diff --git a/ykman/pcsc/__init__.py b/ykman/pcsc/__init__.py
index 32b8738f..8dd0515d 100644
--- a/ykman/pcsc/__init__.py
+++ b/ykman/pcsc/__init__.py
@@ -41,6 +41,10 @@
 import subprocess  # nosec
 import logging
 
+import os
+import psutil
+import signal
+
 logger = logging.getLogger(__name__)
 
 
@@ -95,7 +99,7 @@ def _open_smartcard_connection(self) -> SmartCardConnection:
         try:
             return ScardSmartCardConnection(self.reader.createConnection())
         except CardConnectionException as e:
-            if kill_scdaemon():
+            if kill_scdaemon() or kill_yubikey_agent():
                 return ScardSmartCardConnection(self.reader.createConnection())
             raise e
 
@@ -152,6 +156,17 @@ def kill_scdaemon():
     return killed
 
 
+def kill_yubikey_agent():
+    killed = False
+    return_code = subprocess.call(["pkill", "-HUP", "yubikey-agent"])
+    if return_code == 0:
+        killed = True
+    if killed:
+        sleep(0.1)
+
+    return killed
+
+
 def list_readers():
     try:
         return System.readers()