README

Below, we describe the code used in Guo MH and Gregg AR. "Estimating yields of prenatal carrier screening and implications for design of expanded carrier screening panels." Genetics in Medicine. 2019.

Python v2.7 and R v3.1 were used throughout.

#Download parsed ClinVar data:
git clone https://github.com/macarthur-lab/clinvar.git

#Parse and subset ClinVar data
python subset_clinvar.py clinvar_subset_table.txt

#Generate carrier frequencies
Rscript sum_AF.R

#Generate plots
Rscript plot.R