Comparison of Regions-Gene linkages from SCENIC+ vs ABC model

[Xieeeee]

Hi,
Thanks for this great tool! I just wonder whether you have done a comparison of the overlap between long range interactions calculated with Hi-C data (ABC model) vs the regions-gene linkage from scenic+? I found in the manuscript only the correlation of Hi-C across top100 genes.

The reason I asked is bc our lab is having the single cell multiome, Hi-C and H3K27ac data right now and we are deciding how to reconcile the differences between these two strategies. Any comments or input would be helpful.

Thanks,
Yang

[SeppeDeWinter]

Hi @Xieeeee

No, we have not done that comparison I'm afraid. We only did the comparisons shown in the manuscript.

Sorry I can not help you further.

All the best,

Seppe