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FeaturesResearch.xml
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FeaturesResearch.xml
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<?xml version="1.0" encoding="UTF-8"?>
<!-- UPDATE: eLife is updating to the most recent version of JATS, 1.1 -->
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Archiving and Interchange DTD v1.1 20151215//EN" "JATS-archivearticle1.dtd">
<!-- eLife uses the JATS suggested @article-types from the given attribute list. This is the location where we match our content names to known terms,
we use subj-groups to indicate eLife-specific terms. The @article-type on article drives the template used on the html version of the article and is also used for PubMed deposits.
The @article-types currently used are:
article-commentary - Insight
correction - Correction
discussion - Feature 1/Feature 2
editorial - Editorial
research-article - all research content (ie non-feature content)
UPDATE: xmlns:ali="http://www.niso.org/schemas/ali/1.0/" this name space is added in order to add the new license information (see permissions section)
-->
<article article-type="research-article" dtd-version="1.1" xmlns:ali="http://www.niso.org/schemas/ali/1.0/"
xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">
<front>
<!-- journal-meta is standard for all articles published by eLife. Can be boilerplate text as this will not change from article to article.
UPDATE: <journal-id journal-id-type="hwp">eLife</journal-id> has been removed - we are no longer hosted by HighWirePress so this is not required -->
<journal-meta>
<journal-id journal-id-type="nlm-ta">eLife</journal-id>
<journal-id journal-id-type="publisher-id">eLife</journal-id>
<journal-title-group>
<journal-title>eLife</journal-title>
</journal-title-group>
<issn publication-format="electronic" pub-type="epub">2050-084X</issn>
<publisher>
<publisher-name>eLife Sciences Publications, Ltd</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<!-- @pub-id-type publisher-id - this is always a 5 digit number -->
<article-id pub-id-type="publisher-id">00666</article-id>
<!-- @pub-id-type doi - always has eLife prefix (10.7554/eLife.) followed by same 5 digit number as publisher id -->
<!--UPDATE: PDF links to DOIs: from CrossRef: The updated Crossref DOI Display guidelines recommend that https://doi.org/ be used and not http://dx.doi.org/ in DOI links.
Originally the “dx” separated the DOI resolver from the International DOI Foundation (IDF) website but this has changed and the IDF has already updated its recommendations
so we are bringing ours in line with theirs. We are also recommending the use of HTTPS because it makes for more secure browsing.
-->
<!-- UPDATE: DOI prefix removed from XML but must be added to display in PDF and HTML-->
<article-id pub-id-type="doi">10.7554/eLife.00666</article-id>
<article-categories>
<!-- @subj-group-type "display-channel" - eLife-defined article type, controlled list for Research Content (case sensitive):
Research Article
Short Report
Tools and Resources
Research Advance - this article type MUST have related article tagging with an @related-article-type of "article-reference" and an xlink:href to the doi of the related article (e.g."10.7554/eLife.00109")
Registered Report - there will be a different kitchen sink for this article type to indicate how to link to the paper it is being built upon
Replication Study - there will be a different kitchen sink for this article type to indicate how to link to the paper it is being built upon -->
<subj-group subj-group-type="display-channel">
<subject>Research</subject>
</subj-group>
<subj-group subj-group-type="display-channel">
<subject>Feature article</subject>
</subj-group>
<!-- @subj-group-type heading - eLife-defined major subject area. By default, there are up to 2 per article; however more can be added at author
request. This is a controlled list (case sensitive):
Biochemistry
Biophysics and Structural Biology
Cell Biology
Computational and Systems Biology
Developmental Biology and Stem Cells
Ecology
Epidemiology and Global Health
Genes and Chromosomes
Genomics and Evolutionary Biology
Human Biology and Medicine
Immunology
Microbiology and Infectious Disease
Neuroscience
Plant Biology -->
<subj-group subj-group-type="heading">
<subject>Cell Biology</subject>
</subj-group>
<subj-group subj-group-type="heading">
<subject>Plant Biology</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>The eLife research article</article-title>
</title-group>
<contrib-group>
<!-- Each contrib MUST have following attributes:
1) @contrib-type - "author".
2) id="author-XXXXX" - this is the unique number assigned to an author via the submission system (this is output in the XML from the submission system.
The contrib MAY have following attributes:
1) equal-contrib="yes" - can only be used if an author contributed equally with another author and this attribute must be present on both their contribs.
There is no limit on the number authors who can have equal contributions and there can be separate groups of equal contribution.
This is linked to a footnote via an xref.
UPDATE: The rid should be equal-contrib1, equal-contrib2 etc to indicate which equal contrib group each author is part of. Even if there is only one
group, the number suffix is still required.
2) deceased="yes" - only used if author is now dead.
3) corresp="yes" - only used if the author is a corresponding author. There can be more than one corresponding author and there is no limit to the number
of corresponding authors. A corresponding author must have an email address contained within their contrib.
PDF display: Corresponding author footnote on PDF always takes symbol *(*).
Footnotes to affiliations follow the superscript numbering system (1,2,3 etc).
All succeeding footnotes use the following symbols in order: † (†), ‡ (‡), § (§), # (#), ¶ (¶),**,††, ‡‡,§§,## ,¶¶ -->
<contrib contrib-type="author" corresp="yes" equal-contrib="yes" id="author-00001" deceased="yes">
<name>
<surname>Harrison</surname>
<given-names>Melissa</given-names>
<suffix>Jnr</suffix>
</name>
<!-- Corresponding author (correspondent for peer review process) must have an ORCID; all other authors are encouraged but not required to have one.
NOTE: There can be multiple corresponding authors and they may not all have an ORCID as only one will be the primary correspondent for peer review. The
primary corresponding author will be indicated as the corresponding author for the proofing process in the output XML from the submission system, but
this distinction will not be retained in the final XML. -->
<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0003-3523-4408</contrib-id>
<!-- UPDATE: email for corresponding author is contained within contrib and no longer in author notes.
For PDF display footnote "*For correspondence: " must be added as boilerplate followed by the email address pulled in from the XML.If there are multiple
corresponding authors, the email addresses must be added in order of the author list, separated with semicolons. Author initials should to be added in
brackets after each email address. See Kitchen sink PDF for example.-->
<email>[email protected]</email>
<!-- xref links within contrib should be in the following order, which also reflects the order of the footnote symbols:
presence of an email address indicates for correspondence *
Affiliations - take numbered footnotes
Following are optional but in this order:
Equal contributions - first set, second set etc
Present address - 1st, 2nd, etc
Deceased
Other footnotes-->
<!-- Author affiliation(s) are linked to a contrib via the xref link to their "aff". Each affiliation has a unique id, aff1, aff2, aff3 etc, which corresponds
to the number used in the label
Authors can have one or multiple affiliations. There should be one aff per unique affiliation and these are shared between authors, not repeated.
xref link requires display number (e.g. see below "1"). This is required for PMC and PDF build-->
<xref ref-type="aff" rid="aff1">1</xref>
<!-- Equal contributions are linked to a contrib via the footnote with attribute fn-type="fn" and the corresponding id (equal-contrib1, equal-contrib2 etc).-->
<xref ref-type="fn" rid="equal-contrib1">†</xref>
<!-- Present addresses are linked to a contrib via the footnote with attribute fn-type="present-address" and the corresponding id (pa1, pa2 etc). There is no limit
on the number of present addresses allowed per author and multiple authors can share a single present address.-->
<xref ref-type="fn" rid="pa1">§</xref>
<!-- Other footnotes are linked to a contrib via the footnote with attribute fn-type="fn" and the corresponding id (fn1, fn2 etc). No limit on the number allowed
per author and multiple authors can share the same footnote. There is no display text associated with this link.
Other footnotes are rare (they have only been used 3 times in the history of eLife) -->
<xref ref-type="fn" rid="fn1">#</xref>
<xref ref-type="fn" rid="fn2">¶</xref>
<!-- Authors who have funding declared on the article are linked to the relevant <award-group> via an xref link using the"fund" id. Each <award-group> id
should have a unique number e.g. fund1, fund2 etc. Authors can have one or multiple award-groups and multiple authors can be associated with one
award-group. There is no display text associated with this link
UPDATE: ID value changed from par to fund and hyphen removed to be consistent with other IDs. All ids have a number value suffix even if only 1 exist in the article, e.g. fund1, fund2. -->
<xref ref-type="other" rid="fund1"/>
<!-- Author competing interests statement is linked to a contrib via the footnote with attribute fn-type="conflict" and the corresponding id (conf1, conf2 etc).
Only one is allowed per author. If the author has no competing interest, this footnote can be shared with other authors.
Where a competing interest is listed, this must be unique to the author. There is no display text associated with this link within contrib -->
<xref ref-type="fn" rid="conf1"/>
<!-- Author contributions are linked to a contrib via the footnote with attribute fn-type="con" and the corresponding id (con1, con2 etc). Only one is allowed per
author. There is no display text associated with this link-->
<xref ref-type="fn" rid="con1"/>
<!-- Datasets are linked to a contrib using an xref with type "other" and the unique id for the dataset (dataset1, dataset2 etc).
UPDATE: ID value changed from dataro to dataset. All ids have a number value even if only 1 exist in the article. -->
<xref ref-type="other" rid="dataset1"/>
<xref ref-type="other" rid="dataset2"/>
</contrib>
<contrib contrib-type="author" equal-contrib="yes" id="author-00002">
<name>
<surname>Gilbert</surname>
<given-names>James F</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="fn" rid="equal-contrib1">†</xref>
<xref ref-type="other" rid="fund1"/>
<xref ref-type="other" rid="fund2"/>
<xref ref-type="fn" rid="conf2"/>
<xref ref-type="fn" rid="con2"/>
</contrib>
<!-- UPDATE: group authors. If the individuals of the group are listed, they now will be listed as a contrib-group and contributors within collab.
They are no longer separated from their group name in tagging and linked by author key. Multiple group authors are allowed and their position in the author
list displayed in the PDF is retained as per the XML order-->
<contrib contrib-type="author">
<collab>eLife Editorial Production Group
<contrib-group>
<!-- UPDATE: use of role in group authors. If a group author is subdivided into sections or sub-groups, this is indicated using the role tag-->
<role>Writing group</role>
<contrib>
<name>
<surname>Shearer</surname>
<given-names>Alistair</given-names>
</name>
<aff>
<institution>eLife</institution>
<addr-line>
<named-content content-type="city">Cambridge</named-content>
</addr-line>
<country>United Kingdom</country>
</aff>
</contrib>
<contrib>
<name>
<surname>Caton</surname>
<given-names>Hannah</given-names>
</name>
<aff>
<institution>eLife</institution>
<addr-line>
<named-content content-type="city">Cambridge</named-content>
</addr-line>
<country>United Kingdom</country>
</aff>
<aff>
<institution>eLife Institute</institution>
<addr-line>
<named-content content-type="city">Cambridge</named-content>
</addr-line>
<country>United Kingdom</country>
</aff>
</contrib>
</contrib-group>
<contrib-group>
<role>Editing group</role>
<contrib>
<name>
<surname>Chan</surname>
<given-names>Wei Mun</given-names>
</name>
<aff>
<institution>eLife</institution>
<addr-line>
<named-content content-type="city">Cambridge</named-content>
</addr-line>
<country>United Kingdom</country>
</aff>
</contrib>
<contrib>
<name>
<surname>Drury</surname>
<given-names>Hannah</given-names>
</name>
<aff>
<institution>eLife</institution>
<addr-line>
<named-content content-type="city">Cambridge</named-content>
</addr-line>
<country>United Kingdom</country>
</aff>
</contrib>
<contrib>
<name>
<surname>Guerreiro</surname>
<given-names>Maria</given-names>
</name>
<aff>
<institution>eLife</institution>
<addr-line>
<named-content content-type="city">Cambridge</named-content>
</addr-line>
<country>United Kingdom</country>
</aff>
</contrib>
<contrib>
<name>
<surname>Richmond</surname>
<given-names>Susanna</given-names>
</name>
<aff>
<institution>eLife</institution>
<addr-line>
<named-content content-type="city">Cambridge</named-content>
</addr-line>
<country>United Kingdom</country>
</aff>
</contrib>
</contrib-group>
</collab>
<xref ref-type="fn" rid="equal-contrib2">‡</xref>
<xref ref-type="fn" rid="con3"/>
<xref ref-type="fn" rid="conf2"/>
</contrib>
<contrib contrib-type="author" equal-contrib="yes" corresp="yes">
<collab>eLife Technology Group
<contrib-group>
<!-- UPDATE: A group author member can have an affiliation, but it is contained within the contrib after their name rather than listed separately. Group author
affiliations are truncated compared to normal author affiliations (usually just institution, city and country) -->
<!-- A group author member can have an ORCID, although this is not required -->
<contrib>
<name>
<surname>Nott</surname>
<given-names>Graham</given-names>
</name>
<aff>
<institution>Graham Nott Enterprises</institution>
<addr-line>
<named-content content-type="city">Victoria</named-content>
</addr-line>
<country>Canada</country>
</aff>
</contrib>
<contrib>
<name>
<surname>Wilkinson</surname>
<given-names>Chris</given-names>
</name>
<email>[email protected]</email>
<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0003-4921-6155</contrib-id>
<aff>
<institution>eLife</institution>
<addr-line>
<named-content content-type="city">Cambridge</named-content>
</addr-line>
<country>United Kingdom</country>
</aff>
</contrib>
<contrib>
<name>
<surname>Skibinski</surname>
<given-names>Luke</given-names>
</name>
<aff>
<institution>eLife</institution>
<addr-line>
<named-content content-type="city">Cambridge</named-content>
</addr-line>
<country>United Kingdom</country>
</aff>
</contrib>
</contrib-group>
</collab>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="fn" rid="equal-contrib2">‡</xref>
<xref ref-type="fn" rid="conf3"/>
<xref ref-type="fn" rid="con4"/>
</contrib>
<!-- 'on behalf of' can be used in any position of the author list. It must be retained in the correct position in the author list.
Most of the time it is the last entry, but this is not a requirement.
Note: if the display requires on behalf of, this is required in the textaul entry. This is because it might be "for" instead of "on-behalf of" and the html display
cannot make that distinction by reading the textual entry-->
<on-behalf-of>for the eLife Staff Team</on-behalf-of>
<!-- Affiliations are granular and a department field must contain only one department. For example, two departments at one institution (see below) generate two
separate affiliations
UPDATE: Punctuation outside of XML tags has been removed as it is not necessary. Commas between department, institution, city and country will
need to be boilerplate for the PDF display-->
<aff id="aff1">
<label>1</label>
<institution content-type="dept">Department of Production</institution>
<institution>eLife</institution>
<addr-line>
<named-content content-type="city">Cambridge</named-content>
</addr-line>
<country>United Kingdom</country>
</aff>
<aff id="aff2">
<label>2</label>
<institution content-type="dept">Department of Technology</institution>
<institution>eLife</institution>
<addr-line><named-content content-type="city">Cambridge</named-content>
</addr-line>
<country>United Kingdom</country>
</aff>
<!-- eLife articles are shepherded through the review process by a reviewing editor, who is listed in the XML and called out in the online and PDF displays.
UPDATE: As above, punctuation outside XML tags has been removed -->
</contrib-group>
<contrib-group content-type="section">
<contrib contrib-type="editor" id="author-10">
<name>
<surname>Collings</surname>
<given-names>Andrew</given-names>
</name>
<role>Reviewing Editor</role>
<aff>
<institution>eLife Sciences</institution>
<country>United Kingdom</country>
</aff>
</contrib>
</contrib-group>
<author-notes>
<!-- UPDATE: Correspondence - removed from author-notes
For PDF display footnote "*For correspondence: " must be added as boilerplate followed by the email address pulled in from the XML.If there are multiple
corresponding authors, the email addresses must be added in order of the author list, separated with semicolons. Author initials should to be added in
brackets after each email address. See Kitchen sink PDF for example.
UPDATE: email for corresponding author is contained within contrib and no longer in author notes.
-->
<!--Equal contributions footnote-->
<fn fn-type="con" id="equal-contrib1">
<label>†</label>
<p>These authors contributed equally to this work</p>
</fn>
<fn fn-type="con" id="equal-contrib2">
<label>‡</label>
<p>These authors also contributed equally to this work</p>
</fn>
<!--Present address s footnote-->
<fn fn-type="present-address" id="pa1">
<label>§</label>
<p>Department of Wellcome Trust, Sanger Institute, London, United Kingdom</p>
</fn>
<!-- Other footnotes Deceased
Other footnotes are rare (they have only been used 3 times in the history of eLife. The text of the footnote is transitioned directly to the website, so the
content must work as a discrete item on each author's roll over and on the display at the end of the article -->
<fn fn-type="fn" id="fn1">
<label>#</label>
<p>Deceased. (not really!!)</p>
</fn>
<fn fn-type="fn" id="fn2">
<label>¶</label>
<p>This footnote text must work in isolation as nothing is processed on the html view to make it "work"</p>
</fn>
</author-notes>
<!-- CHANGE: pub-date will still continue to keep the PoA pub date in the XML but it will also include the updated date that the VoR is published. The first time
an article is published it will contain one date, which will contain the @date-type attribute of "publication". This new instance of the XML will also be added
into pub-date with a @date-type attribute of "update" -->
<pub-date publication-format="electronic" date-type="update">
<day>11</day>
<month>08</month>
<year>2016</year>
</pub-date>
<pub-date publication-format="electronic" date-type="publication">
<day>25</day>
<month>04</month>
<year>2016</year>
</pub-date>
<!-- TO NOTE: pub-type collection required for Continuum to process content as VoR-->
<pub-date pub-type="collection">
<year>2016</year>
</pub-date>
<volume>5</volume>
<elocation-id>e00666</elocation-id>
<!-- CHANGE: All the historical publication information related to an article will be added to the history, with iso-8601-date attributes.
Additionally, the links to the previous published versions will be added, as well as a comment to indicate the changes. This comment will not be
necessary between PoA and VoR, but will be necessary between versions PoA and versions of VoR. The date will have an iso-8601-date= attribute added.
@date-type values:
preprint - The date a preprint was disseminated (electronic or print)
AM - The date a manuscript, was published
EAM - The date a manuscript, was enhanced and re-published
VoR - The date a version of record, typically a full text XML, HTML and typeset PDF, was published
CVoR - The date a version of record, typically a full text XML, HTML and typeset PDF, was corrected (an official correction notice has been published to accompany this article)
EVoR - The date a version of record, typically a full text XML, HTML and typeset PDF, was enhanced and re-published (this article has been updated and republished, with no official correction notice)
retracted - The date an article was retracted
If an article goes through one of these processes more than once, the value should contain a suffix of “-r1”, i.e. an additional VoR enhancement would be EVor-pub-r1
NOT IN PMC YET, will need to discuss with them when we want to implement
-->
<history>
<date date-type="received" iso-8601-date="2016-03-01">
<day>01</day>
<month>03</month>
<year>2016</year>
</date>
<date date-type="accepted" iso-8601-date="2016-04-01">
<day>01</day>
<month>04</month>
<year>2016</year>
</date>
<related-object ext-link-type="url" xlink:href="https://elifesciences.org/content/5/e00666v1">
<date date-type="AM" iso-8601-date="2016-04-25">
<day>25</day>
<month>04</month>
<year>2016</year>
</date>
</related-object>
<related-object ext-link-type="url" xlink:href="https://elifesciences.org/content/5/e00666v2">
<date date-type="EAM" iso-8601-date="2016-06-12">
<day>12</day>
<month>06</month>
<year>2016</year>
</date>
<comment>The first version of this article was enhanced considerably between versions of the XML instance.
These changes can bee seen on <ext-link ext-link-type="uri" xlink:href="https://github.com/elifesciences/XML-mapping/blob/master/eLife00666.xml">Github</ext-link>.</comment>
</related-object>
<related-object ext-link-type="url" xlink:href="https://elifesciences.org/content/5/e00666v3">
<date date-type="VoR" iso-8601-date="2016-06-12">
<day>27</day>
<month>07</month>
<year>2016</year>
</date>
<comment>The first version of this article was enhanced considerably between versions of the XML instance.
These changes can bee seen on <ext-link ext-link-type="uri" xlink:href="https://github.com/elifesciences/XML-mapping/blob/master/eLife00666.xml">Github</ext-link>.</comment>
</related-object>
</history>
<!-- UPDATE: Permissions: this has changed/been updated to include the free_to_reed tag further to NISO recommendations -->
<permissions>
<copyright-statement>© 2016, Harrison et al</copyright-statement>
<copyright-year>2016</copyright-year>
<copyright-holder>Harrison et al</copyright-holder>
<ali:free_to_read/>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/">
<ali:license_ref>http://creativecommons.org/licenses/by/4.0/</ali:license_ref>
<license-p>This article is distributed under the terms of the <ext-link
ext-link-type="uri"
xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative
Commons Attribution License</ext-link>, which permits unrestricted use
and redistribution provided that the original author and source are
credited.</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:href="elife00666.pdf"/>
<!-- Related article linking: Optional.
Set of accepted @related-article-type values:
Research to Research (or Feature to Feature): <related-article related-article-type="article-reference" ext-link-type="doi" xlink:href="10.7554/eLife.01295" id="ra1"/>
Research to Insight: <related-article related-article-type="commentary" ext-link-type="doi" xlink:href="10.7554/eLife.01738" id="ra1"/>
Insight to Research: <related-article related-article-type="commentary-article" ext-link-type="doi" xlink:href="10.7554/eLife.01236" id="ra1"/>
Correction to Research: <related-article related-article-type="corrected-article" ext-link-type="doi" xlink:href="10.7554/eLife.00712" id="ra1"/>
NOTE: id="ra1" is required for PMC, not for eLife publication. Multiple related article links are allowed; each should have a different id e.g. ra1, ra1, ra3 etc.
In discussion with PMC re this
NOTE: research advance MUST contain <related-article related-article-type="article-reference" link to the original article it is building upon
-->
<!-- UPDATE: Abstract: The following is no longer required for the XML file. However, it must be displayed in the PDF:
<bold>DOI:</bold>
<ext-link ext-link-type="doi" xlink:href="10.7554/eLife.00666.001">https://doi.org/10.7554/eLife.00666.001</ext-link> -->
<abstract>
<!-- UPDATE: DOI prefix removed from XML but must be added for display-->
<object-id pub-id-type="doi">10.7554/eLife.00666.001</object-id>
<p>This is the abstract. This article will describe the eLife article and the process.
An abstract can contain any formatting, such as <italic>italics</italic>,
<bold>bold</bold>, <sup>superscript</sup>, <sub>subscript</sub> or <sc>small caps</sc>. MathML is
also allowed:
<inline-formula><mml:math>
<mml:mrow>
<mml:munder>
<mml:mo/>
<mml:mi>m</mml:mi>
</mml:munder>
<mml:mrow>
<mml:msub>
<mml:mover accent="true">
<mml:mi>p</mml:mi>
<mml:mo/>
</mml:mover>
<mml:mi>m</mml:mi>
</mml:msub>
<mml:mo>=</mml:mo>
<mml:mn>0</mml:mn>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
.</p>
<p>eLife does not structure abstracts into sub headings expect in a clinical trial article, but the abstract can have
multiple paragarahs. The sub DOI is always .001 as it is the first asset in any
article. I have added an unmatched > bracket as this has been an issue for PubMed deposits in the past.</p>
<p>If this was a clinical trial the clinical trial details would be listed at the end of the abstract:</p>
<p>Clinical trial Registration: EudraCT2004-000446-20.</p>
</abstract>
<!-- UPDATE: Abstract: The following is no longer required for the XML file. However, it must be displayed in the PDF and the display must include prefix https://doi.org/
<bold>DOI:</bold>
<ext-link ext-link-type="doi" xlink:href="10.7554/eLife.00666.001">https://doi.org/10.7554/eLife.00666.002</ext-link>
Additionally, digest are no longer a required component of all Research Articles and Short Reports. All research content can now be published with no digest -->
<abstract abstract-type="executive-summary">
<!-- UDPATE: Author keywords: removed title from XML - is implicit in the @kwd-group-type
Can contain italics, but no bold or other formatting-->
<kwd-group kwd-group-type="author-keywords">
<kwd>XML</kwd>
<kwd>Housestyle</kwd>
<kwd>eLife</kwd>
<kwd>
<italic>formatting</italic>
</kwd>
</kwd-group>
<!-- Output what is provided during the production process-->
<kwd-group kwd-group-type="research-organism">
<title>Research organsim</title>
<kwd>Human</kwd>
<kwd>Machine</kwd>
</kwd-group>
<!-- Funding: The website will match any author ID contrib which is xref linked to this section and will ignore the name pulled in. However, production want to
leave the name in the XML as we feel it is better for TDM. We can add Schematron validation to ensure the name listed here matches the name listed with the ID.
There is no limit to the number of award groups or on the number of authors assigned to each award group.
Rules:
One award-group per each unique award-id, although award-id is not required for each award-group.
Minimum of one author per funding source. Maximum is the number of authors on the article.
Individual members of a group authorship should not be named in the funding section, only the group author itself as it appears in the main author list
UPDATE: if there is no Fundref ID then the @institution-id-type="FundRef" should not be present-->
<funding-group>
<award-group id="fund1">
<funding-source>
<institution-wrap><institution-id institution-id-type="FundRef">https://dx.doi.org/10.13039/100000011</institution-id>
<institution>Howard Hughes Medical Institute</institution>
</institution-wrap>
</funding-source>
<award-id>F32 GM089018</award-id>
<principal-award-recipient>
<name>
<surname>Harrison</surname>
<given-names>Melissa</given-names>
</name>
</principal-award-recipient>
</award-group>
<award-group id="fund2">
<funding-source>
<institution-wrap>
<institution>Laura and John Arnold Foundation</institution>
</institution-wrap>
</funding-source>
<principal-award-recipient>
<institution>Reproducibility Project: Cancer Biology</institution>
</principal-award-recipient>
</award-group>
<funding-statement>The funders had no role in study design; collection, analysis,
and interpretation of data; writing the article; and or the decision to submit
to the journal.</funding-statement>
</funding-group>
<!-- UPDATE: Custom-meta: no longer using eLife version as was never used properly.
Impact statement:-->
<custom-meta-group>
<custom-meta specific-use="meta-only">
<meta-name>Author impact statement</meta-name>
<meta-value>How to tag an eLife article using JATS XML.</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
<body>
<!--
The headings used by eLife are standardised at the top level and sec is used, with a sec-type.
An A heading can be identified by the ID not having a further subdivision, for example S1 is the first section heading.
If there are B headings in this section they will have a sec id of S1-1 etc
eLife allowed A heads for research content are:
Introduction - sec-type="intro"
Results - sec-type="results"
Discussion - sec-type="discussion"
Materials and methods - sec-type="materials|methods"
Exceptions:
A merged results and discussion section is acceptable:
Results and discussion - sec-type="results|discussion"
Discussion - sec-type="discussion"
For Methods articles - identifiable as articles that describe models and are generally maths-heavy - the following structure is allowed:
Introduction sec-type="intro"
Model - sec-type="model"
Results - sec-type="results"
Discussion - sec-type="discussion"
OR
Introduction sec-type="intro"
Methods - sec-type="methods"
Results - sec-type="results"
Discussion - sec-type="discussion"
For research advances: Authors have more flexibility with structure and sections can be combined, although the Materials and methods section
is mandatory.
To allow for the flexibility, a title is also appeneded to each section
-->
<sec sec-type="intro" id="s1">
<title>Introduction (Level 1 heading)</title>
<p>This article is a guide to the tagging and display of eLife articles and will
encompass all the elements that can possibly be contained in an eLife article.
It will also include information from the author guide. For this reason, it is colloquially known as the eLife 'kitchen sink'.</p>
<sec id="s1-1">
<title>The eLife editorial process (level 2 heading)</title>
<p>eLife publishes the most highly influential research across the life sciences and biomedicine.
Before you submit your work, please note that eLife is a very selective journal that aims to publish
work of the highest scientific standards and importance. Leading academic
researchers evaluate new submissions and approximately two-thirds are returned to
the authors without further peer review. See <xref ref-type="bibr" rid="bib12">DeLano, 2002</xref> and <xref ref-type="bibr" rid="bib13">
Morgan, 2016</xref>. Approximately half of the articles that are
selected for peer review go on to be published (<xref ref-type="bibr" rid="bib5">Brettar et al., 2004a</xref>). If other researchers publish similar
findings after submission, this will not be a reason for rejection. The eLife
editorial process broadly occurs in three phases (<xref ref-type="bibr" rid="bib48">Turlings and Wäckers, 2004</xref>; <xref ref-type="bibr" rid="bib50">
Wolski et al., 2008</xref>; <xref ref-type="bibr" rid="bib49">Walker, 1995</xref>; <xref ref-type="bibr" rid="bib44">Tanaka et al., 2016</xref>). If you are interested in
submitting your work to eLife, please review the guidelines relating to initial
submissions. If you have received an encouraging response to your initial
submission, please review the guidelines relating to full submissions. If your full
submission has been peer reviewed and you have been asked to make revisions, please
review our guidelines for revised submissions (<xref ref-type="bibr" rid="bib6">Brettar et al., 2004b</xref>).</p>
<sec id="s1-1-1">
<title>Initial submission (level 3 heading)</title>
<p>eLife publishes research of the very highest (<xref ref-type="bibr" rid="bib7">Bricogne et al., 2011</xref>) standard and significance,
so many manuscripts are returned to the authors without in-depth peer review. During the initial submission
phase, members of eLife’s senior editorial team rapidly assess new submissions,
often in consultation with members of the Board of Reviewing Editors or with
external guest editors where necessary, to identify the ones that are appropriate
for in-depth peer review (<xref ref-type="bibr" rid="bib8">Cardé and Millar, 2004</xref>; <xref ref-type="bibr" rid="bib9">Cartwright, 2016</xref>;
<xref ref-type="bibr" rid="bib10">Chmeil, 2008</xref>). To simplify the submission process, authors should submit
their full manuscript as a single PDF. Limited additional information is collected
via the submission screen questions to complete the submission (<xref ref-type="bibr" rid="bib6">Brettar et al., 2004b</xref>).</p>
</sec>
<sec id="s1-1-2">
<title>Full submission (level 3 heading)</title>
<p>For manuscripts that are invited for in-depth peer review, see <xref ref-type="bibr" rid="bib11">Coyne et al., 1989</xref>
and <xref ref-type="bibr" rid="bib14">Du et al., 2014</xref>, we request detailed
information about the work to support the peer review process, to ensure that the
work meets appropriate standards for the reporting of new findings, and, if
accepted, to assist in rapid publication and further dissemination of the work in
relevant indexes and repositories. Authors are asked to agree to publish their work
under the terms of the Creative Commons Attribution license (PDF of the agreement),
or the Creative Commons CC0 public domain dedication (PDF of the agreement) if one
or more authors are US-government employees (<xref ref-type="bibr" rid="bib23">Hubbard and Thornton, 1993</xref>;
<xref ref-type="bibr" rid="bib19">GlaxoSmithKline UK, 2016</xref>; <xref ref-type="bibr" rid="bib24">Jain et al., 2010</xref>).</p>
</sec>
<sec id="s1-1-3">
<title>Revised submission (level 3 heading)</title>
<p>We will require a response to the essential revision requirements outlined in the decision letter. A
response to minor comments is optional. In the event of acceptance, the substantive
revision requests and the authors’ response will be published, under the terms of
the Creative Commons Attribution license. In preparation for submission, authors
should ensure they have all the materials and information necessary to expedite the
submission and assessment of their work (<xref ref-type="bibr" rid="bib15">Eisen, 2016</xref>;
<xref ref-type="bibr" rid="bib16">Ferry et al., 2014</xref>; <xref ref-type="bibr" rid="bib18">Gavrilov et al., 2014</xref>;
<xref ref-type="bibr" rid="bib20">Goodstadt, 2010</xref>; <xref ref-type="bibr" rid="bib21">Hoang et al., 2015</xref>).</p>
</sec>
</sec>
<sec id="s1-2">
<title>The eLife production process (level 2 heading)</title>
<sec id="s1-2-1">
<title>Immediate publication (accepted manuscript) (level 3 heading)</title>
<p>On acceptance an eLife article can be published in accepted manuscript form immediately.
The mean time from acceptance to publication at this stage is 1 day. Using SQl, basic metadata is exported from the submission system to an
AWS bucket as CSV files. The author files are exported to another AWS bucket and an eLife process generates a package of this information and the
author files to deliver to the online platform, Continuum.</p>
</sec>
<sec id="s1-2-2">
<title>Publication of the full version (version of record) (level 3 heading)</title>
<p>The production process includes an author proofing cycle, the output of which is the final full text version of the article online, as well as a typeset PDF.</p>
</sec>
<sec id="s1-2-3">
<title>Publication of versions (level 3 heading)</title>
<p>eLife allows the publication of updates to an article after the full version has been produced. These are treated as new versions of the article. All previous
versions of the article will continue to exist online and will be accessible from the latest live version.</p>
<sec id="s1-2-3-1">
<title>level 4 heading</title>
<p>eLife allows up to four levels of headings and no more. This is a demonstration of a level 4 heading.</p>
</sec>
</sec>
</sec>
</sec>
<sec sec-type="results" id="s2">
<title>Results</title>
<!-- UPDATE: where appendices are cited in the main text they must be cross linked -->
<p>This section will be used to demostrate the majority of eLife XML tagging and editorial policies. However, the Introduction section was used to demostrate heading levels.
See <xref ref-type="appendix" rid="s8">Appendix 1</xref> and <xref ref-type="appendix" rid="s9">2</xref>.</p>
<sec id="s2-1">
<title>eLife controlled lists</title>
<p>eLife has no strict requirements for the display of lists. Below we will show examples of how to present lists.
See <xref ref-type="fig" rid="fig2s1">Figure 2—figure supplement 1</xref> for the representation of the Major Subject Areas, Research
Organisms and author keywords on the eLife HTML page (<xref ref-type="bibr" rid="bib45">The <italic>Shigella</italic> Genome Sequencing Consortium,
2015a</xref>).
</p>
<sec id="s2-1-1">
<title>Article types</title>
<p>This is an example of a list where the prefix character is a lowercase roman numeral. eLife Article Types are taken from a controlled list:</p>
<list list-type="roman-lower">
<list-item><p>Research article</p></list-item>
<list-item><p>Short Report</p></list-item>
<list-item><p>Tools and Resources</p></list-item>
<list-item><p>Research Advance</p></list-item>
<list-item><p>Registered Report</p></list-item>
<list-item><p>Replication Study</p></list-item>
</list>
<sec id="s2-1-1-1">
<title>Article types (XML only, not display) (level 4 heading)</title>
<p>This is an example of a list where the prefix character is a uppercase roman numeral. This is a controlled list from the JATS DTD</p>
<list list-type="roman-upper">
<list-item><p>article-commentary (used for Insights)</p></list-item>
<list-item><p>correction</p></list-item>
<list-item><p>discussion (used for Feature 1 and Feature 2)</p></list-item>
<list-item><p>editorial</p></list-item>
<list-item><p>research-article (all reseasrch content)</p></list-item>
</list>
<p>Nested lists are allowed and these are very common in Registered Peports. Below is an example of a nested list to 3 levels.</p>
<list list-type="roman-upper">
<list-item>
<p>Genus: Plasmodium; following species are known to infect humans</p>
<list list-type="roman-lower">
<list-item>
<p><italic>P. falciparum</italic></p>
</list-item>
<list-item>
<p><italic>P. vivax</italic></p>
</list-item>
<list-item>
<p><italic>P. ovale</italic></p>
</list-item>
<list-item>
<p><italic>P. malariae</italic></p>
</list-item>
<list-item>
<p><italic>P. knowlesi</italic></p>
</list-item>
</list>
</list-item>
<list-item>
<p>Genus: Leishmania. There are 3 subgenus of Leishmania:</p>
<list list-type="roman-lower">
<list-item>
<p>Leishmania</p>
</list-item>
<list-item>
<p>Sauroleishmania</p>
</list-item>
<list-item>
<p>Viannia</p>
</list-item>
<list-item>
<p>Within Viannia subgenus, there are 11 species:</p>
<list list-type="bullet">
<list-item>
<p><italic>L. braziliensis</italic></p>
</list-item>
<list-item>
<p><italic>L. colombiensis</italic></p>
</list-item>
<list-item>
<p><italic>L. equatorensis</italic></p>
</list-item>
<list-item>
<p><italic>L. guyanensis</italic></p>
</list-item>
<list-item>
<p><italic>L. lainsoni</italic></p>
</list-item>
<list-item>
<p><italic>L. naiffi</italic></p>
</list-item>
<list-item>
<p><italic>L. panamensis</italic></p>
</list-item>
<list-item>
<p><italic>L. peruviana</italic></p>
</list-item>
<list-item>
<p><italic>L. pifanoi</italic></p>
</list-item>
<list-item>
<p><italic>L. shawi</italic></p>
</list-item>
<list-item>
<p><italic>L. utingensis</italic></p>
</list-item>
</list>
</list-item>
</list>
</list-item>
</list>
</sec>
</sec>
<sec id="s2-1-2">
<title>Major Subject Areas</title>
<p>This is an example of a bulleted list. eLife Major subject areas are taken from a controlled list:</p>
<list list-type="bullet">
<list-item><p>Biochemistry</p></list-item>
<list-item><p>Biophysics and Structural Biology</p></list-item>
<list-item><p>Cell Biology</p></list-item>
<list-item><p>Computational and Systems Biology</p></list-item>
<list-item><p>Developmental Biology and Stem Cells</p></list-item>
<list-item><p>Ecology</p></list-item>
<list-item><p>Epidemiology and Global Health</p></list-item>
<list-item><p>Genes and Chromosomes</p></list-item>
<list-item><p>Genomics and Evolutionary Biology</p></list-item>
<list-item><p>Human Biology and Medicine</p></list-item>
<list-item><p>Immunology</p></list-item>
<list-item><p>Microbiology and Infectious Disease</p></list-item>
<list-item><p>Neuroscience</p></list-item>
<list-item><p>Plant Biology</p></list-item>
</list>
</sec>
<sec id="s2-1-3">
<title>Multi-lists</title>
<list list-type="order">
<list-item>
<p>Here is an example of a list with multiple paragraphs and equations.</p>
<p>A discrete three-dimensional model space was generated (represented as a
three-dimensional matrix; <xref ref-type="fig" rid="fig2s1">Figure
2—figure supplement 1A</xref>, left), with dimensions
corresponding to population µ, population σ, and f value.
Any given value in the matrix indicates P(f|μ,σ),
that is, the probability of a given frequency given a particular
μ and σ. The columns (all f values for a given μ
and σ combination; <xref ref-type="fig" rid="fig2s1">Figure
2—figure supplement 1</xref>, upper-right) thus constitute
the forward model (by which stimuli are generated), and the planes (all
combinations of μ and σ for a given f value; <xref
ref-type="fig" rid="fig2s1">Figure 2—figure supplement
1</xref>, lower-middle) constitute the inverse model (by which
hidden parameters can be estimated from observed f values).</p>
</list-item>
<list-item>
<p>2) For each segment, the model was inverted for its particular f value,
yielding a two-dimensional probability distribution for the hidden
parameters (<xref ref-type="fig" rid="fig2s1">Figure 2—figure
supplement 1</xref>, lower-middle). Steps 3-6 were then worked
through for each stimulus segment in order, starting at the beginning of
the stimulus.</p>
</list-item>
<list-item>
<p>These probability distributions, for each segment subsequent to the most
recent estimated population change (as defined later), were multiplied
together, and scaled to a sum of 1. The resulting probability
distribution (<xref ref-type="fig" rid="fig2s1">Figure 2—figure
supplement 1</xref>, lower-right) thus reflects parameter
probabilities taking into account all relevant f values</p>
</list-item>
<list-item>
<p>This combined parameter probability distribution was then scalar
multiplied with the full model space, in order to weight each of the
forward model columns (each corresponding to a particular parameter
combination) by the probability of that parameter combination being in
effect. The resulting weighted model space was then averaged across
parameter dimensions, to yield a one-dimensional (forward) probability
distribution, constituting an optimal prediction about the f value of
the next stimulus segment, provided a population change did not occur
before then. A probability distribution applicable if a population
change were to occur was calculated the same way, but without weighting
the forward model columns (so as to encompass every possible parameter
combination).</p>
</list-item>
<list-item>
<p>It was assumed that a population change occurred immediately prior to the
first stimulus segment. To infer subsequent population changes, for each
segment the probability of observing the present f value was compared
for the two probability distributions (the distribution assuming a
population change, and the distribution assuming no change),
that is, P(f|c) and P(f|~c), respectively, with c denoting
a population change. The probabilities were compared, in conjunction
with the known prior probability of a population change (1/8), using
Bayes’ rule, as stated in Equation 2:<disp-formula id="equ2"
><label>(2)</label><mml:math id="m2"
><mml:mrow><mml:mi>P</mml:mi><mml:mo>(</mml:mo><mml:mi>c</mml:mi><mml:mo>|</mml:mo><mml:mi>f</mml:mi><mml:mo>)</mml:mo><mml:mo>=</mml:mo><mml:mfrac><mml:mrow><mml:mi>P</mml:mi><mml:mrow><mml:mo>(</mml:mo><mml:mrow><mml:mi>f</mml:mi><mml:mtext>|</mml:mtext><mml:mi>c</mml:mi></mml:mrow><mml:mo>)</mml:mo></mml:mrow><mml:mi>P</mml:mi><mml:mo>(</mml:mo><mml:mi>c</mml:mi><mml:mo>)</mml:mo></mml:mrow><mml:mrow><mml:mi>P</mml:mi><mml:mo>(</mml:mo><mml:mi>f</mml:mi><mml:mo>)</mml:mo></mml:mrow></mml:mfrac></mml:mrow></mml:math></disp-formula></p>
<p>Here, P(c|f) is the chance that a population change occurred at that
particular time. Given that P(c) is known to be 1/8, and P(f), the total
probability of the observed f value, can be rewritten
P(f|c)P(c)+P(f|~c)(1-P(c)), the above equation can be rewritten
as Equation 3:<disp-formula id="equ3"><label>(3)</label><mml:math
id="m3"
><mml:mrow><mml:mi>P</mml:mi><mml:mrow><mml:mo>(</mml:mo><mml:mrow><mml:mi>c</mml:mi><mml:mtext>|</mml:mtext><mml:mi>f</mml:mi></mml:mrow><mml:mo>)</mml:mo></mml:mrow><mml:mo>=</mml:mo><mml:mfrac><mml:mn>1</mml:mn><mml:mrow><mml:mn>1</mml:mn><mml:mo>+</mml:mo><mml:mfrac><mml:mrow><mml:mn>7</mml:mn><mml:mi>P</mml:mi><mml:mo>(</mml:mo><mml:mi>f</mml:mi><mml:mo>|</mml:mo><mml:mo>~</mml:mo><mml:mi>c</mml:mi><mml:mo>)</mml:mo></mml:mrow><mml:mrow><mml:mi>P</mml:mi><mml:mo>(</mml:mo><mml:mi>f</mml:mi><mml:mo>|</mml:mo><mml:mi>c</mml:mi><mml:mo>)</mml:mo></mml:mrow></mml:mfrac></mml:mrow></mml:mfrac></mml:mrow></mml:math></disp-formula></p>
</list-item>
<list-item>
<p>For each segment, the above calculation of P(c|f) was made not only with
respect to the immediately preceding segment, but also a number of
segments preceding that, up to a maximum of 4. Therefore, for segment t,
it was possible to conclude that a population change had occurred
immediately prior to t, t-1, t-2, t-3, or none of the above. A
population change was judged to have occurred at the time point with the
highest value of P(c|f), provided this value was greater than 0.5. Using
more than 4 lags did not appreciably alter the estimates obtained by
model inversion. Importantly, any retrospective inference of population
changes did not retrospectively alter any prior predictions generated by
the model (e.g. at time t, if a population change were inferred to have
occurred at time t-3 then the priors for t-2, t-1 and t were not
affected, but only the priors for t+1 onwards).</p>
</list-item>
<list-item>
<p>Once the above steps were worked through for each stimulus segment in
order, the optimal prior predictions were used to calculate the
perceptual inference variables of interest. Predictions themselves were
summarised by their mean (μ) and precision (1/variance). Changes
to predictions (Δµ) were calculated as the absolute change
(in octaves) in μ from one prediction to the next. Surprise (S)
was calculated as the negative log probability of the observed f value
given the prior prediction, and prediction error (irrespective of
prediction precision) was calculated as the absolute difference (in
octaves) between the observed f value and the mean of the prior
prediction. Mathematically, surprise is directly proportional to
prediction precision multiplied by prediction error. Finally, Δf
was calculated as the absolute difference between the current and
preceding value of f.</p>
</list-item>
</list>
</sec>
<sec id="s2-1-4">
<title>Research Organisms</title>
<p>This is an example of an ordered list, the "system" will default to numbers. eLife Research organsims are taken from a controlled list from the submission system:</p>
<list list-type="order">
<list-item><p><italic>Arabidopsis</italic></p></list-item>
<list-item><p><italic>B</italic>. <italic>subtilis</italic></p></list-item>
<list-item><p><italic>C</italic>. <italic>elegans</italic></p></list-item>
<list-item><p><italic>C</italic>. <italic>intestinalis</italic></p></list-item>
<list-item><p>Chicken</p></list-item>
<list-item><p><italic>D</italic>. <italic>melanogaster</italic></p></list-item>
<list-item><p><italic>Dictyostelium</italic></p></list-item>
<list-item><p><italic>E</italic>. <italic>coli</italic></p></list-item>
<list-item><p>Frog</p></list-item>
<list-item><p>Human</p></list-item>
<list-item><p><italic>M</italic>. <italic>mulatta</italic></p></list-item>
<list-item><p>Maize</p></list-item>
<list-item><p>Mouse</p></list-item>
<list-item><p><italic>M</italic>. <italic>thermophila</italic></p></list-item>
<list-item><p><italic>M</italic>. <italic>crassa</italic></p></list-item>
<list-item><p><italic>Neurospora</italic></p></list-item>
<list-item><p>None</p></list-item>
<list-item><p>Other</p></list-item>
<list-item><p><italic>O</italic>. <italic>fasciatus</italic></p></list-item>
<list-item><p><italic>P</italic>. <italic>falciparum</italic></p></list-item>
<list-item><p><italic>P</italic>. <italic>dumerilii</italic></p></list-item>
<list-item><p>Rat</p></list-item>
<list-item><p><italic>S</italic>. <italic>cerevisiae</italic></p></list-item>
<list-item><p><italic>S</italic>. <italic>pombe</italic></p></list-item>
<list-item><p><italic>S</italic>. <italic>enterica</italic>serovar Typhi</p></list-item>
<list-item><p><italic>S</italic>. <italic>pyogenes</italic></p></list-item>
<list-item><p>Virus</p></list-item>
<list-item><p><italic>Volvox</italic></p></list-item>
<list-item><p><italic>Xenopus</italic></p></list-item>
<list-item><p><italic>P</italic>. <italic>cynocephalus</italic></p></list-item>
<list-item><p>Zebrafish</p></list-item>
</list>
<p>However, additional research organisms can be added during the production process so this is not a controlled list once it is output from the editorial system.
The research organism "Other" is hidden from display on the eLife website.</p>
</sec>
</sec>
<!-- Update: Most asset IDs have changed. Please see elife-00666-supp1 and elife_file_naming_2016_08_25.md for complete list and explanation -->
<sec id="s2-2">
<title>Tables</title>
<!-- Update: Table ids have been changed from tbl to table
Table containing coloured text and cells crossing multiple rows. It is wide enough that it would appear in landscape orientation in the PDF file (Table 1)
UPDATE: Example of how to deal with spans in a citation. We cannot add the links to all the items and the HTML view will only link to the first one, so do
not add all rids to the xref as it does not work. Only add the first one -->
<p>This section is an example of different tables, there are four in total(<xref ref-type="table" rid="table1">Tables 1 to 3</xref> and an unnamed inline table).</p>
<table-wrap id="table1" position="float">
<!-- UPDATE: DOI prefix removed from XML but must be added for display-->
<object-id pub-id-type="doi">10.7554/eLife.00666.003</object-id>
<label>Table 1.</label>
<caption>
<title>This is the title.</title>
<p>This is the caption: A table containing interesting formating that is large enough to require landscape orientation in the PDF.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>