diff --git a/podman/domain/images_manager.py b/podman/domain/images_manager.py
index 0ebf57c5..8cc3cdbe 100644
--- a/podman/domain/images_manager.py
+++ b/podman/domain/images_manager.py
@@ -158,17 +158,22 @@ def prune(
         deleted: List[Dict[str, str]] = []
         error: List[str] = []
         reclaimed: int = 0
-        for element in response.json():
-            if "Err" in element and element["Err"] is not None:
-                error.append(element["Err"])
-            else:
-                reclaimed += element["Size"]
-                deleted.append(
-                    {
-                        "Deleted": element["Id"],
-                        "Untagged": "",
-                    }
-                )
+        # If the prune doesn't remove images, the API returns "null"
+        # and it's interpreted as None (NoneType)
+        # so the for loop throws "TypeError: 'NoneType' object is not iterable".
+        # The below if condition fixes this issue.
+        if response.json() is not None:
+            for element in response.json():
+                if "Err" in element and element["Err"] is not None:
+                    error.append(element["Err"])
+                else:
+                    reclaimed += element["Size"]
+                    deleted.append(
+                        {
+                            "Deleted": element["Id"],
+                            "Untagged": "",
+                        }
+                    )
         if len(error) > 0:
             raise APIError(response.url, response=response, explanation="; ".join(error))
 
diff --git a/podman/tests/unit/test_imagesmanager.py b/podman/tests/unit/test_imagesmanager.py
index 6de8910f..c51cef8b 100644
--- a/podman/tests/unit/test_imagesmanager.py
+++ b/podman/tests/unit/test_imagesmanager.py
@@ -223,6 +223,15 @@ def test_prune_failure(self, mock):
             self.client.images.prune()
         self.assertEqual(e.exception.explanation, "Test prune failure in response body.")
 
+    @requests_mock.Mocker()
+    def test_prune_empty(self, mock):
+        """Unit test if prune API responses null (None)."""
+        mock.post(tests.LIBPOD_URL + "/images/prune", text="null")
+
+        report = self.client.images.prune()
+        self.assertEqual(report["ImagesDeleted"], [])
+        self.assertEqual(report["SpaceReclaimed"], 0)
+
     @requests_mock.Mocker()
     def test_get(self, mock):
         mock.get(