GPR curation for Glycosphingolipid metabolism and Glycosylphosphatidylinositol (GPI)-anchor biosynthesis (3)

[JHL-452b]

Current behavior:

25 genes are discovered to be uncorrelated with their corresponding reactions in Glycosphingolipid metabolism and Glycosylphosphatidylinositol (GPI)-anchor biosynthesis.

Gene	UniProtID	Reaction	GPR	Correlation	Manually check
ENSG00000179913	Q9Y2A9	MAR00924: D-galactosyl-N-acylsphingosine + UDP-galactose --> digalactosylceramide + H+ + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000179913 encodes a protein with Beta-1,3-N-acetylglucosaminyltransferase activity, involved in the synthesis of poly-N-acetyllactosamine and formation of sulfo sialyl Lewis x on extended core1 O-glycans through catalysis involving UDP-N-acetyl-alpha-D-glucosamine. However, the provided reaction involves the conversion of D-galactosyl-N-acylsphingosine and UDP-galactose to digalactosylceramide, which does not align with the described function and catalytic activities of this gene. Therefore, the gene is not related to the given reaction.	No
ENSG00000172728	Q6P4F1	MAR00924: D-galactosyl-N-acylsphingosine + UDP-galactose --> digalactosylceramide + H+ + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000172728 encodes for a protein that fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors, specifically catalyzing the transfer of a fucosyl moiety from GDP-beta-L-fucose. This function is distinct and unrelated to the reaction provided, which involves the conversion of D-galactosyl-N-acylsphingosine and UDP-galactose into digalactosylceramide, H+, and UDP. The gene's function does not align with the formation of digalactosylceramide from sphingosine and UDP-galactose, which involves a different substrate and reaction mechanism.	No
ENSG00000176597	Q9BYG0	MAR00924: D-galactosyl-N-acylsphingosine + UDP-galactose --> digalactosylceramide + H+ + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000176597 encodes for an enzyme that functions as a Beta-1,3-N-acetylglucosaminyltransferase, which is involved in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids. It catalyzes the transfer of N-acetylglucosamine to specific substrates such as lactosylceramide and neolactotetraosylceramide. However, the reaction provided involves the transfer of galactose to D-galactosyl-N-acylsphingosine, forming digalactosylceramide, which does not match the substrates or activity of the enzyme encoded by ENSG00000176597. Therefore, the gene is not relevant to the reaction provided.	No
ENSG00000177191	Q7Z7M8	MAR00925: D-galactosyl-N-acylsphingosine + UDP-galactose --> digalactosylceramide + H+ + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000177191 encodes for a Beta-1,3-N-acetylglucosaminyltransferase, which is involved in the elongation of specific branch structures of multiantennary N-glycans. Contrarily, the reaction detailed involves the transformation of D-galactosyl-N-acylsphingosine with UDP-galactose to produce digalactosylceramide, H+, and UDP. The gene's function does not pertain to this reaction as it does not involve ceramide synthesis or the utilization of UDP-galactose in the described manner.	No
ENSG00000170340	Q9NY97	MAR00925: D-galactosyl-N-acylsphingosine + UDP-galactose --> digalactosylceramide + H+ + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000170340 encodes an enzyme that functions as a Beta-1,3-N-acetylglucosaminyltransferase, which is involved in the synthesis of poly-N-acetyllactosamine. The enzyme catalyzes the initiation and elongation of poly-N-acetyllactosamine chains by transferring N-acetylglucosamine to specific galactosylated acceptors, as indicated in the provided annotation. However, the reaction described (D-galactosyl-N-acylsphingosine + UDP-galactose --> digalactosylceramide + H+ + UDP) involves the enzymatic activity of transferring galactose to form digalactosylceramide, which is not part of the poly-N-acetyllactosamine synthesis pathway. Therefore, the gene ENSG00000170340 is not relevant to the reaction provided.	No
ENSG00000139044	Q6L9W6	MAR00925: D-galactosyl-N-acylsphingosine + UDP-galactose --> digalactosylceramide + H+ + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000139044 encodes an enzyme that transfers N-acetylgalactosamine (GalNAc) to N-acetylglucosamine to form N,N'-diacetyllactosediamine structures in glycans. This activity is described by its catalytic role in a specific reaction where it uses UDP-GalNAc as a donor. However, the reaction provided involves D-galactosyl-N-acylsphingosine and UDP-galactose to produce digalactosylceramide and UDP. These substrates and products indicate a different enzymatic activity unrelated to the gene's known function, which involves glycan formation rather than ceramide modification. Therefore, the gene does not align with the described reaction.	No
ENSG00000060642	Q9NUD9	MAR00925: D-galactosyl-N-acylsphingosine + UDP-galactose --> digalactosylceramide + H+ + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000060642 codes for an alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis, specifically in transferring the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly. The reaction provided involves D-galactosyl-N-acylsphingosine and UDP-galactose, forming digalactosylceramide, H+, and UDP, which does not relate to the function or catalytic activity of alpha-1,6-mannosyltransferase. Therefore, the gene and the reaction are unrelated.	No
ENSG00000179913	Q9Y2A9	MAR00925: D-galactosyl-N-acylsphingosine + UDP-galactose --> digalactosylceramide + H+ + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000179913 encodes a Beta-1,3-N-acetylglucosaminyltransferase, which is involved in the synthesis of poly-N-acetyllactosamine. The catalytic activities described for this gene involve the transfer of N-acetylglucosamine to various protein-linked oligosaccharides and glycosaminyl derivatives. However, the provided reaction involves the formation of digalactosylceramide from D-galactosyl-N-acylsphingosine and UDP-galactose, which pertains to a different enzymatic activity and pathway not associated with the functions of the gene ENSG00000179913.	No
ENSG00000187676	Q6Y288	MAR00925: D-galactosyl-N-acylsphingosine + UDP-galactose --> digalactosylceramide + H+ + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000187676 encodes for an O-glucosyltransferase that specifically transfers glucose to fucose with a beta-1,3 linkage and glucosylates O-linked fucosylglycans on TSP type-1 domains of proteins. However, the reaction provided involves D-galactosyl-N-acylsphingosine and UDP-galactose to form digalactosylceramide, H+, and UDP, which is unrelated to the O-glucosyltransferase activity described for the gene.	No
ENSG00000147162	O15294	MAR00925: D-galactosyl-N-acylsphingosine + UDP-galactose --> digalactosylceramide + H+ + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The function of the gene ENSG00000147162 involves catalyzing the transfer of N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in proteins, glycosylating a diverse array of proteins to regulate cellular processes. However, the reaction provided involves the transfer of galactose to produce digalactosylceramide, which is not related to the glycosylation activities mediated by the gene ENSG00000147162. Therefore, the gene and the reaction are not related.	No
ENSG00000176597	Q9BYG0	MAR00925: D-galactosyl-N-acylsphingosine + UDP-galactose --> digalactosylceramide + H+ + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000176597 encodes for a Beta-1,3-N-acetylglucosaminyltransferase, which is involved in the synthesis of carbohydrate chains on glycolipids, specifically targeting lactosylceramide and neolactotetraosylceramide, resulting in compounds like Lc(3)Cer and nLc(5)Cer. However, the reaction provided involves the conversion of D-galactosyl-N-acylsphingosine and UDP-galactose into digalactosylceramide, a process not related to the gene's annotated function of adding N-acetylglucosamine into the glycolipid synthesis pathway.	No
ENSG00000143315	Q9H3S5	MAR00925: D-galactosyl-N-acylsphingosine + UDP-galactose --> digalactosylceramide + H+ + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000143315 has a function related to mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis, specifically transferring alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. The reaction described involves D-galactosyl-N-acylsphingosine and UDP-galactose converting to digalactosylceramide, H+, and UDP, which is related to galactosyltransferase activity, not mannosyltransferase activity. Therefore, the gene and the reaction are not related.	No
ENSG00000198488	Q6ZMB0	MAR00925: D-galactosyl-N-acylsphingosine + UDP-galactose --> digalactosylceramide + H+ + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000198488 encodes for Beta-1,3-N-acetylglucosaminyltransferase, which is involved in the synthesis of mucin-type O-glycans by transferring N-acetylglucosamine to certain protein substrates. It catalyzes specific reactions involving 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] or 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] and UDP-N-acetyl-alpha-D-glucosamine. However, the provided reaction involves D-galactosyl-N-acylsphingosine and UDP-galactose to produce digalactosylceramide, H+, and UDP, which does not match the catalytic activities annotated for the gene ENSG00000198488. Thus, the gene and the reaction are unrelated based on their differing substrates and products.	No
ENSG00000069943	Q92521	MAR00926: glucosylceramide pool + UDP-galactose --> H+ + LacCer pool + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000069943 encodes a mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis, specifically transferring alpha-1,2-mannose to Man2-GlcN-acyl-PI. The provided reaction involves the conversion of glucosylceramide and UDP-galactose to LacCer and UDP, which is unrelated to the gene's function in GPI-anchor biosynthesis. Therefore, the gene and the reaction are not related.	No
ENSG00000147162	O15294	MAR00926: glucosylceramide pool + UDP-galactose --> H+ + LacCer pool + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000147162 encodes a protein that functions as an N-acetylglucosaminyltransferase, catalyzing the transfer of N-acetylglucosamine to serine or threonine residues in proteins. The provided reaction involves the conversion of glucosylceramide and UDP-galactose into LacCer and UDP, which does not involve the addition of N-acetylglucosamine or protein modification processes described for the gene ENSG00000147162. Thus, the gene and the reaction are not related.	No
ENSG00000176597	Q9BYG0	MAR00926: glucosylceramide pool + UDP-galactose --> H+ + LacCer pool + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000176597 encodes an enzyme that primarily catalyzes the N-acetylglucosaminylation of lactosylceramide (LacCer) and neolactotetraosylceramide (nLc4Cer), which are specific reactions involved in the synthesis of lacto- or neolacto-series glycolipids. In contrast, the provided reaction involves the synthesis of lactosylceramide (LacCer) from glucosylceramide and UDP-galactose, which is a different enzymatic process involving galactosylation rather than N-acetylglucosaminylation. Therefore, the gene's annotated functions and catalytic activities do not match the reaction described.	No
ENSG00000138641	Q15034	MAR08379: PI pool + UDP-N-acetylglucosamine --> H+ + N-acetyl-D-glucosaminylphosphatidylinositol + UDP	(ENSG00000007541 and ENSG00000100564 and ENSG00000135845 and ENSG00000165195) or ENSG00000138641 or ENSG00000145337 or ENSG00000185808 or ENSG00000255072	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000138641 encodes an E3 ubiquitin-protein ligase, which transfers ubiquitin to targeted substrates. This function is related to the process of ubiquitination. In contrast, the provided reaction involves the transfer of N-acetylglucosamine to phosphatidylinositol, which is a glycosylation process unrelated to ubiquitination. Therefore, the gene's function does not correspond to the described reaction.	No
ENSG00000138641	Q15034	MAR07185: PI pool + UDP-N-acetylglucosamine --> H+ + N-acetyl-D-glucosaminylphosphatidylinositol + UDP	(ENSG00000007541 and ENSG00000100564 and ENSG00000135845 and ENSG00000165195) or ENSG00000138641 or ENSG00000145337 or ENSG00000185808 or ENSG00000255072	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000138641 encodes an E3 ubiquitin-protein ligase, which is involved in the ubiquitination process, facilitating the transfer of ubiquitin from an E2 enzyme to a substrate protein. The provided reaction, however, describes the biosynthesis of N-acetyl-D-glucosaminylphosphatidylinositol from UDP-N-acetylglucosamine and a PI pool, which is unrelated to the ubiquitination pathway. Therefore, the gene function does not align with the described biochemical reaction.	No
ENSG00000115850	P09848	MAR00830: GM1 + H2O --> galactose + GM2	ENSG00000115850 and ENSG00000163521 and ENSG00000170266 and ENSG00000188167	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000115850 encodes a broad specificity glycosidase that hydrolyzes lactose and other beta-glucosides and beta-galactopyranosides, such as lactose, phlorizin, cellobiose, quercetin glucosides, and glycosylceramides, to various sugars including beta-D-glucose and beta-D-galactose. However, the specific reaction GM1 + H2O --> galactose + GM2 is not among the reactions catalyzed by this gene's product, which focuses on different substrates and different types of glycosidic linkages. Therefore, the gene and the provided reaction are not related.	No
ENSG00000156413	P51993	MAR00873: G00040 + GDP + H+ <=> GDP-L-fucose + type I B glycolipid	ENSG00000130383 or ENSG00000156413 or ENSG00000171124	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000156413 encodes for an isoform that primarily catalyzes the transfer of L-fucose to N-acetyl glucosamine (GlcNAc) on glycoproteins and glycolipids, through an alpha-1,3 glycosidic linkage. It is involved in the formation of sialyl Lewis X, Lewis X, and related determinants. However, it does not have activity towards type 1 and H-type 1 chain acceptor substrates. The reaction provided involves GDP-L-fucose and type I B glycolipid, which is not a recognized substrate for the catalytic activities described for this gene. Therefore, the gene and the reaction are not related.	No
ENSG00000196371	P22083	MAR00924: D-galactosyl-N-acylsphingosine + UDP-galactose --> digalactosylceramide + H+ + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000196371 encodes for enzymes that catalyze the fucosylation of glycan structures, specifically the transfer of fucose from GDP-beta-L-fucose to N-acetyl glucosamine within various glycans. The annotated reactions involve the formation of Lewis X antigens and other fucosylated glycan derivatives. In contrast, the provided reaction describes the glycosylation involving the transfer of galactose from UDP-galactose to D-galactosyl-N-acylsphingosine to form digalactosylceramide. Since the annotated functions of the gene involve fucosylation and not galactosylation, it is not relevant to the provided reaction.	No
ENSG00000182272	Q76KP1	MAR00924: D-galactosyl-N-acylsphingosine + UDP-galactose --> digalactosylceramide + H+ + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000182272 encodes an enzyme that transfers N-acetylgalactosamine (GalNAc) to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage, forming N,N'-diacetyllactosediamine structures in N-linked and possibly O-linked glycans. The catalytic activity described involves the transfer of UDP-N-acetyl-alpha-D-galactosamine to an N-acetyl-beta-D-glucosaminyl derivative. However, the reaction provided involves D-galactosyl-N-acylsphingosine and UDP-galactose to form digalactosylceramide, which does not match the specific activity or substrates of the gene ENSG00000182272. Therefore, they are not related.	No
ENSG00000102595	Q9NYU1	MAR00925: D-galactosyl-N-acylsphingosine + UDP-galactose --> digalactosylceramide + H+ + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000102595 encodes a protein involved in recognizing glycoproteins with minor folding defects and reglucosylating single N-glycans to facilitate protein quality control in the endoplasmic reticulum. Its catalytic activity involves the reglucosylation of N-glycans on misfolded proteins, using UDP-alpha-D-glucose. On the other hand, the specific reaction described (D-galactosyl-N-acylsphingosine + UDP-galactose --> digalactosylceramide + H+ + UDP) is not related to this function and instead involves the synthesis of digalactosylceramide. The two processes are distinct and involve different substrates and enzymes, thus the gene is not relevant to the provided reaction.	No
ENSG00000177191	Q7Z7M8	MAR00926: glucosylceramide pool + UDP-galactose --> H+ + LacCer pool + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000177191 encodes a Beta-1,3-N-acetylglucosaminyltransferase that is involved in the elongation of N-glycans, specifically targeting tetraantennary and 2,6 triantennary structures. However, the reaction described involves the conversion of a glucosylceramide pool and UDP-galactose to LacCer pool and UDP, which suggests a different enzymatic function related to glycosphingolipid metabolism rather than N-glycan elongation. As a result, the gene and the reaction are not related.	No
ENSG00000054983	P54803	MAR00793: D-galactosyl-N-acylsphingosine + H2O --> ceramide pool + glucose	ENSG00000054983	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000054983 encodes an enzyme that hydrolyzes galactose ester bonds of glycolipids, specifically galactosylceramide and galactosylsphingosine, leading to the production of D-galactose and acyl-sphingoid bases. The given reaction results in the production of ceramide and glucose from D-galactosyl-N-acylsphingosine and water, which does not align with the described catalytic activities and products of the enzyme encoded by ENSG00000054983. Thus, the gene's function does not match the reaction outcomes.	Yes