diff --git a/easybuild/easyconfigs/e/EpiSCORE/EpiSCORE-0.9.5-20220621-foss-2022a-R-4.2.1.eb b/easybuild/easyconfigs/e/EpiSCORE/EpiSCORE-0.9.5-20220621-foss-2022a-R-4.2.1.eb
new file mode 100644
index 00000000000..0f291cf4317
--- /dev/null
+++ b/easybuild/easyconfigs/e/EpiSCORE/EpiSCORE-0.9.5-20220621-foss-2022a-R-4.2.1.eb
@@ -0,0 +1,30 @@
+easyblock = 'RPackage'
+
+name = 'EpiSCORE'
+local_commit = '4f7daef'
+# see DESCRIPTION to determine version,
+# but also take date of last commit into account (since version isn't always bumped)
+version = '0.9.5-20220621'
+versionsuffix = '-R-%(rver)s'
+
+homepage = 'https://github.com/aet21/EpiSCORE'
+description = "Epigenetic cell-type deconvolution from Single-Cell Omic Reference profiles"
+
+toolchain = {'name': 'foss', 'version': '2022a'}
+
+source_urls = ['https://github.com/aet21/EpiSCORE/archive/']
+sources = [{'download_filename': '%s.tar.gz' % local_commit, 'filename': SOURCE_TAR_GZ}]
+checksums = ['85ce52efe0555295ceaab79518244bcbea8c3b7d454f84c74b99e577f56e1481']
+
+dependencies = [
+    ('R', '4.2.1'),
+    ('R-bundle-Bioconductor', '3.15', versionsuffix),
+    ('presto', '1.0.0-20230113', versionsuffix),
+]
+
+sanity_check_paths = {
+    'files': [],
+    'dirs': [name],
+}
+
+moduleclass = 'bio'