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ALANYL-TRNA SYNTHETASE (PTHR11777)-FBgn0027094 #5546

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hattrill opened this issue Nov 22, 2024 · 3 comments
Open

ALANYL-TRNA SYNTHETASE (PTHR11777)-FBgn0027094 #5546

hattrill opened this issue Nov 22, 2024 · 3 comments

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@hattrill
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  • PTHR ID & PTN node:
    ALANYL-TRNA SYNTHETASE (PTHR11777)
    PTN000206953

  • Sequences with problematic annotation (ID + gene/protein name):
    FBgn0027094 AlaRS

  • Type of Issue: Erroneous source or erroneous propagation, or other issue

  • Block propagation of mitochondrion GO:0005739 to FBgn0027094 as this is the cytoplasmic version of this enzyme

  • Add the label 'high priority' if needed. Generally high priority issues affect a lot of proteins, and annotations are incorrect (as opposed to just imprecise).

@ValWood
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ValWood commented Nov 24, 2024

These will be tricky to propagate correctly. The localizations don't always align well with the ortholog. For example, the family member is the only alanyl-tRNA synthase in pombe, and is both mitochondrial and cytosolic

@pgaudet
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pgaudet commented Nov 25, 2024

This is when 'cytoplasmic' may be useful ;)

@hattrill
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I think that in these cases, not propagating a CC is the correct choice. As Ronan Keating once said, "you say it best when you say nothing at all"

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