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SBOL cannot express recursive structures #214

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bbartley opened this issue Jun 13, 2019 · 0 comments
Open

SBOL cannot express recursive structures #214

bbartley opened this issue Jun 13, 2019 · 0 comments
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@bbartley
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Hi, this is a little bit of an edge case, but a real one I have encountered, and also one that is philosophically interesting. The use case involved recursive nesting of recombinatorial logic in a way that controlled successive cell differentiation events. I don't know if anyone has ever actually implemented such a genetic circuit, or if real examples of recursive genetic logic exist in nature, but my scientific hunch is that recursive genetic logic could be a valid and interesting engineering approach in synthetic biology. However, we can't represent a recursive structure in SBOL without breaking validation rules. It would be interesting to explore this use case in discussions about SBOL 3.

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