SDC (Sex Differences in Cancer)

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Web server

http://sdc.anticancer.xyz

Use with Docker

SDC has corresponding docker image at https://hub.docker.com/r/longfei8533/sdc-server, you can install the latest version with:

docker pull longfei8533/sdc-server

Run the docker image：

docker run --rm -ti --user shiny -p 3838:3838 longfei8533/sdc-server

Open your preferred web browser and type the following URL: localhost:3838 or [Host IP]:3838

Raw data

All Raw data can be downloaded from follow link. Put the raw data into rawdata folder for subsequent analysis.

Phenotype

• TCGA TARGET GTEX selected phenotypes (n=19,131) UCSC Toil RNA-seq Recompute
• Curated clinical data (n=12,591) Pan-Cancer Atlas Hub
• Molecular subtype (n=7734)

Gene expression RNAseq

• RSEM expected_count (n=19,109) UCSC Toil RNA-seq Recompute

• RSEM tpm (n=19,131) UCSC Toil RNA-seq Recompute

miRNA gene quantification

• Illumina HiSeq

DNA methylation

• Methylation450k

Somatic mutation (SNP and INDEL)

• MC3 public version

Copy number

• copy number (gene-level)

• copy number segments

Pathway

• z score of 1387 constituent PARADIGM pathways

Immunotherapy response

• Summary of TME subtype for each analyzed tumor (Table S6)

Drug sensitivity

• Genomics of Drug Sensitivity in Cancer (GDSC)
• Cancer Cell Line Encyclopedia(CCLE)

About

Cite us!

L.-F. Zhao, J.-G. Zhang, F.-Y. Qi, W.-Y. Hou, Y.-R. Li, D.-D. Shen, L.-J. Zhao, L. Qi, H.-M. Liu, Y.-C. Zheng, SDC: An Integrated Database for Sex Differences in Cancer, Computational and Structural Biotechnology Journal (2022). https://doi.org/10.1016/j.csbj.2022.02.023.

Contact:

Longfei Zhao: [email protected]

Yichao Zheng: [email protected]