSomeValuesFrom(<htt
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0140537> "transcription regulator activator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0140537> <http://purl.obolibrary.org/obo/GO_0140677>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0140537> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/GO_0010468>))
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0140537> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0140110>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0140546> (defense response to symbiont)
 
@@ -94945,6 +95322,7 @@ AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_0140603> "
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0140631> "aldehyde dehydrogenase (NAD+) inhibitor activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0140631> <http://purl.obolibrary.org/obo/GO_0004857>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0140631> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0004029>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0140657> (ATP-dependent activity)
 
@@ -94972,18 +95350,21 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_0140962> <http://purl.obolibrary.o
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0141108> "transporter regulator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0141108> <http://purl.obolibrary.org/obo/GO_0098772>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0141108> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0005215>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0141109> (transporter activator activity)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0141109> "transporter activator activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0141109> <http://purl.obolibrary.org/obo/GO_0140677>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0141109> <http://purl.obolibrary.org/obo/GO_0141108>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0141109> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0005215>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0141110> (transporter inhibitor activity)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_0141110> "transporter inhibitor activity")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0141110> <http://purl.obolibrary.org/obo/GO_0140678>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_0141110> <http://purl.obolibrary.org/obo/GO_0141108>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_0141110> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0005215>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_0141124> (intracellular signaling cassette)
 
@@ -95387,24 +95768,24 @@ AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_1900413> "
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_1900418> "obsolete positive regulation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter")
 AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_1900418> "true"^^xsd:boolean)
 
-# Class: <http://purl.obolibrary.org/obo/GO_1900419> (regulation of cellular alcohol catabolic process)
+# Class: <http://purl.obolibrary.org/obo/GO_1900419> (regulation of alcohol catabolic process)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_1900419> "regulation of cellular alcohol catabolic process")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_1900419> "regulation of alcohol catabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1900419> <http://purl.obolibrary.org/obo/GO_0009894>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1900419> <http://purl.obolibrary.org/obo/GO_0062012>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1900419> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0046164>))
 
-# Class: <http://purl.obolibrary.org/obo/GO_1900420> (negative regulation of cellular alcohol catabolic process)
+# Class: <http://purl.obolibrary.org/obo/GO_1900420> (negative regulation of alcohol catabolic process)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_1900420> "negative regulation of cellular alcohol catabolic process")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_1900420> "negative regulation of alcohol catabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1900420> <http://purl.obolibrary.org/obo/GO_0009895>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1900420> <http://purl.obolibrary.org/obo/GO_0062014>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1900420> <http://purl.obolibrary.org/obo/GO_1900419>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1900420> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0046164>))
 
-# Class: <http://purl.obolibrary.org/obo/GO_1900421> (positive regulation of cellular alcohol catabolic process)
+# Class: <http://purl.obolibrary.org/obo/GO_1900421> (positive regulation of alcohol catabolic process)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_1900421> "positive regulation of cellular alcohol catabolic process")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_1900421> "positive regulation of alcohol catabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1900421> <http://purl.obolibrary.org/obo/GO_0009896>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1900421> <http://purl.obolibrary.org/obo/GO_0062013>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1900421> <http://purl.obolibrary.org/obo/GO_1900419>)
@@ -95848,13 +96229,14 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_1901706> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_1901715> "regulation of gamma-aminobutyric acid catabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1901715> <http://purl.obolibrary.org/obo/GO_0006521>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_1901715> <http://purl.obolibrary.org/obo/GO_0031329>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_1901715> <http://purl.obolibrary.org/obo/GO_0009894>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_1901715> <http://purl.obolibrary.org/obo/GO_0062012>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1901715> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0009450>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_1901716> (negative regulation of gamma-aminobutyric acid catabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_1901716> "negative regulation of gamma-aminobutyric acid catabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_1901716> <http://purl.obolibrary.org/obo/GO_0031330>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_1901716> <http://purl.obolibrary.org/obo/GO_0009895>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1901716> <http://purl.obolibrary.org/obo/GO_0045763>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1901716> <http://purl.obolibrary.org/obo/GO_0062014>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1901716> <http://purl.obolibrary.org/obo/GO_1901715>)
@@ -95863,7 +96245,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_1901716> ObjectSomeValuesFrom(<htt
 # Class: <http://purl.obolibrary.org/obo/GO_1901717> (positive regulation of gamma-aminobutyric acid catabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_1901717> "positive regulation of gamma-aminobutyric acid catabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_1901717> <http://purl.obolibrary.org/obo/GO_0031331>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_1901717> <http://purl.obolibrary.org/obo/GO_0009896>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1901717> <http://purl.obolibrary.org/obo/GO_0045764>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1901717> <http://purl.obolibrary.org/obo/GO_0062013>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1901717> <http://purl.obolibrary.org/obo/GO_1901715>)
@@ -95879,14 +96261,14 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_1901738> ObjectSomeValuesFrom(<htt
 # Class: <http://purl.obolibrary.org/obo/GO_1901856> (negative regulation of cellular respiration)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_1901856> "negative regulation of cellular respiration")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_1901856> <http://purl.obolibrary.org/obo/GO_0031324>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_1901856> <http://purl.obolibrary.org/obo/GO_0009892>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1901856> <http://purl.obolibrary.org/obo/GO_0043457>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1901856> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0045333>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_1901857> (positive regulation of cellular respiration)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_1901857> "positive regulation of cellular respiration")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_1901857> <http://purl.obolibrary.org/obo/GO_0031325>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_1901857> <http://purl.obolibrary.org/obo/GO_0009893>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1901857> <http://purl.obolibrary.org/obo/GO_0043457>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1901857> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0045333>))
 
@@ -96051,6 +96433,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_1902222> <http://purl.obolibrary.o
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_1902224> "ketone body metabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1902224> <http://purl.obolibrary.org/obo/GO_0006091>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_1902224> <http://purl.obolibrary.org/obo/GO_0044281>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1902224> <http://purl.obolibrary.org/obo/GO_1901568>)
 
 # Class: <http://purl.obolibrary.org/obo/GO_1902262> (apoptotic process involved in blood vessel morphogenesis)
@@ -96967,7 +97350,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_1903781> ObjectSomeValuesFrom(<htt
 # Class: <http://purl.obolibrary.org/obo/GO_1903786> (regulation of glutathione biosynthetic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_1903786> "regulation of glutathione biosynthetic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_1903786> <http://purl.obolibrary.org/obo/GO_0031326>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_1903786> <http://purl.obolibrary.org/obo/GO_0009889>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1903786> <http://purl.obolibrary.org/obo/GO_0034248>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1903786> <http://purl.obolibrary.org/obo/GO_0042762>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1903786> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0006750>))
@@ -96975,7 +97358,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_1903786> ObjectSomeValuesFrom(<htt
 # Class: <http://purl.obolibrary.org/obo/GO_1903787> (negative regulation of glutathione biosynthetic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_1903787> "negative regulation of glutathione biosynthetic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_1903787> <http://purl.obolibrary.org/obo/GO_0031327>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_1903787> <http://purl.obolibrary.org/obo/GO_0009890>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1903787> <http://purl.obolibrary.org/obo/GO_0034249>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1903787> <http://purl.obolibrary.org/obo/GO_0051175>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1903787> <http://purl.obolibrary.org/obo/GO_1903786>)
@@ -96984,7 +97367,7 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_1903787> ObjectSomeValuesFrom(<htt
 # Class: <http://purl.obolibrary.org/obo/GO_1903788> (positive regulation of glutathione biosynthetic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_1903788> "positive regulation of glutathione biosynthetic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_1903788> <http://purl.obolibrary.org/obo/GO_0031328>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_1903788> <http://purl.obolibrary.org/obo/GO_0009891>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1903788> <http://purl.obolibrary.org/obo/GO_0034250>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1903788> <http://purl.obolibrary.org/obo/GO_0051176>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1903788> <http://purl.obolibrary.org/obo/GO_1903786>)
@@ -97276,14 +97659,12 @@ AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_1904228> "
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_1904251> "regulation of bile acid metabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1904251> <http://purl.obolibrary.org/obo/GO_0019218>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_1904251> <http://purl.obolibrary.org/obo/GO_0031323>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1904251> <http://purl.obolibrary.org/obo/GO_0062012>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1904251> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0008206>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_1904252> (negative regulation of bile acid metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_1904252> "negative regulation of bile acid metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_1904252> <http://purl.obolibrary.org/obo/GO_0031324>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1904252> <http://purl.obolibrary.org/obo/GO_0045939>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1904252> <http://purl.obolibrary.org/obo/GO_0062014>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1904252> <http://purl.obolibrary.org/obo/GO_1904251>)
@@ -97292,7 +97673,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_1904252> ObjectSomeValuesFrom(<htt
 # Class: <http://purl.obolibrary.org/obo/GO_1904253> (positive regulation of bile acid metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_1904253> "positive regulation of bile acid metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_1904253> <http://purl.obolibrary.org/obo/GO_0031325>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1904253> <http://purl.obolibrary.org/obo/GO_0045940>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1904253> <http://purl.obolibrary.org/obo/GO_0062013>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1904253> <http://purl.obolibrary.org/obo/GO_1904251>)
@@ -97305,13 +97685,10 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_1904254> <http://purl.obolibrary.o
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1904254> <http://purl.obolibrary.org/obo/GO_0034759>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1904254> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0005381>))
 
-# Class: <http://purl.obolibrary.org/obo/GO_1904255> (negative regulation of iron ion transmembrane transporter activity)
+# Class: <http://purl.obolibrary.org/obo/GO_1904255> (obsolete negative regulation of iron ion transmembrane transporter activity)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_1904255> "negative regulation of iron ion transmembrane transporter activity")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_1904255> <http://purl.obolibrary.org/obo/GO_0032413>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_1904255> <http://purl.obolibrary.org/obo/GO_0034760>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_1904255> <http://purl.obolibrary.org/obo/GO_1904254>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_1904255> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0005381>))
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_1904255> "obsolete negative regulation of iron ion transmembrane transporter activity")
+AnnotationAssertion(owl:deprecated <http://purl.obolibrary.org/obo/GO_1904255> "true"^^xsd:boolean)
 
 # Class: <http://purl.obolibrary.org/obo/GO_1904256> (obsolete positive regulation of iron ion transmembrane transporter activity)
 
@@ -97546,16 +97923,16 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_1904748> ObjectSomeValuesFrom(<htt
 # Class: <http://purl.obolibrary.org/obo/GO_1904774> (negative regulation of ubiquinone biosynthetic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_1904774> "negative regulation of ubiquinone biosynthetic process")
+SubClassOf(<http://purl.obolibrary.org/obo/GO_1904774> <http://purl.obolibrary.org/obo/GO_0009890>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1904774> <http://purl.obolibrary.org/obo/GO_0010795>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_1904774> <http://purl.obolibrary.org/obo/GO_0031327>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1904774> <http://purl.obolibrary.org/obo/GO_0062014>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1904774> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0006744>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_1904775> (positive regulation of ubiquinone biosynthetic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_1904775> "positive regulation of ubiquinone biosynthetic process")
+SubClassOf(<http://purl.obolibrary.org/obo/GO_1904775> <http://purl.obolibrary.org/obo/GO_0009891>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1904775> <http://purl.obolibrary.org/obo/GO_0010795>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_1904775> <http://purl.obolibrary.org/obo/GO_0031328>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1904775> <http://purl.obolibrary.org/obo/GO_0062013>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1904775> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0006744>))
 
@@ -97610,7 +97987,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_1905030> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_1905038> "regulation of membrane lipid metabolic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1905038> <http://purl.obolibrary.org/obo/GO_0019216>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_1905038> <http://purl.obolibrary.org/obo/GO_0031323>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_1905038> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0006643>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_1905039> (carboxylic acid transmembrane transport)
@@ -98183,14 +98559,13 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_2000066> ObjectSomeValuesFrom(<htt
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_2000082> "regulation of L-ascorbic acid biosynthetic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000082> <http://purl.obolibrary.org/obo/GO_0010565>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000082> <http://purl.obolibrary.org/obo/GO_0030656>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_2000082> <http://purl.obolibrary.org/obo/GO_0031326>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000082> <http://purl.obolibrary.org/obo/GO_0043255>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000082> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0019853>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_2000083> (negative regulation of L-ascorbic acid biosynthetic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_2000083> "negative regulation of L-ascorbic acid biosynthetic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_2000083> <http://purl.obolibrary.org/obo/GO_0031327>)
+SubClassOf(<http://purl.obolibrary.org/obo/GO_2000083> <http://purl.obolibrary.org/obo/GO_0009890>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000083> <http://purl.obolibrary.org/obo/GO_0045912>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000083> <http://purl.obolibrary.org/obo/GO_0046137>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000083> <http://purl.obolibrary.org/obo/GO_2000082>)
@@ -98275,7 +98650,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_2000214> ObjectSomeValuesFrom(<htt
 # Class: <http://purl.obolibrary.org/obo/GO_2000215> (negative regulation of proline metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_2000215> "negative regulation of proline metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_2000215> <http://purl.obolibrary.org/obo/GO_0031324>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000215> <http://purl.obolibrary.org/obo/GO_0045763>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000215> <http://purl.obolibrary.org/obo/GO_0062014>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000215> <http://purl.obolibrary.org/obo/GO_2000214>)
@@ -98284,7 +98658,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_2000215> ObjectSomeValuesFrom(<htt
 # Class: <http://purl.obolibrary.org/obo/GO_2000216> (positive regulation of proline metabolic process)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_2000216> "positive regulation of proline metabolic process")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_2000216> <http://purl.obolibrary.org/obo/GO_0031325>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000216> <http://purl.obolibrary.org/obo/GO_0045764>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000216> <http://purl.obolibrary.org/obo/GO_0062013>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000216> <http://purl.obolibrary.org/obo/GO_2000214>)
@@ -98301,7 +98674,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_2000224> ObjectSomeValuesFrom(<htt
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_2000225> "negative regulation of testosterone biosynthetic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000225> <http://purl.obolibrary.org/obo/GO_0010894>)
-SubClassOf(<http://purl.obolibrary.org/obo/GO_2000225> <http://purl.obolibrary.org/obo/GO_0031327>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000225> <http://purl.obolibrary.org/obo/GO_0062014>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000225> <http://purl.obolibrary.org/obo/GO_2000224>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000225> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0061370>))
@@ -98443,9 +98815,9 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_2000273> <http://purl.obolibrary.o
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000273> <http://purl.obolibrary.org/obo/GO_0044093>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000273> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0038023>))
 
-# Class: <http://purl.obolibrary.org/obo/GO_2000282> (regulation of cellular amino acid biosynthetic process)
+# Class: <http://purl.obolibrary.org/obo/GO_2000282> (regulation of amino acid biosynthetic process)
 
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_2000282> "regulation of cellular amino acid biosynthetic process")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_2000282> "regulation of amino acid biosynthetic process")
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000282> <http://purl.obolibrary.org/obo/GO_0006521>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000282> <http://purl.obolibrary.org/obo/GO_0009889>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000282> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0008652>))
@@ -98607,14 +98979,12 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_2000543> ObjectSomeValuesFrom(<htt
 # Class: <http://purl.obolibrary.org/obo/GO_2000609> (regulation of thyroid hormone generation)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_2000609> "regulation of thyroid hormone generation")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_2000609> <http://purl.obolibrary.org/obo/GO_0031323>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000609> <http://purl.obolibrary.org/obo/GO_0032350>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000609> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002211> <http://purl.obolibrary.org/obo/GO_0006590>))
 
 # Class: <http://purl.obolibrary.org/obo/GO_2000610> (negative regulation of thyroid hormone generation)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_2000610> "negative regulation of thyroid hormone generation")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_2000610> <http://purl.obolibrary.org/obo/GO_0031324>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000610> <http://purl.obolibrary.org/obo/GO_0032351>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000610> <http://purl.obolibrary.org/obo/GO_2000609>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000610> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002212> <http://purl.obolibrary.org/obo/GO_0006590>))
@@ -98622,7 +98992,6 @@ SubClassOf(<http://purl.obolibrary.org/obo/GO_2000610> ObjectSomeValuesFrom(<htt
 # Class: <http://purl.obolibrary.org/obo/GO_2000611> (positive regulation of thyroid hormone generation)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/GO_2000611> "positive regulation of thyroid hormone generation")
-SubClassOf(<http://purl.obolibrary.org/obo/GO_2000611> <http://purl.obolibrary.org/obo/GO_0031325>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000611> <http://purl.obolibrary.org/obo/GO_0032352>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000611> <http://purl.obolibrary.org/obo/GO_2000609>)
 SubClassOf(<http://purl.obolibrary.org/obo/GO_2000611> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002213> <http://purl.obolibrary.org/obo/GO_0006590>))
@@ -137034,6 +137403,16 @@ SubClassOf(<http://purl.obolibrary.org/obo/NCBITaxon_9639> <http://purl.obolibra
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCBITaxon_9643> "Ursus americanus")
 SubClassOf(<http://purl.obolibrary.org/obo/NCBITaxon_9643> <http://purl.obolibrary.org/obo/NCBITaxon_9639>)
 
+# Class: <http://purl.obolibrary.org/obo/NCBITaxon_9645> (Ailuropoda)
+
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCBITaxon_9645> "Ailuropoda")
+SubClassOf(<http://purl.obolibrary.org/obo/NCBITaxon_9645> <http://purl.obolibrary.org/obo/NCBITaxon_9632>)
+
+# Class: <http://purl.obolibrary.org/obo/NCBITaxon_9646> (Ailuropoda melanoleuca)
+
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCBITaxon_9646> "Ailuropoda melanoleuca")
+SubClassOf(<http://purl.obolibrary.org/obo/NCBITaxon_9646> <http://purl.obolibrary.org/obo/NCBITaxon_9645>)
+
 # Class: <http://purl.obolibrary.org/obo/NCBITaxon_9647> (Procyonidae)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/NCBITaxon_9647> "Procyonidae")
diff --git a/src/ontology/mondo-edit.obo b/src/ontology/mondo-edit.obo
index 9657bf3649..9eebce12bb 100644
--- a/src/ontology/mondo-edit.obo
+++ b/src/ontology/mondo-edit.obo
@@ -341795,8 +341795,8 @@ xref: Orphanet:476084 {source="DOID:0110290", source="MONDO:equivalentTo"}
 xref: UMLS:C5568138 {source="MEDGEN:1799561", source="MONDO:equivalentTo", source="MONDO:MEDGEN"}
 is_a: MONDO:0015152 {source="DOID:0110290", source="MONDO:Redundant", source="OMIM:616812", source="Orphanet:476084"} ! autosomal recessive limb-girdle muscular dystrophy
 intersection_of: MONDO:0015152 ! autosomal recessive limb-girdle muscular dystrophy
-intersection_of: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/1152 ! BVES
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/1152 {source="MONDO:mim2gene_medgen"} ! BVES
+intersection_of: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/1152 ! POPDC1
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/1152 {source="MONDO:mim2gene_medgen"} ! POPDC1
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/4521" xsd:anyURI
 
 [Term]
@@ -554140,7 +554140,7 @@ xref: OMIM:619975 {source="MONDO:equivalentTo"}
 xref: Orphanet:661526 {source="MONDO:equivalentTo"}
 xref: UMLS:C5774186 {source="MONDO:equivalentTo", source="MONDO:MEDGEN", source="MEDGEN:1823959"}
 is_a: MONDO:0015356 {source="OMIM:619975", source="Orphanet:661526"} ! hereditary neoplastic syndrome
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/6919 {source="OMIM:619975"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/6919 {source="OMIM:619975"} ! MBD4
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/8214" xsd:anyURI
 
 [Term]
@@ -585191,7 +585191,7 @@ synonym: "Arachnomelia, SUOX-related, cattle" EXACT [OMIA:000059-9913]
 xref: OMIA:000059-9913 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:000059-9913", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1012955 {source="OMIA:000059-9913", source="https://orcid.org/0000-0002-5002-8648"} ! arachnomelia syndrome, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/509837 {source="OMIA:000059-9913", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/509837 {source="OMIA:000059-9913", source="https://orcid.org/0000-0002-5002-8648"} ! SUOX
 relationship: in_taxon NCBITaxon:9913 {source="OMIA:000059-9913"} ! Bos taurus
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585205,7 +585205,7 @@ synonym: "HMLR" EXACT ABBREVIATION [OMIA:001374-9615]
 xref: OMIA:001374-9615 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:001374-9615", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1012963 {source="OMIA:001374-9615", source="https://orcid.org/0000-0002-5002-8648"} ! centronuclear myopathy, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/574011 {source="OMIA:001374-9615", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/574011 {source="OMIA:001374-9615", source="https://orcid.org/0000-0002-5002-8648"} ! HACD1
 relationship: in_taxon NCBITaxon:9615 {source="OMIA:001374-9615"} ! Canis lupus familiaris
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585217,7 +585217,7 @@ synonym: "Arachnomelia, MOCS1-related in Bos taurus (taurine cattle)" EXACT [OMI
 xref: OMIA:001541-9913 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:001541-9913", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1012955 {source="OMIA:001541-9913", source="https://orcid.org/0000-0002-5002-8648"} ! arachnomelia syndrome, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/281917 {source="OMIA:001541-9913", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/281917 {source="OMIA:001541-9913", source="https://orcid.org/0000-0002-5002-8648"} ! MOCS1
 relationship: in_taxon NCBITaxon:9913 {source="OMIA:001541-9913"} ! Bos taurus
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585231,7 +585231,7 @@ xref: OMIA:001596-9615 {source="MONDO:equivalentTo"}
 is_a: MONDO:1010411 {source="OMIA:001596-9615", source="https://orcid.org/0000-0002-5002-8648"} ! epilepsy, dog
 is_a: MONDO:1011321 {source="OMIA:001596-9615", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 relationship: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/488853 {source="OMIA:001596-9615", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/488853 {source="OMIA:001596-9615", source="https://orcid.org/0000-0002-5002-8648"} ! LGI2
 relationship: in_taxon NCBITaxon:9615 {source="OMIA:001596-9615"} ! Canis lupus familiaris
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585253,7 +585253,7 @@ synonym: "inherited myopathy of Great Danes" NARROW [OMIA:001660-9615]
 xref: OMIA:001660-9615 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:001660-9615", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1012963 {source="OMIA:001660-9615", source="https://orcid.org/0000-0002-5002-8648"} ! centronuclear myopathy, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/483870 {source="OMIA:001660-9615", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/483870 {source="OMIA:001660-9615", source="https://orcid.org/0000-0002-5002-8648"} ! BIN1
 relationship: in_taxon NCBITaxon:9615 {source="OMIA:001660-9615"} ! Canis lupus familiaris
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585265,7 +585265,7 @@ synonym: "ataxia, cerebellar, progressive early-onset, SEL1L-related, dog" EXACT
 xref: OMIA:001692-9615 {source="MONDO:equivalentTo"}
 is_a: MONDO:1012957 {source="OMIA:001692-9615", source="https://orcid.org/0000-0002-5002-8648"} ! cerebellar ataxia, dog
 is_a: MONDO:1012960 {source="OMIA:001692-9615", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary cerebellar ataxia, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/480409 {source="OMIA:001692-9615", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/480409 {source="OMIA:001692-9615", source="https://orcid.org/0000-0002-5002-8648"} ! SEL1L
 relationship: in_taxon NCBITaxon:9615 {source="OMIA:001692-9615"} ! Canis lupus familiaris
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585278,7 +585278,7 @@ synonym: "canine hereditary ataxia" RELATED [OMIA:001913-9615]
 xref: OMIA:001913-9615 {source="MONDO:equivalentTo"}
 is_a: MONDO:1012957 {source="OMIA:001913-9615", source="https://orcid.org/0000-0002-5002-8648"} ! cerebellar ataxia, dog
 is_a: MONDO:1012959 {source="OMIA:001913-9615", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary ataxia, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/479277 {source="OMIA:001913-9615", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/479277 {source="OMIA:001913-9615", source="https://orcid.org/0000-0002-5002-8648"} ! RAB24
 relationship: in_taxon NCBITaxon:9615 {source="OMIA:001913-9615"} ! Canis lupus familiaris
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585290,7 +585290,7 @@ synonym: "achondrogenesis, type II in Sus scrofa (pig)" RELATED [OMIA:001926-982
 xref: OMIA:001926-9823 {source="MONDO:equivalentTo"}
 is_a: MONDO:1010306 {source="OMIA:001926-9823", source="https://orcid.org/0000-0002-5002-8648"} ! osteochondrodysplasia, non-human animal
 is_a: MONDO:1011321 {source="OMIA:001926-9823", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/397323 {source="OMIA:001926-9823", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/397323 {source="OMIA:001926-9823", source="https://orcid.org/0000-0002-5002-8648"} ! COL2A1
 relationship: in_taxon NCBITaxon:9823 {source="OMIA:001926-9823"} ! Sus scrofa
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585303,7 +585303,7 @@ synonym: "bulldog calf syndrome" EXACT [PMID:32894162]
 xref: OMIA:001926-9913 {source="MONDO:equivalentTo"}
 is_a: MONDO:1010306 {source="OMIA:001926-9913", source="https://orcid.org/0000-0002-5002-8648"} ! osteochondrodysplasia, non-human animal
 is_a: MONDO:1011321 {source="OMIA:001926-9913", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/407142 {source="OMIA:001926-9913", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/407142 {source="OMIA:001926-9913", source="https://orcid.org/0000-0002-5002-8648"} ! COL2A1
 relationship: in_taxon NCBITaxon:9913 {source="OMIA:001926-9913"} ! Bos taurus
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585315,7 +585315,7 @@ synonym: "cataract, recessive, NID1-related, cattle" EXACT [OMIA:001936-9913]
 xref: OMIA:001936-9913 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:001936-9913", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1012962 {source="OMIA:001936-9913", source="https://orcid.org/0000-0002-5002-8648"} ! cataract, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/534319 {source="OMIA:001936-9913", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/534319 {source="OMIA:001936-9913", source="https://orcid.org/0000-0002-5002-8648"} ! NID1
 relationship: in_taxon NCBITaxon:9913 {source="OMIA:001936-9913"} ! Bos taurus
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585328,7 +585328,7 @@ synonym: "inferior cerebellar hypoplasia" RELATED [OMIA:001947-9615]
 xref: OMIA:001947-9615 {source="MONDO:equivalentTo"}
 is_a: MONDO:1012957 {source="OMIA:001947-9615", source="https://orcid.org/0000-0002-5002-8648"} ! cerebellar ataxia, dog
 is_a: MONDO:1012960 {source="OMIA:001947-9615", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary cerebellar ataxia, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/476336 {source="OMIA:001947-9615", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/476336 {source="OMIA:001947-9615", source="https://orcid.org/0000-0002-5002-8648"} ! VLDLR
 relationship: in_taxon NCBITaxon:9615 {source="OMIA:001947-9615"} ! Canis lupus familiaris
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585339,7 +585339,7 @@ def: "Any cancer that occurs in golden hamster due to a mutation in the TP53 gen
 xref: OMIA:001990-10036 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:001990-10036", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1011828 {source="OMIA:001990-10036", source="https://orcid.org/0000-0002-5002-8648"} ! cancer, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/101833915 {source="OMIA:001990-10036", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/101833915 {source="OMIA:001990-10036", source="https://orcid.org/0000-0002-5002-8648"} ! Tp53
 relationship: in_taxon NCBITaxon:10036 {source="OMIA:001990-10036"} ! Mesocricetus auratus
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585350,7 +585350,7 @@ def: "Any cancer that occurs in crab-eating macaques due to a mutation in the TP
 xref: OMIA:001990-9541 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:001990-9541", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1011828 {source="OMIA:001990-9541", source="https://orcid.org/0000-0002-5002-8648"} ! cancer, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/102135998 {source="OMIA:001990-9541", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/102135998 {source="OMIA:001990-9541", source="https://orcid.org/0000-0002-5002-8648"} ! TP53
 relationship: in_taxon NCBITaxon:9541 {source="OMIA:001990-9541"} ! Macaca fascicularis
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585361,7 +585361,7 @@ def: "Any cancer that occurs in pigs due to a mutation in the TP53 gene created
 xref: OMIA:001990-9823 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:001990-9823", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1011828 {source="OMIA:001990-9823", source="https://orcid.org/0000-0002-5002-8648"} ! cancer, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/397276 {source="OMIA:001990-9823", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/397276 {source="OMIA:001990-9823", source="https://orcid.org/0000-0002-5002-8648"} ! TP53
 relationship: in_taxon NCBITaxon:9823 {source="OMIA:001990-9823"} ! Sus scrofa
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585372,7 +585372,7 @@ def: "Any arthrogryposis multiplex congenita that occurs in cattle due to a muta
 xref: OMIA:002022-9913 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:002022-9913", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1011474 {source="OMIA:002022-9913", source="https://orcid.org/0000-0002-5002-8648"} ! arthrogryposis multiplex congenita, cattle
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/282179 {source="OMIA:002022-9913", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/282179 {source="OMIA:002022-9913", source="https://orcid.org/0000-0002-5002-8648"} ! CHRNB1
 relationship: in_taxon NCBITaxon:9913 {source="OMIA:002022-9913"} ! Bos taurus
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585383,7 +585383,7 @@ def: "Progressive cerebellar ataxia that occurs in dogs due to a mutation in the
 xref: OMIA:002034-9615 {source="MONDO:equivalentTo"}
 is_a: MONDO:1012957 {source="OMIA:002034-9615", source="https://orcid.org/0000-0002-5002-8648"} ! cerebellar ataxia, dog
 is_a: MONDO:1012960 {source="OMIA:002034-9615", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary cerebellar ataxia, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/474985 {source="OMIA:002034-9615", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/474985 {source="OMIA:002034-9615", source="https://orcid.org/0000-0002-5002-8648"} ! SNX14
 relationship: in_taxon NCBITaxon:9615 {source="OMIA:002034-9615"} ! Canis lupus familiaris
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585394,7 +585394,7 @@ def: "Any cancer that occurs in pigs due to a mutation in the RUNX gene created
 xref: OMIA:002054-9823 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:002054-9823", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1011828 {source="OMIA:002054-9823", source="https://orcid.org/0000-0002-5002-8648"} ! cancer, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/403159 {source="OMIA:002054-9823", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/403159 {source="OMIA:002054-9823", source="https://orcid.org/0000-0002-5002-8648"} ! RUNX3
 relationship: in_taxon NCBITaxon:9823 {source="OMIA:002054-9823"} ! Sus scrofa
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585410,7 +585410,7 @@ synonym: "spongy degeneration with cerebellar ataxia 1" RELATED [OMIA:002089-961
 xref: OMIA:002089-9615 {source="MONDO:equivalentTo"}
 is_a: MONDO:1012957 {source="OMIA:002089-9615", source="https://orcid.org/0000-0002-5002-8648"} ! cerebellar ataxia, dog
 is_a: MONDO:1012960 {source="OMIA:002089-9615", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary cerebellar ataxia, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/488635 {source="OMIA:002089-9615", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/488635 {source="OMIA:002089-9615", source="https://orcid.org/0000-0002-5002-8648"} ! KCNJ10
 relationship: in_taxon NCBITaxon:9615 {source="OMIA:002089-9615"} ! Canis lupus familiaris
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585423,7 +585423,7 @@ synonym: "neonatal cerebellar cortical degeneration" RELATED [OMIA:002092-9615]
 xref: OMIA:002092-9615 {source="MONDO:equivalentTo"}
 is_a: MONDO:1012957 {source="OMIA:002092-9615", source="https://orcid.org/0000-0002-5002-8648"} ! cerebellar ataxia, dog
 is_a: MONDO:1012960 {source="OMIA:002092-9615", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary cerebellar ataxia, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/483706 {source="OMIA:002092-9615", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/483706 {source="OMIA:002092-9615", source="https://orcid.org/0000-0002-5002-8648"} ! SPTBN2
 relationship: in_taxon NCBITaxon:9615 {source="OMIA:002092-9615"} ! Canis lupus familiaris
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585436,7 +585436,7 @@ synonym: "SCAIS" EXACT ABBREVIATION [OMIA:002097-9615]
 xref: OMIA:002097-9615 {source="MONDO:equivalentTo"}
 is_a: MONDO:1012957 {source="OMIA:002097-9615", source="https://orcid.org/0000-0002-5002-8648"} ! cerebellar ataxia, dog
 is_a: MONDO:1012960 {source="OMIA:002097-9615", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary cerebellar ataxia, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/476548 {source="OMIA:002097-9615", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/476548 {source="OMIA:002097-9615", source="https://orcid.org/0000-0002-5002-8648"} ! ITPR1
 relationship: in_taxon NCBITaxon:9615 {source="OMIA:002097-9615"} ! Canis lupus familiaris
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585449,7 +585449,7 @@ synonym: "spongy degeneration with cerebellar ataxia 2" RELATED []
 xref: OMIA:002110-9615 {source="MONDO:equivalentTo"}
 is_a: MONDO:1012957 {source="OMIA:002110-9615", source="https://orcid.org/0000-0002-5002-8648"} ! cerebellar ataxia, dog
 is_a: MONDO:1012959 {source="OMIA:002110-9615", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary ataxia, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/489479 {source="OMIA:002110-9615", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/489479 {source="OMIA:002110-9615", source="https://orcid.org/0000-0002-5002-8648"} ! ATP1B2
 relationship: in_taxon NCBITaxon:9615 {source="OMIA:002110-9615"} ! Canis lupus familiaris
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585462,7 +585462,7 @@ synonym: "Morgagnian cataract" RELATED [OMIA:002111-9913]
 xref: OMIA:002111-9913 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:002111-9913", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1012962 {source="OMIA:002111-9913", source="https://orcid.org/0000-0002-5002-8648"} ! cataract, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/100298265 {source="OMIA:002111-9913", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/100298265 {source="OMIA:002111-9913", source="https://orcid.org/0000-0002-5002-8648"} ! CPAMD8
 relationship: in_taxon NCBITaxon:9913 {source="OMIA:002111-9913"} ! Bos taurus
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585476,7 +585476,7 @@ synonym: "curly calf syndrome" RELATED [OMIA:002135-9913]
 xref: OMIA:002135-9913 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:002135-9913", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1011474 {source="OMIA:002135-9913", source="https://orcid.org/0000-0002-5002-8648"} ! arthrogryposis multiplex congenita, cattle
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/525795 {source="OMIA:002135-9913", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/525795 {source="OMIA:002135-9913", source="https://orcid.org/0000-0002-5002-8648"} ! AGRN
 relationship: in_taxon NCBITaxon:9913 {source="OMIA:002135-9913"} ! Bos taurus
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585488,7 +585488,7 @@ synonym: "ataxia, spinocerebellar, SCN8A-related, dog" EXACT [OMIA:002194-9615]
 xref: OMIA:002194-9615 {source="MONDO:equivalentTo"}
 is_a: MONDO:1012957 {source="OMIA:002194-9615", source="https://orcid.org/0000-0002-5002-8648"} ! cerebellar ataxia, dog
 is_a: MONDO:1012960 {source="OMIA:002194-9615", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary cerebellar ataxia, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/477604 {source="OMIA:002194-9615", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/477604 {source="OMIA:002194-9615", source="https://orcid.org/0000-0002-5002-8648"} ! SCN8A
 relationship: in_taxon NCBITaxon:9615 {source="OMIA:002194-9615"} ! Canis lupus familiaris
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585501,7 +585501,7 @@ synonym: "progressive cerebellar ataxia" RELATED [OMIA:002240-9615]
 xref: OMIA:002240-9615 {source="MONDO:equivalentTo"}
 is_a: MONDO:1012957 {source="OMIA:002240-9615", source="https://orcid.org/0000-0002-5002-8648"} ! cerebellar ataxia, dog
 is_a: MONDO:1012960 {source="OMIA:002240-9615", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary cerebellar ataxia, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/479129 {source="OMIA:002240-9615", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/479129 {source="OMIA:002240-9615", source="https://orcid.org/0000-0002-5002-8648"} ! KCNIP4
 relationship: in_taxon NCBITaxon:9615 {source="OMIA:002240-9615"} ! Canis lupus familiaris
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585513,7 +585513,7 @@ synonym: "ataxia, spinocerebellar, SLC12A6-related, dog" EXACT [OMIA:002279-9615
 xref: OMIA:002279-9615 {source="MONDO:equivalentTo"}
 is_a: MONDO:1012957 {source="OMIA:002279-9615", source="https://orcid.org/0000-0002-5002-8648"} ! cerebellar ataxia, dog
 is_a: MONDO:1012960 {source="OMIA:002279-9615", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary cerebellar ataxia, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/478239 {source="OMIA:002279-9615", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/478239 {source="OMIA:002279-9615", source="https://orcid.org/0000-0002-5002-8648"} ! SLC12A6
 relationship: in_taxon NCBITaxon:9615 {source="OMIA:002279-9615"} ! Canis lupus familiaris
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585525,7 +585525,7 @@ xref: OMIA:002283-9823 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:002283-9823", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1011475 {source="OMIA:002283-9823", source="https://orcid.org/0000-0002-5002-8648"} ! arthrogryposis multiplex congenita, pig
 relationship: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/100520674 {source="OMIA:002283-9823", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/100520674 {source="OMIA:002283-9823", source="https://orcid.org/0000-0002-5002-8648"} ! KIF21A
 relationship: in_taxon NCBITaxon:9823 {source="OMIA:002283-9823"} ! Sus scrofa
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585538,7 +585538,7 @@ xref: OMIA:002294-9615 {source="MONDO:equivalentTo"}
 is_a: MONDO:1010917 {source="OMIA:002294-9615", source="https://orcid.org/0000-0002-5002-8648"} ! myopathy, dog
 is_a: MONDO:1012957 {source="OMIA:002294-9615", source="https://orcid.org/0000-0002-5002-8648"} ! cerebellar ataxia, dog
 is_a: MONDO:1012960 {source="OMIA:002294-9615", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary cerebellar ataxia, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/478798 {source="OMIA:002294-9615", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/478798 {source="OMIA:002294-9615", source="https://orcid.org/0000-0002-5002-8648"} ! SLC25A12
 relationship: in_taxon NCBITaxon:9615 {source="OMIA:002294-9615"} ! Canis lupus familiaris
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585549,8 +585549,8 @@ def: "Any cataract that occurs in giant pandas due to a mutation in the MIP gene
 xref: OMIA:002309-9646 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:002309-9646", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1012962 {source="OMIA:002309-9646", source="https://orcid.org/0000-0002-5002-8648"} ! cataract, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/100472661 {source="OMIA:002309-9646", source="https://orcid.org/0000-0002-5002-8648"}
-relationship: in_taxon NCBITaxon:9646 {source="OMIA:002309-9646"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/100472661 {source="OMIA:002309-9646", source="https://orcid.org/0000-0002-5002-8648"} ! MIP
+relationship: in_taxon NCBITaxon:9646 {source="OMIA:002309-9646"} ! Ailuropoda melanoleuca
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
 [Term]
@@ -585571,7 +585571,7 @@ def: "Abnormal locomotion defined by the loss of typical jumping and blindness a
 xref: OMIA:002317-9986 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:002317-9986", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1011360 {source="OMIA:002317-9986", source="https://orcid.org/0000-0002-5002-8648"} ! syndromic disease, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/100345295 {source="OMIA:002317-9986", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/100345295 {source="OMIA:002317-9986", source="https://orcid.org/0000-0002-5002-8648"} ! RORB
 relationship: in_taxon NCBITaxon:9986 {source="OMIA:002317-9986"} ! Oryctolagus cuniculus
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585585,7 +585585,7 @@ synonym: "CNS atrophy with cerebellar ataxia" RELATED [OMIA:002367-9615]
 xref: OMIA:002367-9615 {source="MONDO:equivalentTo"}
 is_a: MONDO:1012957 {source="OMIA:002367-9615", source="https://orcid.org/0000-0002-5002-8648"} ! cerebellar ataxia, dog
 is_a: MONDO:1012960 {source="OMIA:002367-9615", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary cerebellar ataxia, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/479346 {source="OMIA:002367-9615", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/479346 {source="OMIA:002367-9615", source="https://orcid.org/0000-0002-5002-8648"} ! SELENOP
 relationship: in_taxon NCBITaxon:9615 {source="OMIA:002367-9615"} ! Canis lupus familiaris
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585597,7 +585597,7 @@ synonym: "ataxia, spinocerebellar, ATXN3-related, white-tufted-ear marmoset" EXA
 xref: OMIA:002473-9483 {source="MONDO:equivalentTo"}
 is_a: MONDO:1012956 {source="OMIA:002473-9483", source="https://orcid.org/0000-0002-5002-8648"} ! cerebellar ataxia, non-human animal
 is_a: MONDO:1012960 {source="OMIA:002473-9483", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary cerebellar ataxia, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/100393557 {source="OMIA:002473-9483", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/100393557 {source="OMIA:002473-9483", source="https://orcid.org/0000-0002-5002-8648"} ! ATXN3
 relationship: in_taxon NCBITaxon:9483 {source="OMIA:002473-9483"} ! Callithrix jacchus
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585608,7 +585608,7 @@ def: "Any amyotrophic lateral sclerosis that occurs in pigs due to a mutation in
 xref: OMIA:002491-9823 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011322 {source="OMIA:002491-9823", source="https://orcid.org/0000-0002-5002-8648"} ! iatrogenic disease, non-human animal
 is_a: MONDO:1012954 {source="OMIA:002491-9823", source="https://orcid.org/0000-0002-5002-8648"} ! amyotrophic lateral sclerosis, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/397036 {source="OMIA:002491-9823", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/397036 {source="OMIA:002491-9823", source="https://orcid.org/0000-0002-5002-8648"} ! SOD1
 relationship: in_taxon NCBITaxon:9823 {source="OMIA:002491-9823"} ! Sus scrofa
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585619,7 +585619,7 @@ def: "Any amyotrophic lateral sclerosis that occurs in crab-eating macaque due t
 xref: OMIA:002492-9541 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011322 {source="OMIA:002492-9541", source="https://orcid.org/0000-0002-5002-8648"} ! iatrogenic disease, non-human animal
 is_a: MONDO:1012954 {source="OMIA:002492-9541", source="https://orcid.org/0000-0002-5002-8648"} ! amyotrophic lateral sclerosis, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/101926677 {source="OMIA:002492-9541", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/101926677 {source="OMIA:002492-9541", source="https://orcid.org/0000-0002-5002-8648"} ! TARDBP
 relationship: in_taxon NCBITaxon:9541 {source="OMIA:002492-9541"} ! Macaca fascicularis
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585630,7 +585630,7 @@ def: "Any amyotrophic lateral sclerosis that occurs in Rhesus monkey due to a mu
 xref: OMIA:002492-9544 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011322 {source="OMIA:002492-9544", source="https://orcid.org/0000-0002-5002-8648"} ! iatrogenic disease, non-human animal
 is_a: MONDO:1012954 {source="OMIA:002492-9544", source="https://orcid.org/0000-0002-5002-8648"} ! amyotrophic lateral sclerosis, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/100423163 {source="OMIA:002492-9544", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/100423163 {source="OMIA:002492-9544", source="https://orcid.org/0000-0002-5002-8648"} ! TARDBP
 relationship: in_taxon NCBITaxon:9544 {source="OMIA:002492-9544"} ! Macaca mulatta
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585641,7 +585641,7 @@ def: "Any amyotrophic lateral sclerosis that occurs in pigs due to a mutation in
 xref: OMIA:002492-9823 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011322 {source="OMIA:002492-9823", source="https://orcid.org/0000-0002-5002-8648"} ! iatrogenic disease, non-human animal
 is_a: MONDO:1012954 {source="OMIA:002492-9823", source="https://orcid.org/0000-0002-5002-8648"} ! amyotrophic lateral sclerosis, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/100739753 {source="OMIA:002492-9823", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/100739753 {source="OMIA:002492-9823", source="https://orcid.org/0000-0002-5002-8648"} ! TARDBP
 relationship: in_taxon NCBITaxon:9823 {source="OMIA:002492-9823"} ! Sus scrofa
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585652,7 +585652,7 @@ def: "Alzheimer disease that occurs in pigs due to a mutation in the PSEN1 gene
 xref: OMIA:002493-9823 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:002493-9823", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1011443 {source="OMIA:002493-9823", source="https://orcid.org/0000-0002-5002-8648"} ! Alzheimer disease, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/780411 {source="OMIA:002493-9823", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/780411 {source="OMIA:002493-9823", source="https://orcid.org/0000-0002-5002-8648"} ! PSEN1
 relationship: in_taxon NCBITaxon:9823 {source="OMIA:002493-9823"} ! Sus scrofa
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585663,7 +585663,7 @@ def: "Any ataxia that occurs in dogs due to a mutation in the HACE1 gene." [MOND
 xref: OMIA:002522-9615 {source="MONDO:equivalentTo"}
 is_a: MONDO:1012958 {source="OMIA:002522-9615", source="https://orcid.org/0000-0002-5002-8648"} ! atactic disorder, non-human animal
 is_a: MONDO:1012959 {source="OMIA:002522-9615", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary ataxia, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/475010 {source="OMIA:002522-9615", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/475010 {source="OMIA:002522-9615", source="https://orcid.org/0000-0002-5002-8648"} ! HACE1
 relationship: in_taxon NCBITaxon:9615 {source="OMIA:002522-9615"} ! Canis lupus familiaris
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585673,7 +585673,7 @@ name: abdominal hernia, TWIST1-related, cattle
 def: "Hernia of the linea alba that occurs in cattle due to a mutation in the TWIST1 gene." [PMID:35187669]
 xref: OMIA:002532-9913 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:002532-9913", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/782170 {source="OMIA:002532-9913", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/782170 {source="OMIA:002532-9913", source="https://orcid.org/0000-0002-5002-8648"} ! TWIST1
 relationship: in_taxon NCBITaxon:9913 {source="OMIA:002532-9913"} ! Bos taurus
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585687,7 +585687,7 @@ synonym: "centronuclear myopathy 1, DNM2-related, dog" EXACT [OMIA:002534-9615]
 xref: OMIA:002534-9615 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:002534-9615", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1012963 {source="OMIA:002534-9615", source="https://orcid.org/0000-0002-5002-8648"} ! centronuclear myopathy, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/484949 {source="OMIA:002534-9615", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/484949 {source="OMIA:002534-9615", source="https://orcid.org/0000-0002-5002-8648"} ! DNM2
 relationship: in_taxon NCBITaxon:9615 {source="OMIA:002534-9615"} ! Canis lupus familiaris
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585698,7 +585698,7 @@ def: "Any cataract that occurs in cattle due to a mutation in the ADAMTSL4 gene.
 xref: OMIA:002535-9913 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:002535-9913", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1012962 {source="OMIA:002535-9913", source="https://orcid.org/0000-0002-5002-8648"} ! cataract, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/507654 {source="OMIA:002535-9913", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/507654 {source="OMIA:002535-9913", source="https://orcid.org/0000-0002-5002-8648"} ! ADAMTSL4
 relationship: in_taxon NCBITaxon:9913 {source="OMIA:002535-9913"} ! Bos taurus
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585710,7 +585710,7 @@ synonym: "Juvenile cataract" RELATED [OMIA:002536-9615]
 xref: OMIA:002536-9615 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:002536-9615", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1012962 {source="OMIA:002536-9615", source="https://orcid.org/0000-0002-5002-8648"} ! cataract, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/476649 {source="OMIA:002536-9615", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/476649 {source="OMIA:002536-9615", source="https://orcid.org/0000-0002-5002-8648"} ! FYCO1
 relationship: in_taxon NCBITaxon:9615 {source="OMIA:002536-9615"} ! Canis lupus familiaris
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585721,7 +585721,7 @@ def: "Alzheimer disease that occurs in white-tufted-ear marmoset due to a mutati
 xref: OMIA:002538-9483 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:002538-9483", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1011443 {source="OMIA:002538-9483", source="https://orcid.org/0000-0002-5002-8648"} ! Alzheimer disease, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/100407052 {source="OMIA:002538-9483", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/100407052 {source="OMIA:002538-9483", source="https://orcid.org/0000-0002-5002-8648"} ! APP
 relationship: in_taxon NCBITaxon:9483 {source="OMIA:002538-9483"} ! Callithrix jacchus
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585732,7 +585732,7 @@ def: "Alzheimer disease that occurs in crab-eating macaque due to a mutation in
 xref: OMIA:002538-9541 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:002538-9541", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1011443 {source="OMIA:002538-9541", source="https://orcid.org/0000-0002-5002-8648"} ! Alzheimer disease, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/101926433 {source="OMIA:002538-9541", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/101926433 {source="OMIA:002538-9541", source="https://orcid.org/0000-0002-5002-8648"} ! APP
 relationship: in_taxon NCBITaxon:9541 {source="OMIA:002538-9541"} ! Macaca fascicularis
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585743,7 +585743,7 @@ def: "Alzheimer disease that occurs in Rhesus monkey due to a mutation in the AP
 xref: OMIA:002538-9544 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:002538-9544", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1011443 {source="OMIA:002538-9544", source="https://orcid.org/0000-0002-5002-8648"} ! Alzheimer disease, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/100427716 {source="OMIA:002538-9544", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/100427716 {source="OMIA:002538-9544", source="https://orcid.org/0000-0002-5002-8648"} ! APP
 relationship: in_taxon NCBITaxon:9544 {source="OMIA:002538-9544"} ! Macaca mulatta
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585754,7 +585754,7 @@ def: "Alzheimer disease that occurs in pigs due to a mutation in the APP gene cr
 xref: OMIA:002538-9823 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:002538-9823", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1011443 {source="OMIA:002538-9823", source="https://orcid.org/0000-0002-5002-8648"} ! Alzheimer disease, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/397663 {source="OMIA:002538-9823", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/397663 {source="OMIA:002538-9823", source="https://orcid.org/0000-0002-5002-8648"} ! APP
 relationship: in_taxon NCBITaxon:9823 {source="OMIA:002538-9823"} ! Sus scrofa
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585766,7 +585766,7 @@ synonym: "Alzheimer, SORL1-related in Sus scrofa (pig)" EXACT [OMIA:002575-9823]
 xref: OMIA:002575-9823 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:002575-9823", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1011443 {source="OMIA:002575-9823", source="https://orcid.org/0000-0002-5002-8648"} ! Alzheimer disease, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/100626812 {source="OMIA:002575-9823", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/100626812 {source="OMIA:002575-9823", source="https://orcid.org/0000-0002-5002-8648"} ! SORL1
 relationship: in_taxon NCBITaxon:9823 {source="OMIA:002575-9823"} ! Sus scrofa
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585777,7 +585777,7 @@ def: "Any amelogenesis imperfecta that occurs in rabbits due to a mutation in th
 xref: OMIA:002600-9986 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:002600-9986", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1012952 {source="OMIA:002600-9986", source="https://orcid.org/0000-0002-5002-8648"} ! amelogenesis imperfecta, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/103347222 {source="OMIA:002600-9986", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/103347222 {source="OMIA:002600-9986", source="https://orcid.org/0000-0002-5002-8648"} ! FAM83H
 relationship: in_taxon NCBITaxon:9986 {source="OMIA:002600-9986"} ! Oryctolagus cuniculus
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585789,7 +585789,7 @@ xref: OMIA:002602-9615 {source="MONDO:equivalentTo"}
 is_a: MONDO:1012038 {source="OMIA:002602-9615", source="https://orcid.org/0000-0002-5002-8648"} ! cerebellar abiotrophy, dog
 is_a: MONDO:1012960 {source="OMIA:002602-9615", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary cerebellar ataxia, non-human animal
 relationship: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/119881609 {source="OMIA:002602-9615", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/119881609 {source="OMIA:002602-9615", source="https://orcid.org/0000-0002-5002-8648"} ! VMP1
 relationship: in_taxon NCBITaxon:9615 {source="OMIA:002602-9615"} ! Canis lupus familiaris
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585810,7 +585810,7 @@ xref: OMIA:002538-9615 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:002538-9615", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1011461 {source="OMIA:002538-9615", source="https://orcid.org/0000-0002-5002-8648"} ! Alzheimer disease, dog
 relationship: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/403407 {source="OMIA:002538-9615", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/403407 {source="OMIA:002538-9615", source="https://orcid.org/0000-0002-5002-8648"} ! APP
 relationship: in_taxon NCBITaxon:9615 {source="OMIA:002538-9615"} ! Canis lupus familiaris
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585821,7 +585821,7 @@ def: "Alzheimer disease that occurs in white-tufted-ear marmoset due to a mutati
 xref: OMIA:002493-9483 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:002493-9483", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1011443 {source="OMIA:002493-9483", source="https://orcid.org/0000-0002-5002-8648"} ! Alzheimer disease, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/100401034 {source="OMIA:002493-9483", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/100401034 {source="OMIA:002493-9483", source="https://orcid.org/0000-0002-5002-8648"} ! PSEN1
 relationship: in_taxon NCBITaxon:9483 {source="OMIA:002493-9483"} ! Callithrix jacchus
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
@@ -585832,7 +585832,7 @@ def: "Alzheimer disease that occurs in crab-eating macaque due to a mutation in
 xref: OMIA:002493-9541 {source="MONDO:equivalentTo"}
 is_a: MONDO:1011321 {source="OMIA:002493-9541", source="https://orcid.org/0000-0002-5002-8648"} ! hereditary disease, non-human animal
 is_a: MONDO:1011443 {source="OMIA:002493-9541", source="https://orcid.org/0000-0002-5002-8648"} ! Alzheimer disease, non-human animal
-relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/102138674 {source="OMIA:002493-9541", source="https://orcid.org/0000-0002-5002-8648"}
+relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/ncbigene/102138674 {source="OMIA:002493-9541", source="https://orcid.org/0000-0002-5002-8648"} ! PSEN1
 relationship: in_taxon NCBITaxon:9541 {source="OMIA:002493-9541"} ! Macaca fascicularis
 property_value: IAO:0000233 "https://github.com/monarch-initiative/mondo/issues/7271" xsd:anyURI
 
diff --git a/src/sparql/construct/construct-ncbigene.sparql b/src/sparql/construct/construct-ncbigene.sparql
index 898cc4fcf1..ca26f925c4 100644
--- a/src/sparql/construct/construct-ncbigene.sparql
+++ b/src/sparql/construct/construct-ncbigene.sparql
@@ -82,6 +82,7 @@ WHERE {
     <http://identifiers.org/ncbigene/103347222>
     <http://identifiers.org/ncbigene/107305840>
     <http://identifiers.org/ncbigene/119881609>
+    <http://identifiers.org/ncbigene/2236>
     <http://identifiers.org/ncbigene/280798>
     <http://identifiers.org/ncbigene/280916>
     <http://identifiers.org/ncbigene/281187>