diff --git a/.github/workflows/ci.yaml b/.github/workflows/ci.yaml
index 778ab8b064777..fa05f6082a20e 100644
--- a/.github/workflows/ci.yaml
+++ b/.github/workflows/ci.yaml
@@ -42,7 +42,7 @@ env:
   MYPY_CACHE_VERSION: 9
   HA_SHORT_VERSION: "2024.12"
   DEFAULT_PYTHON: "3.12"
-  ALL_PYTHON_VERSIONS: "['3.12']"
+  ALL_PYTHON_VERSIONS: "['3.12', '3.13']"
   # 10.3 is the oldest supported version
   # - 10.3.32 is the version currently shipped with Synology (as of 17 Feb 2022)
   # 10.6 is the current long-term-support
diff --git a/.github/workflows/wheels.yml b/.github/workflows/wheels.yml
index ef01bb122d39b..b9f54bba08144 100644
--- a/.github/workflows/wheels.yml
+++ b/.github/workflows/wheels.yml
@@ -112,7 +112,7 @@ jobs:
     strategy:
       fail-fast: false
       matrix:
-        abi: ["cp312"]
+        abi: ["cp312", "cp313"]
         arch: ${{ fromJson(needs.init.outputs.architectures) }}
     steps:
       - name: Checkout the repository
@@ -156,7 +156,7 @@ jobs:
     strategy:
       fail-fast: false
       matrix:
-        abi: ["cp312"]
+        abi: ["cp312", "cp313"]
         arch: ${{ fromJson(needs.init.outputs.architectures) }}
     steps:
       - name: Checkout the repository
@@ -198,6 +198,7 @@ jobs:
           split -l $(expr $(expr $(cat requirements_all.txt | wc -l) + 1) / 3) requirements_all_wheels_${{ matrix.arch }}.txt requirements_all.txt
 
       - name: Create requirements for cython<3
+        if: matrix.abi == 'cp312'
         run: |
           # Some dependencies still require 'cython<3'
           # and don't yet use isolated build environments.
@@ -209,6 +210,7 @@ jobs:
 
       - name: Build wheels (old cython)
         uses: home-assistant/wheels@2024.11.0
+        if: matrix.abi == 'cp312'
         with:
           abi: ${{ matrix.abi }}
           tag: musllinux_1_2
@@ -231,7 +233,7 @@ jobs:
           wheels-key: ${{ secrets.WHEELS_KEY }}
           env-file: true
           apk: "bluez-dev;libffi-dev;openssl-dev;glib-dev;eudev-dev;libxml2-dev;libxslt-dev;libpng-dev;libjpeg-turbo-dev;tiff-dev;cups-dev;gmp-dev;mpfr-dev;mpc1-dev;ffmpeg-dev;gammu-dev;yaml-dev;openblas-dev;fftw-dev;lapack-dev;gfortran;blas-dev;eigen-dev;freetype-dev;glew-dev;harfbuzz-dev;hdf5-dev;libdc1394-dev;libtbb-dev;mesa-dev;openexr-dev;openjpeg-dev;uchardet-dev;nasm;zlib-dev"
-          skip-binary: aiohttp;charset-normalizer;grpcio;multidict;SQLAlchemy;propcache;protobuf;pydantic;pymicro-vad;yarl
+          skip-binary: aiohttp;charset-normalizer;grpcio;multidict;SQLAlchemy;propcache;protobuf;pymicro-vad;yarl
           constraints: "homeassistant/package_constraints.txt"
           requirements-diff: "requirements_diff.txt"
           requirements: "requirements_all.txtaa"
@@ -245,7 +247,7 @@ jobs:
           wheels-key: ${{ secrets.WHEELS_KEY }}
           env-file: true
           apk: "bluez-dev;libffi-dev;openssl-dev;glib-dev;eudev-dev;libxml2-dev;libxslt-dev;libpng-dev;libjpeg-turbo-dev;tiff-dev;cups-dev;gmp-dev;mpfr-dev;mpc1-dev;ffmpeg-dev;gammu-dev;yaml-dev;openblas-dev;fftw-dev;lapack-dev;gfortran;blas-dev;eigen-dev;freetype-dev;glew-dev;harfbuzz-dev;hdf5-dev;libdc1394-dev;libtbb-dev;mesa-dev;openexr-dev;openjpeg-dev;uchardet-dev;nasm;zlib-dev"
-          skip-binary: aiohttp;charset-normalizer;grpcio;multidict;SQLAlchemy;propcache;protobuf;pydantic;pymicro-vad;yarl
+          skip-binary: aiohttp;charset-normalizer;grpcio;multidict;SQLAlchemy;propcache;protobuf;pymicro-vad;yarl
           constraints: "homeassistant/package_constraints.txt"
           requirements-diff: "requirements_diff.txt"
           requirements: "requirements_all.txtab"
@@ -259,7 +261,7 @@ jobs:
           wheels-key: ${{ secrets.WHEELS_KEY }}
           env-file: true
           apk: "bluez-dev;libffi-dev;openssl-dev;glib-dev;eudev-dev;libxml2-dev;libxslt-dev;libpng-dev;libjpeg-turbo-dev;tiff-dev;cups-dev;gmp-dev;mpfr-dev;mpc1-dev;ffmpeg-dev;gammu-dev;yaml-dev;openblas-dev;fftw-dev;lapack-dev;gfortran;blas-dev;eigen-dev;freetype-dev;glew-dev;harfbuzz-dev;hdf5-dev;libdc1394-dev;libtbb-dev;mesa-dev;openexr-dev;openjpeg-dev;uchardet-dev;nasm;zlib-dev"
-          skip-binary: aiohttp;charset-normalizer;grpcio;multidict;SQLAlchemy;propcache;protobuf;pydantic;pymicro-vad;yarl
+          skip-binary: aiohttp;charset-normalizer;grpcio;multidict;SQLAlchemy;propcache;protobuf;pymicro-vad;yarl
           constraints: "homeassistant/package_constraints.txt"
           requirements-diff: "requirements_diff.txt"
           requirements: "requirements_all.txtac"
diff --git a/homeassistant/components/huum/__init__.py b/homeassistant/components/huum/__init__.py
index 75faf1923df6c..c533ca34ef3a5 100644
--- a/homeassistant/components/huum/__init__.py
+++ b/homeassistant/components/huum/__init__.py
@@ -3,23 +3,30 @@
 from __future__ import annotations
 
 import logging
-
-from huum.exceptions import Forbidden, NotAuthenticated
-from huum.huum import Huum
+import sys
 
 from homeassistant.config_entries import ConfigEntry
 from homeassistant.const import CONF_PASSWORD, CONF_USERNAME
 from homeassistant.core import HomeAssistant
-from homeassistant.exceptions import ConfigEntryNotReady
+from homeassistant.exceptions import ConfigEntryNotReady, HomeAssistantError
 from homeassistant.helpers.aiohttp_client import async_get_clientsession
 
 from .const import DOMAIN, PLATFORMS
 
+if sys.version_info < (3, 13):
+    from huum.exceptions import Forbidden, NotAuthenticated
+    from huum.huum import Huum
+
 _LOGGER = logging.getLogger(__name__)
 
 
 async def async_setup_entry(hass: HomeAssistant, entry: ConfigEntry) -> bool:
     """Set up Huum from a config entry."""
+    if sys.version_info >= (3, 13):
+        raise HomeAssistantError(
+            "Huum is not supported on Python 3.13. Please use Python 3.12."
+        )
+
     username = entry.data[CONF_USERNAME]
     password = entry.data[CONF_PASSWORD]
 
diff --git a/homeassistant/components/huum/climate.py b/homeassistant/components/huum/climate.py
index df740aea3d120..b659e33038a57 100644
--- a/homeassistant/components/huum/climate.py
+++ b/homeassistant/components/huum/climate.py
@@ -3,13 +3,9 @@
 from __future__ import annotations
 
 import logging
+import sys
 from typing import Any
 
-from huum.const import SaunaStatus
-from huum.exceptions import SafetyException
-from huum.huum import Huum
-from huum.schemas import HuumStatusResponse
-
 from homeassistant.components.climate import (
     ClimateEntity,
     ClimateEntityFeature,
@@ -24,6 +20,12 @@
 
 from .const import DOMAIN
 
+if sys.version_info < (3, 13):
+    from huum.const import SaunaStatus
+    from huum.exceptions import SafetyException
+    from huum.huum import Huum
+    from huum.schemas import HuumStatusResponse
+
 _LOGGER = logging.getLogger(__name__)
 
 
diff --git a/homeassistant/components/huum/config_flow.py b/homeassistant/components/huum/config_flow.py
index 6a5fd96b99d95..10c3137818464 100644
--- a/homeassistant/components/huum/config_flow.py
+++ b/homeassistant/components/huum/config_flow.py
@@ -3,10 +3,9 @@
 from __future__ import annotations
 
 import logging
+import sys
 from typing import Any
 
-from huum.exceptions import Forbidden, NotAuthenticated
-from huum.huum import Huum
 import voluptuous as vol
 
 from homeassistant.config_entries import ConfigFlow, ConfigFlowResult
@@ -15,6 +14,10 @@
 
 from .const import DOMAIN
 
+if sys.version_info < (3, 13):
+    from huum.exceptions import Forbidden, NotAuthenticated
+    from huum.huum import Huum
+
 _LOGGER = logging.getLogger(__name__)
 
 STEP_USER_DATA_SCHEMA = vol.Schema(
diff --git a/homeassistant/components/huum/manifest.json b/homeassistant/components/huum/manifest.json
index cc393f3785ff6..025d1b97f216f 100644
--- a/homeassistant/components/huum/manifest.json
+++ b/homeassistant/components/huum/manifest.json
@@ -5,5 +5,5 @@
   "config_flow": true,
   "documentation": "https://www.home-assistant.io/integrations/huum",
   "iot_class": "cloud_polling",
-  "requirements": ["huum==0.7.11"]
+  "requirements": ["huum==0.7.11;python_version<'3.13'"]
 }
diff --git a/homeassistant/components/profiler/__init__.py b/homeassistant/components/profiler/__init__.py
index 9b2b97365746e..389e3384ad9b9 100644
--- a/homeassistant/components/profiler/__init__.py
+++ b/homeassistant/components/profiler/__init__.py
@@ -436,6 +436,10 @@ async def _async_generate_memory_profile(hass: HomeAssistant, call: ServiceCall)
     # Imports deferred to avoid loading modules
     # in memory since usually only one part of this
     # integration is used at a time
+    if sys.version_info >= (3, 13):
+        raise HomeAssistantError(
+            "Memory profiling is not supported on Python 3.13. Please use Python 3.12."
+        )
     from guppy import hpy  # pylint: disable=import-outside-toplevel
 
     start_time = int(time.time() * 1000000)
diff --git a/homeassistant/components/profiler/manifest.json b/homeassistant/components/profiler/manifest.json
index 9f27ee7f7d076..8d2814c8c7f58 100644
--- a/homeassistant/components/profiler/manifest.json
+++ b/homeassistant/components/profiler/manifest.json
@@ -7,7 +7,7 @@
   "quality_scale": "internal",
   "requirements": [
     "pyprof2calltree==1.4.5",
-    "guppy3==3.1.4.post1",
+    "guppy3==3.1.4.post1;python_version<'3.13'",
     "objgraph==3.5.0"
   ],
   "single_config_entry": true
diff --git a/homeassistant/package_constraints.txt b/homeassistant/package_constraints.txt
index 2c03e45892038..0606cdd343563 100644
--- a/homeassistant/package_constraints.txt
+++ b/homeassistant/package_constraints.txt
@@ -13,6 +13,7 @@ async-interrupt==1.2.0
 async-upnp-client==0.41.0
 atomicwrites-homeassistant==1.4.1
 attrs==24.2.0
+audioop-lts==0.2.1;python_version>='3.13'
 av==13.1.0
 awesomeversion==24.6.0
 bcrypt==4.2.0
@@ -59,6 +60,8 @@ PyYAML==6.0.2
 requests==2.32.3
 securetar==2024.2.1
 SQLAlchemy==2.0.31
+standard-aifc==3.13.0;python_version>='3.13'
+standard-telnetlib==3.13.0;python_version>='3.13'
 typing-extensions>=4.12.2,<5.0
 ulid-transform==1.0.2
 urllib3>=1.26.5,<2
diff --git a/pyproject.toml b/pyproject.toml
index 3cb7fa0e43943..c18f616abad22 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -36,6 +36,7 @@ dependencies    = [
     "async-interrupt==1.2.0",
     "attrs==24.2.0",
     "atomicwrites-homeassistant==1.4.1",
+    "audioop-lts==0.2.1;python_version>='3.13'",
     "awesomeversion==24.6.0",
     "bcrypt==4.2.0",
     "certifi>=2021.5.30",
@@ -65,6 +66,8 @@ dependencies    = [
     "requests==2.32.3",
     "securetar==2024.2.1",
     "SQLAlchemy==2.0.31",
+    "standard-aifc==3.13.0;python_version>='3.13'",
+    "standard-telnetlib==3.13.0;python_version>='3.13'",
     "typing-extensions>=4.12.2,<5.0",
     "ulid-transform==1.0.2",
     # Constrain urllib3 to ensure we deal with CVE-2020-26137 and CVE-2021-33503
@@ -617,6 +620,17 @@ filterwarnings = [
     # https://github.com/ssaenger/pyws66i/blob/v1.1/pyws66i/__init__.py#L2
     "ignore:'telnetlib' is deprecated and slated for removal in Python 3.13:DeprecationWarning:pyws66i",
 
+    # -- New in Python 3.13
+    # https://github.com/kurtmckee/feedparser/pull/389 - >6.0.11
+    # https://github.com/kurtmckee/feedparser/issues/481
+    "ignore:'count' is passed as positional argument:DeprecationWarning:feedparser.html",
+    # https://github.com/youknowone/python-deadlib - Backports for aifc, telnetlib
+    "ignore:aifc was removed in Python 3.13.*'standard-aifc':DeprecationWarning:speech_recognition",
+    "ignore:telnetlib was removed in Python 3.13.*'standard-telnetlib':DeprecationWarning:homeassistant.components.hddtemp.sensor",
+    "ignore:telnetlib was removed in Python 3.13.*'standard-telnetlib':DeprecationWarning:ndms2_client.connection",
+    "ignore:telnetlib was removed in Python 3.13.*'standard-telnetlib':DeprecationWarning:plumlightpad.lightpad",
+    "ignore:telnetlib was removed in Python 3.13.*'standard-telnetlib':DeprecationWarning:pyws66i",
+
     # -- unmaintained projects, last release about 2+ years
     # https://pypi.org/project/agent-py/ - v0.0.23 - 2020-06-04
     "ignore:with timeout\\(\\) is deprecated:DeprecationWarning:agent.a",
diff --git a/requirements.txt b/requirements.txt
index f69fc2b02bf1c..d3c60eb302e0a 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -13,6 +13,7 @@ astral==2.2
 async-interrupt==1.2.0
 attrs==24.2.0
 atomicwrites-homeassistant==1.4.1
+audioop-lts==0.2.1;python_version>='3.13'
 awesomeversion==24.6.0
 bcrypt==4.2.0
 certifi>=2021.5.30
@@ -37,6 +38,8 @@ PyYAML==6.0.2
 requests==2.32.3
 securetar==2024.2.1
 SQLAlchemy==2.0.31
+standard-aifc==3.13.0;python_version>='3.13'
+standard-telnetlib==3.13.0;python_version>='3.13'
 typing-extensions>=4.12.2,<5.0
 ulid-transform==1.0.2
 urllib3>=1.26.5,<2
diff --git a/requirements_all.txt b/requirements_all.txt
index cb0b156cfff58..7813e5fc7331c 100644
--- a/requirements_all.txt
+++ b/requirements_all.txt
@@ -1066,7 +1066,7 @@ gspread==5.5.0
 gstreamer-player==1.1.2
 
 # homeassistant.components.profiler
-guppy3==3.1.4.post1
+guppy3==3.1.4.post1;python_version<'3.13'
 
 # homeassistant.components.iaqualink
 h2==4.1.0
@@ -1148,7 +1148,7 @@ httplib2==0.20.4
 huawei-lte-api==1.10.0
 
 # homeassistant.components.huum
-huum==0.7.11
+huum==0.7.11;python_version<'3.13'
 
 # homeassistant.components.hyperion
 hyperion-py==0.7.5
diff --git a/requirements_test_all.txt b/requirements_test_all.txt
index a13f27c3b9828..2843974cc9a6f 100644
--- a/requirements_test_all.txt
+++ b/requirements_test_all.txt
@@ -904,7 +904,7 @@ growattServer==1.5.0
 gspread==5.5.0
 
 # homeassistant.components.profiler
-guppy3==3.1.4.post1
+guppy3==3.1.4.post1;python_version<'3.13'
 
 # homeassistant.components.iaqualink
 h2==4.1.0
@@ -971,7 +971,7 @@ httplib2==0.20.4
 huawei-lte-api==1.10.0
 
 # homeassistant.components.huum
-huum==0.7.11
+huum==0.7.11;python_version<'3.13'
 
 # homeassistant.components.hyperion
 hyperion-py==0.7.5
diff --git a/tests/components/huum/conftest.py b/tests/components/huum/conftest.py
new file mode 100644
index 0000000000000..da66cc54b72ea
--- /dev/null
+++ b/tests/components/huum/conftest.py
@@ -0,0 +1,6 @@
+"""Skip test collection for Python 3.13."""
+
+import sys
+
+if sys.version_info >= (3, 13):
+    collect_ignore_glob = ["test_*.py"]
diff --git a/tests/components/profiler/test_init.py b/tests/components/profiler/test_init.py
index 3f0e0b92056ac..37940df437bd3 100644
--- a/tests/components/profiler/test_init.py
+++ b/tests/components/profiler/test_init.py
@@ -5,6 +5,7 @@
 import logging
 import os
 from pathlib import Path
+import sys
 from unittest.mock import patch
 
 from freezegun.api import FrozenDateTimeFactory
@@ -70,6 +71,9 @@ def _mock_path(filename: str) -> str:
     await hass.async_block_till_done()
 
 
+@pytest.mark.skipif(
+    sys.version_info >= (3, 13), reason="not yet available on Python 3.13"
+)
 async def test_memory_usage(hass: HomeAssistant, tmp_path: Path) -> None:
     """Test we can setup and the service is registered."""
     test_dir = tmp_path / "profiles"
@@ -101,6 +105,24 @@ def _mock_path(filename: str) -> str:
     await hass.async_block_till_done()
 
 
+@pytest.mark.skipif(sys.version_info < (3, 13), reason="still works on python 3.12")
+async def test_memory_usage_py313(hass: HomeAssistant, tmp_path: Path) -> None:
+    """Test raise an error on python3.13."""
+    entry = MockConfigEntry(domain=DOMAIN)
+    entry.add_to_hass(hass)
+
+    assert await hass.config_entries.async_setup(entry.entry_id)
+    await hass.async_block_till_done()
+    assert hass.services.has_service(DOMAIN, SERVICE_MEMORY)
+    with pytest.raises(
+        HomeAssistantError,
+        match="Memory profiling is not supported on Python 3.13. Please use Python 3.12.",
+    ):
+        await hass.services.async_call(
+            DOMAIN, SERVICE_MEMORY, {CONF_SECONDS: 0.000001}, blocking=True
+        )
+
+
 async def test_object_growth_logging(
     hass: HomeAssistant,
     caplog: pytest.LogCaptureFixture,