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 # PlatinumTRs
-Annotation of ~7.8 million tandem repeat loci in the human genome
+Annotation of tandem repeat loci in the human genome
+
+- ~7.8 million loci: STRs and VNTRs
+- Minimum locus size 10 bp
+- Maximum locus size 10,000 bp
+- Loci within 50 bp are merged to produce compound/complex loci
+- CHM13-T2T and GRCh38 genomes
+- TRGT locus definitions and bed files
+- Generated using Tandem Repeats Finder and tr-solve
+ 
+These catalogs were used to call tandem repeat genotypes using TRGT by the [Platinum Pedigree Consortium](https://github.com/Platinum-Pedigree-Consortium).
+
+
+## Defining the TR catalogs
+The command `trf-mod -s 20 -l 160 {reference.fasta}` was used, resulting in a minimum reference locus size of 10 bp and motif sizes of 1 to 2000 bp, see [TRF-mod](https://github.com/lh3/TRF-mod). Loci within 50 bp were merged, and then any loci >10,000 bp were discarded. The remaining loci were annotated with [tr-solve](https://github.com/trgt-paper/tr-solve) to resolve locus structure in compound loci. Only TRs annotated on chromosomes 1-22, X, and Y were considered.
+
+The catalogs are available on Zenodo [DOI 10.5281/zenodo.13178745](https://zenodo.org/doi/10.5281/zenodo.13178745)