Creating a combined reference from multiple datasets

[OdmaaBayar]

Hi,

I have two .h5ad files from different datasets. Is there a way I can either (1) build a reference that combines these two (will I need to do integration etc.) or (2) during spot deconvolution input two references? How can I convert/process these .h5ad files to generate RCTD compatible references?
Thank you!

[sondvo]

I had the same question, any updates on this?

[sondvo]

just found this:

#109

[mtrussart]

Hi, I am also curious about any recommendations on how to run the RCTD method on multiple references datasets combined. I have read the recommendation from 2022 and so I would like to know if you recommend a method/pipeline that has been shown to work correctly on multiple references datasets combined?