GPR curation for Transport reactions (14)

[JHL-452b]

50 genes are discovered to be uncorrelated with their corresponding reactions in Transport reactions.

Gene	UniProtID	Reaction	GPR	Correlation	Manually check
ENSG00000103064	Q92536	MAR05818: isoleucine + Na+ + phenylalanine --> isoleucine + Na+ + phenylalanine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions primarily as an antiporter, exchanging cationic amino acids such as L-arginine with other neutral amino acids like L-leucine, L-glutamine, and isoleucine, in addition to sodium ions. The described catalytic activities also involve exchanges between L-arginine and various other amino acids. However, the provided reaction involves the exchange of isoleucine, Na+, and phenylalanine, which does not align with any activities attributed to this gene. Therefore, the gene's function does not match the specified reaction.	No
ENSG00000103064	Q92536	MAR05821: isoleucine + leucine + Na+ --> isoleucine + leucine + Na+	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions primarily as an antiporter, exchanging cationic amino acids such as L-arginine with neutral amino acids like L-leucine and L-glutamine, among others, often in a sodium-dependent manner. However, the reaction provided involves only isoleucine, leucine, and sodium ions without involving L-arginine or cationic and neutral amino acid exchange. Therefore, the gene's function does not align with the reaction described.	No
ENSG00000103064	Q92536	MAR05826: homoserine + isoleucine + Na+ --> homoserine + isoleucine + Na+	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The enzyme described in the provided gene annotation involves the exchange of various amino acids (like L-arginine, L-leucine, L-glutamine, L-lysine, etc.) and sodium ions. The specific reactions for which evidence is provided do not include homoserine. The gene's function is focused on cationic and neutral amino acids exchanges while the reaction provided involves homoserine, which is not mentioned as a substrate in the gene's catalytic activities. Therefore, there is no direct link between the gene and the provided reaction.	No
ENSG00000103064	Q92536	MAR05832: alanine + lysine + Na+ --> alanine + lysine + Na+	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a protein that functions as an antiporter involved in the exchange of L-arginine with other amino acids such as L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine, often in association with sodium ions. The annotated catalytic activities detail specific exchanges involving these amino acids and sodium ions. However, the provided reaction involves alanine and lysine in the presence of sodium ions, which does not match any of the described activities of the gene product. Therefore, based on the annotation, the gene is not related to the given reaction.	Yes
ENSG00000103064	Q92536	MAR05834: alanine + Na+ + ornithine --> alanine + Na+ + ornithine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes for a protein involved in the transport of cationic amino acids like L-arginine in exchange for neutral amino acids such as L-leucine, L-glutamine, and others, along with its interactions with sodium ions. The described catalytic activities specify the exchanges between L-arginine and various amino acids including L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine. However, the reaction provided involves alanine, Na+, and ornithine, which are not mentioned as substrates or products in any of the catalytic activities related to the gene ENSG00000103064. Therefore, there is no functional correlation or relevance between the gene and the reaction provided.	Yes
ENSG00000103064	Q92536	MAR05865: histidine + Na+ + tyrosine --> histidine + Na+ + tyrosine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a protein that primarily functions as an antiporter involved in the exchange of cationic amino acids (such as L-arginine) with neutral amino acids (like L-leucine, L-glutamine) and sodium ions. It mediates several specific amino acid exchanges as described in its catalytic activities. However, the provided reaction "histidine + Na+ + tyrosine --> histidine + Na+ + tyrosine" does not involve L-arginine or any of the described neutral amino acids, indicating that the gene¡¯s antiporter function is not related to the specified reaction.	Yes
ENSG00000103064	Q92536	MAR05870: cysteine + histidine + Na+ --> cysteine + histidine + Na+	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The provided gene ENSG00000103064 encodes a protein that functions as an antiporter, facilitating the exchange of cationic amino acids like L-arginine with neutral amino acids such as L-leucine in a sodium-dependent manner. However, the reaction in question is: cysteine + histidine + Na+ --> cysteine + histidine + Na+, which does not involve any cationic amino acids or the specific antiporter functions described for this gene. Therefore, the gene and the reaction are not related.	Yes
ENSG00000103064	Q92536	MAR05891: citrulline + Na+ + valine --> citrulline + Na+ + valine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064, according to its function and annotated catalytic activities, mainly facilitates the exchange of L-arginine with various other amino acids (such as L-leucine, L-lysine, L-glutamine, L-histidine, L-cysteine, and L-methionine) often in a sodium-dependent manner. The provided reaction involves citrulline and valine, which are not mentioned in the gene's annotated functionalities or reactions. Therefore, the gene does not participate in the cited reaction.	No
ENSG00000103064	Q92536	MAR05895: histidine + Na+ + threonine --> histidine + Na+ + threonine	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter facilitating the exchange of cationic and neutral amino acids, such as L-arginine with L-leucine, L-glutamine, and L-lysine among others, often involving sodium ions. However, the provided reaction only describes the interconversion of histidine and threonine along with sodium without involving the amino acids or the specific transport mechanism mentioned for the gene. Therefore, the gene's function and the reaction are not related.	Yes
ENSG00000103064	Q92536	MAR05897: homoserine + lysine + Na+ --> homoserine + lysine + Na+	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 is involved in the antiport exchange of cationic amino acids like L-arginine with neutral amino acids in the presence of sodium ions. The gene's described reactions primarily involve the exchange of L-arginine with various amino acids such as L-leucine, L-glutamine, L-cysteine, and sodium ions. The provided reaction, "homoserine + lysine + Na+ --> homoserine + lysine + Na+," does not match any of the documented functions or catalytic activities of this gene, confirming its irrelevance to the specified reaction.	Yes
ENSG00000103064	Q92536	MAR05901: citrulline + homoserine + Na+ --> citrulline + homoserine + Na+	ENSG00000103064	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064, encodes a protein that functions primarily as an antiporter for cationic and neutral amino acids such as L-arginine, L-leucine, and L-glutamine, among others, in exchange with sodium ions. However, the provided reaction, which involves citrulline, homoserine, and sodium ions, does not correspond to the known catalytic activities of the gene product stated in the text. The gene is involved in specific amino acid transport processes that do not include the substrates or the specific transformation described in the provided reaction.	No
ENSG00000021488	P82251	MAR05910: lysine + serine --> lysine + serine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 encodes a protein that functions as part of a transporter complex, facilitating the exchange of cationic and neutral amino acids with high affinity for specific substrates such as L-cystine and L-cysteine. The catalytic activities listed involve the exchange of L-arginine with other amino acids like L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. In contrast, the provided reaction is a simple interchange between lysine and serine, which does not align with the described activities of the transporter complex encoded by this gene. Therefore, the gene's function and known catalytic activities do not correspond to the reaction involving lysine and serine.	Yes
ENSG00000021488	P82251	MAR05916: leucine + lysine --> leucine + lysine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 is involved in the electrogenic exchange of cationic amino acids and neutral amino acids, including reactions involving L-arginine and various other amino acids (e.g., L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine). The provided reaction, leucine + lysine --> leucine + lysine, does not align with any of the specified catalytic activities of the gene product, which involve the exchange between different amino acids rather than the conversion within the same amino acids. Therefore, the gene is not relevant to the provided reaction.	Yes
ENSG00000021488	P82251	MAR05918: asparagine + lysine --> asparagine + lysine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 is involved in the transport and exchange of various cationic and neutral amino acids such as L-arginine, L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. However, the provided reaction involves asparagine and lysine, which do not correspond to the catalytic activities listed for this gene. Therefore, the gene is not relevant to the reaction involving asparagine and lysine.	Yes
ENSG00000021488	P82251	MAR05919: lysine + valine --> lysine + valine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 encodes a protein that functions as a transporter for cationic and neutral amino acids with specific catalytic activities involving the exchange of L-arginine with other amino acids such as L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. However, the provided reaction is lysine + valine --> lysine + valine, which does not involve the specific amino acid exchanges mediated by the gene's protein product. Therefore, the gene is not relevant to the given reaction.	Yes
ENSG00000103064	Q92536	MAR05920: lysine + threonine --> lysine + threonine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes for a protein that functions as an antiporter, exchanging cationic and neutral amino acids such as L-arginine, L-leucine, L-glutamine, and L-lysine, often in a sodium-dependent manner. The described catalysis involves specific exchanges, notably with L-arginine and various other amino acids, but does not describe a direct involvement in a reaction between lysine and threonine. Hence, based on the annotation, the gene and the provided reaction are not related.	Yes
ENSG00000021488	P82251	MAR05937: arginine + homoserine --> arginine + homoserine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000021488 encodes a protein that functions as a transporter for cationic and neutral amino acids, mediating their exchange with a stoichiometry of 1:1. The annotated catalytic activities involve exchanges between L-arginine and other amino acids like L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. However, the provided reaction involves the interaction between arginine and homoserine, which is not mentioned as part of the gene's functional or catalytic activities. Therefore, the gene does not pertain to the reaction given.	Yes
ENSG00000021488	P82251	MAR05939: glycine + ornithine --> glycine + ornithine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000021488 encodes a transporter involved in the electrogenic exchange of cationic amino acids and neutral amino acids, such as L-arginine, L-leucine, L-histidine, L-phenylalanine, L-cysteine, and L-cystine. The provided reaction involves glycine and ornithine, which are not substrates or products associated with the transporter activity of the gene. Therefore, the gene is not related to the reaction.	Yes
ENSG00000021488	P82251	MAR05953: homoserine + ornithine --> homoserine + ornithine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000021488 is associated with the transport of cationic and neutral amino acids, mediating exchanges such as L-arginine with L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. However, the reaction provided, homoserine + ornithine --> homoserine + ornithine, does not involve any of the specific amino acid exchanges that involve cationic and neutral amino acids as described in the gene's function and catalytic activities. Therefore, the gene ENSG00000021488 does not appear to be related to the provided reaction.	Yes
ENSG00000021488	P82251	MAR05956: alanine + histidine --> alanine + histidine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 is involved in the electrogenic exchange of cationic and neutral amino acids, specifically L-arginine with L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. The reaction provided, alanine + histidine --> alanine + histidine, does not involve any of these amino acids nor does it align with the gene's catalytic activities specified in the function and catalytic activity descriptions. Therefore, the gene and the reaction are not related.	Yes
ENSG00000103064	Q92536	MAR05961: histidine + phenylalanine --> histidine + phenylalanine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions primarily as an antiporter involved in the exchange of cationic and neutral amino acids such as L-arginine, L-lysine, L-leucine, L-glutamine, and others, often in the presence of sodium ions. This description does not align with the reaction given, which involves the exchange between histidine and phenylalanine. Therefore, the function of the gene does not relate to the reaction of histidine and phenylalanine, making it irrelevant.	Yes
ENSG00000021488	P82251	MAR05963: cysteine + histidine --> cysteine + histidine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000021488 encodes a transporter that specifically mediates the exchange between certain cationic amino acids and neutral amino acids, such as L-arginine with L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. The provided reaction, cysteine + histidine --> cysteine + histidine, does not align with the gene's known catalytic activities or the specific substrate exchanges it facilitates. Therefore, the gene and the reaction are not related.	Yes
ENSG00000103064	Q92536	MAR05965: histidine + proline --> histidine + proline	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a transporter protein that functions as an antiporter, primarily involved in exchanging L-arginine with various amino acids such as L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine, either in a sodium-dependent or sodium-independent manner. It does not mediate the catalysis of the reaction histidine + proline --> histidine + proline. Therefore, the gene's function does not align with the provided reaction.	Yes
ENSG00000021488	P82251	MAR05972: alanine + citrulline --> alanine + citrulline	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000021488 encodes a protein that forms a functional transporter complex with SLC3A1, facilitating the exchange of various amino acids such as cationic amino acids and L-cystine with neutral amino acids. The catalytic activities described involve exchanges between amino acids like L-arginine, L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. However, the reaction provided ("alanine + citrulline --> alanine + citrulline") does not involve the amino acids specified in the gene's function or catalytic activity, nor does it describe an exchange process as outlined in the gene's annotated activities.	No
ENSG00000021488	P82251	MAR05973: citrulline + glutamine --> citrulline + glutamine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000021488 encodes a protein that functions as a transporter complex for the exchange of cationic amino acids and neutral amino acids. Specific catalytic activities include the exchange of L-arginine with L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. However, the reaction provided (citrulline + glutamine --> citrulline + glutamine) does not involve any of these substrates or transport activities, thus making the gene irrelevant to the given reaction.	No
ENSG00000103064	Q92536	MAR05976: citrulline + tryptophan --> citrulline + tryptophan	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter, exchanging various amino acids (like L-arginine, L-leucine, L-glutamine, etc.) across cell membranes, often in a sodium-dependent manner. However, the provided reaction involves citrulline and tryptophan, which are not listed among the substrates or products associated with the antiporter activities described for the gene. Therefore, the gene's function does not match the reaction provided.	No
ENSG00000021488	P82251	MAR05977: citrulline + phenylalanine --> citrulline + phenylalanine	ENSG00000021488 and ENSG00000103064 and ENSG00000138079	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000021488 encodes a transporter protein that mediates the exchange between cationic amino acids (such as L-arginine) and neutral amino acids (such as L-leucine) with a specific stoichiometry and substrate affinity. The reaction mentioned (citrulline + phenylalanine --> citrulline + phenylalanine) does not involve the transport of amino acids across the membrane but rather indicates a simple exchange or equilibrium of citrulline and phenylalanine, which does not align with the specific catalytic activities and physiological function of the gene product. Therefore, they are not related.	No
ENSG00000100156	O95907	MAR06005: acetoacetate + retinoate <=> acetoacetate + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The reaction mentioned involves acetoacetate and retinoate, whereas the gene ENSG00000100156 encodes for a probable proton-coupled L-lactate transporter, which is related to the transport of lactate and hydrogen ions. The functions and catalytic activities described for the gene do not involve acetoacetate or retinoate, indicating no relevance to the reaction provided.	No
ENSG00000108932	O15403	MAR06007: 2-hydroxybutyrate + pyruvate <=> 2-hydroxybutyrate + pyruvate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 encodes for a monocarboxylate transporter selective for taurine, facilitating the efflux or influx of taurine across the plasma membrane. The catalytic activity associated with the gene involves taurine transport, which is pH- and sodium-independent. However, the reaction provided involves the conversion between 2-hydroxybutyrate and pyruvate, which does not relate to taurine transport, thus making the gene irrelevant to the provided reaction.	No
ENSG00000141526	O15427	MAR06010: 2-hydroxybutyrate + propanoate <=> 2-hydroxybutyrate + propanoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 encodes for a proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate but does not participate in the reaction involving 2-hydroxybutyrate and propanoate. The annotated functions and catalytic activities of the gene do not mention any involvement with 2-hydroxybutyrate or propanoate, indicating that the gene and the reaction are unrelated.	No
ENSG00000141526	O15427	MAR06016: formate + pyruvate <=> formate + pyruvate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 encodes a proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate. The annotated catalytic activities involve the transport of (S)-lactate and pyruvate across membranes, facilitated by proton gradients. However, the reaction provided (formate + pyruvate <=> formate + pyruvate) does not involve the transmembrane transport of these monocarboxylates or protons, and it does not match the specific physiological directions or molecular activities associated with the gene's function.	No
ENSG00000108932	O15403	MAR06022: acetate + AKG <=> acetate + AKG	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 encodes a monocarboxylate transporter that specifically mediates the transport of taurine across the plasma membrane. This transport is pH- and sodium-independent and involves the exchange of taurine between the extracellular and intracellular environments. However, the provided reaction is the interconversion of acetate and AKG (alpha-ketoglutarate), which does not involve taurine and is therefore unrelated to the function of the gene's encoded protein.	No
ENSG00000141526	O15427	MAR06027: AKG + butyrate <=> AKG + butyrate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 encodes a protein involved in the proton-dependent transport of monocarboxylates such as L-lactate and pyruvate. Its catalytic activities include the exchange of L-lactate and protons across membranes and the transport of pyruvate in a proton-gradient-dependent manner, as evidenced by several PubMed studies. However, the provided reaction involves the exchange of alpha-ketoglutarate (AKG) and butyrate, which is not related to the transport functions of the gene product. Therefore, the gene is not relevant to the given reaction.	No
ENSG00000100156	O95907	MAR06029: (R)-3-hydroxybutanoate + AKG <=> (R)-3-hydroxybutanoate + AKG	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000100156 encodes a proton-coupled L-lactate transporter involved in transporting L-lactate and H(+) ions. The reaction provided involves (R)-3-hydroxybutanoate and alpha-ketoglutarate (AKG), which does not involve L-lactate or proton transport, making the gene unrelated to the reaction described.	No
ENSG00000155380	P53985	MAR06039: butyrate + formate <=> butyrate + formate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000155380 encodes a bidirectional proton-coupled monocarboxylate transporter involved in the transport and regulation of various monocarboxylates such as lactate, pyruvate, and acetate, as well as ketone bodies across the plasma membrane. The provided reaction involves butyrate and formate, which are not substrates relevant to the catalytic activity or functions described for this gene. Hence, there is no connection between the gene's annotated function and the provided reaction.	No
ENSG00000155380	P53985	MAR06040: formate + retinoate <=> formate + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000155380 encodes for a bidirectional proton-coupled monocarboxylate transporter that facilitates the rapid transport of various monocarboxylates such as lactate, pyruvate, acetate, and ketone bodies across the plasma membrane. The primary function pertains to maintaining intracellular pH and modulating cellular levels of lactate and pyruvate, particularly under conditions like a high-fat diet or muscle cell acidification. The specified reaction involving formate and retinoate does not align with this monocarboxylate transporter's known substrates or functions, indicating that the gene is not related to the reaction in question.	No
ENSG00000100156	O95907	MAR06043: butyrate + propanoate <=> butyrate + propanoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000100156 encodes a probable retinal pigment epithelium-specific proton-coupled L-lactate transporter, which facilitates the transport of lactate and H+ ions. The annotated catalytic activity involves the transport of (S)-lactate and H+ across membranes. In contrast, the reaction provided involves butyrate and propanoate, which are not substrates for the transporter encoded by this gene. Therefore, the gene and the reaction are not related.	No
ENSG00000108932	O15403	MAR06048: butyrate + L-lactate <=> butyrate + L-lactate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000108932 encodes a monocarboxylate transporter selective for taurine, facilitating the efflux or influx of taurine across the plasma membrane. Its function and catalytic activity specifically involve taurine transport, which is pH- and sodium-independent. The reaction given involves the exchange of butyrate and L-lactate, which is not related to taurine transport. Therefore, the gene and the provided reaction are unrelated.	No
ENSG00000118596	O60669	MAR06051: butyrate + retinoate <=> butyrate + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000118596 functions as a proton-coupled monocarboxylate symporter, catalyzing the rapid transport of specific monocarboxylates such as L-lactate, pyruvate, and various ketone bodies across the plasma membrane. The reaction provided involves butyrate and retinoate, which are not substrates relevant to the gene's known transport activities. Therefore, the gene is not related to the provided reaction.	No
ENSG00000108932	O15403	MAR06053: (R)-3-hydroxybutanoate + retinoate <=> (R)-3-hydroxybutanoate + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000108932 encodes a monocarboxylate transporter that is selective for taurine, facilitating its efflux or influx across the plasma membrane. The provided reaction, involving (R)-3-hydroxybutanoate and retinoate, does not pertain to taurine transport and thus is not related to the gene function.	No
ENSG00000141526	O15427	MAR06053: (R)-3-hydroxybutanoate + retinoate <=> (R)-3-hydroxybutanoate + retinoate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis: The gene ENSG00000141526 encodes a proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate, facilitating their translocation across the cell membrane. The specific reactions it catalyzes involve the exchange of L-lactate and protons or pyruvate and protons, as documented in various studies (PubMed:11101640, PubMed:23935841, PubMed:31719150). However, the provided reaction involves (R)-3-hydroxybutanoate and retinoate, which are not substrates or products relevant to the gene's annotated functions or catalytic activities. Therefore, the gene does not have a biological role in the specified reaction.	No
ENSG00000100156	O95907	MAR06054: (R)-3-hydroxybutanoate + 2-hydroxybutyrate <=> (R)-3-hydroxybutanoate + 2-hydroxybutyrate	ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. Based on the annotation, the gene ENSG00000100156 encodes a protein that functions as a retinal pigment epithelium-specific proton-coupled L-lactate transporter, facilitating the transport of lactate and H(+) ions. The provided reaction involves (R)-3-hydroxybutanoate and 2-hydroxybutyrate, which are different substrates from lactate. Therefore, the gene does not relate to the specified reaction.	No
ENSG00000084453	P46721	MAR06216: acetylcholine + GSH + HCO3- <=> acetylcholine + GSH + HCO3-	ENSG00000084453 and ENSG00000111700	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000084453 encodes a protein that functions as a Na(+)-independent transporter for a variety of organic anions but does not have any known function related to the reaction involving acetylcholine, GSH, and HCO3-. The listed catalytic activities and substrates (such as bile acids, steroid sulfates, thyroid hormones, prostaglandins, and neuropeptides) do not include acetylcholine or components of the specified reaction. Therefore, based on the annotated function and catalytic activities, the gene and the provided reaction are not related.	No
ENSG00000163082	Q8IWX5	MAR06512: FAD <=> FAD	ENSG00000039123 or ENSG00000054148 or ENSG00000063601 or ENSG00000067113 or ENSG00000072756 or ENSG00000087053 or ENSG00000126821 or ENSG00000139505 or ENSG00000141934 or ENSG00000162407 or ENSG00000163082	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000163082 encodes an enzyme with specific phosphohydrolase activity towards sphingoid base 1-phosphates, including dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P). It plays a role in sphingosine recycling and attenuating S1P signaling, among other functions. However, the reaction FAD <=> FAD is unrelated to the gene's annotated activities, which do not involve FAD or its interconversion. Therefore, the gene does not relate to the given reaction.	No
ENSG00000063601	Q13613	MAR06512: FAD <=> FAD	ENSG00000039123 or ENSG00000054148 or ENSG00000063601 or ENSG00000067113 or ENSG00000072756 or ENSG00000087053 or ENSG00000126821 or ENSG00000139505 or ENSG00000141934 or ENSG00000162407 or ENSG00000163082	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000063601 encodes a lipid phosphatase with high specificity for various forms of phosphatidylinositol phosphates and has several demonstrated catalytic activities involving these substrates. However, the reaction provided, which is a reversible conversion of FAD, does not involve any phosphatidylinositol phosphate substrates and is not related to the gene's specified lipid phosphatase activities. Therefore, the gene and the reaction are not related.	No
ENSG00000130304	Q6PCB7	MAR08946: lignocerate + Na+ --> lignocerate + Na+	ENSG00000113396 or ENSG00000130304 or ENSG00000143554 or ENSG00000167114	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000130304 is primarily involved in the transport and activation of long-chain and very-long-chain fatty acids by facilitating their import at the plasma membrane and catalyzing the ATP-dependent formation of fatty acyl-CoA. The described reactions in the gene¡¯s annotation include various fatty acids being transported and converted to their acyl-CoA derivatives. However, the reaction provided, "lignocerate + Na+ --> lignocerate + Na+," does not involve the transport, activation, or modification of fatty acids by ATP-dependent processes as described in the gene¡¯s function and catalytic activities. Therefore, the gene's described functions do not relate to the provided reaction.	No
ENSG00000196517	P48067	MAR09597: chloride + methionine + 2.0 Na+ --> chloride + methionine + 2.0 Na+	ENSG00000196517 or ENSG00000268104	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000196517 encodes a sodium- and chloride-dependent glycine transporter, which specifically functions to regulate glycine concentrations at inhibitory glycinergic synapses by transporting glycine along with sodium and chloride ions. The annotated catalytic activity involves the transport of glycine, chloride, and sodium ions. Conversely, the provided reaction involves methionine, which is not related to the transport function of the glycine transporter encoded by the gene ENSG00000196517. Therefore, the gene and the reaction are not related.	No
ENSG00000143797	Q6ZWT7	MAR00158: butyryl-CoA + L-carnitine <=> butyryl-CoA + L-carnitine	ENSG00000012660 or ENSG00000026652 or ENSG00000100344 or ENSG00000102125 or ENSG00000111684 or ENSG00000123684 or ENSG00000125505 or ENSG00000141446 or ENSG00000143797 or ENSG00000146648 or ENSG00000151093 or ENSG00000160216 or ENSG00000169359 or ENSG00000170522 or ENSG00000171320 or ENSG00000176454 or ENSG00000186792 or ENSG00000197977	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000143797 encodes an acyltransferase involved in the acylation of lysophospholipids and phospholipid remodeling pathways, specifically catalyzing reactions involving various acyl-CoA and lysophospholipid substrates. However, the provided reaction involves butyryl-CoA and L-carnitine, which does not match any of the catalytic activities of the acyltransferase encoded by this gene.	No
ENSG00000176454	Q643R3	MAR00158: butyryl-CoA + L-carnitine <=> butyryl-CoA + L-carnitine	ENSG00000012660 or ENSG00000026652 or ENSG00000100344 or ENSG00000102125 or ENSG00000111684 or ENSG00000123684 or ENSG00000125505 or ENSG00000141446 or ENSG00000143797 or ENSG00000146648 or ENSG00000151093 or ENSG00000160216 or ENSG00000169359 or ENSG00000170522 or ENSG00000171320 or ENSG00000176454 or ENSG00000186792 or ENSG00000197977	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene specified, ENSG00000176454, encodes a protein with acyl-CoA-dependent lysophospholipid acyltransferase activity involved in the conversion of various lysophospholipids to phospholipids. It shows specific catalytic activities with a variety of acyl-CoA and lysophospholipid substrates. However, the provided reaction involving butyryl-CoA and L-carnitine is not within the scope of the annotated activities for this gene. Therefore, the gene and the reaction are not related.	No
ENSG00000146648	P00533	MAR00158: butyryl-CoA + L-carnitine <=> butyryl-CoA + L-carnitine	ENSG00000012660 or ENSG00000026652 or ENSG00000100344 or ENSG00000102125 or ENSG00000111684 or ENSG00000123684 or ENSG00000125505 or ENSG00000141446 or ENSG00000143797 or ENSG00000146648 or ENSG00000151093 or ENSG00000160216 or ENSG00000169359 or ENSG00000170522 or ENSG00000171320 or ENSG00000176454 or ENSG00000186792 or ENSG00000197977	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000146648 encodes for a receptor tyrosine kinase that binds ligands of the EGF family and activates several signaling cascades related to cellular responses, including pathways like RAS-RAF-MEK-ERK, PI3 kinase-AKT, and others. Its catalytic activity involves phosphorylating tyrosine residues on proteins using ATP. However, the reaction provided, "butyryl-CoA + L-carnitine <=> butyryl-CoA + L-carnitine," is unrelated to tyrosine phosphorylation and involves a different biochemical process, specifically the transfer of acyl groups to carnitine. This indicates that the gene and the reaction are not linked.	No

[hhl-24]

All of these seem fine to me.