Review annotations: sequestering process terms and regulation of sequestering process

[edwong57]

Dear all,

The proposal has been made to obsolete the following terms:

GO:0006880 | intracellular sequestering of iron ion | 39
GO:0006881 | extracellular sequestering of iron ion | 15
GO:0007253 | cytoplasmic sequestering of NF-kappaB | 36
GO:0010891 | negative regulation of sequestering of triglyceride | 11
GO:0010890 | positive regulation of sequestering of triglyceride | 10
GO:0030730 | sequestering of triglyceride | 11
GO:0010889 | regulation of sequestering of triglyceride | 1
GO:0042137 | sequestering of neurotransmitter | 2
GO:0042989 | sequestering of actin monomers | 24
GO:0042994 | cytoplasmic sequestering of transcription factor | 18
GO:0051220 | cytoplasmic sequestering of protein | 23
GO:0032119 | sequestering of zinc ion | 5
GO:0051238 | sequestering of metal ion | 6
GO:0097578 | sequestering of copper ion | 2
GO:0097577 | sequestering of iron ion | 4
GO:1990659 sequestering of manganese ion|0

see geneontology/go-ontology#17075

Experimental annotations that need to be reviewed are here: https://docs.google.com/spreadsheets/d/1WM-8BXKb1WMamR5ONCw3hxtppqQ3CR1ZVAxBalgjpGE/edit?usp=sharing

Impacted groups:
AgBase 12
ARUK-UCL 1
BHF-UCL 24
CAFA 3
dictyBase 2
DisProt 5
FlyBase 19
GeneDB 1
GO_Central 3
MGI 18
ParkinsonsUK-UCL 2
PINC 7
PseudoCAP 6
RGD 26
SGD 4
UniProt 74
WB 4

---

Mappings that need to be reviewed: (InterPro2GO, UniProt-Keywords, UniRule)

GO:0006880 interpro2go InterPro:IPR030909 IMEF encapsulin system ferritin-like cargo > GO:intracellular sequestering of iron ion ; GO:0006880
GO:0006880 unirule2go UniRule:UR001903787 > GO:intracellular sequestering of iron ion ; GO:0006880

Thanks.

[edwong57]

SGD done

[pgaudet]

@Antonialock
From this sentence in PMID:8797820

Thus, the rescue of nuclear localization of Myf5 by the SV40 NLS suggests that I-mfa sequesters myogenic regulatory factors in the cytoplasm through direct protein interaction which masks the NLS of these factors.

I would say this is negative regulation of some signaling pathway?

[slaulederkind]

RGD finished.

[RLovering]

UCL done

[sarach06]

Hi,
Thank you very much. I have removed GO:0006880 from the InterPro entry you mentioned. This will be visible in InterPro release 103.0.
Best,
Sara