diff --git a/sdks/python/apache_beam/runners/portability/prism_runner_test.py b/sdks/python/apache_beam/runners/portability/prism_runner_test.py
index 04a2dbd4faed..bc72d551f966 100644
--- a/sdks/python/apache_beam/runners/portability/prism_runner_test.py
+++ b/sdks/python/apache_beam/runners/portability/prism_runner_test.py
@@ -213,6 +213,24 @@ def test_expand_kafka_write(self):
   def test_sql(self):
     raise unittest.SkipTest("Requires an expansion service to execute.")
 
+  # The following tests require additional implementation in Prism.
+
+  def test_custom_merging_window(self):
+    raise unittest.SkipTest(
+        "Requires Prism to support Custom Window " +
+        "Coders, and Merging Custom Windows. " +
+        "https://github.com/apache/beam/issues/31921")
+
+  def test_custom_window_type(self):
+    raise unittest.SkipTest(
+        "Requires Prism to support Custom Window Coders." +
+        " https://github.com/apache/beam/issues/31921")
+
+  def test_pack_combiners(self):
+    raise unittest.SkipTest(
+        "Requires Prism to support coder:" +
+        " 'beam:coder:tuple:v1'. https://github.com/apache/beam/issues/32636")
+
 
 # Inherits all other tests.
 
diff --git a/sdks/python/pytest.ini b/sdks/python/pytest.ini
index b10acaac71cd..b62a44aa25e7 100644
--- a/sdks/python/pytest.ini
+++ b/sdks/python/pytest.ini
@@ -49,6 +49,7 @@ markers =
     sickbay_direct: run without sickbay-direct
     sickbay_spark: run without sickbay-spark
     sickbay_flink: run without sickbay-flink
+    sickbay_prism: run without sickbay-prism
     sickbay_dataflow: run without sickbay-dataflow
     # Tests using this marker conflict with the xdist plugin in some way, such
     # as enabling save_main_session.
diff --git a/sdks/python/test-suites/gradle.properties b/sdks/python/test-suites/gradle.properties
index f8c04e0f5609..d027cd3144d3 100644
--- a/sdks/python/test-suites/gradle.properties
+++ b/sdks/python/test-suites/gradle.properties
@@ -47,5 +47,10 @@ samza_validates_runner_postcommit_py_versions=3.9,3.12
 # spark runner test-suites
 spark_examples_postcommit_py_versions=3.9,3.12
 
+# prism runner test-suites
+prism_validates_runner_precommit_py_versions=3.12
+prism_validates_runner_postcommit_py_versions=3.9,3.12
+prism_examples_postcommit_py_versions=3.9,3.12
+
 # cross language postcommit python test suites
 cross_language_validates_py_versions=3.9,3.12
diff --git a/sdks/python/test-suites/portable/build.gradle b/sdks/python/test-suites/portable/build.gradle
index 390c39a10899..41cd88acfb6a 100644
--- a/sdks/python/test-suites/portable/build.gradle
+++ b/sdks/python/test-suites/portable/build.gradle
@@ -31,12 +31,31 @@ tasks.register("samzaValidatesRunner") {
   }
 }
 
+tasks.register("prismValidatesRunner") {
+  getVersionsAsList('prism_validates_runner_postcommit_py_versions').each {
+    dependsOn.add(":sdks:python:test-suites:portable:py${getVersionSuffix(it)}:prismValidatesRunner")
+  }
+}
+
 tasks.register("flinkValidatesRunnerPrecommit") {
   getVersionsAsList('flink_validates_runner_precommit_py_versions').each {
     dependsOn.add(":sdks:python:test-suites:portable:py${getVersionSuffix(it)}:flinkValidatesRunner")
   }
 }
 
+tasks.register("prismValidatesRunnerPrecommit") {
+  getVersionsAsList('prism_validates_runner_precommit_py_versions').each {
+    dependsOn.add(":sdks:python:test-suites:portable:py${getVersionSuffix(it)}:prismValidatesRunner")
+  }
+}
+
+// TODO merge with above once passing. Currently for convenience.
+tasks.register("prismTriggerTranscript") {
+  getVersionsAsList('prism_validates_runner_precommit_py_versions').each {
+    dependsOn.add(":sdks:python:test-suites:portable:py${getVersionSuffix(it)}:prismTriggerTranscript")
+  }
+}
+
 tasks.register("flinkExamplesPostCommit") {
   getVersionsAsList('flink_examples_postcommit_py_versions').each {
     dependsOn.add(":sdks:python:test-suites:portable:py${getVersionSuffix(it)}:flinkExamples")
@@ -48,3 +67,9 @@ tasks.register("sparkExamplesPostCommit") {
     dependsOn.add(":sdks:python:test-suites:portable:py${getVersionSuffix(it)}:sparkExamples")
   }
 }
+
+tasks.register("prismExamplesPostCommit") {
+  getVersionsAsList('prism_examples_postcommit_py_versions').each {
+    dependsOn.add(":sdks:python:test-suites:portable:py${getVersionSuffix(it)}:prismExamples")
+  }
+}
diff --git a/sdks/python/test-suites/portable/common.gradle b/sdks/python/test-suites/portable/common.gradle
index 4f232c5b104f..5fd1b182a471 100644
--- a/sdks/python/test-suites/portable/common.gradle
+++ b/sdks/python/test-suites/portable/common.gradle
@@ -201,6 +201,56 @@ tasks.register("sparkValidatesRunner") {
   dependsOn 'sparkCompatibilityMatrixLOOPBACK'
 }
 
+def createPrismRunnerTestTask(String workerType) {
+  def taskName = "prismCompatibilityMatrix${workerType}"
+
+  def prismBin = "${rootDir}/runners/prism/build/tmp/prism"
+  def options = "--prism_bin=${prismBin} --environment_type=${workerType}"
+  if (workerType == 'PROCESS') {
+    options += " --environment_options=process_command=${buildDir.absolutePath}/sdk_worker.sh"
+  }
+  def task = toxTask(taskName, 'prism-runner-test', options)
+  task.configure {
+    dependsOn ":runners:prism:build"
+    // The Java SDK worker is required to execute external transforms.
+    def suffix = getSupportedJavaVersion()
+    dependsOn ":sdks:java:container:${suffix}:docker"
+    if (workerType == 'DOCKER') {
+      dependsOn pythonContainerTask
+    } else if (workerType == 'PROCESS') {
+      dependsOn createProcessWorker
+    }
+  }
+  return task
+}
+
+createPrismRunnerTestTask('DOCKER')
+createPrismRunnerTestTask('PROCESS')
+createPrismRunnerTestTask('LOOPBACK')
+
+tasks.register("prismValidatesRunner") {
+  dependsOn 'prismCompatibilityMatrixLOOPBACK'
+}
+
+tasks.register("prismTriggerTranscript") {
+  dependsOn 'setupVirtualenv'
+  dependsOn ':runners:prism:build'
+  def prismBin = "${rootDir}/runners/prism/build/tmp/prism"
+  doLast {
+    exec {
+      executable 'sh'
+      args '-c', """
+          . ${envdir}/bin/activate \\
+          && cd ${pythonRootDir} \\
+          && pip install -e .[test] \\
+          && pytest \\
+              apache_beam/transforms/trigger_test.py::WeakTestStreamTranscriptTest \\
+              --test-pipeline-options='--runner=PrismRunner --environment_type=LOOPBACK --prism_location=${prismBin}'
+          """
+    }
+  }
+}
+
 project.tasks.register("preCommitPy${pythonVersionSuffix}") {
   dependsOn = [":sdks:python:container:py${pythonVersionSuffix}:docker",
                ":runners:flink:${latestFlinkVersion}:job-server:shadowJar",
@@ -283,6 +333,37 @@ project.tasks.register("sparkExamples") {
   }
 }
 
+project.tasks.register("prismExamples") {
+  dependsOn = [
+          'setupVirtualenv',
+          'installGcpTest',
+          ':runners:prism:build',
+  ] 
+  def prismBin = "${rootDir}/runners/prism/build/tmp/prism"
+  doLast {
+    def testOpts = [
+            "--log-cli-level=INFO",
+    ]
+    def pipelineOpts = [
+            "--runner=PrismRunner",
+            "--project=apache-beam-testing",
+            "--environment_type=LOOPBACK",
+            "--temp_location=gs://temp-storage-for-end-to-end-tests/temp-it",
+            "--prism_location=${prismBin}",
+    ]
+    def cmdArgs = mapToArgString([
+            "test_opts": testOpts,
+            "suite": "postCommitExamples-prism-py${pythonVersionSuffix}",
+            "pipeline_opts": pipelineOpts.join(" "),
+            "collect": "examples_postcommit and not sickbay_prism"
+    ])
+    exec {
+      executable 'sh'
+      args '-c', ". ${envdir}/bin/activate && ${pythonRootDir}/scripts/run_integration_test.sh $cmdArgs"
+    }
+  }
+}
+
 project.tasks.register("postCommitPy${pythonVersionSuffix}IT") {
   dependsOn = [
           'setupVirtualenv',
diff --git a/sdks/python/tox.ini b/sdks/python/tox.ini
index d733fd17fb6b..2dfe0670ed0f 100644
--- a/sdks/python/tox.ini
+++ b/sdks/python/tox.ini
@@ -285,6 +285,10 @@ extras = test
 commands =
   bash {toxinidir}/scripts/pytest_validates_runner.sh {envname} {toxinidir}/apache_beam/runners/portability/spark_runner_test.py {posargs}
 
+[testenv:prism-runner-test]
+extras = test
+commands =
+  bash {toxinidir}/scripts/pytest_validates_runner.sh {envname} {toxinidir}/apache_beam/runners/portability/prism_runner_test.py {posargs}
 
 [testenv:py{39,310}-pyarrow-{3,9,10,11,12,13,14,15,16}]
 deps =