Author: Arya Bakhtiar
The contents of this repository represent a curated selection of our files, specifically tailored for public research purposes. Please note that this collection encompasses only a fraction of our comprehensive archive. All data files are protected under HIPAA and UCSF patient data policy. Please reach out for more inquiry regarding the project.
Last update: January 2020
The inhibition of glutathione, a buffer which maintains redox balance in neural cells, has recently been implicated as part of the pathology of multiple sclerosis (MS), a chronic and debilitating neurological disease. Magnetic resonance spectroscopy is a non-invasive technique which can quantitatively measure glutathione, amongst other metabolites, in the brain using the semi-localized by adiabatic selective refocusing sequence (SLASER) and J-Difference Editing (JDE). This proposal aims to apply this technique to image the concentration of various metabolites implicated in the regulation of redox potentials in the central nervous system on the NAC study cohort at UCSF. After development of an automatic quantification technique for metabolite concentrations, spatial localization of metabolite concentrations will then be computed. Further analysis, such as concentration GABA as a function of distance from MS lesions, may yield novel insights into the progression of multiple sclerosis. Furthermore, metabolite abnormalities will be evaluated on their potential as diagnostically relevant biomarkers.
Distributed under the License. See LICENSE for more information.
Below is an image of the software for measuring specific metabolites based on input subject files.
