diff --git a/tools/system_libs.py b/tools/system_libs.py
index e6bbf1c3435b1..7d8de1298bde1 100644
--- a/tools/system_libs.py
+++ b/tools/system_libs.py
@@ -765,6 +765,9 @@ def get_cflags(self):
     cflags = super().get_cflags()
     if not self.is_debug:
       cflags += ['-DNDEBUG']
+      # To make reproducible builds and the results of code size tests
+      # consistent, don't embed the actual __FILE__ paths in release builds.
+      cflags += ['-D__FILE__=""', '-Wno-builtin-macro-redefined']
     return cflags
 
   def get_base_name(self):