diff --git a/src/components-examples/material/select/index.ts b/src/components-examples/material/select/index.ts
index 698b773b35a5..594bd086b375 100644
--- a/src/components-examples/material/select/index.ts
+++ b/src/components-examples/material/select/index.ts
@@ -12,4 +12,5 @@ export {SelectResetExample} from './select-reset/select-reset-example';
 export {SelectValueBindingExample} from './select-value-binding/select-value-binding-example';
 export {SelectReactiveFormExample} from './select-reactive-form/select-reactive-form-example';
 export {SelectInitialValueExample} from './select-initial-value/select-initial-value-example';
+export {SelectSelectableNullExample} from './select-selectable-null/select-selectable-null-example';
 export {SelectHarnessExample} from './select-harness/select-harness-example';
diff --git a/src/components-examples/material/select/select-selectable-null/select-selectable-null-example.html b/src/components-examples/material/select/select-selectable-null/select-selectable-null-example.html
new file mode 100644
index 000000000000..a1bc2340a5c8
--- /dev/null
+++ b/src/components-examples/material/select/select-selectable-null/select-selectable-null-example.html
@@ -0,0 +1,19 @@
+<h4>mat-select allowing selection of nullable options</h4>
+<mat-form-field>
+  <mat-label>State</mat-label>
+  <mat-select [(ngModel)]="value" canSelectNullableOptions>
+    @for (option of options; track option) {
+      <mat-option [value]="option.value">{{option.label}}</mat-option>
+    }
+  </mat-select>
+</mat-form-field>
+
+<h4>mat-select with default configuration</h4>
+<mat-form-field>
+  <mat-label>State</mat-label>
+  <mat-select [(ngModel)]="value">
+    @for (option of options; track option) {
+      <mat-option [value]="option.value">{{option.label}}</mat-option>
+    }
+  </mat-select>
+</mat-form-field>
diff --git a/src/components-examples/material/select/select-selectable-null/select-selectable-null-example.ts b/src/components-examples/material/select/select-selectable-null/select-selectable-null-example.ts
new file mode 100644
index 000000000000..a5b29834cae1
--- /dev/null
+++ b/src/components-examples/material/select/select-selectable-null/select-selectable-null-example.ts
@@ -0,0 +1,21 @@
+import {Component} from '@angular/core';
+import {FormsModule} from '@angular/forms';
+import {MatInputModule} from '@angular/material/input';
+import {MatSelectModule} from '@angular/material/select';
+import {MatFormFieldModule} from '@angular/material/form-field';
+
+/** @title Select with selectable null options */
+@Component({
+  selector: 'select-selectable-null-example',
+  templateUrl: 'select-selectable-null-example.html',
+  imports: [MatFormFieldModule, MatSelectModule, MatInputModule, FormsModule],
+})
+export class SelectSelectableNullExample {
+  value: number | null = null;
+  options = [
+    {label: 'None', value: null},
+    {label: 'One', value: 1},
+    {label: 'Two', value: 2},
+    {label: 'Three', value: 3},
+  ];
+}
diff --git a/src/material/select/select.md b/src/material/select/select.md
index c91a694cb18b..2a00d2849caf 100644
--- a/src/material/select/select.md
+++ b/src/material/select/select.md
@@ -66,6 +66,15 @@ If you want one of your options to reset the select's value, you can omit specif
 
 <!-- example(select-reset) -->
 
+### Allowing nullable options to be selected
+
+By default any options with a `null` or `undefined` value will reset the select's value. If instead
+you want the nullable options to be selectable, you can enable the `canSelectNullableOptions` input.
+The default value for the input can be controlled application-wide through the `MAT_SELECT_CONFIG`
+injection token.
+
+<!-- example(select-selectable-null) -->
+
 ### Creating groups of options
 
 The `<mat-optgroup>` element can be used to group common options under a subheading. The name of the
diff --git a/src/material/select/select.spec.ts b/src/material/select/select.spec.ts
index c865d3f74dcf..bb7ca95eba22 100644
--- a/src/material/select/select.spec.ts
+++ b/src/material/select/select.spec.ts
@@ -3508,7 +3508,7 @@ describe('MatSelect', () => {
       expect(trigger.textContent).not.toContain('None');
     }));
 
-    it('should not mark the reset option as selected ', fakeAsync(() => {
+    it('should not mark the reset option as selected', fakeAsync(() => {
       options[5].click();
       fixture.detectChanges();
       flush();
@@ -3545,6 +3545,102 @@ describe('MatSelect', () => {
     });
   });
 
+  describe('allowing selection of nullable options', () => {
+    beforeEach(waitForAsync(() => configureMatSelectTestingModule([ResetValuesSelect])));
+
+    let fixture: ComponentFixture<ResetValuesSelect>;
+    let trigger: HTMLElement;
+    let formField: HTMLElement;
+    let options: NodeListOf<HTMLElement>;
+    let label: HTMLLabelElement;
+
+    beforeEach(fakeAsync(() => {
+      fixture = TestBed.createComponent(ResetValuesSelect);
+      fixture.componentInstance.canSelectNullableOptions = true;
+      fixture.detectChanges();
+      trigger = fixture.debugElement.query(By.css('.mat-mdc-select-trigger'))!.nativeElement;
+      formField = fixture.debugElement.query(By.css('.mat-mdc-form-field'))!.nativeElement;
+      label = formField.querySelector('label')!;
+
+      trigger.click();
+      fixture.detectChanges();
+      flush();
+
+      options = overlayContainerElement.querySelectorAll('mat-option') as NodeListOf<HTMLElement>;
+      options[0].click();
+      fixture.detectChanges();
+      flush();
+    }));
+
+    it('should select an option with an undefined value', fakeAsync(() => {
+      options[4].click();
+      fixture.detectChanges();
+      flush();
+
+      expect(fixture.componentInstance.control.value).toBe(undefined);
+      expect(fixture.componentInstance.select.selected).toBeTruthy();
+      expect(label.classList).toContain('mdc-floating-label--float-above');
+      expect(trigger.textContent).toContain('Undefined');
+    }));
+
+    it('should select an option with a null value', fakeAsync(() => {
+      options[5].click();
+      fixture.detectChanges();
+      flush();
+
+      expect(fixture.componentInstance.control.value).toBe(null);
+      expect(fixture.componentInstance.select.selected).toBeTruthy();
+      expect(label.classList).toContain('mdc-floating-label--float-above');
+      expect(trigger.textContent).toContain('Null');
+    }));
+
+    it('should select a blank option', fakeAsync(() => {
+      options[6].click();
+      fixture.detectChanges();
+      flush();
+
+      expect(fixture.componentInstance.control.value).toBe(undefined);
+      expect(fixture.componentInstance.select.selected).toBeTruthy();
+      expect(label.classList).toContain('mdc-floating-label--float-above');
+      expect(trigger.textContent).toContain('None');
+    }));
+
+    it('should mark a nullable option as selected', fakeAsync(() => {
+      options[5].click();
+      fixture.detectChanges();
+      flush();
+
+      fixture.componentInstance.select.open();
+      fixture.detectChanges();
+      flush();
+
+      expect(options[5].classList).toContain('mdc-list-item--selected');
+    }));
+
+    it('should not reset when any other falsy option is selected', fakeAsync(() => {
+      options[3].click();
+      fixture.detectChanges();
+      flush();
+
+      expect(fixture.componentInstance.control.value).toBe(false);
+      expect(fixture.componentInstance.select.selected).toBeTruthy();
+      expect(label.classList).toContain('mdc-floating-label--float-above');
+      expect(trigger.textContent).toContain('Falsy');
+    }));
+
+    it('should consider the nullable values as selected when resetting the form control', () => {
+      expect(label.classList).toContain('mdc-floating-label--float-above');
+
+      fixture.componentInstance.control.reset();
+      fixture.detectChanges();
+
+      expect(fixture.componentInstance.control.value).toBe(null);
+      expect(fixture.componentInstance.select.selected).toBeTruthy();
+      expect(label.classList).toContain('mdc-floating-label--float-above');
+      expect(trigger.textContent).toContain('Null');
+    });
+  });
+
   describe('with reset option and a form control', () => {
     let fixture: ComponentFixture<SelectWithResetOptionAndFormControl>;
     let options: HTMLElement[];
@@ -5057,7 +5153,7 @@ class BasicSelectWithTheming {
   template: `
     <mat-form-field>
       <mat-label>Select a food</mat-label>
-      <mat-select [formControl]="control">
+      <mat-select [formControl]="control" [canSelectNullableOptions]="canSelectNullableOptions">
         @for (food of foods; track food) {
           <mat-option [value]="food.value">{{ food.viewValue }}</mat-option>
         }
@@ -5076,7 +5172,8 @@ class ResetValuesSelect {
     {viewValue: 'Undefined'},
     {value: null, viewValue: 'Null'},
   ];
-  control = new FormControl('' as string | boolean | null);
+  control = new FormControl('' as string | boolean | null | undefined);
+  canSelectNullableOptions = false;
 
   @ViewChild(MatSelect) select: MatSelect;
 }
diff --git a/src/material/select/select.ts b/src/material/select/select.ts
index c81a601a8954..3c5937e6da8c 100644
--- a/src/material/select/select.ts
+++ b/src/material/select/select.ts
@@ -135,6 +135,12 @@ export interface MatSelectConfig {
    * If set to null or an empty string, the panel will grow to match the longest option's text.
    */
   panelWidth?: string | number | null;
+
+  /**
+   * Whether nullable options can be selected by default.
+   * See `MatSelect.canSelectNullableOptions` for more information.
+   */
+  canSelectNullableOptions?: boolean;
 }
 
 /** Injection token that can be used to provide the default options the select module. */
@@ -218,8 +224,8 @@ export class MatSelect
   protected _parentFormField = inject<MatFormField>(MAT_FORM_FIELD, {optional: true});
   ngControl = inject(NgControl, {self: true, optional: true})!;
   private _liveAnnouncer = inject(LiveAnnouncer);
-
   protected _defaultOptions = inject(MAT_SELECT_CONFIG, {optional: true});
+  private _initialized = new Subject();
 
   /** All of the defined select options. */
   @ContentChildren(MatOption, {descendants: true}) options: QueryList<MatOption>;
@@ -552,7 +558,14 @@ export class MatSelect
       ? this._defaultOptions.panelWidth
       : 'auto';
 
-  private _initialized = new Subject();
+  /**
+   * By default selecting an option with a `null` or `undefined` value will reset the select's
+   * value. Enable this option if the reset behavior doesn't match your requirements and instead
+   * the nullable options should become selected. The value of this input can be controlled app-wide
+   * using the `MAT_SELECT_CONFIG` injection token.
+   */
+  @Input({transform: booleanAttribute})
+  canSelectNullableOptions: boolean = this._defaultOptions?.canSelectNullableOptions ?? false;
 
   /** Combined stream of all of the child options' change events. */
   readonly optionSelectionChanges: Observable<MatOptionSelectionChange> = defer(() => {
@@ -1098,7 +1111,10 @@ export class MatSelect
 
       try {
         // Treat null as a special reset value.
-        return option.value != null && this._compareWith(option.value, value);
+        return (
+          (option.value != null || this.canSelectNullableOptions) &&
+          this._compareWith(option.value, value)
+        );
       } catch (error) {
         if (typeof ngDevMode === 'undefined' || ngDevMode) {
           // Notify developers of errors in their comparator.
@@ -1243,7 +1259,7 @@ export class MatSelect
   private _onSelect(option: MatOption, isUserInput: boolean): void {
     const wasSelected = this._selectionModel.isSelected(option);
 
-    if (option.value == null && !this._multiple) {
+    if (!this.canSelectNullableOptions && option.value == null && !this._multiple) {
       option.deselect();
       this._selectionModel.clear();
 
diff --git a/tools/public_api_guard/material/select.md b/tools/public_api_guard/material/select.md
index 10a5fdb41d89..a39d47dbd3d6 100644
--- a/tools/public_api_guard/material/select.md
+++ b/tools/public_api_guard/material/select.md
@@ -84,6 +84,7 @@ export class MatSelect implements AfterContentInit, OnChanges, OnDestroy, OnInit
     ariaLabel: string;
     ariaLabelledby: string;
     protected _canOpen(): boolean;
+    canSelectNullableOptions: boolean;
     // (undocumented)
     protected _changeDetectorRef: ChangeDetectorRef;
     close(): void;
@@ -121,6 +122,8 @@ export class MatSelect implements AfterContentInit, OnChanges, OnDestroy, OnInit
     get multiple(): boolean;
     set multiple(value: boolean);
     // (undocumented)
+    static ngAcceptInputType_canSelectNullableOptions: unknown;
+    // (undocumented)
     static ngAcceptInputType_disabled: unknown;
     // (undocumented)
     static ngAcceptInputType_disableOptionCentering: unknown;
@@ -209,7 +212,7 @@ export class MatSelect implements AfterContentInit, OnChanges, OnDestroy, OnInit
     protected _viewportRuler: ViewportRuler;
     writeValue(value: any): void;
     // (undocumented)
-    static ɵcmp: i0.ɵɵComponentDeclaration<MatSelect, "mat-select", ["matSelect"], { "userAriaDescribedBy": { "alias": "aria-describedby"; "required": false; }; "panelClass": { "alias": "panelClass"; "required": false; }; "disabled": { "alias": "disabled"; "required": false; }; "disableRipple": { "alias": "disableRipple"; "required": false; }; "tabIndex": { "alias": "tabIndex"; "required": false; }; "hideSingleSelectionIndicator": { "alias": "hideSingleSelectionIndicator"; "required": false; }; "placeholder": { "alias": "placeholder"; "required": false; }; "required": { "alias": "required"; "required": false; }; "multiple": { "alias": "multiple"; "required": false; }; "disableOptionCentering": { "alias": "disableOptionCentering"; "required": false; }; "compareWith": { "alias": "compareWith"; "required": false; }; "value": { "alias": "value"; "required": false; }; "ariaLabel": { "alias": "aria-label"; "required": false; }; "ariaLabelledby": { "alias": "aria-labelledby"; "required": false; }; "errorStateMatcher": { "alias": "errorStateMatcher"; "required": false; }; "typeaheadDebounceInterval": { "alias": "typeaheadDebounceInterval"; "required": false; }; "sortComparator": { "alias": "sortComparator"; "required": false; }; "id": { "alias": "id"; "required": false; }; "panelWidth": { "alias": "panelWidth"; "required": false; }; }, { "openedChange": "openedChange"; "_openedStream": "opened"; "_closedStream": "closed"; "selectionChange": "selectionChange"; "valueChange": "valueChange"; }, ["customTrigger", "options", "optionGroups"], ["mat-select-trigger", "*"], true, never>;
+    static ɵcmp: i0.ɵɵComponentDeclaration<MatSelect, "mat-select", ["matSelect"], { "userAriaDescribedBy": { "alias": "aria-describedby"; "required": false; }; "panelClass": { "alias": "panelClass"; "required": false; }; "disabled": { "alias": "disabled"; "required": false; }; "disableRipple": { "alias": "disableRipple"; "required": false; }; "tabIndex": { "alias": "tabIndex"; "required": false; }; "hideSingleSelectionIndicator": { "alias": "hideSingleSelectionIndicator"; "required": false; }; "placeholder": { "alias": "placeholder"; "required": false; }; "required": { "alias": "required"; "required": false; }; "multiple": { "alias": "multiple"; "required": false; }; "disableOptionCentering": { "alias": "disableOptionCentering"; "required": false; }; "compareWith": { "alias": "compareWith"; "required": false; }; "value": { "alias": "value"; "required": false; }; "ariaLabel": { "alias": "aria-label"; "required": false; }; "ariaLabelledby": { "alias": "aria-labelledby"; "required": false; }; "errorStateMatcher": { "alias": "errorStateMatcher"; "required": false; }; "typeaheadDebounceInterval": { "alias": "typeaheadDebounceInterval"; "required": false; }; "sortComparator": { "alias": "sortComparator"; "required": false; }; "id": { "alias": "id"; "required": false; }; "panelWidth": { "alias": "panelWidth"; "required": false; }; "canSelectNullableOptions": { "alias": "canSelectNullableOptions"; "required": false; }; }, { "openedChange": "openedChange"; "_openedStream": "opened"; "_closedStream": "closed"; "selectionChange": "selectionChange"; "valueChange": "valueChange"; }, ["customTrigger", "options", "optionGroups"], ["mat-select-trigger", "*"], true, never>;
     // (undocumented)
     static ɵfac: i0.ɵɵFactoryDeclaration<MatSelect, never>;
 }
@@ -231,6 +234,7 @@ export class MatSelectChange {
 
 // @public
 export interface MatSelectConfig {
+    canSelectNullableOptions?: boolean;
     disableOptionCentering?: boolean;
     hideSingleSelectionIndicator?: boolean;
     overlayPanelClass?: string | string[];