diff --git a/test/e2e/config.go b/test/e2e/config.go
index af9364502d..d046d5979d 100644
--- a/test/e2e/config.go
+++ b/test/e2e/config.go
@@ -2,16 +2,27 @@
 
 package integration
 
+import (
+	"fmt"
+	"os"
+	"os/exec"
+	"path/filepath"
+	"strings"
+
+	. "github.com/onsi/ginkgo/v2" //nolint:stylecheck  // FIXME
+)
+
 var (
 	REDIS_IMAGE       = "quay.io/libpod/redis:alpine" //nolint:revive,stylecheck
 	fedoraMinimal     = "quay.io/libpod/systemd-image:20240124"
 	ALPINE            = "quay.io/libpod/alpine:latest"
 	ALPINELISTTAG     = "quay.io/libpod/alpine:3.10.2"
-	ALPINELISTDIGEST  = "quay.io/libpod/alpine@sha256:fa93b01658e3a5a1686dc3ae55f170d8de487006fb53a28efcd12ab0710a2e5f"
-	ALPINEAMD64DIGEST = "quay.io/libpod/alpine@sha256:634a8f35b5f16dcf4aaa0822adc0b1964bb786fca12f6831de8ddc45e5986a00"
+	ALPINELISTDIGEST  = "quay.io/libpod/alpine@" + digestOrCachedTop("quay.io/libpod/alpine", "sha256:fa93b01658e3a5a1686dc3ae55f170d8de487006fb53a28efcd12ab0710a2e5f")
+	ALPINEAMD64DIGEST = "quay.io/libpod/alpine@" + digestOrCachedArch("quay.io/libpod/alpine", "amd64", "sha256:634a8f35b5f16dcf4aaa0822adc0b1964bb786fca12f6831de8ddc45e5986a00")
 	ALPINEAMD64ID     = "961769676411f082461f9ef46626dd7a2d1e2b2a38e6a44364bcbecf51e66dd4"
-	ALPINEARM64DIGEST = "quay.io/libpod/alpine@sha256:f270dcd11e64b85919c3bab66886e59d677cf657528ac0e4805d3c71e458e525"
+	ALPINEARM64DIGEST = "quay.io/libpod/alpine@" + digestOrCachedArch("quay.io/libpod/alpine", "arm64", "sha256:f270dcd11e64b85919c3bab66886e59d677cf657528ac0e4805d3c71e458e525")
 	ALPINEARM64ID     = "915beeae46751fc564998c79e73a1026542e945ca4f73dc841d09ccc6c2c0672"
+	BUSYBOXARMDIGEST  = "quay.io/libpod/busybox@" + digestOrCachedArch("quay.io/libpod/busybox", "arm", "sha256:6655df04a3df853b029a5fac8836035ac4fab117800c9a6c4b69341bb5306c3d")
 	INFRA_IMAGE       = "quay.io/libpod/k8s-pause:3.5" //nolint:revive,stylecheck
 	BB                = "quay.io/libpod/busybox:latest"
 	HEALTHCHECK_IMAGE = "quay.io/libpod/alpine_healthcheck:latest" //nolint:revive,stylecheck
@@ -23,3 +34,34 @@ var (
 	// Note: "ImageCacheDir" has nothing to do with "PODMAN_TEST_IMAGE_CACHE_DIR".
 	ImageCacheDir = ""
 )
+
+func digestOrCachedTop(image string, standardDigest string) string {
+	if !UsingCacheRegistry() {
+		return standardDigest
+	}
+	cwd, _ := os.Getwd()
+	cmd := exec.Command("skopeo", "inspect", "-n", "docker://"+image, "--format", "{{.Digest}}")
+	cmd.Env = append(os.Environ(), "CONTAINERS_REGISTRIES_CONF="+filepath.Join(cwd, "..", "registries-cached.conf"))
+	out, err := cmd.Output()
+	if err != nil {
+		panic(fmt.Sprintf("Running %q: %s", cmd.String(), err.Error()))
+	}
+	GinkgoWriter.Printf("Digest of %q = %q", image, string(out))
+	return strings.TrimSpace(string(out))
+}
+
+func digestOrCachedArch(image string, arch string, standardDigest string) string {
+	if !UsingCacheRegistry() {
+		return standardDigest
+	}
+	cwd, _ := os.Getwd()
+	cmd := exec.Command("sh", "-c", `skopeo inspect --raw docker://`+image+
+		` | jq -r '.manifests | map(select(.platform.architecture == "`+arch+`"))[0].digest'`)
+	cmd.Env = append(os.Environ(), "CONTAINERS_REGISTRIES_CONF="+filepath.Join(cwd, "..", "registries-cached.conf"))
+	out, err := cmd.Output()
+	if err != nil {
+		panic(fmt.Sprintf("Running %q: %s", cmd.String(), err.Error()))
+	}
+	GinkgoWriter.Printf("Digest of %q arc %s = %q", image, arch, string(out))
+	return strings.TrimSpace(string(out))
+}
diff --git a/test/e2e/manifest_test.go b/test/e2e/manifest_test.go
index 22bf064b4e..f3a1f128a3 100644
--- a/test/e2e/manifest_test.go
+++ b/test/e2e/manifest_test.go
@@ -69,13 +69,13 @@ func verifyInstanceCompression(descriptor []imgspecv1.Descriptor, compression st
 
 var _ = Describe("Podman manifest", func() {
 
-	const (
+	var (
 		imageList                      = "docker://quay.io/libpod/testimage:00000004"
-		imageListInstance              = "docker://quay.io/libpod/testimage@sha256:1385ce282f3a959d0d6baf45636efe686c1e14c3e7240eb31907436f7bc531fa"
-		imageListARM64InstanceDigest   = "sha256:1385ce282f3a959d0d6baf45636efe686c1e14c3e7240eb31907436f7bc531fa"
-		imageListAMD64InstanceDigest   = "sha256:1462c8e885d567d534d82004656c764263f98deda813eb379689729658a133fb"
-		imageListPPC64LEInstanceDigest = "sha256:9b7c3300f5f7cfe94e3101a28d1f0a28728f8dbc854fb16dd545b7e5aa351785"
-		imageListS390XInstanceDigest   = "sha256:cb68b7bfd2f4f7d36006efbe3bef04b57a343e0839588476ca336d9ff9240dbf"
+		imageListARM64InstanceDigest   = digestOrCachedArch("quay.io/libpod/testimage:00000004", "arm64", "sha256:1385ce282f3a959d0d6baf45636efe686c1e14c3e7240eb31907436f7bc531fa")
+		imageListInstance              = "docker://quay.io/libpod/testimage@" + imageListARM64InstanceDigest
+		imageListAMD64InstanceDigest   = digestOrCachedArch("quay.io/libpod/testimage:00000004", "amd64", "sha256:1462c8e885d567d534d82004656c764263f98deda813eb379689729658a133fb")
+		imageListPPC64LEInstanceDigest = digestOrCachedArch("quay.io/libpod/testimage:00000004", "ppc64le", "sha256:9b7c3300f5f7cfe94e3101a28d1f0a28728f8dbc854fb16dd545b7e5aa351785")
+		imageListS390XInstanceDigest   = digestOrCachedArch("quay.io/libpod/testimage:00000004", "s390x", "sha256:cb68b7bfd2f4f7d36006efbe3bef04b57a343e0839588476ca336d9ff9240dbf")
 	)
 
 	It("create w/o image and attempt push w/o dest", func() {
@@ -120,7 +120,7 @@ var _ = Describe("Podman manifest", func() {
 		Expect(session).Should(ExitCleanly())
 
 		// inspect manifest of single image
-		session = podmanTest.Podman([]string{"manifest", "inspect", "quay.io/libpod/busybox@sha256:6655df04a3df853b029a5fac8836035ac4fab117800c9a6c4b69341bb5306c3d"})
+		session = podmanTest.Podman([]string{"manifest", "inspect", BUSYBOXARMDIGEST})
 		session.WaitWithDefaultTimeout()
 		Expect(session).Should(Exit(0))
 		// yet another warning message that is not seen by remote client