diff --git a/docker-compose.env.example b/.env.example
similarity index 66%
rename from docker-compose.env.example
rename to .env.example
index 95de5df..ee07172 100644
--- a/docker-compose.env.example
+++ b/.env.example
@@ -5,6 +5,3 @@ TIMELINE_FILE=./../../../data/sr2silo/demo_real/timeline.tsv
 PRIMER_FILE=./tests/data/samples_large/primers.yaml
 NEXTCLADE_REFERENCE=sars-cov2
 RESULTS_DIR=./../results/A1_10_2024_09_30/20241018_AAG55WNM5/1000/
-AWS_ACCESS_KEY_ID="XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX"
-AWS_SECRET_ACCESS_KEY="XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX"
-AWS_DEFAULT_REGION="eu-central-1"
diff --git a/.github/workflows/docker-build-test.yml b/.github/workflows/docker-build-test.yml
index fb324a8..852d4b7 100644
--- a/.github/workflows/docker-build-test.yml
+++ b/.github/workflows/docker-build-test.yml
@@ -42,10 +42,62 @@ jobs:
           username: ${{ secrets.DOCKER_USERNAME }}
           password: ${{ secrets.DOCKER_PASSWORD }}
 
+      - name: Create .env file
+        run: |
+          echo SAMPLE_DIR=${{ secrets.SAMPLE_DIR }} >> .env
+          echo SAMPLE_ID=${{ secrets.SAMPLE_ID }} >> .env
+          echo BATCH_ID=${{ secrets.BATCH_ID }} >> .env
+          echo TIMELINE_FILE=${{ secrets.TIMELINE_FILE }} >> .env
+          echo PRIMER_FILE=${{ secrets.PRIMER_FILE }} >> .env
+          echo NEXTCLADE_REFERENCE=${{ secrets.NEXTCLADE_REFERENCE }} >> .env
+          echo RESULTS_DIR=${{ secrets.RESULTS_DIR }} >> .env
+          echo AWS_ACCESS_KEY_ID=${{ secrets.AWS_ACCESS_KEY_ID }} >> .env
+          echo AWS_SECRET_ACCESS_KEY=${{ secrets.AWS_SECRET_ACCESS_KEY }} >> .env
+          echo AWS_DEFAULT_REGION=${{ secrets.AWS_DEFAULT_REGION }} >> .env
+
       - name: Build Docker image
-        run: docker-compose --env-file docker-compose.env build
+        run: docker-compose --env-file .env build
 
       - name: Push to DockerHub
         if: github.ref == 'refs/heads/main'
         run: |
           docker-compose push
+
+  test:
+    needs: build
+    runs-on: ubuntu-latest
+
+    steps:
+      - name: Checkout code
+        uses: actions/checkout@v3
+
+      - name: Set up Docker Compose
+        run: |
+          sudo curl -L "https://github.com/docker/compose/releases/download/1.29.2/docker-compose-$(uname -s)-$(uname -m)" -o /usr/local/bin/docker-compose
+          sudo chmod +x /usr/local/bin/docker-compose
+          docker-compose --version
+
+      - name: Create .env file
+        run: |
+          echo SAMPLE_DIR=${{ secrets.SAMPLE_DIR }} >> .env
+          echo SAMPLE_ID=${{ secrets.SAMPLE_ID }} >> .env
+          echo BATCH_ID=${{ secrets.BATCH_ID }} >> .env
+          echo TIMELINE_FILE=${{ secrets.TIMELINE_FILE }} >> .env
+          echo PRIMER_FILE=${{ secrets.PRIMER_FILE }} >> .env
+          echo NEXTCLADE_REFERENCE=${{ secrets.NEXTCLADE_REFERENCE }} >> .env
+          echo RESULTS_DIR=${{ secrets.RESULTS_DIR }} >> .env
+
+
+      - name: Create Docker secrets files
+        run: |
+          mkdir -p ./secrets
+          echo "${{ secrets.AWS_ACCESS_KEY_ID }}" > ./secrets/aws_access_key_id.txt
+          echo "${{ secrets.AWS_SECRET_ACCESS_KEY }}" > ./secrets/aws_secret_access_key.txt
+          echo "${{ secrets.AWS_DEFAULT_REGION }}" > ./secrets/aws_default_region.txt
+
+
+      - name: Run Docker Compose
+        run: docker-compose --env-file .env up
+
+      - name: Tear down Docker Compose
+        run: docker-compose down
diff --git a/README.md b/README.md
index 34ac11d..2bb1d67 100644
--- a/README.md
+++ b/README.md
@@ -71,7 +71,48 @@ $ poetry shell
 $ pytest
 ```
 
-#### Tool Sections
+### [WIP]: Run V-Pipe to SILO Transformation
+This is currently implemented as script and under heavy development.
+To run, we recommend a build as a docker compose as it relies on other RUST components.
+
+#### Configuration
+
+Edit the `docker-compose.env` file in the `docker-compose` directory with the following paths:
+
+```env
+SAMPLE_DIR=../../../data/sr2silo/daemon_test/samples/A1_05_2024_10_08/20241024_2411515907/alignments/
+SAMPLE_ID=A1_05_2024_10_08
+BATCH_ID=20241024_2411515907
+TIMELINE_FILE=../../../data/sr2silo/daemon_test/timeline.tsv
+NEXTCLADE_REFERENCE=sars-cov2
+RESULTS_DIR=./results
+```
+
+
+#### Docker Secrets
+To upload the processed outputs S3 storage is required.
+
+For sensitive information like AWS credentials, use Docker secrets. Create the following files in the secrets directory:
+
+- secrets/aws_access_key_id.txt:
+```YourAWSAccessKeyId````
+
+- secrets/aws_secret_access_key.txt:
+```YourAWSSecretAccessKey````
+
+- secrets/aws_default_region.txt:
+```YourAWSRegion```
+
+#### Run Transformation
+
+To process a single sample, run the following command:
+
+```sh
+docker-compose --env-file .env up --build
+```
+
+
+### Tool Sections
 The code quality checks run on GitHub can be seen in
  - ``.github/workflows/test.yml`` for the python package CI/CD,
 
diff --git a/docker-compose.env b/docker-compose.env
deleted file mode 100644
index 9a71e1b..0000000
--- a/docker-compose.env
+++ /dev/null
@@ -1,7 +0,0 @@
-SAMPLE_DIR=./tests/data/samples_large/A1_05_2024_10_08/20241024_2411515907/alignments
-SAMPLE_ID=A1_05_2024_10_08
-BATCH_ID=20241024_2411515907
-TIMELINE_FILE=./tests/data/samples_large/timeline_A1_05_2024_10_08.tsv
-PRIMER_FILE=./tests/data/samples_large/primers.yaml
-NEXTCLADE_REFERENCE=sars-cov2
-RESULTS_DIR=./results
diff --git a/docker-compose.yml b/docker-compose.yml
index 6819e53..cf59daa 100644
--- a/docker-compose.yml
+++ b/docker-compose.yml
@@ -1,3 +1,5 @@
+version: '3.8'
+
 services:
   sr2silo:
     build: .
@@ -7,7 +9,7 @@ services:
       - ${PRIMER_FILE}:/app/primers.yaml
       - ${RESULTS_DIR}:/app/results
       - ./scripts/database_config.yaml:/app/scripts/database_config.yaml
-      - ./scripts/reference_genomes.json:/app/scripts/- ./scripts/database_config.yaml:/app/scripts/reference_genomes.json
+      - ./scripts/reference_genomes.json:/app/scripts/reference_genomes.json
     environment:
       - PYTHONUNBUFFERED=1
       - SAMPLE_DIR=${SAMPLE_DIR}
@@ -16,9 +18,18 @@ services:
       - TIMELINE_FILE=${TIMELINE_FILE}
       - PRIMER_FILE=${PRIMER_FILE}
       - RESULTS_DIR=${RESULTS_DIR}
-      - AWS_ACCESS_KEY_ID=${AWS_ACCESS_KEY_ID}
-      - AWS_SECRET_ACCESS_KEY=${AWS_SECRET_ACCESS_KEY}
-      - AWS_DEFAULT_REGION=${AWS_DEFAULT_REGION}
+    secrets:
+      - aws_access_key_id
+      - aws_secret_access_key
+      - aws_default_region
+
+secrets:
+  aws_access_key_id:
+    file: ./secrets/aws_access_key_id.txt
+  aws_secret_access_key:
+    file: ./secrets/aws_secret_access_key.txt
+  aws_default_region:
+    file: ./secrets/aws_default_region.txt
 
 volumes:
   results:
diff --git a/scripts/README.md b/scripts/README.md
deleted file mode 100644
index 16f8224..0000000
--- a/scripts/README.md
+++ /dev/null
@@ -1,22 +0,0 @@
-# Docker: Process a Single BAM File
-
-## Configuration
-
-Edit the `docker-compose.env` file in the `docker-compose` directory with the following paths:
-
-```env
-SAMPLE_DIR=../../../data/sr2silo/daemon_test/samples/A1_05_2024_10_08/20241024_2411515907/alignments/
-SAMPLE_ID=A1_05_2024_10_08
-BATCH_ID=20241024_2411515907
-TIMELINE_FILE=../../../data/sr2silo/daemon_test/timeline.tsv
-NEXTCLADE_REFERENCE=sars-cov2
-RESULTS_DIR=./results
-```
-
-## Processing
-
-To process a single sample, run the following command:
-
-```sh
-docker-compose --env-file docker-compose.env up --build
-```
diff --git a/src/sr2silo/s3.py b/src/sr2silo/s3.py
index 99965de..2353330 100644
--- a/src/sr2silo/s3.py
+++ b/src/sr2silo/s3.py
@@ -3,7 +3,6 @@
 from __future__ import annotations
 
 import bz2
-import os
 import shutil
 from pathlib import Path
 
@@ -23,13 +22,34 @@ def compress_bz2(input_fp: Path, output_fp: Path) -> None:
             shutil.copyfileobj(f_in, f_out)
 
 
+def get_aws_credentials():
+    """Get AWS credentials from Docker secrets.
+
+    Returns:
+        Tuple[str, str, str]: AWS access key ID, AWS secret access key,
+        and AWS default region.
+
+    Raises:
+        RuntimeError: If any of the required secrets are missing.
+    """
+    try:
+        with open("/run/secrets/aws_access_key_id") as f:
+            aws_access_key_id = f.read().strip()
+        with open("/run/secrets/aws_secret_access_key") as f:
+            aws_secret_access_key = f.read().strip()
+        with open("/run/secrets/aws_default_region") as f:
+            aws_default_region = f.read().strip()
+    except FileNotFoundError as e:
+        raise RuntimeError("Required secret is missing: " + str(e))
+
+    return aws_access_key_id, aws_secret_access_key, aws_default_region
+
+
 def get_s3_client():
     """Get an S3 client using AWS credentials from environment variables."""
 
     # Get AWS credentials from environment variables
-    aws_access_key_id = os.getenv("AWS_ACCESS_KEY_ID")
-    aws_secret_access_key = os.getenv("AWS_SECRET_ACCESS_KEY")
-    aws_default_region = os.getenv("AWS_DEFAULT_REGION")
+    aws_access_key_id, aws_secret_access_key, aws_default_region = get_aws_credentials()
 
     # Create an S3 client
     s3_client = boto3.client(