diff --git a/.api-reports/api-report-core.md b/.api-reports/api-report-core.md
index 935e04317d7..119bc538d4e 100644
--- a/.api-reports/api-report-core.md
+++ b/.api-reports/api-report-core.md
@@ -601,6 +601,8 @@ export class DocumentTransform {
     // (undocumented)
     static identity(): DocumentTransform;
     // (undocumented)
+    resetCache(): void;
+    // (undocumented)
     static split(predicate: (document: DocumentNode) => boolean, left: DocumentTransform, right?: DocumentTransform): DocumentTransform;
     // (undocumented)
     transformDocument(document: DocumentNode): DocumentNode;
diff --git a/.api-reports/api-report-react.md b/.api-reports/api-report-react.md
index ceee7f54aac..d7a73cbefd3 100644
--- a/.api-reports/api-report-react.md
+++ b/.api-reports/api-report-react.md
@@ -728,6 +728,8 @@ class DocumentTransform {
     // (undocumented)
     static identity(): DocumentTransform;
     // (undocumented)
+    resetCache(): void;
+    // (undocumented)
     static split(predicate: (document: DocumentNode) => boolean, left: DocumentTransform, right?: DocumentTransform): DocumentTransform;
     // (undocumented)
     transformDocument(document: DocumentNode): DocumentNode;
@@ -2221,7 +2223,7 @@ interface WatchQueryOptions<TVariables extends OperationVariables = OperationVar
 // src/core/watchQueryOptions.ts:191:3 - (ae-forgotten-export) The symbol "UpdateQueryFn" needs to be exported by the entry point index.d.ts
 // src/react/hooks/useBackgroundQuery.ts:24:3 - (ae-forgotten-export) The symbol "FetchMoreFunction" needs to be exported by the entry point index.d.ts
 // src/react/hooks/useBackgroundQuery.ts:25:3 - (ae-forgotten-export) The symbol "RefetchFunction" needs to be exported by the entry point index.d.ts
-// src/utilities/graphql/DocumentTransform.ts:122:7 - (ae-forgotten-export) The symbol "DocumentTransformCacheKey" needs to be exported by the entry point index.d.ts
+// src/utilities/graphql/DocumentTransform.ts:130:7 - (ae-forgotten-export) The symbol "DocumentTransformCacheKey" needs to be exported by the entry point index.d.ts
 
 // (No @packageDocumentation comment for this package)
 
diff --git a/.api-reports/api-report-react_components.md b/.api-reports/api-report-react_components.md
index ab9ab7432fb..f55534f61a1 100644
--- a/.api-reports/api-report-react_components.md
+++ b/.api-reports/api-report-react_components.md
@@ -635,6 +635,8 @@ class DocumentTransform {
     // (undocumented)
     static identity(): DocumentTransform;
     // (undocumented)
+    resetCache(): void;
+    // (undocumented)
     static split(predicate: (document: DocumentNode) => boolean, left: DocumentTransform, right?: DocumentTransform): DocumentTransform;
     // (undocumented)
     transformDocument(document: DocumentNode): DocumentNode;
@@ -1753,7 +1755,7 @@ interface WatchQueryOptions<TVariables extends OperationVariables = OperationVar
 // src/core/types.ts:178:3 - (ae-forgotten-export) The symbol "MutationQueryReducer" needs to be exported by the entry point index.d.ts
 // src/core/types.ts:205:5 - (ae-forgotten-export) The symbol "Resolver" needs to be exported by the entry point index.d.ts
 // src/core/watchQueryOptions.ts:191:3 - (ae-forgotten-export) The symbol "UpdateQueryFn" needs to be exported by the entry point index.d.ts
-// src/utilities/graphql/DocumentTransform.ts:122:7 - (ae-forgotten-export) The symbol "DocumentTransformCacheKey" needs to be exported by the entry point index.d.ts
+// src/utilities/graphql/DocumentTransform.ts:130:7 - (ae-forgotten-export) The symbol "DocumentTransformCacheKey" needs to be exported by the entry point index.d.ts
 
 // (No @packageDocumentation comment for this package)
 
diff --git a/.api-reports/api-report-react_context.md b/.api-reports/api-report-react_context.md
index 949a46e67e6..60b50cd6d1b 100644
--- a/.api-reports/api-report-react_context.md
+++ b/.api-reports/api-report-react_context.md
@@ -618,6 +618,8 @@ class DocumentTransform {
     // (undocumented)
     static identity(): DocumentTransform;
     // (undocumented)
+    resetCache(): void;
+    // (undocumented)
     static split(predicate: (document: DocumentNode) => boolean, left: DocumentTransform, right?: DocumentTransform): DocumentTransform;
     // (undocumented)
     transformDocument(document: DocumentNode): DocumentNode;
@@ -1649,7 +1651,7 @@ interface WatchQueryOptions<TVariables extends OperationVariables = OperationVar
 // src/core/types.ts:178:3 - (ae-forgotten-export) The symbol "MutationQueryReducer" needs to be exported by the entry point index.d.ts
 // src/core/types.ts:205:5 - (ae-forgotten-export) The symbol "Resolver" needs to be exported by the entry point index.d.ts
 // src/core/watchQueryOptions.ts:191:3 - (ae-forgotten-export) The symbol "UpdateQueryFn" needs to be exported by the entry point index.d.ts
-// src/utilities/graphql/DocumentTransform.ts:122:7 - (ae-forgotten-export) The symbol "DocumentTransformCacheKey" needs to be exported by the entry point index.d.ts
+// src/utilities/graphql/DocumentTransform.ts:130:7 - (ae-forgotten-export) The symbol "DocumentTransformCacheKey" needs to be exported by the entry point index.d.ts
 
 // (No @packageDocumentation comment for this package)
 
diff --git a/.api-reports/api-report-react_hoc.md b/.api-reports/api-report-react_hoc.md
index bf4d99a6b7b..f7c631ffc7c 100644
--- a/.api-reports/api-report-react_hoc.md
+++ b/.api-reports/api-report-react_hoc.md
@@ -620,6 +620,8 @@ class DocumentTransform {
     // (undocumented)
     static identity(): DocumentTransform;
     // (undocumented)
+    resetCache(): void;
+    // (undocumented)
     static split(predicate: (document: DocumentNode) => boolean, left: DocumentTransform, right?: DocumentTransform): DocumentTransform;
     // (undocumented)
     transformDocument(document: DocumentNode): DocumentNode;
@@ -1694,7 +1696,7 @@ export function withSubscription<TProps extends TGraphQLVariables | {} = {}, TDa
 // src/core/types.ts:178:3 - (ae-forgotten-export) The symbol "MutationQueryReducer" needs to be exported by the entry point index.d.ts
 // src/core/types.ts:205:5 - (ae-forgotten-export) The symbol "Resolver" needs to be exported by the entry point index.d.ts
 // src/core/watchQueryOptions.ts:191:3 - (ae-forgotten-export) The symbol "UpdateQueryFn" needs to be exported by the entry point index.d.ts
-// src/utilities/graphql/DocumentTransform.ts:122:7 - (ae-forgotten-export) The symbol "DocumentTransformCacheKey" needs to be exported by the entry point index.d.ts
+// src/utilities/graphql/DocumentTransform.ts:130:7 - (ae-forgotten-export) The symbol "DocumentTransformCacheKey" needs to be exported by the entry point index.d.ts
 
 // (No @packageDocumentation comment for this package)
 
diff --git a/.api-reports/api-report-react_hooks.md b/.api-reports/api-report-react_hooks.md
index cc90b7ced12..f5909f15f50 100644
--- a/.api-reports/api-report-react_hooks.md
+++ b/.api-reports/api-report-react_hooks.md
@@ -699,6 +699,8 @@ class DocumentTransform {
     // (undocumented)
     static identity(): DocumentTransform;
     // (undocumented)
+    resetCache(): void;
+    // (undocumented)
     static split(predicate: (document: DocumentNode) => boolean, left: DocumentTransform, right?: DocumentTransform): DocumentTransform;
     // (undocumented)
     transformDocument(document: DocumentNode): DocumentNode;
@@ -2115,7 +2117,7 @@ interface WatchQueryOptions<TVariables extends OperationVariables = OperationVar
 // src/core/watchQueryOptions.ts:191:3 - (ae-forgotten-export) The symbol "UpdateQueryFn" needs to be exported by the entry point index.d.ts
 // src/react/hooks/useBackgroundQuery.ts:24:3 - (ae-forgotten-export) The symbol "FetchMoreFunction" needs to be exported by the entry point index.d.ts
 // src/react/hooks/useBackgroundQuery.ts:25:3 - (ae-forgotten-export) The symbol "RefetchFunction" needs to be exported by the entry point index.d.ts
-// src/utilities/graphql/DocumentTransform.ts:122:7 - (ae-forgotten-export) The symbol "DocumentTransformCacheKey" needs to be exported by the entry point index.d.ts
+// src/utilities/graphql/DocumentTransform.ts:130:7 - (ae-forgotten-export) The symbol "DocumentTransformCacheKey" needs to be exported by the entry point index.d.ts
 
 // (No @packageDocumentation comment for this package)
 
diff --git a/.api-reports/api-report-react_ssr.md b/.api-reports/api-report-react_ssr.md
index 9f6a2cdaf8e..7b892850871 100644
--- a/.api-reports/api-report-react_ssr.md
+++ b/.api-reports/api-report-react_ssr.md
@@ -588,6 +588,8 @@ class DocumentTransform {
     // (undocumented)
     static identity(): DocumentTransform;
     // (undocumented)
+    resetCache(): void;
+    // (undocumented)
     static split(predicate: (document: DocumentNode) => boolean, left: DocumentTransform, right?: DocumentTransform): DocumentTransform;
     // (undocumented)
     transformDocument(document: DocumentNode): DocumentNode;
@@ -1635,7 +1637,7 @@ interface WatchQueryOptions<TVariables extends OperationVariables = OperationVar
 // src/core/types.ts:178:3 - (ae-forgotten-export) The symbol "MutationQueryReducer" needs to be exported by the entry point index.d.ts
 // src/core/types.ts:205:5 - (ae-forgotten-export) The symbol "Resolver" needs to be exported by the entry point index.d.ts
 // src/core/watchQueryOptions.ts:191:3 - (ae-forgotten-export) The symbol "UpdateQueryFn" needs to be exported by the entry point index.d.ts
-// src/utilities/graphql/DocumentTransform.ts:122:7 - (ae-forgotten-export) The symbol "DocumentTransformCacheKey" needs to be exported by the entry point index.d.ts
+// src/utilities/graphql/DocumentTransform.ts:130:7 - (ae-forgotten-export) The symbol "DocumentTransformCacheKey" needs to be exported by the entry point index.d.ts
 
 // (No @packageDocumentation comment for this package)
 
diff --git a/.api-reports/api-report-testing.md b/.api-reports/api-report-testing.md
index bf0c8a517dc..b4e7b99862a 100644
--- a/.api-reports/api-report-testing.md
+++ b/.api-reports/api-report-testing.md
@@ -582,6 +582,8 @@ class DocumentTransform {
     // (undocumented)
     static identity(): DocumentTransform;
     // (undocumented)
+    resetCache(): void;
+    // (undocumented)
     static split(predicate: (document: DocumentNode) => boolean, left: DocumentTransform, right?: DocumentTransform): DocumentTransform;
     // (undocumented)
     transformDocument(document: DocumentNode): DocumentNode;
@@ -1698,7 +1700,7 @@ export function withWarningSpy<TArgs extends any[], TResult>(it: (...args: TArgs
 // src/core/types.ts:178:3 - (ae-forgotten-export) The symbol "MutationQueryReducer" needs to be exported by the entry point index.d.ts
 // src/core/types.ts:205:5 - (ae-forgotten-export) The symbol "Resolver" needs to be exported by the entry point index.d.ts
 // src/core/watchQueryOptions.ts:191:3 - (ae-forgotten-export) The symbol "UpdateQueryFn" needs to be exported by the entry point index.d.ts
-// src/utilities/graphql/DocumentTransform.ts:122:7 - (ae-forgotten-export) The symbol "DocumentTransformCacheKey" needs to be exported by the entry point index.d.ts
+// src/utilities/graphql/DocumentTransform.ts:130:7 - (ae-forgotten-export) The symbol "DocumentTransformCacheKey" needs to be exported by the entry point index.d.ts
 
 // (No @packageDocumentation comment for this package)
 
diff --git a/.api-reports/api-report-testing_core.md b/.api-reports/api-report-testing_core.md
index c4ee5f52cf0..db8ba43820e 100644
--- a/.api-reports/api-report-testing_core.md
+++ b/.api-reports/api-report-testing_core.md
@@ -581,6 +581,8 @@ class DocumentTransform {
     // (undocumented)
     static identity(): DocumentTransform;
     // (undocumented)
+    resetCache(): void;
+    // (undocumented)
     static split(predicate: (document: DocumentNode) => boolean, left: DocumentTransform, right?: DocumentTransform): DocumentTransform;
     // (undocumented)
     transformDocument(document: DocumentNode): DocumentNode;
@@ -1654,7 +1656,7 @@ export function withWarningSpy<TArgs extends any[], TResult>(it: (...args: TArgs
 // src/core/types.ts:178:3 - (ae-forgotten-export) The symbol "MutationQueryReducer" needs to be exported by the entry point index.d.ts
 // src/core/types.ts:205:5 - (ae-forgotten-export) The symbol "Resolver" needs to be exported by the entry point index.d.ts
 // src/core/watchQueryOptions.ts:191:3 - (ae-forgotten-export) The symbol "UpdateQueryFn" needs to be exported by the entry point index.d.ts
-// src/utilities/graphql/DocumentTransform.ts:122:7 - (ae-forgotten-export) The symbol "DocumentTransformCacheKey" needs to be exported by the entry point index.d.ts
+// src/utilities/graphql/DocumentTransform.ts:130:7 - (ae-forgotten-export) The symbol "DocumentTransformCacheKey" needs to be exported by the entry point index.d.ts
 
 // (No @packageDocumentation comment for this package)
 
diff --git a/.api-reports/api-report-utilities.md b/.api-reports/api-report-utilities.md
index 4661d99d1f3..db99ac83b43 100644
--- a/.api-reports/api-report-utilities.md
+++ b/.api-reports/api-report-utilities.md
@@ -759,6 +759,8 @@ export class DocumentTransform {
     // (undocumented)
     static identity(): DocumentTransform;
     // (undocumented)
+    resetCache(): void;
+    // (undocumented)
     static split(predicate: (document: DocumentNode) => boolean, left: DocumentTransform, right?: DocumentTransform): DocumentTransform;
     // (undocumented)
     transformDocument(document: DocumentNode): DocumentNode;
diff --git a/.api-reports/api-report.md b/.api-reports/api-report.md
index a9d2cce7e79..174182d1f2c 100644
--- a/.api-reports/api-report.md
+++ b/.api-reports/api-report.md
@@ -751,6 +751,8 @@ export class DocumentTransform {
     // (undocumented)
     static identity(): DocumentTransform;
     // (undocumented)
+    resetCache(): void;
+    // (undocumented)
     static split(predicate: (document: DocumentNode) => boolean, left: DocumentTransform, right?: DocumentTransform): DocumentTransform;
     // (undocumented)
     transformDocument(document: DocumentNode): DocumentNode;
diff --git a/.changeset/hot-ducks-burn.md b/.changeset/hot-ducks-burn.md
new file mode 100644
index 00000000000..c0f8ac1836c
--- /dev/null
+++ b/.changeset/hot-ducks-burn.md
@@ -0,0 +1,5 @@
+---
+"@apollo/client": patch
+---
+
+Add a `resetCache` method to `DocumentTransform` and hook `InMemoryCache.addTypenameTransform` up to `InMemoryCache.gc`
diff --git a/.size-limit.cjs b/.size-limit.cjs
index bd4497ec3a5..a15bd6aa160 100644
--- a/.size-limit.cjs
+++ b/.size-limit.cjs
@@ -1,7 +1,7 @@
 const checks = [
   {
     path: "dist/apollo-client.min.cjs",
-    limit: "38101",
+    limit: "38124",
   },
   {
     path: "dist/main.cjs",
@@ -10,7 +10,7 @@ const checks = [
   {
     path: "dist/index.js",
     import: "{ ApolloClient, InMemoryCache, HttpLink }",
-    limit: "32132",
+    limit: "32162",
   },
   ...[
     "ApolloProvider",
diff --git a/src/cache/inmemory/inMemoryCache.ts b/src/cache/inmemory/inMemoryCache.ts
index 3fe7ab56fdf..1297b6eeb19 100644
--- a/src/cache/inmemory/inMemoryCache.ts
+++ b/src/cache/inmemory/inMemoryCache.ts
@@ -295,6 +295,7 @@ export class InMemoryCache extends ApolloCache<NormalizedCacheObject> {
   }) {
     canonicalStringify.reset();
     print.reset();
+    this.addTypenameTransform.resetCache();
     const ids = this.optimisticData.gc();
     if (options && !this.txCount) {
       if (options.resetResultCache) {
diff --git a/src/utilities/graphql/DocumentTransform.ts b/src/utilities/graphql/DocumentTransform.ts
index 0a614df4190..d88bcf7615b 100644
--- a/src/utilities/graphql/DocumentTransform.ts
+++ b/src/utilities/graphql/DocumentTransform.ts
@@ -80,6 +80,14 @@ export class DocumentTransform {
     }
   }
 
+  /**
+   * Resets the internal cache of this transform, if it has one.
+   */
+  resetCache() {
+    this.stableCacheKeys =
+      this.stableCacheKeys && new Trie(canUseWeakMap, (key) => ({ key }));
+  }
+
   transformDocument(document: DocumentNode) {
     // If a user passes an already transformed result back to this function,
     // immediately return it.