From d4848b8aa758ee6ed663ed1e79e29248513ffaa1 Mon Sep 17 00:00:00 2001 From: Preeti Date: Tue, 29 May 2018 15:48:53 -0400 Subject: [PATCH 001/102] add portalversion bean properties for ALS portal --- grails-app/conf/Config.groovy | 46 ++++++++++++++++++++++++++++++++--- 1 file changed, 42 insertions(+), 4 deletions(-) diff --git a/grails-app/conf/Config.groovy b/grails-app/conf/Config.groovy index 3d2152b62..0a19635a0 100755 --- a/grails-app/conf/Config.groovy +++ b/grails-app/conf/Config.groovy @@ -290,7 +290,7 @@ environments { // grails.serverURL = "http://stroke-qasrvr-1.us-east-1.elasticbeanstalk.com" - grails.serverURL = "http://www.type2diabetesgenetics.org" +// grails.serverURL = "http://www.type2diabetesgenetics.org" // grails.serverURL = "http://ci-env.elasticbeanstalk.com" // grails.serverURL = "http://type2diabetes-dev.elasticbeanstalk.com" // grails.serverURL = "http://type2diabetesgen-qasrvr.elasticbeanstalk.com" @@ -310,8 +310,8 @@ environments { // grails.serverURL = "http://strokeprodnew.us-east-1.elasticbeanstalk.com" // grails.serverURL = "http://broadcvdi.org" // CVDKP (MI portal) production -// grails.serverURL = "http://mi-qasrvr.us-east-1.elasticbeanstalk.com" // CVDKP (MI portal) test site -// grails.serverURL = "http://miprodportal.us-east-1.elasticbeanstalk.com" + grails.serverURL = "http://mi-qasrvr.us-east-1.elasticbeanstalk.com" // CVDKP (MI portal) test site + // grails.serverURL = "http://miprodportal.us-east-1.elasticbeanstalk.com" // grails.serverURL = "http://miprod-env.us-east-1.elasticbeanstalk.com" // grails.serverURL = "http://sleepportal-prodsrvr.us-east-1.elasticbeanstalk.com" @@ -559,7 +559,7 @@ grails.plugin.springsecurity.userLookup.authorityJoinClassName = 'org.broadinsti grails.plugin.springsecurity.authority.className = 'org.broadinstitute.mpg.people.Role' -portal.type.override = "t2d" // options are "t2d", "stroke", "mi", "ibd", "epilepsy", or "sleep". What is the portal type for all nonsystem users? +portal.type.override = "als" // options are "t2d", "stroke", "mi", "ibd", "epilepsy", or "sleep". What is the portal type for all nonsystem users? portal.data.versionDesignator = [ new PortalVersionBean("t2d", // label for this portal type @@ -723,6 +723,39 @@ portal.data.versionDesignator = [ new PortalVersionBean("t2d", // label for 0, 0,0,0, 0 + ) + , + new PortalVersionBean("als", + "ALS", + "mdv60", + "ALS", // make sure your default phenotype exists in your default data set + "GWAS_ALS2018_mdv60",// used to pick a default data set for a gene query + [""],// no tissue for ALS portal + ["NEUROLOGICAL"], // most important phenotype group name + [], + "[1,2]", + "GWAS_IBDGenomics_eu_mdv80", + "images/epilepsy/front_epilepsy_logo_2018.svg", + "portal.epilepsy.header.tagline", + [], + ["CDKL5"], + [], + ["chr14:35,907,000-36,400,000"], + "images/epilepsy/front_epilepsy_bg_2018.png", + "", + "images/epilepsy/epilepsy_header_logo.svg", + "images/menu_bg_2017_5.png", + "false", + "", + "", + '5414069947481666863', + 0, + 1, + 0, + 1, + 0, + 0,0,0, + 0 ), new PortalVersionBean("sleep", "Sleep", @@ -757,3 +790,8 @@ portal.data.versionDesignator = [ new PortalVersionBean("t2d", // label for 0 ) ] + + +// Here the secret authentication strings +auth.providers.twitter.secret = 'l3dJBs3w9QraAuivcfaqdjVGkJ4cxQSMMNNkZ6v9bwz8nXBCXQ' +oauth.providers.google.secret = 'HKIxi3AOLAgyFV6lDJQCfEgY' \ No newline at end of file From 68d48172710d812d6a4dd1e7ddb5a9224bea44e7 Mon Sep 17 00:00:00 2001 From: dkjang Date: Mon, 11 Jun 2018 13:53:33 -0400 Subject: [PATCH 002/102] Images for ALS portal added --- grails-app/conf/Config.groovy | 6 +- web-app/images/als/als_header_logo.svg | 38 +++++++ web-app/images/als/front_als_banner_2018.png | Bin 0 -> 306973 bytes web-app/images/als/front_als_logo_2018.svg | 108 +++++++++++++++++++ 4 files changed, 149 insertions(+), 3 deletions(-) create mode 100644 web-app/images/als/als_header_logo.svg create mode 100644 web-app/images/als/front_als_banner_2018.png create mode 100644 web-app/images/als/front_als_logo_2018.svg diff --git a/grails-app/conf/Config.groovy b/grails-app/conf/Config.groovy index 97ad1ea29..f20f23e42 100755 --- a/grails-app/conf/Config.groovy +++ b/grails-app/conf/Config.groovy @@ -753,15 +753,15 @@ portal.data.versionDesignator = [ new PortalVersionBean("t2d", // label for [], "[1,2]", "GWAS_IBDGenomics_eu_mdv80", - "images/epilepsy/front_epilepsy_logo_2018.svg", + "images/als/front_als_logo_2018.svg", "portal.epilepsy.header.tagline", [], ["CDKL5"], [], ["chr14:35,907,000-36,400,000"], - "images/epilepsy/front_epilepsy_bg_2018.png", + "images/als/front_als_banner_2018.png", "", - "images/epilepsy/epilepsy_header_logo.svg", + "images/als/als_header_logo.svg", "images/menu_bg_2017_5.png", "false", "", diff --git a/web-app/images/als/als_header_logo.svg b/web-app/images/als/als_header_logo.svg new file mode 100644 index 000000000..8dd6a831c --- /dev/null +++ b/web-app/images/als/als_header_logo.svg @@ -0,0 +1,38 @@ + + + + + + + + + + + + + + + + + + + + + + + diff --git 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z#W#P72lcj7ZXP$`wnAl1Djlp^TlgC{mhK>j{j5V6B z(LEZTh~v!IGjX8^Gg-Sq&w$T+{+Jr)52!m(wSyb2k=-XUn^_v=F<2M1T2y6p8S12Q z<1n>M(wTHa<$B=1j{K1p#~RrSs|h_zU%8Y(nKLLuxXEzlTp|>g4wQr<-kxi`J__kjvEWgffYd zJD1xS3YN59n$T=GKID;C3V)KK>#;4ba3W8&KUd2qGOGjNY)zP;%KmH41G0RwzT5 z0fBrD5DPa*Lg=fj9}`&mWh!Smx?QEUEZ~!_TXF-5VH4VQ-u;_2hxvn_yo4yRhr5LY7Tp$rStzk1 z{!R8jf5p8(w|D*iKX3g%0|c;{p`!nD)c^WSor@5BoKL-pCZTi_@% literal 0 HcmV?d00001 diff --git a/web-app/images/als/front_als_logo_2018.svg b/web-app/images/als/front_als_logo_2018.svg new file mode 100644 index 000000000..f3e8c0da4 --- /dev/null +++ b/web-app/images/als/front_als_logo_2018.svg @@ -0,0 +1,108 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + From 273e8c422a7bbe1ae1baa21b8dc6106ccdcdecb4 Mon Sep 17 00:00:00 2001 From: Preeti Date: Tue, 12 Jun 2018 17:57:58 -0400 Subject: [PATCH 003/102] changes for als portal --- grails-app/conf/Config.groovy | 45 +++++++---------------------------- 1 file changed, 9 insertions(+), 36 deletions(-) diff --git a/grails-app/conf/Config.groovy b/grails-app/conf/Config.groovy index 0bff6031f..781bffb74 100755 --- a/grails-app/conf/Config.groovy +++ b/grails-app/conf/Config.groovy @@ -716,11 +716,11 @@ portal.data.versionDesignator = [ new PortalVersionBean("t2d", // label for 1, 1 ), - new PortalVersionBean("epilepsy", - "Epilepsy", - "mdv100", - "GGE", // make sure your default phenotype exists in your default data set - "ExSeq_Epi25k_mdv100",// used to pick a default data set for a gene query + new PortalVersionBean("als", + "ALS", + "mdv60", + "ALS", // make sure your default phenotype exists in your default data set + "GWAS_ALS2018_mdv60",// used to pick a default data set for a gene query ["8_Genic_enhancer","9_Active_enhancer_1","10_Active_enhancer_2","11_Weak_enhancer"], ["8_Genic_enhancer","9_Active_enhancer_1","10_Active_enhancer_2","11_Weak_enhancer"], ["AnteriorCaudate"], @@ -731,7 +731,7 @@ portal.data.versionDesignator = [ new PortalVersionBean("t2d", // label for "images/epilepsy/front_epilepsy_logo_2018.svg", "portal.epilepsy.header.tagline", [], - ["CDKL5"], + ["SOD1"], [], ["chr14:35,907,000-36,400,000"], "images/epilepsy/front_epilepsy_bg_2018.png", @@ -748,39 +748,12 @@ portal.data.versionDesignator = [ new PortalVersionBean("t2d", // label for 1, 0, 0,0,0, - 0 - ) - , - new PortalVersionBean("als", - "ALS", - "mdv60", - "ALS", // make sure your default phenotype exists in your default data set - "GWAS_ALS2018_mdv60",// used to pick a default data set for a gene query - ["8_Genic_enhancer","9_Active_enhancer_1","10_Active_enhancer_2","11_Weak_enhancer"], - ["8_Genic_enhancer","9_Active_enhancer_1","10_Active_enhancer_2","11_Weak_enhancer"], - ["AnteriorCaudate"], - ["PSYCHIATRIC"], // most important phenotype group name - [], - "[1,2]", - "GWAS_IBDGenomics_eu_mdv80", - "images/als/front_als_logo_2018.svg", - "portal.epilepsy.header.tagline", - [], - ["CDKL5"], - [], - ["chr14:35,907,000-36,400,000"], - "images/als/front_als_banner_2018.png", - "", - "images/als/als_header_logo.svg", - "images/menu_bg_2017_5.png", - "false", - "", - "", - '5414069947481666863', 0, 0 ) - , + , + + new PortalVersionBean("sleep", "Sleep", "mdv110", From bb61b0858cfc40023e2969ee6dd55aebe1ec0838 Mon Sep 17 00:00:00 2001 From: Preeti Date: Wed, 13 Jun 2018 16:32:07 -0400 Subject: [PATCH 004/102] als image- DK --- grails-app/conf/Config.groovy | 10 ++++------ 1 file changed, 4 insertions(+), 6 deletions(-) diff --git a/grails-app/conf/Config.groovy b/grails-app/conf/Config.groovy index 781bffb74..ffb66b45f 100755 --- a/grails-app/conf/Config.groovy +++ b/grails-app/conf/Config.groovy @@ -728,15 +728,15 @@ portal.data.versionDesignator = [ new PortalVersionBean("t2d", // label for [], "[1,2]", "GWAS_IBDGenomics_eu_mdv80", - "images/epilepsy/front_epilepsy_logo_2018.svg", + "images/als/front_als_logo_2018.svg", "portal.epilepsy.header.tagline", [], ["SOD1"], [], ["chr14:35,907,000-36,400,000"], - "images/epilepsy/front_epilepsy_bg_2018.png", + "images/als/front_als_banner_2018.png", "", - "images/epilepsy/epilepsy_header_logo.svg", + "images/als/als_header_logo.svg", "images/menu_bg_2017_5.png", "false", "", @@ -750,9 +750,7 @@ portal.data.versionDesignator = [ new PortalVersionBean("t2d", // label for 0,0,0, 0, 0 - ) - , - + ), new PortalVersionBean("sleep", "Sleep", From b2a3af7ba8eb7b4f9ab858d145fa3d386d738ce5 Mon Sep 17 00:00:00 2001 From: Preeti Date: Thu, 14 Jun 2018 14:09:36 -0400 Subject: [PATCH 005/102] add neurological category --- grails-app/conf/Config.groovy | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/grails-app/conf/Config.groovy b/grails-app/conf/Config.groovy index ffb66b45f..104a35e3e 100755 --- a/grails-app/conf/Config.groovy +++ b/grails-app/conf/Config.groovy @@ -724,7 +724,7 @@ portal.data.versionDesignator = [ new PortalVersionBean("t2d", // label for ["8_Genic_enhancer","9_Active_enhancer_1","10_Active_enhancer_2","11_Weak_enhancer"], ["8_Genic_enhancer","9_Active_enhancer_1","10_Active_enhancer_2","11_Weak_enhancer"], ["AnteriorCaudate"], - ["PSYCHIATRIC"], // most important phenotype group name + ["PSYCHIATRIC", "NEUROLOGICAL"], // most important phenotype group name [], "[1,2]", "GWAS_IBDGenomics_eu_mdv80", From 5dc1996a0ffe23c78a9e428c59e4fb1d6e91d961 Mon Sep 17 00:00:00 2001 From: Preeti Date: Mon, 18 Jun 2018 11:08:34 -0400 Subject: [PATCH 006/102] adding als portal grails link --- grails-app/conf/Config.groovy | 8 ++++++-- 1 file changed, 6 insertions(+), 2 deletions(-) diff --git a/grails-app/conf/Config.groovy b/grails-app/conf/Config.groovy index 104a35e3e..34cf736c6 100755 --- a/grails-app/conf/Config.groovy +++ b/grails-app/conf/Config.groovy @@ -320,8 +320,12 @@ environments { // grails.serverURL = "http://strokeprodnew.us-east-1.elasticbeanstalk.com" // grails.serverURL = "http://broadcvdi.org" // CVDKP (MI portal) production - grails.serverURL = "http://mi-qasrvr.us-east-1.elasticbeanstalk.com" // CVDKP (MI portal) test site - // grails.serverURL = "http://miprodportal.us-east-1.elasticbeanstalk.com" + +// grails.serverURL = "http://mi-qasrvr.us-east-1.elasticbeanstalk.com"// CVDKP (MI portal) test site + + grails.serverURL = "http://alsportal.us-east-1.elasticbeanstalk.com" + + // grails.serverURL = "http://miprodportal.us-east-1.elasticbeanstalk.com" // grails.serverURL = "http://miprod-env.us-east-1.elasticbeanstalk.com" // grails.serverURL = "http://sleepportal-prodsrvr.us-east-1.elasticbeanstalk.com" From 01423bff51c7a3f156dca3932ba4d51780539524 Mon Sep 17 00:00:00 2001 From: mariacos Date: Tue, 19 Jun 2018 11:20:31 -0400 Subject: [PATCH 007/102] ALS-specific modifications --- grails-app/conf/Config.groovy | 2 +- grails-app/i18n/informational.properties | 5 + grails-app/i18n/metadata.properties | 28 ++++++ grails-app/i18n/portalHome.properties | 3 + grails-app/views/home/portalHome.gsp | 10 ++ grails-app/views/informational/_about_ALS.gsp | 95 +++++++++++++++++++ grails-app/views/informational/about.gsp | 3 + grails-app/views/informational/data.gsp | 5 + .../informational/data/_GWAS_ALS2016lmm.gsp | 5 + .../informational/data/_GWAS_ALS2016meta.gsp | 5 + .../informational/data/_GWAS_ALS2018.gsp | 5 + .../views/widgets/_datasetsPageTemplate.gsp | 3 + 12 files changed, 168 insertions(+), 1 deletion(-) create mode 100644 grails-app/views/informational/_about_ALS.gsp create mode 100644 grails-app/views/informational/data/_GWAS_ALS2016lmm.gsp create mode 100644 grails-app/views/informational/data/_GWAS_ALS2016meta.gsp create mode 100644 grails-app/views/informational/data/_GWAS_ALS2018.gsp diff --git a/grails-app/conf/Config.groovy b/grails-app/conf/Config.groovy index 104a35e3e..e46b39da3 100755 --- a/grails-app/conf/Config.groovy +++ b/grails-app/conf/Config.groovy @@ -729,7 +729,7 @@ portal.data.versionDesignator = [ new PortalVersionBean("t2d", // label for "[1,2]", "GWAS_IBDGenomics_eu_mdv80", "images/als/front_als_logo_2018.svg", - "portal.epilepsy.header.tagline", + "portal.ALS.header.tagline", [], ["SOD1"], [], diff --git a/grails-app/i18n/informational.properties b/grails-app/i18n/informational.properties index b6f4ab4d1..d6ac2959a 100755 --- a/grails-app/i18n/informational.properties +++ b/grails-app/i18n/informational.properties @@ -997,6 +997,7 @@ A "mega-meta-analysis," Project 3 involves data from 26,488 type 2 diabetes pati This diversity of ancestries is especially important to the study design. Variants that are tightly correlated by location in some ancestry groups (e.g., Europeans) may travel more independently in other groups (e.g., African Americans). Therefore, examining data from many different groups can help distinguish between true causal variants and those that are merely along for the ride.\

aboutTheData.epi.descr=This page lists datasets currently available in the Epilepsy Knowledge Portal. Filter the list by data type and/or by phenotype using the menu at the top. Click on a dataset name to see more details about it. +aboutTheData.als.descr=This page lists datasets currently available in the ALS Knowledge Portal. Filter the list by data type and/or by phenotype using the menu at the top. Click on a dataset name to see more details about it. aboutTheData.stroke.title=About the data aboutTheData.stroke.descr=This page lists datasets currently available in the Cerebrovascular Disease Knowledge Portal. Filter the list by data type and/or by phenotype using the menu at the top. Click on a dataset name to see more details about it. aboutTheData.stroke.datasets.race.title=Risk Assessment of Cerebrovascular Events (RACE) @@ -2189,7 +2190,11 @@ informational.data.accessing.sleep2= tool\ and then on the resulting page, select the UK Biobank Sleep Traits GWAS dataset. informational.about_sleep.header=About the Sleep Disorder Knowledge Portal project informational.about_SleepData.header=Data in the Sleep Disorder Knowledge Portal +informational.about_ALSData.header=Data in the ALS Knowledge Portal informational.about_sleep.section1=Details about data contributors and consortia will go here. +informational.about_ALS.header=About the ALS Knowledge Portal project +informational.about_ALSData.header=Data in the ALS Knowledge Portal +informational.about_ALS.section1=Details about data contributors and consortia will go here. informational.data.exptsumm.EPRI_GWAS=The PR interval exome chip analysis surveyed nearly 93,000 subjects for whom cardiac conduction measurements were available. Subjects were excluded if they exhibited \ any of the following conditions: extreme PR values (≤80 or ≥320 ms); second- or third-degree heart block; AF on baseline ECG; history of myocardial infarction, heart failure, or \ Wolff–Parkinson–White syndrome; pacemaker placement; use of class I or III blocking medications (ATC code pre x C01B); digoxin use (ATC code C01AA05); or pregnancy. PR interval duration, \ diff --git a/grails-app/i18n/metadata.properties b/grails-app/i18n/metadata.properties index d2481c9c5..dc1602285 100755 --- a/grails-app/i18n/metadata.properties +++ b/grails-app/i18n/metadata.properties @@ -27,6 +27,7 @@ metadata.BFP=Body fat percentage metadata.HIPCadjBMI=Hip circumference adj BMI metadata.WAISTadjBMI=Waist circumference adj BMI metadata.WHRadjBMI=Waist-hip ratio adj BMI +metadata.ALS=ALS metadata.intron_variant=intron metadata.missense_variant=missense @@ -2474,6 +2475,33 @@ metadata.GWAS_BFpercent_mdv55=Body fat percentage GWAS metadata.GWAS_EGGC_mdv55=Early Growth Genetics Consortium GWAS metadata.GWAS_HRgene_mdv55=Heart rate GWAS + +#mdv60 is ALSKP + +metadata.GWAS_PGC_mdv60=PGC GWAS +metadata.ExAC_r03_mdv60=ExAC +metadata.ExSeq_EgnomAD_mdv60=gnomAD exomes +metadata.ExSeq_EgnomAD_aa_mdv60=gnomAD exomes: African Americans +metadata.ExSeq_EgnomAD_ea_mdv60=gnomAD exomes: East Asians +metadata.ExSeq_EgnomAD_eu_mdv60=gnomAD exomes: Europeans +metadata.ExSeq_EgnomAD_sa_mdv60=gnomAD exomes: South Asians +metadata.ExSeq_EgnomAD_hs_mdv60=gnomAD exomes: Latinos +metadata.WGS_WgnomAD_mdv60=gnomAD whole genomes +metadata.WGS_WgnomAD_aa_mdv60=gnomAD whole genomes: African Americans +metadata.WGS_WgnomAD_ea_mdv60=gnomAD whole genomes: East Asians +metadata.WGS_WgnomAD_eu_mdv60=gnomAD whole genomes: Europeans +metadata.WGS_WgnomAD_hs_mdv60=gnomAD whole genomes: Latinos +metadata.1kg_phase1_mdv60=1000 Genomes +metadata.1kg_phase1_eu_mdv60=1000 Genomes: Europeans +metadata.1kg_phase1_sa_mdv60=1000 Genomes: East Asians +metadata.1kg_phase1_aa_mdv60=1000 Genomes: African Americans +metadata.1kg_phase1_hs_mdv60=1000 Genomes: Hispanics +metadata.GWAS_ALS2018_mdv60=ALS GWAS 2018 +metadata.GWAS_ALS2016meta_mdv60=ALS GWAS 2016 MetaXcan +metadata.GWAS_ALS2016lmm_mdv60=ALS GWAS 2016 Lmm + + + #mdv70 is stroke production diff --git a/grails-app/i18n/portalHome.properties b/grails-app/i18n/portalHome.properties index a26a3b8e3..e09704047 100755 --- a/grails-app/i18n/portalHome.properties +++ b/grails-app/i18n/portalHome.properties @@ -92,6 +92,7 @@ portal.mi.header.tagline=A platform for accelerating analysis of the genetics of //portal.ibd.header.tagline=A platform for accelerating genetic discoveries in inflammatory bowel disease portal.ibd.header.tagline=This is a demo portal -- we are interested in feedback on the evolving interface portal.epilepsy.header.tagline=A platform for accelerating genetic analysis in epilepsy +portal.ALS.header.tagline=A platform for accelerating genetic discoveries in amyotrophic lateral sclerosis portal.sleep.header.tagline=A platform for accelerating genetic discoveries for sleep disturbance and circadian traits about.the.mi.portal.text=The Cardiovascular Disease Knowledge Portal (CVDKP) framework is being developed by a \ team of scientists and software engineers at the Broad \ @@ -103,6 +104,7 @@ about.the.mi.portal.text=The Cardiovascular Disease Knowledge Portal (CVDKP) fra about.the.ibd.portal.text=Details about the V2F Portal project about.the.epi.portal.text=Details about the Epilepsy Knowledge Portal project and funders' logos about.the.sleep.portal.text=Details about the Sleep Disorder Knowledge Portal project and funders' logos +about.the.ALS.portal.text=Details about the ALS Knowledge Portal project and funders' logos about.the.stroke.portal.text=The Knowledge Portal is being developed by a team of scientists and software engineers at the \ Broad Institute of MIT and Harvard along with collaborators from \ Massachusetts General Hospital and many other institutions across the globe. \ @@ -127,3 +129,4 @@ portal.epi.about.the.data.text=The Epilepsy Knowledge Portal enables browsing, s portal.epi.use.citation.itself= Epilepsy Knowledge Portal. Year Month Date of access; URL of page you are citing. Also cite any paper(s) in which the data were published. portal.sleep.about.the.data.text=The Sleep Disorder Knowledge Portal enables browsing, searching, and analysis of human genetic information linked to sleep disorders and related traits, while protecting the integrity and confidentiality of the underlying data. portal.sleep.use.citation.itself= Sleep Disorder Knowledge Portal. Year Month Date of access; URL of page you are citing. Also cite any paper(s) in which the data were published. +portal.ALS.about.the.data.text=The ALS Knowledge Portal enables browsing, searching, and analysis of human genetic information linked to amyotrophic lateral sclerosis and related traits, while protecting the integrity and confidentiality of the underlying data. \ No newline at end of file diff --git a/grails-app/views/home/portalHome.gsp b/grails-app/views/home/portalHome.gsp index 5e917929a..d86b294eb 100755 --- a/grails-app/views/home/portalHome.gsp +++ b/grails-app/views/home/portalHome.gsp @@ -258,6 +258,12 @@

+ +

+ +

+

+

@@ -480,6 +486,10 @@

+ +

+ +

diff --git a/grails-app/views/informational/_about_ALS.gsp b/grails-app/views/informational/_about_ALS.gsp new file mode 100644 index 000000000..4b9ae0ecc --- /dev/null +++ b/grails-app/views/informational/_about_ALS.gsp @@ -0,0 +1,95 @@ + +

+
+
+
+ +

+ %{--
 
--}% + %{--
--}% + %{--
 
--}% +
+
+
+
+

+

+ +

+

+

+

+ + +
+
+
+
\ No newline at end of file diff --git a/grails-app/views/informational/about.gsp b/grails-app/views/informational/about.gsp index 67387affa..4c9765247 100755 --- a/grails-app/views/informational/about.gsp +++ b/grails-app/views/informational/about.gsp @@ -29,6 +29,9 @@ + + + diff --git a/grails-app/views/informational/data.gsp b/grails-app/views/informational/data.gsp index 95dc94164..51f935812 100755 --- a/grails-app/views/informational/data.gsp +++ b/grails-app/views/informational/data.gsp @@ -96,6 +96,11 @@

+ + +
+

+
diff --git a/grails-app/views/informational/data/_GWAS_ALS2016lmm.gsp b/grails-app/views/informational/data/_GWAS_ALS2016lmm.gsp new file mode 100644 index 000000000..bb63f742a --- /dev/null +++ b/grails-app/views/informational/data/_GWAS_ALS2016lmm.gsp @@ -0,0 +1,5 @@ + \ No newline at end of file diff --git a/grails-app/views/informational/data/_GWAS_ALS2016meta.gsp b/grails-app/views/informational/data/_GWAS_ALS2016meta.gsp new file mode 100644 index 000000000..7385f7709 --- /dev/null +++ b/grails-app/views/informational/data/_GWAS_ALS2016meta.gsp @@ -0,0 +1,5 @@ + \ No newline at end of file diff --git a/grails-app/views/informational/data/_GWAS_ALS2018.gsp b/grails-app/views/informational/data/_GWAS_ALS2018.gsp new file mode 100644 index 000000000..04d30c528 --- /dev/null +++ b/grails-app/views/informational/data/_GWAS_ALS2018.gsp @@ -0,0 +1,5 @@ + \ No newline at end of file diff --git a/grails-app/views/widgets/_datasetsPageTemplate.gsp b/grails-app/views/widgets/_datasetsPageTemplate.gsp index 2646cd134..78afdfb8c 100644 --- a/grails-app/views/widgets/_datasetsPageTemplate.gsp +++ b/grails-app/views/widgets/_datasetsPageTemplate.gsp @@ -72,6 +72,9 @@ + + + From 93623f37437be84bdf6bfec09d92178562ea8932 Mon Sep 17 00:00:00 2001 From: Preeti Date: Tue, 19 Jun 2018 16:45:05 -0400 Subject: [PATCH 008/102] title and heading name for als --- grails-app/conf/Config.groovy | 9 +++++++-- grails-app/i18n/portalHome.properties | 1 + 2 files changed, 8 insertions(+), 2 deletions(-) diff --git a/grails-app/conf/Config.groovy b/grails-app/conf/Config.groovy index 34cf736c6..4feda3684 100755 --- a/grails-app/conf/Config.groovy +++ b/grails-app/conf/Config.groovy @@ -299,7 +299,7 @@ environments { // grails.serverURL = "http://variant2function.org" - grails.serverURL = "http://demo52k.us-east-1.elasticbeanstalk.com" +// grails.serverURL = "http://demo52k.us-east-1.elasticbeanstalk.com" // grails.serverURL = "http://ci-env.elasticbeanstalk.com" // grails.serverURL = "http://type2diabetes-dev.elasticbeanstalk.com" @@ -733,7 +733,7 @@ portal.data.versionDesignator = [ new PortalVersionBean("t2d", // label for "[1,2]", "GWAS_IBDGenomics_eu_mdv80", "images/als/front_als_logo_2018.svg", - "portal.epilepsy.header.tagline", + "portal.als.header.tagline", [], ["SOD1"], [], @@ -792,3 +792,8 @@ portal.data.versionDesignator = [ new PortalVersionBean("t2d", // label for 0 ) ] + + +// Here the secret authentication strings +auth.providers.twitter.secret = 'l3dJBs3w9QraAuivcfaqdjVGkJ4cxQSMMNNkZ6v9bwz8nXBCXQ' +oauth.providers.google.secret = 'HKIxi3AOLAgyFV6lDJQCfEgY' \ No newline at end of file diff --git a/grails-app/i18n/portalHome.properties b/grails-app/i18n/portalHome.properties index a26a3b8e3..b4b70e53f 100755 --- a/grails-app/i18n/portalHome.properties +++ b/grails-app/i18n/portalHome.properties @@ -92,6 +92,7 @@ portal.mi.header.tagline=A platform for accelerating analysis of the genetics of //portal.ibd.header.tagline=A platform for accelerating genetic discoveries in inflammatory bowel disease portal.ibd.header.tagline=This is a demo portal -- we are interested in feedback on the evolving interface portal.epilepsy.header.tagline=A platform for accelerating genetic analysis in epilepsy +portal.als.header.tagline=A platform for accelerating genetic analysis in ALS portal.sleep.header.tagline=A platform for accelerating genetic discoveries for sleep disturbance and circadian traits about.the.mi.portal.text=The Cardiovascular Disease Knowledge Portal (CVDKP) framework is being developed by a \ team of scientists and software engineers at the Broad \ From 145a60b3952dc98380fa77b734a278a71f9b26f6 Mon Sep 17 00:00:00 2001 From: mariacos Date: Thu, 5 Jul 2018 11:44:41 -0400 Subject: [PATCH 009/102] working on data pages --- grails-app/i18n/informational.properties | 9 +- grails-app/i18n/metadata.properties | 4 +- .../informational/data/_GWAS_ALS2016lmm.gsp | 919 +++++++++++++++++- 3 files changed, 927 insertions(+), 5 deletions(-) diff --git a/grails-app/i18n/informational.properties b/grails-app/i18n/informational.properties index d6ac2959a..825b03b76 100755 --- a/grails-app/i18n/informational.properties +++ b/grails-app/i18n/informational.properties @@ -350,6 +350,8 @@ informational.shared.traits.AFxBMI=AF-SNP BMI interaction informational.shared.traits.AFxHTN=AF-SNP hypertension interaction informational.shared.traits.AFxSEX=AF-SNP sex interaction informational.shared.traits.PRI=PR interval +informational.shared.traits.ALS=amyotrophic lateral sclerosis + informational.shared.traits.SleepChronotype=chronotype informational.shared.traits.SleepDuration=sleep duration @@ -632,7 +634,8 @@ informational.shared.publications.Yengo_2018_submitted=Genome-wide \ + association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis. informational.shared.publications.Gaulton_2016_NatGenet.author=Gaulton KJ informational.shared.publications.Wessel_2015_NatCommun.author=Wessel J @@ -706,6 +709,7 @@ informational.shared.publications.Gorski_2017_SciRep.author=Gorski M informational.shared.publications.Shungin_2015_Nature.author=Shungin D informational.shared.publications.Yengo_2018_submitted.author=Yengo L informational.shared.publications.Abecasis_2018_submitted.author=Abecasis G +informational.shared.publications.vanRheenen_2016_NatGenet.author=van Rheenen W informational.shared.publications.Gaulton_2016_NatGenet.citation=Nat Genet. 2015 Dec;47(12):1415-25. doi: 10.1038/ng.3437. informational.shared.publications.Wessel_2015_NatCommun.citation=Nat Commun. 2015 Jan 29;6:5897. doi: 10.1038/ncomms6897. @@ -785,6 +789,7 @@ informational.shared.publications.Gorski_2017_SciRep.citation=Sci Rep. 2017 Apr informational.shared.publications.Shungin_2015_Nature.citation=Nature. 2015 Feb 12;518(7538):187-196. doi: 10.1038/nature14132 informational.shared.publications.Yengo_2018_submitted.citation=Submitted for publication. informational.shared.publications.Abecasis_2018_submitted.citation=Submitted for publication. +informational.shared.publications.vanRheenen_2016_NatGenet.citation=Nat Genet. 2016 Sep;48(9):1043-8. doi: 10.1038/ng.3622 informational.shared.projectpublications.Oxford=Oxford BioBank publication list informational.shared.projectpublications.gnomAD=See also the MacArthur lab publication list. @@ -2361,4 +2366,4 @@ informational.data.overview.52K-3=For each of the 25×2=50 single-variant analys of the variant filters was increased if the distribution of association statistics appeared poorly calibrated. A 25-group fixed-effect inverse-variance weighted \ meta-analysis was then conducted for each of the Firth and EMMAX tests, using METAL. EMMAX results were used for association p-values and Firth results for \ effect size estimates. - +informational.data.exptsumm.ALS2016_GWAS_LMM diff --git a/grails-app/i18n/metadata.properties b/grails-app/i18n/metadata.properties index dc1602285..3559619da 100755 --- a/grails-app/i18n/metadata.properties +++ b/grails-app/i18n/metadata.properties @@ -2496,9 +2496,9 @@ metadata.1kg_phase1_eu_mdv60=1000 Genomes: Europeans metadata.1kg_phase1_sa_mdv60=1000 Genomes: East Asians metadata.1kg_phase1_aa_mdv60=1000 Genomes: African Americans metadata.1kg_phase1_hs_mdv60=1000 Genomes: Hispanics -metadata.GWAS_ALS2018_mdv60=ALS GWAS 2018 +metadata.GWAS_ALS2018_mdv60=ALS exome case/control 2018 metadata.GWAS_ALS2016meta_mdv60=ALS GWAS 2016 MetaXcan -metadata.GWAS_ALS2016lmm_mdv60=ALS GWAS 2016 Lmm +metadata.GWAS_ALS2016lmm_mdv60=ALS GWAS 2016 LMM diff --git a/grails-app/views/informational/data/_GWAS_ALS2016lmm.gsp b/grails-app/views/informational/data/_GWAS_ALS2016lmm.gsp index bb63f742a..f9488ac49 100644 --- a/grails-app/views/informational/data/_GWAS_ALS2016lmm.gsp +++ b/grails-app/views/informational/data/_GWAS_ALS2016lmm.gsp @@ -1,5 +1,922 @@ \ No newline at end of file From f558b72ef04b64479e2113d1796c9aada6f1456a Mon Sep 17 00:00:00 2001 From: mariacos Date: Thu, 5 Jul 2018 12:35:26 -0400 Subject: [PATCH 010/102] added translation and data page for ALS 2016 exome sequencing --- grails-app/i18n/informational.properties | 5 ++++- grails-app/i18n/metadata.properties | 1 + grails-app/views/informational/data/_ExSeq_ALS2016.gsp | 3 +++ grails-app/views/informational/data/_GWAS_ALS2016lmm.gsp | 2 +- grails-app/views/widgets/_datasetsPageTemplate.gsp | 1 + 5 files changed, 10 insertions(+), 2 deletions(-) create mode 100644 grails-app/views/informational/data/_ExSeq_ALS2016.gsp diff --git a/grails-app/i18n/informational.properties b/grails-app/i18n/informational.properties index 825b03b76..b98cb88c8 100755 --- a/grails-app/i18n/informational.properties +++ b/grails-app/i18n/informational.properties @@ -2366,4 +2366,7 @@ informational.data.overview.52K-3=For each of the 25×2=50 single-variant analys of the variant filters was increased if the distribution of association statistics appeared poorly calibrated. A 25-group fixed-effect inverse-variance weighted \ meta-analysis was then conducted for each of the Firth and EMMAX tests, using METAL. EMMAX results were used for association p-values and Firth results for \ effect size estimates. -informational.data.exptsumm.ALS2016_GWAS_LMM +informational.data.exptsumm.ALS2016_GWAS_LMM=7,763 new ALS cases and 4,669 controls were genotyped and data were combined with those from previously published ALS GWAS studies. \ + Cohorts were combined on the basis of genotyping platform and nationality to form 27 case–control strata. A custom reference panel for imputation was constructed based \ + on high-coverage whole-genome sequencing data from 1,246 patients with ALS and 615 controls from the Netherlands. A merged reference panel consisting of the custom \ + panel and the 100 Genomes reference panel was used for imputation. All strata were jointly analyzed in a linear mixed model (LMM). diff --git a/grails-app/i18n/metadata.properties b/grails-app/i18n/metadata.properties index 3559619da..c87eadec2 100755 --- a/grails-app/i18n/metadata.properties +++ b/grails-app/i18n/metadata.properties @@ -2499,6 +2499,7 @@ metadata.1kg_phase1_hs_mdv60=1000 Genomes: Hispanics metadata.GWAS_ALS2018_mdv60=ALS exome case/control 2018 metadata.GWAS_ALS2016meta_mdv60=ALS GWAS 2016 MetaXcan metadata.GWAS_ALS2016lmm_mdv60=ALS GWAS 2016 LMM +metadata.ExSeq_ALS2016_mdv60=ALS 2016 exome sequence analysis diff --git a/grails-app/views/informational/data/_ExSeq_ALS2016.gsp b/grails-app/views/informational/data/_ExSeq_ALS2016.gsp new file mode 100644 index 000000000..86efffdbe --- /dev/null +++ b/grails-app/views/informational/data/_ExSeq_ALS2016.gsp @@ -0,0 +1,3 @@ + \ No newline at end of file diff --git a/grails-app/views/informational/data/_GWAS_ALS2016lmm.gsp b/grails-app/views/informational/data/_GWAS_ALS2016lmm.gsp index f9488ac49..f88aa9f83 100644 --- a/grails-app/views/informational/data/_GWAS_ALS2016lmm.gsp +++ b/grails-app/views/informational/data/_GWAS_ALS2016lmm.gsp @@ -913,7 +913,7 @@ Cases Controls Cohort Ancestry

Accessing ALS GWAS 2016 LMM data

-

Variant Finder

+

diff --git a/grails-app/views/widgets/_datasetsPageTemplate.gsp b/grails-app/views/widgets/_datasetsPageTemplate.gsp index 78afdfb8c..2ea4aa32b 100644 --- a/grails-app/views/widgets/_datasetsPageTemplate.gsp +++ b/grails-app/views/widgets/_datasetsPageTemplate.gsp @@ -75,6 +75,7 @@ + From 31297cbee611af6da819fcd6ca44eb02f321cb41 Mon Sep 17 00:00:00 2001 From: mariacos Date: Thu, 5 Jul 2018 13:43:55 -0400 Subject: [PATCH 011/102] removed forward slash from dataset name --- grails-app/i18n/metadata.properties | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/grails-app/i18n/metadata.properties b/grails-app/i18n/metadata.properties index c87eadec2..f60d0c882 100755 --- a/grails-app/i18n/metadata.properties +++ b/grails-app/i18n/metadata.properties @@ -2496,7 +2496,7 @@ metadata.1kg_phase1_eu_mdv60=1000 Genomes: Europeans metadata.1kg_phase1_sa_mdv60=1000 Genomes: East Asians metadata.1kg_phase1_aa_mdv60=1000 Genomes: African Americans metadata.1kg_phase1_hs_mdv60=1000 Genomes: Hispanics -metadata.GWAS_ALS2018_mdv60=ALS exome case/control 2018 +metadata.GWAS_ALS2018_mdv60=ALS exome case-control 2018 metadata.GWAS_ALS2016meta_mdv60=ALS GWAS 2016 MetaXcan metadata.GWAS_ALS2016lmm_mdv60=ALS GWAS 2016 LMM metadata.ExSeq_ALS2016_mdv60=ALS 2016 exome sequence analysis From d16fbd5f69117b1a394f78323210610c248c1f60 Mon Sep 17 00:00:00 2001 From: Preeti Date: Thu, 19 Jul 2018 13:30:36 -0400 Subject: [PATCH 012/102] nearest gene column replaced by gene, add filter in showVariantforAGene() method --- .../mpg/VariantSearchController.groovy | 12 ++++++++++-- 1 file changed, 10 insertions(+), 2 deletions(-) diff --git a/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy b/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy index 1d22c803e..0b5c29294 100755 --- a/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy +++ b/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy @@ -279,7 +279,15 @@ class VariantSearchController { List filtersForQuery = [] if (chromosome!=null){ + String defaultDataSet = restServerService.retrieveBeanForCurrentPortal().dataSet + String defaultPhenotype = restServerService.retrieveBeanForCurrentPortal().phenotype filtersForQuery << """{"value":"${chromosome}:${extents.startExtent}-${extents.endExtent}","prop":"chromosome","comparator":"="}""".toString() + filtersForQuery << """{"gene":"${geneName}","prop":"gene","value":"${geneName}","comparator":"="}""".toString() +// filtersForQuery << """{"phenotype":"${defaultPhenotype}","dataset":"${defaultDataSet}","prop":"ACA_PH","value":"0","comparator":">"}""".toString() +// filtersForQuery << """{"phenotype":"${defaultPhenotype}","dataset":"${defaultDataSet}","prop":"ACU_PH","value":"0","comparator":">"}]""".toString() + + // filtersForQuery << """{"gene":"${geneName}","comparator":"="}""".toString() + } if ((dataSetName!=null) && (phenotypeName!=null)){ org.broadinstitute.mpg.diabetes.metadata.Property property = metaDataService.getPropertyForPhenotypeAndSampleGroupAndMeaning(phenotypeName,dataSetName, @@ -1220,9 +1228,9 @@ class VariantSearchController { ArrayList listOfCodedFilters = parseFilterJson(listOfQueries); if (requestForAdditionalProperties == null || "".compareTo(requestForAdditionalProperties) == 0) { - // if there are no specified properties, default to these + // if there are no specified properties, dFefault to these requestForAdditionalProperties = - ["common-common-CLOSEST_GENE", + ["common-common-GENE", "common-common-VAR_ID", "common-common-DBSNP_ID", "common-common-Protein_change", From 7dac790c9f0aa71142e1a331b0794dd6a09fe691 Mon Sep 17 00:00:00 2001 From: mariacos Date: Thu, 19 Jul 2018 16:00:24 -0400 Subject: [PATCH 013/102] updated ALS dataset translations --- grails-app/i18n/metadata.properties | 7 +++---- 1 file changed, 3 insertions(+), 4 deletions(-) diff --git a/grails-app/i18n/metadata.properties b/grails-app/i18n/metadata.properties index f60d0c882..b1effdf42 100755 --- a/grails-app/i18n/metadata.properties +++ b/grails-app/i18n/metadata.properties @@ -2496,10 +2496,9 @@ metadata.1kg_phase1_eu_mdv60=1000 Genomes: Europeans metadata.1kg_phase1_sa_mdv60=1000 Genomes: East Asians metadata.1kg_phase1_aa_mdv60=1000 Genomes: African Americans metadata.1kg_phase1_hs_mdv60=1000 Genomes: Hispanics -metadata.GWAS_ALS2018_mdv60=ALS exome case-control 2018 -metadata.GWAS_ALS2016meta_mdv60=ALS GWAS 2016 MetaXcan -metadata.GWAS_ALS2016lmm_mdv60=ALS GWAS 2016 LMM -metadata.ExSeq_ALS2016_mdv60=ALS 2016 exome sequence analysis +metadata.GWAS_ALS2016meta_mdv60=ALS GWAS 2016 meta-analysis +metadata.GWAS_ALS2016lmm_mdv60=ALS GWAS 2016 LMM
 +metadata.ExSeq_ALS2018_mdv60=ALS exome case-control 2018 From b314f4e3c0a9319547601948621b00a501efc254 Mon Sep 17 00:00:00 2001 From: mariacos Date: Thu, 19 Jul 2018 16:01:18 -0400 Subject: [PATCH 014/102] added page for ExSeq_ALS2018 --- grails-app/views/informational/data/_ExSeq_ALS2018.gsp | 1 + 1 file changed, 1 insertion(+) create mode 100644 grails-app/views/informational/data/_ExSeq_ALS2018.gsp diff --git a/grails-app/views/informational/data/_ExSeq_ALS2018.gsp b/grails-app/views/informational/data/_ExSeq_ALS2018.gsp new file mode 100644 index 000000000..7394f7e09 --- /dev/null +++ b/grails-app/views/informational/data/_ExSeq_ALS2018.gsp @@ -0,0 +1 @@ + \ No newline at end of file From 6454851c18bf5fcefb23091df8e87b171b0d358a Mon Sep 17 00:00:00 2001 From: mariacos Date: Thu, 19 Jul 2018 16:01:56 -0400 Subject: [PATCH 015/102] added page for GWAS_ALS2016meta --- grails-app/views/informational/data/_GWAS_ALS2016meta.gsp | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/grails-app/views/informational/data/_GWAS_ALS2016meta.gsp b/grails-app/views/informational/data/_GWAS_ALS2016meta.gsp index 7385f7709..112ed3cb6 100644 --- a/grails-app/views/informational/data/_GWAS_ALS2016meta.gsp +++ b/grails-app/views/informational/data/_GWAS_ALS2016meta.gsp @@ -1,5 +1,5 @@ \ No newline at end of file From ace5940cfbf79b72ba23c0b9f6470847497afcd8 Mon Sep 17 00:00:00 2001 From: mariacos Date: Thu, 19 Jul 2018 16:02:13 -0400 Subject: [PATCH 016/102] enabled ALS data pages --- grails-app/views/widgets/_datasetsPageTemplate.gsp | 3 +-- 1 file changed, 1 insertion(+), 2 deletions(-) diff --git a/grails-app/views/widgets/_datasetsPageTemplate.gsp b/grails-app/views/widgets/_datasetsPageTemplate.gsp index 2ea4aa32b..d6d537354 100644 --- a/grails-app/views/widgets/_datasetsPageTemplate.gsp +++ b/grails-app/views/widgets/_datasetsPageTemplate.gsp @@ -74,8 +74,7 @@ - - + From 1754e592cbbdbcd71d8e3e6e1267c8f90651be5a Mon Sep 17 00:00:00 2001 From: mariacos Date: Fri, 20 Jul 2018 13:57:14 -0400 Subject: [PATCH 017/102] added ALS dataset descriptions --- grails-app/i18n/informational.properties | 12 ++++++++++-- 1 file changed, 10 insertions(+), 2 deletions(-) diff --git a/grails-app/i18n/informational.properties b/grails-app/i18n/informational.properties index b98cb88c8..df1caa191 100755 --- a/grails-app/i18n/informational.properties +++ b/grails-app/i18n/informational.properties @@ -636,6 +636,8 @@ informational.shared.publications.Abecasis_2018_submitted=Genetic discovery and 2 diabetes cases and 24,440 controls from five ancestries. informational.shared.publications.vanRheenen_2016_NatGenet=Genome-wide \ association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis. +informational.shared.publications.Farhan_2018_inPress=Enrichment \ + of rare protein truncating variants in amyotrophic lateral sclerosis patients. informational.shared.publications.Gaulton_2016_NatGenet.author=Gaulton KJ informational.shared.publications.Wessel_2015_NatCommun.author=Wessel J @@ -710,6 +712,7 @@ informational.shared.publications.Shungin_2015_Nature.author=Shungin D informational.shared.publications.Yengo_2018_submitted.author=Yengo L informational.shared.publications.Abecasis_2018_submitted.author=Abecasis G informational.shared.publications.vanRheenen_2016_NatGenet.author=van Rheenen W +informational.shared.publications.Farhan_2018_inPress.author=Farhan SMK informational.shared.publications.Gaulton_2016_NatGenet.citation=Nat Genet. 2015 Dec;47(12):1415-25. doi: 10.1038/ng.3437. informational.shared.publications.Wessel_2015_NatCommun.citation=Nat Commun. 2015 Jan 29;6:5897. doi: 10.1038/ncomms6897. @@ -790,6 +793,7 @@ informational.shared.publications.Shungin_2015_Nature.citation=Nature. 2015 Feb informational.shared.publications.Yengo_2018_submitted.citation=Submitted for publication. informational.shared.publications.Abecasis_2018_submitted.citation=Submitted for publication. informational.shared.publications.vanRheenen_2016_NatGenet.citation=Nat Genet. 2016 Sep;48(9):1043-8. doi: 10.1038/ng.3622 +informational.shared.publications.Farhan_2018_inPress.citation=In press. informational.shared.projectpublications.Oxford=Oxford BioBank publication list informational.shared.projectpublications.gnomAD=See also the MacArthur lab publication list. @@ -2366,7 +2370,11 @@ informational.data.overview.52K-3=For each of the 25×2=50 single-variant analys of the variant filters was increased if the distribution of association statistics appeared poorly calibrated. A 25-group fixed-effect inverse-variance weighted \ meta-analysis was then conducted for each of the Firth and EMMAX tests, using METAL. EMMAX results were used for association p-values and Firth results for \ effect size estimates. -informational.data.exptsumm.ALS2016_GWAS_LMM=7,763 new ALS cases and 4,669 controls were genotyped and data were combined with those from previously published ALS GWAS studies. \ +informational.data.exptsumm.ALS2016_GWAS=7,763 new ALS cases and 4,669 controls were genotyped and data were combined with those from previously published ALS GWAS studies. \ Cohorts were combined on the basis of genotyping platform and nationality to form 27 case–control strata. A custom reference panel for imputation was constructed based \ on high-coverage whole-genome sequencing data from 1,246 patients with ALS and 615 controls from the Netherlands. A merged reference panel consisting of the custom \ - panel and the 100 Genomes reference panel was used for imputation. All strata were jointly analyzed in a linear mixed model (LMM). + panel and the 100 Genomes reference panel was used for imputation. Association results were combined in an inverse-variance- weighted, fixed-effect meta-analysis \ + using METAL to generate the ALS GWAS 2016 meta-analysis dataset. All strata were jointly analyzed in a linear mixed model to create the ALS GWAS 2016 LMM dataset. +informational.data.exptsumm.ALS2018_ExSeq=The ALS exome case-control 2018 dataset comprises exome sequence data from 3,864 amyotrophic lateral \ + sclerosis cases and 7,839 controls. Gene burden testing was used to discover associations of genes with ALS. +informational.data.accessing.ALS2018_ExSeq= \ No newline at end of file From a5a3c8deae93682e1780584a22e6651c5dbf7823 Mon Sep 17 00:00:00 2001 From: mariacos Date: Fri, 20 Jul 2018 13:57:37 -0400 Subject: [PATCH 018/102] created page for ALS exome 2018 --- .../informational/data/_ExSeq_ALS2018.gsp | 30 ++++++++++++++++++- 1 file changed, 29 insertions(+), 1 deletion(-) diff --git a/grails-app/views/informational/data/_ExSeq_ALS2018.gsp b/grails-app/views/informational/data/_ExSeq_ALS2018.gsp index 7394f7e09..1573fe7f8 100644 --- a/grails-app/views/informational/data/_ExSeq_ALS2018.gsp +++ b/grails-app/views/informational/data/_ExSeq_ALS2018.gsp @@ -1 +1,29 @@ - \ No newline at end of file + \ No newline at end of file From 00d1a2cd3900caf04bc211fafa4524b92020201f Mon Sep 17 00:00:00 2001 From: mariacos Date: Fri, 20 Jul 2018 13:59:02 -0400 Subject: [PATCH 019/102] added ALS dataset descriptions --- grails-app/i18n/informational.properties | 1 - 1 file changed, 1 deletion(-) diff --git a/grails-app/i18n/informational.properties b/grails-app/i18n/informational.properties index df1caa191..57a83aae2 100755 --- a/grails-app/i18n/informational.properties +++ b/grails-app/i18n/informational.properties @@ -2377,4 +2377,3 @@ informational.data.exptsumm.ALS2016_GWAS=7,763 new ALS cases and 4,669 controls using METAL to generate the ALS GWAS 2016 meta-analysis dataset. All strata were jointly analyzed in a linear mixed model to create the ALS GWAS 2016 LMM dataset. informational.data.exptsumm.ALS2018_ExSeq=The ALS exome case-control 2018 dataset comprises exome sequence data from 3,864 amyotrophic lateral \ sclerosis cases and 7,839 controls. Gene burden testing was used to discover associations of genes with ALS. -informational.data.accessing.ALS2018_ExSeq= \ No newline at end of file From c59d435882b9e0ecfd745094ea07255e13316188 Mon Sep 17 00:00:00 2001 From: mariacos Date: Fri, 20 Jul 2018 13:59:19 -0400 Subject: [PATCH 020/102] edited page for ALS exome 2018 --- grails-app/views/informational/data/_ExSeq_ALS2018.gsp | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/grails-app/views/informational/data/_ExSeq_ALS2018.gsp b/grails-app/views/informational/data/_ExSeq_ALS2018.gsp index 1573fe7f8..1f2745ff1 100644 --- a/grails-app/views/informational/data/_ExSeq_ALS2018.gsp +++ b/grails-app/views/informational/data/_ExSeq_ALS2018.gsp @@ -18,9 +18,9 @@

-

Accessing ALS exome case-control 2018 data

+%{--

Accessing ALS exome case-control 2018 data

--}% -

+%{--

--}%
From 42c3d8f2ee3abb01c9e3f36ccddc114c2cccb1e3 Mon Sep 17 00:00:00 2001 From: mariacos Date: Fri, 20 Jul 2018 13:59:54 -0400 Subject: [PATCH 021/102] edited ALS 2016 GWAS LMM data page --- grails-app/views/informational/data/_GWAS_ALS2016lmm.gsp | 6 +++--- 1 file changed, 3 insertions(+), 3 deletions(-) diff --git a/grails-app/views/informational/data/_GWAS_ALS2016lmm.gsp b/grails-app/views/informational/data/_GWAS_ALS2016lmm.gsp index f88aa9f83..f6cb07924 100644 --- a/grails-app/views/informational/data/_GWAS_ALS2016lmm.gsp +++ b/grails-app/views/informational/data/_GWAS_ALS2016lmm.gsp @@ -909,11 +909,11 @@ Cases Controls Cohort Ancestry

-

+

-

Accessing ALS GWAS 2016 LMM data

+%{--

Accessing ALS GWAS 2016 LMM data

--}% -

+%{--

--}%
From 54013bea025def8bff52f173bafb177f26b90427 Mon Sep 17 00:00:00 2001 From: mariacos Date: Fri, 20 Jul 2018 14:00:15 -0400 Subject: [PATCH 022/102] edited ALS 2016 GWAS meta data page --- .../informational/data/_GWAS_ALS2016meta.gsp | 918 +++++++++++++++++- 1 file changed, 917 insertions(+), 1 deletion(-) diff --git a/grails-app/views/informational/data/_GWAS_ALS2016meta.gsp b/grails-app/views/informational/data/_GWAS_ALS2016meta.gsp index 112ed3cb6..b8afa996e 100644 --- a/grails-app/views/informational/data/_GWAS_ALS2016meta.gsp +++ b/grails-app/views/informational/data/_GWAS_ALS2016meta.gsp @@ -1,5 +1,921 @@ \ No newline at end of file From efd8a166affc66bb267e2c6b3ea126bb0de9858e Mon Sep 17 00:00:00 2001 From: mariacos Date: Fri, 20 Jul 2018 14:00:56 -0400 Subject: [PATCH 023/102] deleted unnecessary data page --- grails-app/views/informational/data/_ExSeq_ALS2016.gsp | 3 --- 1 file changed, 3 deletions(-) delete mode 100644 grails-app/views/informational/data/_ExSeq_ALS2016.gsp diff --git a/grails-app/views/informational/data/_ExSeq_ALS2016.gsp b/grails-app/views/informational/data/_ExSeq_ALS2016.gsp deleted file mode 100644 index 86efffdbe..000000000 --- a/grails-app/views/informational/data/_ExSeq_ALS2016.gsp +++ /dev/null @@ -1,3 +0,0 @@ - \ No newline at end of file From 10cbd631651faff5e0c8f774e77fff59882765b0 Mon Sep 17 00:00:00 2001 From: Preeti Date: Thu, 16 Aug 2018 10:07:12 -0400 Subject: [PATCH 024/102] add AC filters for ALS --- grails-app/conf/Config.groovy | 41 ++++++++++++++++++- .../mpg/VariantSearchController.groovy | 13 +++--- 2 files changed, 47 insertions(+), 7 deletions(-) diff --git a/grails-app/conf/Config.groovy b/grails-app/conf/Config.groovy index d5166ca46..0f8db0aac 100755 --- a/grails-app/conf/Config.groovy +++ b/grails-app/conf/Config.groovy @@ -755,6 +755,45 @@ portal.data.versionDesignator = [ new PortalVersionBean("t2d", // label for 0, 0 ), + new PortalVersionBean("epilepsy", + "Epilepsy", + "mdv100", + "GGE", // make sure your default phenotype exists in your default data set + "ExSeq_Epi25k_mdv100",// used to pick a default data set for a gene query + ["8_Genic_enhancer","9_Active_enhancer_1","10_Active_enhancer_2","11_Weak_enhancer"], + ["8_Genic_enhancer","9_Active_enhancer_1","10_Active_enhancer_2","11_Weak_enhancer"], + + ["AnteriorCaudate"], + ["PSYCHIATRIC"], // most important phenotype group name + [], + "[1,2]", + "GWAS_IBDGenomics_eu_mdv80", + "images/epilepsy/front_epilepsy_logo_2018.svg", + "portal.epilepsy.header.tagline", + [], + ["CDKL5"], + + [], + ["chr14:35,907,000-36,400,000"], + "images/epilepsy/front_epilepsy_bg_2018.png", + "", + "images/epilepsy/epilepsy_header_logo.svg", + "images/menu_bg_2017_5.png", + "false", + "", + "", + '5414069947481666863', + + 0, + 1, + 0, + 1, + 0, + 0,0,0, + 0, + 0 + ), + new PortalVersionBean("sleep", "Sleep", @@ -796,4 +835,4 @@ portal.data.versionDesignator = [ new PortalVersionBean("t2d", // label for // Here the secret authentication strings auth.providers.twitter.secret = 'l3dJBs3w9QraAuivcfaqdjVGkJ4cxQSMMNNkZ6v9bwz8nXBCXQ' -oauth.providers.google.secret = 'HKIxi3AOLAgyFV6lDJQCfEgY' \ No newline at end of file +oauth.providers.google.secret = 'HKIxi3AOLAgyFV6lDJQCfEgY' diff --git a/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy b/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy index 0b5c29294..85ad1e232 100755 --- a/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy +++ b/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy @@ -283,15 +283,16 @@ class VariantSearchController { String defaultPhenotype = restServerService.retrieveBeanForCurrentPortal().phenotype filtersForQuery << """{"value":"${chromosome}:${extents.startExtent}-${extents.endExtent}","prop":"chromosome","comparator":"="}""".toString() filtersForQuery << """{"gene":"${geneName}","prop":"gene","value":"${geneName}","comparator":"="}""".toString() + filtersForQuery << """{"phenotype":"${defaultPhenotype}","dataset":"${defaultDataSet}","prop":"AC","value":"0","comparator":">"}""".toString() // filtersForQuery << """{"phenotype":"${defaultPhenotype}","dataset":"${defaultDataSet}","prop":"ACA_PH","value":"0","comparator":">"}""".toString() -// filtersForQuery << """{"phenotype":"${defaultPhenotype}","dataset":"${defaultDataSet}","prop":"ACU_PH","value":"0","comparator":">"}]""".toString() + // filtersForQuery << """{"phenotype":"${defaultPhenotype}","dataset":"${defaultDataSet}","prop":"ACU_PH","value":"0","comparator":">"}]""".toString() // filtersForQuery << """{"gene":"${geneName}","comparator":"="}""".toString() } if ((dataSetName!=null) && (phenotypeName!=null)){ org.broadinstitute.mpg.diabetes.metadata.Property property = metaDataService.getPropertyForPhenotypeAndSampleGroupAndMeaning(phenotypeName,dataSetName, - "ACA_PH",MetaDataService.METADATA_VARIANT) + "AC",MetaDataService.METADATA_VARIANT) if (property){ filtersForQuery << """{"phenotype":"${phenotypeName}","dataset":"${dataSetName}","prop":"${property.name}","value":"0","comparator":">"}]""".toString() } @@ -301,9 +302,9 @@ class VariantSearchController { String defaultDataSet = restServerService.retrieveBeanForCurrentPortal().dataSet String defaultPhenotype = restServerService.retrieveBeanForCurrentPortal().phenotype org.broadinstitute.mpg.diabetes.metadata.Property property1 = metaDataService.getPropertyForPhenotypeAndSampleGroupAndMeaning(defaultPhenotype,defaultDataSet, - "ACA_PH",MetaDataService.METADATA_VARIANT) - org.broadinstitute.mpg.diabetes.metadata.Property property2 = metaDataService.getPropertyForPhenotypeAndSampleGroupAndMeaning(defaultPhenotype,defaultDataSet, - "ACU_PH",MetaDataService.METADATA_VARIANT) + "AC",MetaDataService.METADATA_VARIANT) +// org.broadinstitute.mpg.diabetes.metadata.Property property2 = metaDataService.getPropertyForPhenotypeAndSampleGroupAndMeaning(defaultPhenotype,defaultDataSet, +// "ACU_PH",MetaDataService.METADATA_VARIANT) if (property1 && property2){ filtersForQuery << """{"phenotype":"${defaultPhenotype}","dataset":"${defaultDataSet}","prop":"${property1.name}","value":"0","comparator":">"}""".toString() filtersForQuery << """{"phenotype":"${defaultPhenotype}","dataset":"${defaultDataSet}","prop":"${property2.name}","value":"0","comparator":">"}]""".toString() @@ -986,7 +987,7 @@ class VariantSearchController { * This function collects and returns the data to populate the search results table. It * expects data formatted by the Datatables function. */ - def variantSearchAndResultColumnsData() { + def variantSearchAndResFultColumnsData() { String filtersRaw = params['filters'] String propertiesRaw = params['properties'] JSONArray columns = (new JsonSlurper().parseText(params.columns)) as JSONArray; From ba38c3aa3b54f963ca1bffa9d93a1cbcdb1470fc Mon Sep 17 00:00:00 2001 From: Preeti Date: Wed, 22 Aug 2018 15:27:58 -0400 Subject: [PATCH 025/102] change the default function to exeq --- grails-app/conf/Config.groovy | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/grails-app/conf/Config.groovy b/grails-app/conf/Config.groovy index 0f8db0aac..a62e75036 100755 --- a/grails-app/conf/Config.groovy +++ b/grails-app/conf/Config.groovy @@ -724,7 +724,7 @@ portal.data.versionDesignator = [ new PortalVersionBean("t2d", // label for "ALS", "mdv60", "ALS", // make sure your default phenotype exists in your default data set - "GWAS_ALS2018_mdv60",// used to pick a default data set for a gene query + "ExSeq_ALS2018_mdv60",// used to pick a default data set for a gene query ["8_Genic_enhancer","9_Active_enhancer_1","10_Active_enhancer_2","11_Weak_enhancer"], ["8_Genic_enhancer","9_Active_enhancer_1","10_Active_enhancer_2","11_Weak_enhancer"], ["AnteriorCaudate"], From 43903a8b6613db90ff3e53dd9211c6aa30ae3004 Mon Sep 17 00:00:00 2001 From: Preeti Date: Wed, 22 Aug 2018 15:29:47 -0400 Subject: [PATCH 026/102] add the AC filter and add the ACA_PH/ACU_PH filters --- .../mpg/VariantSearchController.groovy | 43 ++++++++++++------- 1 file changed, 28 insertions(+), 15 deletions(-) diff --git a/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy b/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy index 85ad1e232..08c6e7c6b 100755 --- a/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy +++ b/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy @@ -271,6 +271,8 @@ class VariantSearchController { String geneName = params.gene String phenotypeName = params.phenotype String dataSetName = params.dataset + + LinkedHashMap extents = sharedToolsService.getGeneExpandedExtent( geneName,restServerService.EXPAND_ON_EITHER_SIDE_OF_GENE) String chromosome = extents.chrom if (chromosome?.startsWith('chr')){ @@ -281,38 +283,49 @@ class VariantSearchController { if (chromosome!=null){ String defaultDataSet = restServerService.retrieveBeanForCurrentPortal().dataSet String defaultPhenotype = restServerService.retrieveBeanForCurrentPortal().phenotype - filtersForQuery << """{"value":"${chromosome}:${extents.startExtent}-${extents.endExtent}","prop":"chromosome","comparator":"="}""".toString() + + //filtersForQuery << """{"value":"${chromosome}, "pos":${extents.startExtent}-${extents.endExtent}","prop":"chromosome","comparator":"="}""".toString() + filtersForQuery << """{"gene":"${geneName}","prop":"gene","value":"${geneName}","comparator":"="}""".toString() - filtersForQuery << """{"phenotype":"${defaultPhenotype}","dataset":"${defaultDataSet}","prop":"AC","value":"0","comparator":">"}""".toString() +// +// filtersForQuery << """{"phenotype":"${defaultPhenotype}","dataset":"${defaultDataSet}","prop":"AC","value":"0","comparator":">"}""".toString() +// // filtersForQuery << """{"phenotype":"${defaultPhenotype}","dataset":"${defaultDataSet}","prop":"ACA_PH","value":"0","comparator":">"}""".toString() - // filtersForQuery << """{"phenotype":"${defaultPhenotype}","dataset":"${defaultDataSet}","prop":"ACU_PH","value":"0","comparator":">"}]""".toString() +// +// filtersForQuery << """{"phenotype":"${defaultPhenotype}","dataset":"${defaultDataSet}","prop":"ACU_PH","value":"0","comparator":">"}]""".toString() + - // filtersForQuery << """{"gene":"${geneName}","comparator":"="}""".toString() } if ((dataSetName!=null) && (phenotypeName!=null)){ - org.broadinstitute.mpg.diabetes.metadata.Property property = metaDataService.getPropertyForPhenotypeAndSampleGroupAndMeaning(phenotypeName,dataSetName, + org.broadinstitute.mpg.diabetes.metadata.Property property = metaDataService.getPropertyForPhenotypeAndSampleGroupAndMeaning(defaultPhenotype,defaultDataSet, "AC",MetaDataService.METADATA_VARIANT) if (property){ - filtersForQuery << """{"phenotype":"${phenotypeName}","dataset":"${dataSetName}","prop":"${property.name}","value":"0","comparator":">"}]""".toString() + filtersForQuery << """{"phenotype":"${defaultPhenotype}","dataset":"${defaultDataSet}","prop":"${property.name}","value":"0","comparator":">"}]""".toString() } } else { - // let's provide a default data set + String defaultDataSet = restServerService.retrieveBeanForCurrentPortal().dataSet String defaultPhenotype = restServerService.retrieveBeanForCurrentPortal().phenotype - org.broadinstitute.mpg.diabetes.metadata.Property property1 = metaDataService.getPropertyForPhenotypeAndSampleGroupAndMeaning(defaultPhenotype,defaultDataSet, - "AC",MetaDataService.METADATA_VARIANT) -// org.broadinstitute.mpg.diabetes.metadata.Property property2 = metaDataService.getPropertyForPhenotypeAndSampleGroupAndMeaning(defaultPhenotype,defaultDataSet, -// "ACU_PH",MetaDataService.METADATA_VARIANT) - if (property1 && property2){ + + org.broadinstitute.mpg.diabetes.metadata.Property property1 = metaDataService.getPropertyForPhenotypeAndSampleGroupAndMeaning(defaultPhenotype, defaultDataSet, + "ACA_PH", MetaDataService.METADATA_VARIANT) + org.broadinstitute.mpg.diabetes.metadata.Property property2 = metaDataService.getPropertyForPhenotypeAndSampleGroupAndMeaning(defaultPhenotype, defaultDataSet, + "ACU_PH", MetaDataService.METADATA_VARIANT) + org.broadinstitute.mpg.diabetes.metadata.Property property = metaDataService.getPropertyForPhenotypeAndSampleGroupAndMeaning(defaultPhenotype, "ExSeq_ALS2018_mdv60", + "AC", MetaDataService.METADATA_VARIANT) + + if (property1 && property2) { filtersForQuery << """{"phenotype":"${defaultPhenotype}","dataset":"${defaultDataSet}","prop":"${property1.name}","value":"0","comparator":">"}""".toString() filtersForQuery << """{"phenotype":"${defaultPhenotype}","dataset":"${defaultDataSet}","prop":"${property2.name}","value":"0","comparator":">"}]""".toString() + } else { + if (property) { + filtersForQuery << """{"phenotype":"${defaultPhenotype}","dataset":"ExSeq_ALS2018_mdv60","prop":"${property.name}","value":"0","comparator":">"}]""".toString() + } } - - - } + if (filtersForQuery.size()>0) { if ((geneName!=null)&& (geneName.length()>0)){ forward action: "launchAVariantSearch", params:[filters: "[${filtersForQuery.join(',')}]", specificGene:"${geneName}"] From 4f964fbb365f0017e831ac3679516cf2e6ace86d Mon Sep 17 00:00:00 2001 From: Preeti Date: Wed, 22 Aug 2018 16:18:27 -0400 Subject: [PATCH 027/102] fix the typo in function name --- .../org/broadinstitute/mpg/VariantSearchController.groovy | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy b/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy index 08c6e7c6b..2e76229ea 100755 --- a/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy +++ b/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy @@ -1000,7 +1000,7 @@ class VariantSearchController { * This function collects and returns the data to populate the search results table. It * expects data formatted by the Datatables function. */ - def variantSearchAndResFultColumnsData() { + def variantSearchAndResultColumnsData() { String filtersRaw = params['filters'] String propertiesRaw = params['properties'] JSONArray columns = (new JsonSlurper().parseText(params.columns)) as JSONArray; From e49d7fcfc56c7970e0d1410b79773b5958d2fddb Mon Sep 17 00:00:00 2001 From: dkjang Date: Thu, 23 Aug 2018 13:37:15 -0400 Subject: [PATCH 028/102] Code for portal title changed. --- grails-app/views/layouts/t2dGenesCore.gsp | 3 +++ 1 file changed, 3 insertions(+) diff --git a/grails-app/views/layouts/t2dGenesCore.gsp b/grails-app/views/layouts/t2dGenesCore.gsp index d150420bc..cff222e49 100755 --- a/grails-app/views/layouts/t2dGenesCore.gsp +++ b/grails-app/views/layouts/t2dGenesCore.gsp @@ -23,6 +23,9 @@ <g:message code="portal.sleep.header.title.short"/> <g:message code="portal.sleep.header.title.genetics"/> + + ALS portal + <g:message code="portal.header.title.short"/> <g:message code="portal.header.title.genetics"/> From 969c6cdc246d179119cb1ffdf57c41b5eff983c1 Mon Sep 17 00:00:00 2001 From: Preeti Date: Tue, 4 Sep 2018 14:06:21 -0400 Subject: [PATCH 029/102] add more cproperty - not working --- .../broadinstitute/mpg/VariantSearchController.groovy | 4 +++- .../org/broadinstitute/mpg/RestServerService.groovy | 11 ++++++++--- grails-app/views/gene/_geneSignalSummary.gsp | 2 +- 3 files changed, 12 insertions(+), 5 deletions(-) diff --git a/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy b/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy index 2e76229ea..dccd9f317 100755 --- a/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy +++ b/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy @@ -1252,7 +1252,9 @@ class VariantSearchController { "common-common-CHROM", "common-common-POS", "common-common-Reference_Allele", - "common-common-Effect_Allele"].join(":") + "common-common-Effect_Allele", + "common-common-Allele_Frequency", + "common-common-Allele_Count"].join(":") } GetDataQueryHolder getDataQueryHolder = GetDataQueryHolder.createGetDataQueryHolder(listOfCodedFilters, searchBuilderService, metaDataService) diff --git a/grails-app/services/org/broadinstitute/mpg/RestServerService.groovy b/grails-app/services/org/broadinstitute/mpg/RestServerService.groovy index 29370f0bc..8aa0a69f6 100755 --- a/grails-app/services/org/broadinstitute/mpg/RestServerService.groovy +++ b/grails-app/services/org/broadinstitute/mpg/RestServerService.groovy @@ -962,7 +962,9 @@ time required=${(afterCall.time - beforeCall.time) / 1000} seconds "Consequence", "PolyPhen_PRED", "SIFT_PRED", - "Protein_change" + "Protein_change", + "Allele_Frequency", + "Allele_Count" ]) GetDataQueryHolder getDataQueryHolder = GetDataQueryHolder.createGetDataQueryHolder([filters], searchBuilderService, metaDataService) JsonSlurper slurper = new JsonSlurper() @@ -987,7 +989,8 @@ time required=${(afterCall.time - beforeCall.time) / 1000} seconds "Consequence", "PolyPhen_PRED", "SIFT_PRED", - "Protein_change" + "Protein_change", + "Allele_Frequency" ]) GetDataQueryHolder getDataQueryHolder = GetDataQueryHolder.createGetDataQueryHolder([filters], searchBuilderService, metaDataService) Property macProperty = metaDataService.getSampleGroupProperty(dataSet,"MAC",MetaDataService.METADATA_VARIANT) @@ -1872,6 +1875,8 @@ time required=${(afterCall.time - beforeCall.time) / 1000} seconds commonProperties << "Consequence" commonProperties << "CHROM" commonProperties << "POS" + commonProperties << "Allele_Frequency" + commonProperties << "Allele_Count" } // if we don't have a better idea then launch the search based on the filters. Otherwise used our stored criteria @@ -2169,7 +2174,7 @@ time required=${(afterCall.time - beforeCall.time) / 1000} seconds "Consequence", "Reference_Allele", "Effect_Allele", - "Protein_change"]) + "Protein_change","Allele_Frequency","Allele_Count"]) resultColumnsToDisplay = buildColumnsRequestForPProperties(resultColumnsToDisplay, "DIR", technology, sampleGroupName ) resultColumnsToDisplay = buildColumnsRequestForPProperties(resultColumnsToDisplay, "BETA", technology, sampleGroupName) resultColumnsToDisplay = buildColumnsRequestForPProperties(resultColumnsToDisplay, "ODDS_RATIO", technology, sampleGroupName) diff --git a/grails-app/views/gene/_geneSignalSummary.gsp b/grails-app/views/gene/_geneSignalSummary.gsp index 1094c708b..88527e059 100755 --- a/grails-app/views/gene/_geneSignalSummary.gsp +++ b/grails-app/views/gene/_geneSignalSummary.gsp @@ -52,7 +52,7 @@ proteinEffectsListInfo:"transcript_ablation%3Atranscript+ablation%7Esplice_donor_variant%3Asplice+donor+variant%7Esplice_acceptor_variant%3Asplice+acceptor+variant%7Estop_gained%3Astop+gained%7Eframeshift_variant%3Aframeshift+variant%7Estop_lost%3Astop+lost%7Einitiator_codon_variant%3Ainitiator+codon+variant%7Einframe_insertion%3Ainframe+insertion%7Einframe_deletion%3Ainframe+deletion%7Emissense_variant%3Amissense+variant%7Etranscript_amplification%3Atransript+amplification%7Esplice_region_variant%3Asplice+region+variant%7Eincomplete_terminal_codon_variant%3Aincomplete+terminal+codon+variant%7Esynonymous_variant%3Asynonymous+variant%7Estop_retained_variant%3Astop+retained+variant%7Ecoding_sequence_variant%3Acoding+sequence+variant%7Emature_miRNA_variant%3Amature+miRNA+variant%7E5_prime_UTR_variant%3A5%27+UTR+variant%7E3_prime_UTR_variant%3A3%27+UTR+variant%7Enon_coding_exon_variant%3Anon+coding+exon+variant%7Enc_transcript_variant%3Anc+transcript+variant%7Eintron_variant%3Aintron+variant%7ENMD_transcript_variant%3Anmd+transcript+variant%7Eupstream_gene_variant%3Aupstream+gene+variant%7Edownstream_gene_variant%3Adownstream+gene+variant%7ETFBS_ablation%3Atfbs+ablation%7ETFBS_amplification%3Atfbs+amplification%7ETF_binding_site_variant%3Atf+binding+site+variant%7Eregulatory_region_variant%3Aregulatory+region+variant%7Eregulatory_region_ablation%3Aregulatory+region+ablation%7Eregulatory_region_amplification%3Aregulatory+region+amplification%7Efeature_elongation%3Afeature+elongation%7Efeature_truncation%3Afeature+truncation%7Eintergenic_variant%3Aintergenic+variant", localeInfo:"en_US", translatedFiltersInfo:"Fasting insulin[CAMP GWAS]P-value<0.001", - additionalPropertiesInfo:"common-common-CLOSEST_GENE:common-common-VAR_ID:common-common-DBSNP_ID:common-common-Protein_change:common-common-Consequence:common-common-CHROM:common-common-POS", + additionalPropertiesInfo:"common-common-CLOSEST_GENE:common-common-VAR_ID:common-common-DBSNP_ID:common-common-Protein_change:common-common-Consequence:common-common-CHROM:common-common-POS:common-common-Allele_Frequency:common-common-Allele_Count", filtersAsJsonInfo:filtersAsJson, copyMsg:'', printMsg:'', From e90520d8f6846d24f7e5e16aa4cec326d04739aa Mon Sep 17 00:00:00 2001 From: mariacos Date: Tue, 20 Nov 2018 11:50:03 -0500 Subject: [PATCH 030/102] edited error message text --- .../org/broadinstitute/mpg/VariantSearchController.groovy | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy b/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy index dccd9f317..19fbf94e4 100755 --- a/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy +++ b/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy @@ -335,7 +335,7 @@ class VariantSearchController { return } } - forward controller:"home", action:"portalHome", params:[errorText:"No record for gene=${geneName}. Please try different gene"] + forward controller:"home", action:"portalHome", params:[errorText:"No record for gene=${geneName}. Please try a different gene name."] return } From 82f2d1e3605f5b60e757688dcd1e8fdb8da14656 Mon Sep 17 00:00:00 2001 From: mariacos Date: Tue, 20 Nov 2018 11:50:28 -0500 Subject: [PATCH 031/102] added ALS blogID --- grails-app/conf/Config.groovy | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/grails-app/conf/Config.groovy b/grails-app/conf/Config.groovy index a62e75036..ee4a637ef 100755 --- a/grails-app/conf/Config.groovy +++ b/grails-app/conf/Config.groovy @@ -745,7 +745,7 @@ portal.data.versionDesignator = [ new PortalVersionBean("t2d", // label for "false", "", "", - '5414069947481666863', + '2854182648437419920', 0, 1, 0, From 14c0bc82f01c9778e50e552a5411a6b75c63504e Mon Sep 17 00:00:00 2001 From: mariacos Date: Tue, 20 Nov 2018 12:59:45 -0500 Subject: [PATCH 032/102] updated ALS dataset names --- grails-app/views/widgets/_datasetsPageTemplate.gsp | 6 +++--- 1 file changed, 3 insertions(+), 3 deletions(-) diff --git a/grails-app/views/widgets/_datasetsPageTemplate.gsp b/grails-app/views/widgets/_datasetsPageTemplate.gsp index d6d537354..8ee80978d 100644 --- a/grails-app/views/widgets/_datasetsPageTemplate.gsp +++ b/grails-app/views/widgets/_datasetsPageTemplate.gsp @@ -72,9 +72,9 @@ - - - + + + From 1aa5cadd664127a37dfba104ae0b792a2fff90ad Mon Sep 17 00:00:00 2001 From: mariacos Date: Tue, 20 Nov 2018 13:00:13 -0500 Subject: [PATCH 033/102] updated ALS dataset names --- .../data/_GWAS_ALS2016lmm_eu.gsp | 922 ++++++++++++++++++ 1 file changed, 922 insertions(+) create mode 100644 grails-app/views/informational/data/_GWAS_ALS2016lmm_eu.gsp diff --git a/grails-app/views/informational/data/_GWAS_ALS2016lmm_eu.gsp b/grails-app/views/informational/data/_GWAS_ALS2016lmm_eu.gsp new file mode 100644 index 000000000..e5c90c6da --- /dev/null +++ b/grails-app/views/informational/data/_GWAS_ALS2016lmm_eu.gsp @@ -0,0 +1,922 @@ + \ No newline at end of file From 75399399e12b329b0e0792c2afd61abfb3021e55 Mon Sep 17 00:00:00 2001 From: mariacos Date: Tue, 20 Nov 2018 13:00:35 -0500 Subject: [PATCH 034/102] updated ALS dataset namesgrails-app/views/informational/data/_GWAS_ALS2016meta_eu.gsp --- ...xSeq_ALS2018.gsp => _ExSeq_ALS2018_eu.gsp} | 2 +- .../informational/data/_GWAS_ALS2016lmm.gsp | 922 ------------------ ...S2016meta.gsp => _GWAS_ALS2016meta_eu.gsp} | 2 +- ..._GWAS_ALS2018.gsp => _GWAS_ALS2018_eu.gsp} | 0 4 files changed, 2 insertions(+), 924 deletions(-) rename grails-app/views/informational/data/{_ExSeq_ALS2018.gsp => _ExSeq_ALS2018_eu.gsp} (92%) delete mode 100644 grails-app/views/informational/data/_GWAS_ALS2016lmm.gsp rename grails-app/views/informational/data/{_GWAS_ALS2016meta.gsp => _GWAS_ALS2016meta_eu.gsp} (99%) rename grails-app/views/informational/data/{_GWAS_ALS2018.gsp => _GWAS_ALS2018_eu.gsp} (100%) diff --git a/grails-app/views/informational/data/_ExSeq_ALS2018.gsp b/grails-app/views/informational/data/_ExSeq_ALS2018_eu.gsp similarity index 92% rename from grails-app/views/informational/data/_ExSeq_ALS2018.gsp rename to grails-app/views/informational/data/_ExSeq_ALS2018_eu.gsp index 1f2745ff1..0bfdf0a13 100644 --- a/grails-app/views/informational/data/_ExSeq_ALS2018.gsp +++ b/grails-app/views/informational/data/_ExSeq_ALS2018_eu.gsp @@ -1,4 +1,4 @@ - \ No newline at end of file diff --git a/grails-app/views/informational/data/_GWAS_ALS2016meta.gsp b/grails-app/views/informational/data/_GWAS_ALS2016meta_eu.gsp similarity index 99% rename from grails-app/views/informational/data/_GWAS_ALS2016meta.gsp rename to grails-app/views/informational/data/_GWAS_ALS2016meta_eu.gsp index b8afa996e..6915bab8a 100644 --- a/grails-app/views/informational/data/_GWAS_ALS2016meta.gsp +++ b/grails-app/views/informational/data/_GWAS_ALS2016meta_eu.gsp @@ -1,4 +1,4 @@ - From 3cd9237f258bc3808f30a1cf0755f323b5df1d39 Mon Sep 17 00:00:00 2001 From: mariacos Date: Mon, 28 Jan 2019 15:24:13 -0500 Subject: [PATCH 069/102] edited home page text --- grails-app/i18n/portalHome.properties | 3 +-- 1 file changed, 1 insertion(+), 2 deletions(-) diff --git a/grails-app/i18n/portalHome.properties b/grails-app/i18n/portalHome.properties index 705b93764..b078194be 100755 --- a/grails-app/i18n/portalHome.properties +++ b/grails-app/i18n/portalHome.properties @@ -17,8 +17,7 @@ portal.header.nav.grs=GRS portal.header.data_portal=Data portal portal.header.tagline=Providing data and tools to promote understanding and treatment of type 2 diabetes and its complications portal.home.collaborate=Click here to learn more -primary.text.input.header=Explore data on a gene, variant, or region -primary.text.input.header.als=Explore data on a gene or region +primary.text.input.header=Explore data on a gene or region regionSpecificVersion.text.input.header=Explore data on a genomic region primary.text.input.examples=examples: SLC30A8, rs13266634, chr9:21,940,000-22,190,000 variant.search.header=Variant Finder From 41614d43bed56d8ddeab562b5bf0e2bd87ef3833 Mon Sep 17 00:00:00 2001 From: Preeti Date: Mon, 28 Jan 2019 21:50:51 -0500 Subject: [PATCH 070/102] changes in the gene table as requested by Sali --- .../mpg/VariantSearchController.groovy | 27 +++++++++++++------ 1 file changed, 19 insertions(+), 8 deletions(-) diff --git a/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy b/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy index c30382320..e9ddab6da 100755 --- a/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy +++ b/grails-app/controllers/org/broadinstitute/mpg/VariantSearchController.groovy @@ -1014,7 +1014,7 @@ class VariantSearchController { if(filters.contains("ALS[ExSeq_ALS2018_eu_mdv60]AC_PH>0")){ LinkedHashMap> requestedPpropertiesMap = new LinkedHashMap() - requestedPpropertiesMap.put("ExSeq_ALS2018_eu_mdv60",["ACA_PH", "ACU_PH","HETA", "HOMA"]) + requestedPpropertiesMap.put("ExSeq_ALS2018_eu_mdv60",["ACA_PH", "ACU_PH","HETA", "HOMA", "HETU", "HOMU"]) requestedProperties.put("pProperty",requestedPpropertiesMap) } @@ -1026,16 +1026,21 @@ class VariantSearchController { if(filters.contains("ALS[ExSeq_ALS2018_eu_mdv60]AC_PH>0")){ LinkedHashMap datasetDpropertiesMap2 = new LinkedHashMap() datasetDpropertiesMap2.put("ExSeq_EgnomAD_mdv60",["AC", "HOM", "MAF"] ) - resultColumnsToDisplay["dproperty"].putAt("None",datasetDpropertiesMap2) + datasetDpropertiesMap2.put("WGS_WgnomAD_mdv60",["AC", "HOM", "MAF"] ) + resultColumnsToDisplay["dproperty"].putAt("Additional controls",datasetDpropertiesMap2) + LinkedHashMap datasetDpropertiesMap3 = new LinkedHashMap() datasetDpropertiesMap3.put("ExSeq_EgnomAD_mdv60",[]) - resultColumnsToDisplay["pproperty"].putAt("None",datasetDpropertiesMap3) + datasetDpropertiesMap3.put("WGS_WgnomAD_mdv60",[]) + resultColumnsToDisplay["pproperty"].putAt("Additional controls",datasetDpropertiesMap3) LinkedHashMap datasetDpropertiesMap = new LinkedHashMap() datasetDpropertiesMap.put("ExSeq_ALS2018_eu_mdv60",[]) + datasetDpropertiesMap.put("WGS_WgnomAD_mdv60",[]) resultColumnsToDisplay["dproperty"].putAt("ALS",datasetDpropertiesMap) + } int pageStart = Integer.parseInt(params.start) @@ -1126,7 +1131,7 @@ class VariantSearchController { if(filters.contains("ALS[ExSeq_ALS2018_eu_mdv60]AC_PH>0")){ LinkedHashMap> requestedPpropertiesMap = new LinkedHashMap() - requestedPpropertiesMap.put("ExSeq_ALS2018_eu_mdv60",["ACA_PH", "ACU_PH","HETA", "HOMA"]) + requestedPpropertiesMap.put("ExSeq_ALS2018_eu_mdv60",["ACA_PH", "ACU_PH","HETA", "HOMA", "HETU","HOMU"]) //requestedPpropertiesMap.put("gnomad",[]) requestedProperties.put("pProperty",requestedPpropertiesMap) @@ -1199,13 +1204,20 @@ class VariantSearchController { if(filters.contains("ALS[ExSeq_ALS2018_eu_mdv60]AC_PH>0")){ LinkedHashMap datasetDpropertiesMap2 = new LinkedHashMap() datasetDpropertiesMap2.put("ExSeq_EgnomAD_mdv60",["AC", "HOM", "MAF"] ) - resultColumnsToDisplay["dproperty"].putAt("None",datasetDpropertiesMap2) + datasetDpropertiesMap2.put("WGS_WgnomAD_mdv60",["AC", "HOM", "MAF"] ) + resultColumnsToDisplay["dproperty"].putAt("Additional controls",datasetDpropertiesMap2) + LinkedHashMap datasetDpropertiesMap3 = new LinkedHashMap() datasetDpropertiesMap3.put("ExSeq_EgnomAD_mdv60",[]) - resultColumnsToDisplay["pproperty"].putAt("None",datasetDpropertiesMap3) + datasetDpropertiesMap3.put("WGS_WgnomAD_mdv60",[]) + resultColumnsToDisplay["pproperty"].putAt("Additional controls",datasetDpropertiesMap3) + LinkedHashMap datasetDpropertiesMap = new LinkedHashMap() datasetDpropertiesMap.put("ExSeq_ALS2018_eu_mdv60",[]) + datasetDpropertiesMap.put("WGS_WgnomAD_mdv60",[]) resultColumnsToDisplay["dproperty"].putAt("ALS",datasetDpropertiesMap) + + } //you have to add Properties to resultColumnsToDisplay linkedHashMap so that addProperties can add them @@ -1309,8 +1321,7 @@ class VariantSearchController { "common-common-Allele_Count", "common-common-SIFT_PRED", "common-common-PolyPhen_PRED", - "common-common-CADD_RAW", - "common-common-CADD_PHRED" + "common-common-CADD_RAW" ].join(":") } From e9d16df5bd83d0c0f6f9d84b2ce403a912abf862 Mon Sep 17 00:00:00 2001 From: mariacos Date: Tue, 29 Jan 2019 10:27:39 -0500 Subject: [PATCH 071/102] adding analytics for ALSKP --- grails-app/views/layouts/analyticsALSKP.gsp | 8 ++++++++ 1 file changed, 8 insertions(+) create mode 100644 grails-app/views/layouts/analyticsALSKP.gsp diff --git a/grails-app/views/layouts/analyticsALSKP.gsp b/grails-app/views/layouts/analyticsALSKP.gsp new file mode 100644 index 000000000..4afe31f0e --- /dev/null +++ b/grails-app/views/layouts/analyticsALSKP.gsp @@ -0,0 +1,8 @@ + + \ No newline at end of file From cface411ec07e06d41c63c0195a9f1560167f663 Mon Sep 17 00:00:00 2001 From: mariacos Date: Tue, 29 Jan 2019 10:30:15 -0500 Subject: [PATCH 072/102] adding analytics for ALSKP --- grails-app/views/layouts/t2dGenesCore.gsp | 6 ++++++ 1 file changed, 6 insertions(+) diff --git a/grails-app/views/layouts/t2dGenesCore.gsp b/grails-app/views/layouts/t2dGenesCore.gsp index cff222e49..50c0aad4a 100755 --- a/grails-app/views/layouts/t2dGenesCore.gsp +++ b/grails-app/views/layouts/t2dGenesCore.gsp @@ -51,6 +51,12 @@ + + + + + + From 1e60bc00df8fd48d593cb0185b008125ddea8c80 Mon Sep 17 00:00:00 2001 From: mariacos Date: Tue, 29 Jan 2019 15:53:51 -0500 Subject: [PATCH 073/102] adding FAQ page --- grails-app/views/informational/ALSKP_FAQ.gsp | 77 ++++++++++++++++++++ 1 file changed, 77 insertions(+) create mode 100644 grails-app/views/informational/ALSKP_FAQ.gsp diff --git a/grails-app/views/informational/ALSKP_FAQ.gsp b/grails-app/views/informational/ALSKP_FAQ.gsp new file mode 100644 index 000000000..a5054969e --- /dev/null +++ b/grails-app/views/informational/ALSKP_FAQ.gsp @@ -0,0 +1,77 @@ + + + + + + + + + + + + + +
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+ + + + From f6d77e07f7f2a53bcf0df65e2e89c437e192e3ea Mon Sep 17 00:00:00 2001 From: mariacos Date: Tue, 29 Jan 2019 15:54:29 -0500 Subject: [PATCH 074/102] updating ALSKP content --- grails-app/i18n/informational.properties | 10 ++++++++++ 1 file changed, 10 insertions(+) diff --git a/grails-app/i18n/informational.properties b/grails-app/i18n/informational.properties index b8da9787d..0f7cf288e 100755 --- a/grails-app/i18n/informational.properties +++ b/grails-app/i18n/informational.properties @@ -1343,10 +1343,17 @@ informational.about_MI.section7=Knowledge Portals are intended to be secureinviting to researchers who may want to contribute data and participate in analyses, organic in the continuous incorporation of scientific advances, modular \ in their analytical capabilities and user interfaces, automated, rigorous in the quality of data aggregation and returned results, versatile, and sustainable. informational.dataSubmission.title=Join the AMP T2D Knowledge Portal community! +informational.alsfaq.title=Frequently Asked Questions informational.dataSubmission.subtitle=We are interested in forming collaborations around new data, methods, and tools. We encourage researchers to contact us about \ new data relevant to the genetics of type 2 diabetes and related traits. We also welcome collaboration on development of general methods and tools for analysis and presentation \ of genetic association data for complex diseases and traits. informational.dataSubmission.FAQ.title=Some frequently asked questions: +informational.als.FAQ.title1=General: +informational.als.FAQ.question1=What is the ALS Knowledge Portal and how do I use it? +informational.als.FAQ.answer1=The ALS Knowledge Portal (ALSKP) enables browsing, searching, and analysis of human genetic information linked \ + to amyotrophic lateral sclerosis and related traits, while protecting the integrity and confidentiality of the underlying data. The ALSKP \ + is similar to the Project MinE Variant Browser, which \ + is an excellent resource for displaying variants from ALS whole genomes. informational.dataSubmission.section1title=What kind of data do we need? informational.dataSubmission.section1=
  • Right now, we are ready to receive array, exome sequencing, and whole-genome sequencing data.\
  • We are interested in incorporating both summary statistics and individual-level data.
  • In the future, we will be ready to \ @@ -2219,6 +2226,9 @@ informational.about_ALSData.header=Data in the ALS Knowledge Portal informational.about_sleep.section1=Details about data contributors and consortia will go here. informational.about_ALS.header=About the ALS Knowledge Portal project informational.about_ALSData.header=Data in the ALS Knowledge Portal +informational.about_ALSData.section0.5=Data used in the ALS Knowledge Portal were analyzed by Sali Farhan in the Neale \ + lab. For details about quality control, please visit: Farhan et al., 2018 BioRxiv: https://www.biorxiv.org/content/10.1101/307835v2. Sali Farhan was supported by the ALS Canada Tim E. Noël Postdoctoral Fellowship. informational.about_ALSData.section1=Data in the ALS Knowledge Portal were collected from the Familial ALS (FALS) Consortium and the ALS Genetics (ALSGENS) Consortium. informational.about_ALSData.section2=The members of the FALS Consortium are Giuseppe Lauria, Orla Hardiman, Russell L McLaughlin, Letizia Mazzini, Stefano Duga, Anneloor \ L M A ten Asbroek, Frank Baas, Lucia Corrado, Sandra D'Alfonso, Jonathan D Glass, Meraida Polak, Seneshaw Asress, Antonia Ratti, Cinzia Tiloca, Claudia Colombrita, \ From 8c842d6f50acdf5c7ec03b6441358e941bf2bcc0 Mon Sep 17 00:00:00 2001 From: mariacos Date: Tue, 29 Jan 2019 15:54:52 -0500 Subject: [PATCH 075/102] updating ALSKP content --- grails-app/i18n/metadata.properties | 18 +++++++++--------- 1 file changed, 9 insertions(+), 9 deletions(-) diff --git a/grails-app/i18n/metadata.properties b/grails-app/i18n/metadata.properties index a810f3806..121305283 100755 --- a/grails-app/i18n/metadata.properties +++ b/grails-app/i18n/metadata.properties @@ -486,10 +486,10 @@ metadata.GWAS_GIANT=GIANT GWAS metadata.GWAS_GLGC=GLGC GWAS metadata.GWAS_MAGIC=MAGIC GWAS metadata.GWAS_PGC=PGC GWAS -metadata.HETA=Number of heterozygous cases -metadata.HETU=Number of heterozygous controls -metadata.HOMA=Number of homozygous cases -metadata.HOMU=Number of homozygous controls +metadata.HETA=Heterozygous count (cases) +metadata.HETU=Heterozygous count (controls) +metadata.HOMA=Homozygous count (cases) +metadata.HOMU=Homozygous count (controls) metadata.Hispanic=Latino metadata.HWE_PVALUE=Hardy-Weinberg P—value metadata.IN_EXSEQ=In exome sequencing @@ -3363,11 +3363,11 @@ geneTable.columnHeaders.shared.acu.help.header=Allele Count Unaffected geneTable.columnHeaders.shared.acu.help.text=Total count of minor alleles in the control population geneTable.columnHeaders.shared.aca.help.header=Allele Count Affected geneTable.columnHeaders.shared.aca.help.text=Total count of minor alleles in the case population -metadata.ACU=Allele count controls -metadata.ACA=Allele count cases -metadata.ACU_PH=Allele count (control) -metadata.ACA_PH=Allele count (case) -metadata.AC_PH=Allele count (cases plus controls) +metadata.ACU=Allele count (controls) +metadata.ACA=Allele count (cases) +metadata.ACU_PH=Allele count (controls) +metadata.ACA_PH=Allele count (cases) +metadata.AC_PH=Allele count (cases and controls) #mdv 110 is sleep portal From 6997cd87ecdd362cc5e84266bab69f0016484565 Mon Sep 17 00:00:00 2001 From: mariacos Date: Tue, 29 Jan 2019 15:55:17 -0500 Subject: [PATCH 076/102] updating ALSKP content --- grails-app/i18n/portalHome.properties | 3 ++- 1 file changed, 2 insertions(+), 1 deletion(-) diff --git a/grails-app/i18n/portalHome.properties b/grails-app/i18n/portalHome.properties index b078194be..f84596d90 100755 --- a/grails-app/i18n/portalHome.properties +++ b/grails-app/i18n/portalHome.properties @@ -135,4 +135,5 @@ portal.epi.use.citation.itself= Epilepsy Knowledge Portal. Year Month Date of ac portal.sleep.about.the.data.text=The Sleep Disorder Knowledge Portal enables browsing, searching, and analysis of human genetic information linked to sleep disorders and related traits, while protecting the integrity and confidentiality of the underlying data. portal.sleep.use.citation.itself= Sleep Disorder Knowledge Portal. Year Month Date of access; URL of page you are citing. Also cite any paper(s) in which the data were published. portal.ALS.about.the.data.text=The ALS Knowledge Portal enables browsing, searching, and analysis of human genetic information linked to amyotrophic lateral sclerosis and related traits, while protecting the integrity and confidentiality of the underlying data. -portal.als.use.citation.itself=Amyotrophic Lateral Sclerosis Knowledge Portal. Year Month Date of access; URL of page you are citing. Also cite any paper(s) in which the data were published. \ No newline at end of file +portal.als.use.citation.itself=Amyotrophic Lateral Sclerosis Knowledge Portal. Year Month Date of access; URL of page you are citing. \ + Also, please cite Farhan et al., 2018 BioRxiv: https://www.biorxiv.org/content/10.1101/307835v2. \ No newline at end of file From 700e84fc15d028fda4a02100929ceab43e30118e Mon Sep 17 00:00:00 2001 From: mariacos Date: Tue, 29 Jan 2019 15:56:03 -0500 Subject: [PATCH 077/102] updating ALSKP content --- grails-app/views/informational/_about_ALS.gsp | 1 + 1 file changed, 1 insertion(+) diff --git a/grails-app/views/informational/_about_ALS.gsp b/grails-app/views/informational/_about_ALS.gsp index 04c47e80f..e06ffa07c 100644 --- a/grails-app/views/informational/_about_ALS.gsp +++ b/grails-app/views/informational/_about_ALS.gsp @@ -81,6 +81,7 @@ padding-left: 15px;

    +

    From 0123d7a42107c3bc139f51ba548fe3143a4a4abf Mon Sep 17 00:00:00 2001 From: mariacos Date: Wed, 30 Jan 2019 10:46:46 -0500 Subject: [PATCH 078/102] working on ALSKP FAQ page --- grails-app/views/informational/alskpfaq.gsp | 77 +++++++++++++++++++++ 1 file changed, 77 insertions(+) create mode 100644 grails-app/views/informational/alskpfaq.gsp diff --git a/grails-app/views/informational/alskpfaq.gsp b/grails-app/views/informational/alskpfaq.gsp new file mode 100644 index 000000000..a5054969e --- /dev/null +++ b/grails-app/views/informational/alskpfaq.gsp @@ -0,0 +1,77 @@ + + + + + + + + + + + + + +
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    - - - - From 0256ef38ca38f9a7412278e4456c29d6318c77a1 Mon Sep 17 00:00:00 2001 From: mariacos Date: Wed, 30 Jan 2019 12:10:46 -0500 Subject: [PATCH 080/102] added FAQ page --- .../org/broadinstitute/mpg/InformationalController.groovy | 3 +++ 1 file changed, 3 insertions(+) diff --git a/grails-app/controllers/org/broadinstitute/mpg/InformationalController.groovy b/grails-app/controllers/org/broadinstitute/mpg/InformationalController.groovy index 6b898bddb..79e5a6602 100755 --- a/grails-app/controllers/org/broadinstitute/mpg/InformationalController.groovy +++ b/grails-app/controllers/org/broadinstitute/mpg/InformationalController.groovy @@ -86,6 +86,9 @@ class InformationalController { render(view: 'dataSubmission') } + def alskpfaq() { + render(view: 'alskpfaq') + } def downloads() { render(view: 'downloads') } From 7b859b86b437da63e1e00b9771bc7a381a02b201 Mon Sep 17 00:00:00 2001 From: mariacos Date: Wed, 30 Jan 2019 12:11:06 -0500 Subject: [PATCH 081/102] ALS portal content --- grails-app/i18n/informational.properties | 33 +++++++++++++++++++++++- 1 file changed, 32 insertions(+), 1 deletion(-) diff --git a/grails-app/i18n/informational.properties b/grails-app/i18n/informational.properties index 0f7cf288e..aad3eecbb 100755 --- a/grails-app/i18n/informational.properties +++ b/grails-app/i18n/informational.properties @@ -1354,6 +1354,37 @@ informational.als.FAQ.answer1=The ALS Knowledge Portal (ALSKP) enables browsing, to amyotrophic lateral sclerosis and related traits, while protecting the integrity and confidentiality of the underlying data. The ALSKP \ is similar to the Project MinE Variant Browser, which \ is an excellent resource for displaying variants from ALS whole genomes. +informational.als.FAQ.question2=How should I cite the ALS Knowledge Portal? +informational.als.FAQ.answer2=Please use the following citation when referring to data accessed via this portal: Amyotrophic Lateral \ + Sclerosis Knowledge Portal. Year Month Date of access; URL of page you are citing. Also, please cite Farhan et al., 2018 \ + BioRxiv: https://www.biorxiv.org/content/10.1101/307835v2. +informational.als.FAQ.title2=Technical: +informational.als.FAQ.question3=What types of data are in the ALS Knowledge Portal? +informational.als.FAQ.answer3=Exome data from 3,864 ALS cases and 7,839 ethnically matched non-ALS controls. We also display \ + frequencies for each variant from gnomAD. +informational.als.FAQ.question4=What is the ethnicity of samples? +informational.als.FAQ.answer4=All samples were reported as Caucasian and this was confirmed by PCA. +informational.als.FAQ.question5=Which genome assembly does ALS Knowledge Portal use as a reference? +informational.als.FAQ.answer5=GRCh37/hg19 +informational.als.FAQ.question6=If you used exome sequencing, why are there intronic variants? +informational.als.FAQ.answer6=In addition to exons, regions from adjacent introns may be covered \ + in whole exome sequencing. These regions have been included in the ALSKP because they may impact protein expression (e.g., splice sites). +informational.als.FAQ.question7=How do I report a data error or bug in the database? +informational.als.FAQ.answer7=We welcome your feedback! Please contact us at help@alskp.org. +informational.als.FAQ.question8=I have more questions that are not listed here, who should I contact? +informational.als.FAQ.answer8=Please contact Sali Farhan: sfarhan@broadinstitute.org. +informational.als.FAQ.resources.title=Additional resources: +informational.als.FAQ.resources=Hail
    \ + Project MinE
    ALS Variant Server
    \ + HEX
    gnomAD
    \ + GTEx
    ClinVar
    \ + Neale Lab
    Stanley Center
    Program in Medical and Population Genetics
    Center for Genomic Medicine + + + + + informational.dataSubmission.section1title=What kind of data do we need? informational.dataSubmission.section1=
  • Right now, we are ready to receive array, exome sequencing, and whole-genome sequencing data.\
  • We are interested in incorporating both summary statistics and individual-level data.
  • In the future, we will be ready to \ @@ -2226,7 +2257,7 @@ informational.about_ALSData.header=Data in the ALS Knowledge Portal informational.about_sleep.section1=Details about data contributors and consortia will go here. informational.about_ALS.header=About the ALS Knowledge Portal project informational.about_ALSData.header=Data in the ALS Knowledge Portal -informational.about_ALSData.section0.5=Data used in the ALS Knowledge Portal were analyzed by Sali Farhan in the Neale \ +informational.about_ALSData.section0.5=Data used in the ALS Knowledge Portal were analyzed by the Neale \ lab. For details about quality control, please visit: Farhan et al., 2018 BioRxiv: https://www.biorxiv.org/content/10.1101/307835v2. Sali Farhan was supported by the ALS Canada Tim E. Noël Postdoctoral Fellowship. informational.about_ALSData.section1=Data in the ALS Knowledge Portal were collected from the Familial ALS (FALS) Consortium and the ALS Genetics (ALSGENS) Consortium. From d446b0b5fa7d6923826b7c962d6fdb3d5172f9ab Mon Sep 17 00:00:00 2001 From: mariacos Date: Wed, 30 Jan 2019 12:11:26 -0500 Subject: [PATCH 082/102] adding link to FAQ page --- grails-app/i18n/portalHome.properties | 3 ++- 1 file changed, 2 insertions(+), 1 deletion(-) diff --git a/grails-app/i18n/portalHome.properties b/grails-app/i18n/portalHome.properties index f84596d90..324f12d0a 100755 --- a/grails-app/i18n/portalHome.properties +++ b/grails-app/i18n/portalHome.properties @@ -136,4 +136,5 @@ portal.sleep.about.the.data.text=The Sleep Disorder Knowledge Portal enables bro portal.sleep.use.citation.itself= Sleep Disorder Knowledge Portal. Year Month Date of access; URL of page you are citing. Also cite any paper(s) in which the data were published. portal.ALS.about.the.data.text=The ALS Knowledge Portal enables browsing, searching, and analysis of human genetic information linked to amyotrophic lateral sclerosis and related traits, while protecting the integrity and confidentiality of the underlying data. portal.als.use.citation.itself=Amyotrophic Lateral Sclerosis Knowledge Portal. Year Month Date of access; URL of page you are citing. \ - Also, please cite Farhan et al., 2018 BioRxiv: https://www.biorxiv.org/content/10.1101/307835v2. \ No newline at end of file + Also, please cite Farhan et al., 2018 BioRxiv: https://www.biorxiv.org/content/10.1101/307835v2. +portal.als.header.nav.faq=FAQ \ No newline at end of file From b3dd63d346d76b46f1ce8f7a96037c5a001c5bca Mon Sep 17 00:00:00 2001 From: mariacos Date: Wed, 30 Jan 2019 12:11:55 -0500 Subject: [PATCH 083/102] editing ALSKP FAQ page --- grails-app/views/informational/alskpfaq.gsp | 54 ++++++++++----------- 1 file changed, 27 insertions(+), 27 deletions(-) diff --git a/grails-app/views/informational/alskpfaq.gsp b/grails-app/views/informational/alskpfaq.gsp index a5054969e..9593937f2 100644 --- a/grails-app/views/informational/alskpfaq.gsp +++ b/grails-app/views/informational/alskpfaq.gsp @@ -26,41 +26,41 @@

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