diff --git a/lib/galaxy/dependencies/pinned-requirements.txt b/lib/galaxy/dependencies/pinned-requirements.txt
index cc8d86eec7dc..396004201838 100644
--- a/lib/galaxy/dependencies/pinned-requirements.txt
+++ b/lib/galaxy/dependencies/pinned-requirements.txt
@@ -92,6 +92,7 @@ idna==3.5 ; python_version >= "3.7" and python_version < "3.12"
 importlib-metadata==4.13.0 ; python_version >= "3.7" and python_version < "3.12"
 importlib-resources==5.12.0 ; python_version >= "3.7" and python_version < "3.12"
 isa-rwval==0.10.10 ; python_version >= "3.7" and python_version < "3.12"
+isal==1.3.0 ; python_version >= "3.7" and python_version < "3.12"
 isodate==0.6.1 ; python_version >= "3.7" and python_version < "3.12"
 jinja2==3.1.2 ; python_version >= "3.7" and python_version < "3.12"
 jmespath==1.0.1 ; python_version >= "3.7" and python_version < "3.12"
diff --git a/lib/galaxy/model/store/__init__.py b/lib/galaxy/model/store/__init__.py
index e8a6c95fb377..973cec825999 100644
--- a/lib/galaxy/model/store/__init__.py
+++ b/lib/galaxy/model/store/__init__.py
@@ -2753,7 +2753,7 @@ def _finalize(self) -> None:
             out_file = out_file_name[: -len(".zip")]
         else:
             out_file = out_file_name
-        rval = shutil.make_archive(out_file, "zip", self.export_directory)
+        rval = shutil.make_archive(out_file, "fastzip", self.export_directory)
         if not self.file_source_uri:
             shutil.move(rval, self.out_file)
         else:
diff --git a/lib/galaxy/util/compression_utils.py b/lib/galaxy/util/compression_utils.py
index c10a6b4ed822..2282a7578880 100644
--- a/lib/galaxy/util/compression_utils.py
+++ b/lib/galaxy/util/compression_utils.py
@@ -3,6 +3,7 @@
 import io
 import logging
 import os
+import shutil
 import tarfile
 import tempfile
 import zipfile
@@ -30,6 +31,12 @@
     is_gzip,
 )
 
+try:
+    from isal import isal_zlib
+except ImportError:
+    isal_zlib = None  # type: ignore[assignment]
+
+
 log = logging.getLogger(__name__)
 
 FileObjTypeStr = Union[IO[str], io.TextIOWrapper]
@@ -345,3 +352,84 @@ def zipfile_ok(self, path_to_archive: StrPath) -> bool:
             if not member_path.startswith(basename):
                 return False
         return True
+
+
+class FastZipFile(zipfile.ZipFile):
+    """
+    Simple wrapper around ZipFile that uses the default compression strategy of ISA-L
+    to write zip files. Ignores compresslevel and compresstype arguments, and is
+    3 to 4 times faster than the zlib implementation at the default compression level.
+    """
+
+    def _open_to_write(self, *args, **kwargs):  # type: ignore[no-untyped-def]
+        zwf = super()._open_to_write(*args, **kwargs)  # type: ignore[misc]
+        if isal_zlib:
+            zwf._compressor = isal_zlib.compressobj(isal_zlib.ISAL_DEFAULT_COMPRESSION, isal_zlib.DEFLATED, -15, 9)
+        return zwf
+
+
+# modified from shutil._make_zipfile
+def make_fast_zipfile(
+    base_name: str,
+    base_dir: str,
+    verbose: int = 0,
+    dry_run: int = 0,
+    logger: Optional[logging.Logger] = None,
+    owner: Optional[str] = None,
+    group: Optional[str] = None,
+    root_dir: Optional[str] = None,
+) -> str:
+    """Create a zip file from all the files under 'base_dir'.
+
+    The output zip file will be named 'base_name' + ".zip".  Returns the
+    name of the output zip file.
+    """
+
+    zip_filename = base_name + ".zip"
+    archive_dir = os.path.dirname(base_name)
+
+    if archive_dir and not os.path.exists(archive_dir):
+        if logger is not None:
+            logger.info("creating %s", archive_dir)
+        if not dry_run:
+            os.makedirs(archive_dir)
+
+    if logger is not None:
+        logger.info("creating '%s' and adding '%s' to it", zip_filename, base_dir)
+
+    if not dry_run:
+        with FastZipFile(zip_filename, mode="w", compression=zipfile.ZIP_DEFLATED) as zf:
+            arcname = os.path.normpath(base_dir)
+            if root_dir is not None:
+                base_dir = os.path.join(root_dir, base_dir)
+            base_dir = os.path.normpath(base_dir)
+            if arcname != os.curdir:
+                zf.write(base_dir, arcname)
+                if logger is not None:
+                    logger.info("adding '%s'", base_dir)
+            for dirpath, dirnames, filenames in os.walk(base_dir):
+                arcdirpath = dirpath
+                if root_dir is not None:
+                    arcdirpath = os.path.relpath(arcdirpath, root_dir)
+                arcdirpath = os.path.normpath(arcdirpath)
+                for name in sorted(dirnames):
+                    path = os.path.join(dirpath, name)
+                    arcname = os.path.join(arcdirpath, name)
+                    zf.write(path, arcname)
+                    if logger is not None:
+                        logger.info("adding '%s'", path)
+                for name in filenames:
+                    path = os.path.join(dirpath, name)
+                    path = os.path.normpath(path)
+                    if os.path.isfile(path):
+                        arcname = os.path.join(arcdirpath, name)
+                        zf.write(path, arcname)
+                        if logger is not None:
+                            logger.info("adding '%s'", path)
+
+    if root_dir is not None:
+        zip_filename = os.path.abspath(zip_filename)
+    return zip_filename
+
+
+shutil.register_archive_format("fastzip", make_fast_zipfile)
diff --git a/packages/data/setup.cfg b/packages/data/setup.cfg
index 02f74386b9d5..866021657d87 100644
--- a/packages/data/setup.cfg
+++ b/packages/data/setup.cfg
@@ -44,6 +44,7 @@ install_requires =
     h5grove
     h5py
     isa-rwval
+    isal
     MarkupSafe
     msal
     mrcfile
diff --git a/packages/files/setup.cfg b/packages/files/setup.cfg
index 9f89c257b476..8ef367a9d14f 100644
--- a/packages/files/setup.cfg
+++ b/packages/files/setup.cfg
@@ -34,6 +34,7 @@ include_package_data = True
 install_requires =
     galaxy-util
     fs
+    isal
     typing-extensions
 packages = find:
 python_requires = >=3.7
diff --git a/pyproject.toml b/pyproject.toml
index ec98c6f49ef2..f6d9c0ca03a5 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -71,6 +71,7 @@ h5py = "*"
 importlib-metadata = "<5"  # Work around https://github.com/celery/kombu/issues/1600
 importlib-resources = "*"
 isa-rwval = ">=0.10.10"
+isal = "*"
 kombu = "*"
 lagom = "*"
 Mako = "*"