diff --git a/lib/LongVectorLoweringPass.cpp b/lib/LongVectorLoweringPass.cpp
index 51c30cf45..1a12af07d 100644
--- a/lib/LongVectorLoweringPass.cpp
+++ b/lib/LongVectorLoweringPass.cpp
@@ -1969,6 +1969,8 @@ void clspv::LongVectorLoweringPass::cleanDeadGlobals() {
   for (auto const &Mapping : GlobalVariableMap) {
     auto *GV = Mapping.first;
     GV->removeDeadConstantUsers();
-    GV->eraseFromParent();
+    if (GV->getNumUses() == 0) {
+      GV->eraseFromParent();
+    }
   }
 }
diff --git a/test/PhysicalStorageBuffers/issue-1422.cl b/test/PhysicalStorageBuffers/issue-1422.cl
new file mode 100644
index 000000000..958119c7a
--- /dev/null
+++ b/test/PhysicalStorageBuffers/issue-1422.cl
@@ -0,0 +1,14 @@
+// RUN: clspv -cl-std=CL3.0 -inline-entry-points -cl-single-precision-constant -cl-kernel-arg-info -rounding-mode-rte=16,32,64 -rewrite-packed-structs -std430-ubo-layout -decorate-nonuniform -arch=spir64 -physical-storage-buffers -cl-arm-integer-dot-product --use-native-builtins=acos,acosh,acospi,asin,asinh,asinpi,atan,atan2,atan2pi,atanh,atanpi,ceil,copysign,fdim,floor,fma,fmax,fmin,frexp,half_rsqrt,half_sqrt,isequal,isfinite,isgreater,isgreaterequal,isinf,isless,islessequal,islessgreater,isnan,isnormal,isnotequal,isordered,isunordered,ldexp,mad,rint,round,rsqrt,signbit,sqrt,tanh,trunc, -spv-version=1.6 -max-pushconstant-size=256 -max-ubo-size=65536 -global-offset -long-vector -module-constants-in-storage-buffer -cl-arm-non-uniform-work-group-size -enable-feature-macros=__opencl_c_images,__opencl_c_3d_image_writes,__opencl_c_read_write_images,__opencl_c_atomic_order_acq_rel,__opencl_c_atomic_scope_device,__opencl_c_subgroups,__opencl_c_int64,__opencl_c_fp64,__opencl_c_integer_dot_product_input_4x8bit,__opencl_c_integer_dot_product_input_4x8bit_packed -enable-printf -printf-buffer-size=1048576 %s -o %t.spv
+// RUN: spirv-val --target-env spv1.6 %t.spv
+
+typedef struct myUnpackedStruct {
+  char c;
+  char8 vec;
+} testStruct;
+
+__kernel void test_vec_align_struct(__constant char8 *source,
+                                    __global uint *dest) {
+  __local testStruct test;
+  int tid = get_global_id(0);
+  dest[tid] = (uint)((__local uchar *)&(test.vec));
+}