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Lack of Contrasts Functionality #13

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DarioS opened this issue Jul 23, 2024 · 0 comments
Open

Lack of Contrasts Functionality #13

DarioS opened this issue Jul 23, 2024 · 0 comments

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@DarioS
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DarioS commented Jul 23, 2024

The output of RegParallel is a data.table. Can it be the model fit to allow contrasts? Let's say there is a data that has multiple patients and each patient sample has multiple cell types. It doesn't seem feasible to extract cell type markers by fitting a full model ~cellType + patientID, followed by computing contrasts such as epithelial-(Tcell + Bcell + NKcell)/3 which limma can do.

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